Diagnosis and treatment of Von Hippel-Lindau syndrome: A case series.

The objective of the present case report was to explore the clinical approaches to diagnosing and managing Von Hippel-Lindau (VHL) syndrome. A retrospective review was performed on the clinical presentations, imaging findings and family genetic histories of four patients diagnosed with VHL syndrome. Their clinical features and treatment strategies were systematically analyzed.

Prospective analysis of quantitative EEG indices for predicting functional outcomes in acute ischemic stroke.

Objective: This study aims to assess the effectiveness of quantitative electroencephalography (qEEG) in determining the prognosis of acute ischemic stroke, thus offering a scientific foundation for early prognostic evaluation.

Methods: One hundred sixty-seven patients with acute ischemic stroke were admitted to the Neurology Department of Hebei Provincial People's Hospital between May 2022 and October 2023. All patients received standard treatments, including antiplatelet aggregation and lipid-lowering therapy to stabilize plaques.

Characterizing anterior and posterior circulation strokes using high-resolution magnetic resonance imaging.

Background And Purpose: High-resolution magnetic resonance imaging (HR-MRI) is increasingly used to assess intracranial atherosclerosis (ICAS). The risks for anterior circulation stroke (ACS) and posterior circulation stroke (PCS) differ, and understanding the factors influencing these differences is important for better clinical management. This study investigates the impact of clinical risk factors on ICAS features in ACS and PCS using HR-MRI, focusing on arterial remodeling patterns.

Cloning and Expression Analysis of (Autophagy-Related 8) Gene Family in Solanaceae.

The autophagy-related gene family (Autophagy-related 8) plays an important role in plant growth, development, and stress response. In this study, 15 gene family sequences were amplified from Solanaceae, namely tobacco, tomato, and pepper, using RT-PCR to evaluate their basic properties, protein structure, and function, as well as the role of in autophagy. The physicochemical properties, the predicted secondary and tertiary protein structures, subcellular localisation, gene structures, conserved motifs, and phylogenetic relationships of the genes were analysed using bioinformatic techniques, and their expression patterns under sericin-induced plant disease resistance were investigated by RT-qPCR.

Synchronous Double Primary Tumors of Liver (Small Cell Neuroendocrine Carcinoma and Hepatocellular carcinoma): A Case Report.

This study presents a case of dual primary liver cancer involving small cell neuroendocrine carcinoma and hepatocellular carcinoma. The 58-year-old Chinese male patient, who has a medical history of viral hepatitis B, presented with right upper abdominal pain persisting for one month. Imaging studies indicated the presence of multiple liver masses in segments V and VII-VIII, as well as a mass in the left lung.

The application of polysaccharide-based nanogels in peptides/proteins and anticancer drugs delivery.

Finding adequate carriers for proteins/peptides and anticancer drugs delivery has become an urgent need, owing to the growing number of therapeutic macromolecules and the increasing amount of cancer incidence. Polysaccharide-based nanogels have attracted interest as carriers for proteins/peptides and anticancer drugs because of their characteristic properties like biodegradability, biocompatibility, stimuli-responsive behaviour, softness and swelling to help achieve a controlled, triggered response at the target site. In addition, the groups of the polysaccharide backbone are able to be modified to develop functional nanogels.