Global, regional, and national burden and trends of eating disorders among women of childbearing age from 1990 to 2021: Insights from the global burden of disease study 2021.

Objective: Eating disorders (ED) pose a significant global health challenge for women of childbearing age (WCBA). This study aims to systematically evaluate the global disease burden and temporal trends of eating disorders in this vulnerable population.

Methods: This study utilized Global Burden of Diseases (GBD) data to assess the burden and trends in prevalence, incidence, and Disability-Adjusted Life Years (DALYs) rates of eating disorders, estimating percentage changes and annual percentage changes (EAPC).

Structural characterization and immune-modulating properties of a novel β-galactomannan extracted from black soybean hulls.

Galactomannan soluble in water (BBHW) was extracted from black soybean hulls through acid-assisted extraction and column chromatography and its immune-modulating capacity and features of the structure were elucidated. BBHW had an average molecular mass of 134,194 Da and was made up of mannose, galactose, glucose, and arabinose in a molar ratio of 1.40:1.

Metasurface-assisted multimodal quantum imaging.

Traditional quantum imaging is featured by remarkable sensitivity and signal-to-noise ratio, but limited by bulkiness and static function (either phase contrast imaging or edge detection). Our report synergizes a polarization-entangled source with a metasurface consisting of various sophisticatedly engineered spatial frequency segments. By tuning polarization, we demonstrate multiple "on"-state quantum imaging modes, enabling flexible switching between phase contrast, edge, and arbitrary superimposed imaging mode.

ALCAT1-Mediated Pathological Cardiolipin Remodeling and PLSCR3-Mediated Cardiolipin Transferring Contribute to LPS-Induced Myocardial Injury.

Cardiolipin (CL), a critical phospholipid situated within the mitochondrial membrane, plays a significant role in modulating intramitochondrial processes, especially in the context of certain cardiac pathologies; however, the exact effects of alterations in cardiolipin on septic cardiomyopathy (SCM) are still debated and the underlying mechanisms remain incompletely understood. This study highlights a notable increase in the expressions of ALCAT1 and PLSCR3 during the advanced stage of lipopolysaccharide (LPS)-induced SCM. This up-regulation potential contribution to mitochondrial dysfunction and cellular apoptosis-as indicated by the augmented oxidative stress and cytochrome c (Cytc) release-coupled with reduced mitophagy, decreased levels of the antiapoptotic protein B-cell lymphoma-2 (Bcl-2) and lowered cell viability.

Docosahexaenoic acid alleviates LPS-induced cytotoxicity in HL-1 cardiac cells via improving stress-induced mitochondrial fragmentation.

Sepsis-induced cardiac injury is associated with oxidative stress and mitochondrial dysfunction. Docosahexaenoic acid (DHA), an essential omega-3 fatty acid, protects the injured myocardium by modulating mitochondrial dysfunction. We aimed to confirm whether the cardioprotective effect of DHA is mediated via the alleviation of mitochondrial fragmentation in lipopolysaccharide (LPS)-induced cardiomyopathy in vitro.

ST-ITEF: Spatio-Temporal Intraoperative Task Estimating Framework to recognize surgical phase and predict instrument path based on multi-object tracking in keratoplasty.

Computer-assisted cognition guidance for surgical robotics by computer vision is a potential future outcome, which could facilitate the surgery for both operation accuracy and autonomy level. In this paper, multiple-object segmentation and feature extraction from this segmentation are combined to determine and predict surgical manipulation. A novel three-stage Spatio-Temporal Intraoperative Task Estimating Framework is proposed, with a quantitative expression derived from ophthalmologists' visual information process and also with the multi-object tracking of surgical instruments and human corneas involved in keratoplasty.

GSDMD-mediated pyroptosis restrains intracellular growth in macrophages.

Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense mechanism against microbial infections. Although Chlamydia has been shown to induce pyroptosis, whether pyroptosis directly impacts the growth of Chlamydia has not been demonstrated. In this study, we found that L2 infection of the mouse macrophage RAW 264.

The Association Between Hyperuricemia and Obesity Metabolic Phenotypes in Chinese General Population: A Retrospective Analysis.

Purpose: Serum uric acid (UA) not only affects the development of obesity but also alters the metabolic status in obese subjects; thus we investigated the relationship between serum UA and the overweight/obese metabolic phenotypes.

Methods: The demographic, biochemical, and hematological data were collected for 12,876 patients undergoing routine physical examination, and 6,912 participants were enrolled in our study. Participants were classified into four obesity metabolic phenotypes according to their BMI and the presence of metabolic syndrome: metabolically healthy overweight/obese (MHOO), metabolically healthy and normal weighted (MHNW), metabolically abnormal and overweight/obese (MAOO), and metabolically abnormal but normal weighted (MANW).

A Novel Cleavage Pattern of Complement C5 Induced by Infection the Chlamydial Protease CPAF.

Urogenital infection is one of the most common bacterial sexually transmitted diseases globally. Untreated infections can ascend to the upper genital tract and establish a series of severe complications. Previous studies using C3 and C5 mice models demonstrated that C3-independent activation of C5 occurred during infection.

REPORT-Mild encephalitis/encephalopathy with a reversible splenial lesion associated with mumps infection: A case report.

We describe for the first time an child who demonstrated Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) after mumps infection in China. In this report, a 12-year-old boy came to Children's Hospital Affiliated to Zhengzhou University due to fever, swelling and pain under the earlobe for 4 days, and headache and vomiting for half of a day. Laboratory examinations showed a blood sodium level of 125mmol/L, both the Immunoglobulin M and Polymerase Chain Reaction results for the serum mumps virus were positive.

Shikonin ameliorates injury and inflammatory response of LPS-stimulated WI-38 cells via modulating the miR-489-3p/MAP2K1 axis.

Pneumonia is an inflammatory disease induced by infection with different pathogens. Currently, multiple preclinical studies have revealed that shikonin, a natural naphthoquinone, can mitigate lipopolysaccharide (LPS)-induced inflammation, but its underlying mechanism in pneumonia remains unknown. This research was designed to explore the function and regulatory mechanism of shikonin in LPS-induced cell injury and inflammation in WI-38 cells.

Bioinformatic prediction of immunodominant regions in spike protein for early diagnosis of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Background: To contain the pandemics caused by SARS-CoV-2, early detection approaches with high accuracy and accessibility are critical. Generating an antigen-capture based detection system would be an ideal strategy complementing the current methods based on nucleic acids and antibody detection. The spike protein is found on the outside of virus particles and appropriate for antigen detection.

Circulating levels of IL-33 are elevated by obesity and positively correlated with metabolic disorders in Chinese adults.

Background: Interleukin-33 (IL-33) plays a pivotal role in regulating innate immune response and metabolic homeostasis. However, whether its circulating level is correlated with obesity and metabolic disorders in humans remains largely unknown. We aimed to address this gap by determining IL-33 serum level and its downstream type 2 inflammatory cytokines interleukin-5 (IL-5) and interleukin-13 (IL-13) in overweight/obese population, and analyzing the specific associations between IL-33 and obesity metabolic phenotypes.

Omega-3 fatty acid supplementation is associated with favorable outcomes in patients with sepsis: an updated meta-analysis.

Objectives: The efficacy of omega-3 fatty acids in the treatment of sepsis is controversial. We conducted an updated meta-analysis to clarify the efficacy of omega-3 fatty acids in patients with sepsis.

Methods: PubMed, EMBASE, and the Cochrane Library were searched for randomized clinical trials (RCTs) on omega-3 fatty acid supplementation in adults with sepsis.

Immunodominant regions prediction of nucleocapsid protein for SARS-CoV-2 early diagnosis: a bioinformatics and immunoinformatics study.

COVID-19 caused by SARS-CoV-2 is sweeping the world and posing serious health problems. Rapid and accurate detection along with timely isolation is the key to control the epidemic. Nucleic acid test and antibody-detection have been applied in the diagnosis of COVID-19, while both have their limitations.

Delirium During Recovery in Patients With Severe COVID-19: Two Case Reports.

Novel coronavirus disease (COVID-19), caused by SARS-CoV-2, has rapidly evolved into a worldwide pandemic, leaving patients with life-threatening respiratory, cardiovascular, and cerebral complications. Here we reported on two patients with severe COVID-19 who experienced delirium in the early stage of recovery and mental illness including fatigue, anxiety, and post-traumatic stress disorder in the post-illness stage of COVID-19. Two patients were admitted to hospital due to clinical symptoms and features of CT and were confirmed for COVID-19 by positive results of a throat swab for SARS-CoV-2.

[Prenatal diagnosis for two fetuses carrying partial deletion of Y chromosome].

Objective: To perform prenatal diagosis for two fetuses carrying partial deletion of Y chromosome.

Methods: Routine G- and C-banding were carried out to analyze the chromosomal karyotypes of the fetuses and their fathers. Fetal DNA was also subjected to low-coverage massively parallel copy number variation sequencing (CNV-seq), fluorescence in situ hybridization (FISH), SRY gene and AZF factor testing.

Real-time PCR assay may be used to verify suspicious test results of Ureaplasmas spp. from the liquid culture method.

Ureaplasma spp. are associated with female genital tract infections and are mainly tested by liquid culture in developing countries. To evaluate the accuracy of liquid culture, 686 vaginal swabs were collected and tested by using the Mycoplasma Culturing, Identification, Enumeration, and Susceptibility (IES) Kit.

Replacing Cu(II)Br with Me-TREN in Biphasic Cu(0)/TREN Catalyzed SET-LRP Reveals the Mixed-Ligand Effect.

The mixed-ligand system consisting of tris(2-aminoethyl)amine (TREN) and tris(2-dimethylaminoethyl)amine (Me-TREN) during the Cu(0) wire-catalyzed single electron transfer-living radical polymerization (SET-LRP) of methyl acrylate (MA) in "programmed" biphasic mixtures of the dipolar aprotic solvents NMP, DMF, and DMAc with HO is reported. Kinetic and chain end analysis studies by NMR and MALDI-TOF before and after thio-bromo "click" reaction demonstrated that Me-TREN complements and makes the less expensive TREN a very efficient ligand in the absence of externally added Cu(II)Br. Statistical analysis of the kinetic data together with control experiments demonstrated that this mixed-ligand effect enhanced the apparent rate constant of propagation, monomer conversion, and molecular weight control.