PARK7 is a Key Regulator of Oxidative Stress - Related Breast Cancer Risk: A Multi-Omics Study.

Oxidative stress (OS) is closely associated with the occurrence and progression of breast cancer (BC). However, its role as a potential etiological factor or trigger remains unclear. This study aims to systematically investigate the potential causal effects and mechanisms of OS-related genes in BC by integrating multi-omics data.

Spatiotemporal dynamics of the pre-metastatic niche: remodeling of lung microenvironment before breast cancer metastasis and targeted intervention strategies.

Breast cancer lung metastasis has attracted considerable research attention because of its complex molecular heterogeneity and refractory characteristics. Development of the pre-metastatic niche (PMN) is a key initiating event in the cancer metastatic cascade. The PMN can remodel the tissue microenvironment through the spatiotemporal induction of extracellular matrix remodeling, activation of inflammatory responses, formation of an immunosuppressive state, vascular anomalies, and metabolic reprogramming.

The integrated single-cell analysis interpret the lactate metabolism-driven immune suppression in triple-negative breast cancer.

Background: Individuals with triple-negative breast cancer (TNBC) exhibit elevated lactate levels, which offers a valuable lead for investigating the molecular mechanisms underlying the tumor microenvironment (TME) and identifying more efficacious treatments.

Methods: TNBC samples were classified based on lactate-associated genes. A single-cell transcriptomic approach was employed to examine functional differences across cells with varying lactate metabolism.

Galectin-9 in cancer therapy: from immune checkpoint ligand to promising therapeutic target.

Galectin-9 (Gal-9) is a vital member of the galectin family, functioning as a multi-subtype galactose lectin with diverse biological roles. Recent research has revealed that Gal-9's interaction with tumors is an independent factor that influences tumor progression. Furthermore, Gal-9 in the immune microenvironment cross-talks with tumor-associated immune cells, informing the clarification of Gal-9's identity as an immune checkpoint.