Sensitization to inhaled and food allergen sources in patients with allergic diseases in Eastern China.

Background: Allergen exposure plays a critical role in the onset of allergic disease, and the distribution of allergens varies by geographic location, climate, and lifestyle.

Methods: A retrospective analysis was conducted on the data of 4,149 patients with clinically suspected allergic diseases who sought medical care at Changzhou Third People's Hospital. The total IgE and specific IgE (sIgE) levels for 19 inhaled and food allergen sources were assessed using the Mediwiss AllergyScreen system.

Mycn Is Essential for Pubertal Mammary Gland Development and Promotes the Activation of Bcl11b-Maintained Quiescent Stem Cells.

This investigation examines the function of the mouse gene in regulating and activating quiescent mammary stem cells, which are vital for mammary gland development. The mammary gland, consisting of luminal and basal cells, progresses through complex developmental stages from embryonic development through puberty, adulthood, pregnancy, lactation, and involution. Quiescent stem cells, existing in a reversible non-proliferative state, are essential for gland maintenance, yet their activation mechanisms remain poorly understood.

Safety of Concomitant Ascending Aortic Aneurysm Repair During Coronary Artery Bypass Grafting: A Society of Thoracic Surgeons Database Study.

Background: The 2022 ACC/AHA Aortic Disease guideline recommends concomitant ascending aortic replacement at the same size criteria for all cardiac operations. We sought to determine the added risk of performing an elective prophylactic ascending aortic replacement during coronary artery bypass grafting (CABG) using the STS database.

Methods: The STS database was queried for all elective adult CABG patients from 2014-2022 with either triple vessel or left main disease >50%.

An's anorectal fumigation lotion for nuclear factor kappa-B pathway-targeted treatment of inflammatory mixed hemorrhoids.

Objective: To investigate the mechanism by which An's anorectal fumigation lotion (AAFL) treats inflammatory mixed hemorrhoids.

Methods: Eighty Sprague-Dawley rats, with an equal number of males and females, were randomly assigned to the following four groups: control, model, AAFL, and positive groups. Following hemorrhoid induction, hemorrhoidal tissues were collected from the rats for analysis.

Connectedness effects in enumeration of small numbers.

The connectedness effect is the tendency to perceive connected items as fewer units, such as two connected dots seen as one. It commonly occurs with intermediate numerosity perception alongside the activity of the approximate number system (ANS), indicating that intermediate quantities are perceived as discrete units rather than continuous magnitudes. The present study explored how this effect influences the enumeration of small numerosities (fewer than 5), which are accurately assessed through a mechanism known as subitizing under normal conditions.

Dual-Functional Viologen-Based Metal-Organic Framework for Thermochromic and Fluorescence Detection of Fe, CrO, and Tetracycline.

The development of dual-functional viologen-based metal-organic frameworks (MOFs) combining thermochromic properties with fluorescence sensing capabilities remains a significant challenge in materials science. This study addresses this gap by designing a novel viologen-incorporated MOF for simultaneous thermochromic behavior and multianalyte detection. We synthesized a viologen-based MOF (CUST-851) through solvothermal assembly of Cd(II) ions with 1,1-bis(4-carboxylbenzyl)-4,4-bipyridine dichloride (HbpybcCl) and 1,4-naphthalenedicarboxylic acid (1,4-ndc).

Electric-Field-Driven Generative Nanoimprinting for Tilted Metasurface Nanostructures.

Tilted metasurface nanostructures, with excellent physical properties and enormous application potential, pose an urgent need for manufacturing methods. Here, electric-field-driven generative-nanoimprinting technique is proposed. The electric field applied between the template and the substrate drives the contact, tilting, filling, and holding processes.

Effects of dietary prickly ash seeds supplementation on muscle development and volatile compounds of Hu sheep.

Prickly ash seeds (PAS), a nutrient-rich by-product, show potential as a sustainable feed for Hu sheep. The current study aims to explore the effects of dietary supplementation with PAS on muscle development and volatile compounds of Hu sheep through multi-omics analysis. The increased muscle fiber diameter and cross-sectional area was associated with dietary supplementation with PAS compared with the CK group ( < 0.

Multi-scenario simulation of future marine microplastic distribution under data scarcity: A deep learning approach.

Assessing future trends in marine microplastic (MP) abundance is a crucial step toward mitigating MP pollution. However, this task is challenged by the scarcity of observational data and the pronounced spatiotemporal heterogeneity of MPs driven by multiple interacting factors. In this study, we introduce CGMAT, a novel deep learning (DL) framework that integrates Few-Shot Learning (FSL) with a Transformer-based architecture.

Heterogeneity of lymphoid cells in PBMCs in the acute phase of SFTS: single-cell transcriptome profiling.

Severe fever with thrombocytopenia syndrome (SFTS), caused by (DBV), triggers aberrant immune activation and cytokine storm, contributing to poor prognosis, yet its immune dysfunction mechanism remains unclear. Current treatments rely on symptomatic treatment and glucocorticoids without a standardized guideline. This study investigated the mechanism of abnormal lymphocyte function in acute-phase SFTS and glucocorticoid-induced alterations in lymphoid cells using single-cell RNA sequencing (scRNA-seq) and bioinformatics analysis.

Tailoring the Heterostructure Interfaces of Solid-State Supercapacitors for High-Power Density.

Solid-state supercapacitors (SSCs) using gel electrolytes show high promise for safety and mechanical flexibility, but their power densities are typically lower than those using liquid electrolytes due to the ill-fitted heterostructure interfaces among gel electrolyte, electrode film, and current collector. Herein, a strategy of tailoring the heterostructure interfaces is proposed, where the current collector and electrode film are one-step microimprinted into a unified film with dual 3D microstructures at their interface and surface, facilitating infiltration of gel electrolyte and ion/electron transport concurrently. As a result, the generated SSCs based on activated carbon retain 81% capacitance at a high current density of 30 A g, not less than that using the corresponding liquid electrolyte.

Exploring the sublayer formation process in layer V of the neocortex through two newly identified molecular markers.

The precisely organized six-layered architecture of the mammalian neocortex containing diverse types of neurons arises from tightly orchestrated developmental programs. Notably, layer V comprises two principal subtypes of excitatory pyramidal neurons distinguished by their axonal projection targets and stratifies into anatomically distinct sublayers: layer Va and layer Vb. Nevertheless, the mechanisms orchestrating neuronal diversification and their defining molecular markers have yet to be fully elucidated.

Time-dose response of oxygen delivery during cardiopulmonary bypass in mitral valve surgery: does surgical approach matter?

IntroductionIncreased time-dose-response (TDR) of suboptimal oxygen delivery (DO) during cardiopulmonary bypass (CPB) has been associated with increased postoperative complications. The impact of surgical approach - minimally invasive vs. median sternotomy - on TDR during mitral valve surgery has not been studied.

Initial survival and short-term pulmonary comorbidities in infants with congenital diaphragmatic hernia of differing indices of social determinants of health.

Purpose: To assess the association between social determinants of health (SDoH) and both mortality and pulmonary outcomes in infants with congenital diaphragmatic hernia (CDH).

Methods: We conducted a retrospective observational cohort study of all patients with CDH at our institution from January 2004 to July 2023. Child opportunity index (COI) and area deprivation index (ADI) were determined from reported addresses at birth.

Decoupling physicochemical-biological dynamics in marine oil spills: early adaptive microbial response to hydrodynamic forcing unveils zonal impact gradients.

Oil spills involve complex interactions of physicochemical and biological factors. The coupled physicochemical and biological behavior in the early stages significantly complicates the transport and transformation processes of oil at sea. Here, we conducted a comprehensive assessment of the early-stage environmental impacts of "A Symphony", China's largest recent oil spill, using first-hand data from satellite and drone monitoring, as well as navigation surveys across nine sites (R1→R9).

Motion artifact suppression method based on adaptive time-varying homogeneous field correction for OPM-MEG.

Optically pumped magnetometer-based magnetoencephalography (OPM-MEG) offers significant advantages over traditional systems based on superconducting quantum interference devices, including flexibility and the ability to record brain activity without cryogenic cooling. However, OPM-MEG is highly susceptible to motion artifacts due to its sensitivity to external magnetic field fluctuations.To address this challenge, we propose an Adaptive Time-varying (ATH) Homogeneous field correction (HFC) method, which integrates time-varying HFC with adaptive filtering to suppress head motion artifacts.

Metagenomic insights into the effects of Chive seed flavonoid on intestinal fermentation, morphology, and microbiota composition in sheep.

Chive seed flavonoid (CSF) exhibits antioxidant, digestive, and immunomodulatory properties, yet their effects on ruminant intestinal development and microbial ecosystems remain underexplored. This study systematically evaluated CSF supplementation (0.25% of concentrate) on intestinal morphology, volatile fatty acids (VFAs) dynamics, and microbiota composition in 16 weaned Hu lambs (3 months; 19.

Ion interference induced by Ca-Mn nanoplatform enhances ferroptosis and promotes immune response for osteosarcoma treatment.

Introduction: Ion interference therapy has emerged as a promising new treatment for Osteosarcoma (OS). However, its efficacy is significantly restricted by inadequate hydrogen peroxide (HO) under the complex tumor microenvironment (TME).

Objectives: This study aimed to supply sufficient HO to enhance tumor therapy efficacy and address the limitations associated with ion interference.

Design of multifunctional tunable dual-layer metalens based on deep learning.

To address the challenges of complex control in individually tunable meta-atoms and the limited modulation performance of single-layer holistic tunable metalenses, we propose a dual-layer tunable multifunctional metalens that utilizes holistic modulation based on the tunable BaTiO (BTO) material. This design enables rapid switching between different functionalities to be achieved by varying the voltage across the top and bottom layers. To accelerate the device design process, we employ a deep learning algorithm based on the transformer structure and incorporate a band embedding method that aids in predicting the high-frequency response.

A PROTAC-Based Cuproptosis Sensitizer in Lung Cancer Therapy.

As an autonomous form of regulated cell death, cuproptosis depends on copper (Cu) and mitochondrial metabolism. However, the principle metabolic pathway known as glycolysis (Warburg effect) and high glutathione (GSH) levels of tumor cells inevitably lead to suboptimal efficacy in cuproptosis. Hence, depleting the endogenous GSH within tumors and shifting from glycolysis to mitochondrial respiration are crucial factors for augmenting cuproptosis.

Glutamate transporter SLC1A6 promotes resistance to immunotherapy in cancer.

Background: Resistance to immune checkpoint inhibitors remains a significant challenge in the treatment of cancer. Emerging evidence suggests that metabolic reprogramming plays a crucial role in tumor metabolism and progression. Our study strived to investigate the role and underlying mechanisms of the glutamate transporter SLC1A6 in resistance to immunotherapy of cancer.

Probiotic alleviates acute kidney injury by protecting the intestinal barrier and modulating gut microbiota and metabolites.

Acute kidney injury (AKI) is a critical condition with limited effective therapies. ( ) is a probiotic with multiple beneficial effects, including epithelial cell tight junctions regulation. Since renal pathophysiology is associated with gut barrier integrity, we hypothesized that may have potential preventive effects on AKI.

Pyroptosis-Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple-Negative Breast Cancer.

Pyroptosis has attracted significant attention for its role in cancer chemotherapy and immunotherapy. However, few drugs have been reported to induce pyroptosis via the Caspase-3/gasdermin E (GSDME) pathway. Herein, three novel Pt prodrugs, MRP, DRP, and HRP are rationally designed by conjugating DNA methyltransferase (DNMT) inhibitor (RG108) and/or histone deacetylase (HDAC) inhibitor (PhB) to the Pt center.

Respiratory transmission potential of severe fever with thrombocytopenia syndrome bunyavirus: evidence from intranasal exposure in a humanized mouse model.

Severe Fever with Thrombocytopenia Syndrome Bunyavirus (SFTSV) is a highly lethal pathogen with expanding endemic regions in Asia. While primarily transmitted by ticks, recent evidence suggests potential airborne transmission, raising significant public health concerns. This study investigates the potential for respiratory transmission and pathogenesis using humanized NCG mice inoculated with SFTSV via subcutaneous injection challenge (SIC) or intranasal drop challenge (IDC).