Adenine/adenine contacts defined in the G-quadruplex for highly selective Tb binding.

The folding of nucleic acids is strongly dependent on metal ions. For example, G-quadruplex (G4) structures are usually determined by the specific K/Na coordination. However, G4 constructs highly selective to high-valent metal ions (for instance, trivalent metal ions) have not been found due to their strong and nonspecific phosphate backbone interactions.

Optimization and mechanism for Ni/Ag/Ni ohmic contact to p-AlGaN.

The optimal conditions and mechanism of ohmic contact formation between Ni/Ag/Ni and p-AlGaN contact layer on deep ultraviolet light-emitting diode (DUV-LED) epitaxial wafers were investigated. By optimizing the metal structures and annealing conditions, the specific contact resistivity between Ni/Ag/Ni (1/50/2 nm) and p-AlGaN was reduced to 1.36 × 10 Ω cm after annealing at 550 °C for 2 minutes in an air ambient, which was two orders of magnitude lower than that of Ni/Au contact.

Dehybridization-Free and Fluorescent Cleavage-Active DNAzyme by a Catalytic Core-Associative Fluorogen.

Metal-ion-dependent cleavage-active DNAzymes (caDz) are increasingly utilized in fields of sensing, environmental monitoring, and diagnostics. Currently, screening caDz and programming its cleavage activity rely on the "catalytic beacon" approach needing covalent duplex arm modifications by fluorophores and quenchers (thus named AM-caDz). Although this approach is widely used, the tedious modifications for operation limit its utilization in ordinary laboratories.

Nuclear localization of platelet activating factor receptor accounts for microglial phagocytosis in ischemic stroke.

Ischemic stroke (IS) is a leading cause of global morbidity and mortality. A critical strategy for improving the prognosis of IS involves mitigating neuronal loss to enhance neuroplasticity, with microglia playing a vital role in neuronal survival. The platelet activating factor receptor (PTAFR) participates in the pathological processes underlying IS; however, little is known about its mechanism in pathological stress.

CrackNet: A Hybrid Model for Crack Segmentation with Dynamic Loss Function.

Cracks are a common form of damage in infrastructure, posing significant risks to both personal safety and property. Along with the development of deep learning, visual-based crack automatic detection has been widely studied. However, this task is still challenging due to complex crack topology, noisy backgrounds, unbalanced categories, etc.

Metagenomic analysis of the effects of salinity on microbial community and functional gene diversity in glacial meltwater estuary, Ny-Alesund, Arctic.

Due to the inflow of meltwater from the Midre Lovénbreen glacier upstream of Kongsfjorden, the nutrient concentration of Kongsfjorden change from the estuary to the interior of the fjord. Our objective was to explore the changes in bacterial community structure and metabolism-related genes from the estuary to fjord by metagenomic analysis. Our data indicate that glacial meltwater input has altered the physicochemical properties of the fjords, with a significant effect, in particular, on fjords salinity, thus altering the relative abundance of some specific bacterial groups.

Study of Archaeal Diversity in the Arctic Meltwater Lake Region.

Two typical lakes formed from meltwater in the Ny-Ålesund area were taken as the study subjects in 2018. To investigate the archaeal community compositions of the two lakes, 16S rRNA genes from soil samples from the intertidal and subtidal zones of the two lakes were sequenced with high throughput. At the phylum level, the intertidal zone was dominated by Crenarchaeota and the subtidal zone was dominated by Halobacter; at the genus level, the intertidal zone was dominated by and Candidatus_, while the subtidal zone was dominated by .

Functional probiotics of lactic acid bacteria from Hu sheep milk.

Background: Probiotics are being considered as valuable microorganisms related to human health. Hu sheep is referred as one of the important sheep breeds in China. Goat milk produced by Hu sheep is characterized with high nutritional value and hypoallergenic in nature.