Ginkgo ketone ester tablets for the treatment of cognitive impairment associated with chemotherapy for breast cancer - a prospective cohort study.

Background: Chemotherapy-related cognitive impairment (CRCI) affects up to 75% of breast cancer patients during treatment, with 35% experiencing persistent post-treatment deficits. Current interventions show limited efficacy, creating urgent need for targeted therapies. Ginkgo Ketone Ester (GBE), containing neuroprotective flavonoids and terpene lactones, represents a potential therapeutic strategy.

Physical activity paradox and aging: A population-based study on the association of domain-specific physical activity with biological aging.

Objectives: A physical activity paradox is suggested by recent evidence that leisure-time physical activity (LTPA) is beneficial, whereas it may be detrimental to those with high occupational physical activity (OPA) levels. We aimed to investigate the association of domain-specific PA on the age of the whole body and organs (heart, kidneys, and liver).

Study Design: The analysis utilized data from NHANES, a cross-sectional study with 14,168 enrolled adult participants.

Effects of Reduced-Sugar Messages on Chiffon Cake Ratings and Human Chewing Behavior.

Reducing sugar in baked goods has become a widely discussed healthy eating topic today. Reduced-sugar messages on product packaging can help consumers make smarter food choices and reduce their sugar intake. Therefore, the aim of this study was to investigate the effects of different types of reduced-sugar messages (including nutritional, taste, and social messages) and reduced-sugar interest groups on chiffon cake ratings and consumer chewing behavior over time.

Controlled Synthesis of Tungsten Oxide Nanomaterials with Different Morphologies and Their Gas-Sensing Properties for Formaldehyde in Vegetables.

Formaldehyde is illegally applied to vegetables by vendors as a preservative to extend their shelf life, and it poses health risks to consumers. Herein, a series of WO with different morphologies were synthesized and employed as the sensing material in gas sensors to detect formaldehyde in vegetables rapidly. Among all the samples, the WO nanoplate sensor exhibited the best sensitivity (16.

Association of circadian syndrome with functional disability among middle-aged and older adults in China.

Background: Circadian syndrome (CircS) is a complex syndrome involving disorders of biological rhythms and multidimensional health risks. The objective of this research is to explore the association between CircS and functional disability.

Methods: This research utilized data from CHARLS, spanning the years 2011-2015.

Multi-Omics Revealed the Effects of Different Feeding Systems on Rumen Microorganisms, Cellulose Degradation, and Metabolites in Mongolian Cattle.

Rumen microbiota is crucial for cellulose degradation and nutrient metabolism in ruminants. Different feeding systems like grazing and housed feeding can significantly impact it. Mongolian cattle show unique cellulose degradation ability, but functional changes under different feeding conditions are unclear.

Large-Scale Fabrication of 5 nm Plasmonic Hybrid Nanoslit Arrays.

Surface plasmon resonance harnessed through nanometer-scale metallic gaps generates intense near-fields, unlocking vast potential for applications in nanophotonics and biosensing. However, the scarcity of scalable and reproducible nanofabrication techniques capable of achieving a sub-10 nm gap remains a significant barrier to widespread implementation. Here, we present a high-throughput method combining deep-UV interference lithography, molecular self-assembly, and peeling to fabricate large-scale arrays of an ∼ 5 nm Au-Ag hybrid nanoslit.

Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease.

This review explores interleukin (IL)-17D and its receptor CD93, highlighting their structural, functional, and clinical aspects. Identifying CD93 as the receptor for IL-17D has advanced understanding of the IL-17 family and its signaling pathways. IL-17D, with its unique glycoprotein structure, plays diverse roles in oxidative stress response and potential antitumor therapies.

Quantification of infrapatellar fat pad fibrosis using magnetic resonance imaging-derived proton density fat fraction: a pathology-controlled study.

Background: Knee osteoarthritis (KOA) is a degenerative joint disease leading to disability in the elderly. Fibrosis of the infrapatellar fat pad (IPFP) impacts knee joint function and disease progression. Accurate assessment of IPFP fibrosis aids early intervention and treatment.

Multi-Indicator analysis of the impact of preoperative inflammatory states on complications following pancreatoduodenectomy.

Purpose: Pancreatoduodenectomy (PD) is a complex surgery with a high rate of postoperative complications, for which effective preoperative indicators are currently lacking. Inflammatory indices such as the pan-immune-inflammation value (PIV), platelet-neutrophil product (PPN), and platelet-albumin ratio (PAR) have shown potential as biomarkers for postoperative prognosis in various cancers. However, their predictive value for complications in open-PD (OPD) patients remains underexplored.

Global research trends and emerging hotspots in acute high altitude illness: a bibliometric analysis and review (1937-2024).

Introduction: Acute High Altitude Illness (AHAI) includes conditions such as Acute Mountain Sickness (AMS), High Altitude Cerebral Edema (HACE), and High Altitude Pulmonary Edema (HAPE), which result from rapid ascent to altitudes exceeding 2,500 m. Although interest in AHAI research has been growing, a systematic and comprehensive analysis of global research trends remains lacking.

Content: A total of 3,214 articles and reviews published from 1937 to 2024 were retrieved from the Web of Science Core Collection.

Suppression of TP Rat Pancreatic Acinar Cell Apoptosis by hucMSC-Ex Carrying hsa-miR-21-5p via PTEN/PI3K Regulation.

The traumatic pancreatitis (TP) has an alarmingly high mortality rate. Our previous research has demonstrated that human umbilical cord mesenchymal stem cells-derived exosomes (hucMSC-Exs) could treat TP by inhibiting acinar cell apoptosis. Accordingly, the objective of this study is to unravel the intricate mechanism behind the repair of pancreatic injury in TP rats.

Examining the dietary contributions of lipids to pancreatic cancer burden (1990-2021): incidence trends and future projections.

Background: Pancreatic cancer (PC) ranks sixth globally among cancer deaths, imposing a significant burden on healthcare systems worldwide. Although diet is known to be a major risk factor, Although diet is a well-established risk factor for PC, the precise dietary components linked to the disease remain inconclusive, with studies showing varying results across different populations and regions. This study addresses this gap through a comprehensive analysis of PC incidence trends from 1990 to 2021, with a specific focus on associations with age, dietary patterns, and socio-demographic determinants.

Minimally invasive pancreaticoduodenectomy: A bibliometric method applied to the top one hundred cited articles.

Background: Minimally invasive pancreaticoduodenectomy (MIPD) is considered one of the most complex procedures in general surgery. The number of articles on MIPD has been increasing annually. However, published reports often have complex research directions, and the focal points frequently change.

Effect of Whey Protein Changes on Milk Flavor and Sensory Characteristics During Heating.

The flavor of dairy products crucially affects consumer purchase preference. Although the flavor and sensory perception of milk can be influenced by heat treatment during processing, the exact mechanism remains unclear. Therefore, this study analyzed the whey protein content and structural changes of milk heated at different time and temperature combinations and evaluated the flavor compounds and sensory characteristics of milk.

Understanding the impact of COVID-19 on quality of life using surveys and Mendelian randomization.

The COVID-19 pandemic has significantly impacted the quality of life (QoL) of individuals in China, affecting both their physical and mental well-being. This study aims to comprehensively analyze the factors influencing QoL in China during the pandemic. In 2022, we collected data using a self-developed questionnaire (dataset 2) and obtained dataset 1 from the 2021 China General Social Survey (CGSS).

Effects of Peanut Shell Flavonoids on Composite Film Properties and Cherry Tomato Preservation.

This study investigated the effects of varying concentrations of peanut shell flavonoids (PSFs) on the properties of peanut meal extract-tilapia skin protein composite films and their impact on cherry tomatoes preservation. Peanut meal alcohol extract (Pe) and tilapia skin protein (Co) were used as base materials, combined with PSFs to prepare composite films with excellent antioxidant properties. The results demonstrated that the optimized composite films exhibited superior mechanical properties, with a tensile strength of 9.

The Lyn/RUVBL1 Complex Promotes Colorectal Cancer Liver Metastasis by Regulating Arachidonic Acid Metabolism Through Chromatin Remodeling.

Liver metastasis is a common cause of death in colorectal cancer (CRC) patients, but epigenetic remodeling and metabolic reprogramming for CRC liver metastasis remain unclear. The study revealed that the Lyn/RUVBL1 complex is highly expressed in CRC and is closely correlated with liver metastasis. On the one hand, ATAC-seq and HiCut suggested that Lyn/RUVBL1 regulates the expression of TRIB3 through the POL II-mediated chromatin conformation of TRIB3 and thus the expression of β-catenin.

BMI Mediates the Association between Macronutrient Subtypes and Phenotypic Age Acceleration.

There is growing evidence that diet and aging are associated; however, few studies have examined the relationship between macronutrient subtypes and phenotypic age acceleration, and the extent to which BMI (body mass index) mediates this association is unclear. This study included 6911 individuals who were 20 years or older and had participated in the National Health and Nutrition Examination Survey. Daily macronutrient intakes were calculated and classified by the quartile of their subtypes.

Associations between Plant-Based Dietary Patterns and Sensory Impairments among Chinese Older Adults: Based on the Chinese Longitudinal Healthy Longevity Survey.

Introduction: The aim of this study was to investigate the relationship between the plant-based dietary index and vision impairment (VI), hearing impairment (HI), and dual sensory impairment (DSI) among Chinese aged 65 and older.

Methods: Based on the 2018 data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a cross-sectional study was conducted on 14,859 samples. The assessment of dietary quality utilized the plant-based diet index (PDI), healthy plant-based diet index (hPDI), and unhealthy plant-based diet index (uPDI).