Impact of irritating infusates via midline catheters on vascular complications: a multicentre prospective cohort study protocol in China.

Introduction: Midline catheters (MCs) longer than 15 cm are increasingly used for intravenous therapy. However, a consensus on the safe administration of irritating infusates (pH <5 or >9, osmolality >900 mOsm/L) is lacking. The current guidelines do not specify how the catheter tip position (axillary vein of the chest wall or subclavian vein) modulates the complication risks.

Capsid structure of phage SPO1 reveals novel minor capsid proteins and insights into capsid stabilization.

SPO1-related bacteriophages are promising candidates for phage therapy. We present the 3.0 Å cryo-electron microscopy (cryo-EM) structure of the SPO1 capsid with a triangulation number T = 16, enabling the construction of an atomic model comprising the major capsid protein and three types of minor capsid proteins: gp29.

Comparative safety and efficacy of midline catheters versus long peripheral catheters in patients undergoing bariatric surgery: a randomised controlled trial.

Bariatric surgery is an effective treatment for moderate-to-severe obesity, however, reliable vascular access during the perioperative period remains a challenge in this population. This study compared the safety and efficacy of midline catheters (MCs) and long peripheral catheters (LPCs) in patients who underwent bariatric surgery. This single-blind, randomised controlled trial was conducted at a tertiary acute hospital between September 2023 and January 2024.

Light green background enhances reading performance in visual display terminal tasks.

Visual context plays an important role in reading behavior. However, the effects of background color on reading performance remain underexplored. This study investigated how background color (white vs.

Machine learning to predict postdialysis fatigue in patients undergoing hemodialysis.

Background: Machine learning (ML) has been widely used to predict complications and prognosis in patients undergoing hemodialysis (HD). However, accurate and efficient models for predicting postdialysis fatigue (PDF) in this population are still needed because PDF is surprisingly prevalent.

Aims: This study aimed to explore the potential of ML models for predicting PDF in patients undergoing HD.

Area of Habitat maps for national key protected wildlife in China.

Area of Habitat (AOH) maps depict species distribution patterns, which are essential for predicting species survival, assessing species habitat loss or restoration, and developing biodiversity conservation strategies. AOH maps are generated by extracting suitable elevation ranges and habitat types from species' geographic range. National Key Protected Wildlife (NKPW) are species protected by Chinese law, playing a critical role in maintaining the country's biodiversity and ecological security.

Estrogen-Regulated Proline-Rich Acidic Protein 1 in Endometrial Epithelial Cells Affects Embryo Implantation by Regulating Mucin 1 in Mice.

This study explores the regulatory role of proline-rich acidic protein 1 () effects on embryo implantation. A high estrogen model and ovariectomized mice were employed to demonstrate that estrogen regulates expression. Uterine tissues were collected from E 1.

Comprehensive Analysis of 15 Cases of ELOC-RCC and Identification of Novel Mutation Site.

ELOC-mutated renal cell carcinoma (ELOC-RCC), a newly recognized tumor entity in the fifth edition of the WHO Classification of Tumors of Urinary and Male Genital Organ Tumors (5th WHO Classification), presents morphologic and immunohistochemical (IHC) features overlapping those of clear cell RCC (ccRCC), RCC with fibromyomatous stroma (RCC-FMS), and clear cell papillary renal cell tumor (ccPRCT). Confirmation of an ELOC mutation is required for a definitive diagnosis. This study aims to enhance the understanding of ELOC-RCC's morphologic and molecular characteristics and to develop an affordable and practical panel for its preliminary differentiation based on morphologic and IHC features.

Factors affecting postdialysis fatigue among hemodialysis patients: a multi-group path analysis according to nutritional status.

Purpose: The aim was to investigate a structural postdialysis fatigue model, to verify the factors which affect the postdialysis fatigue of hemodialysis patients, and to evaluate the moderating effects of nutritional status on postdialysis fatigue through multi-group analysis.

Methods: This multicenter cross-sectional study was conducted in six blood purification centers across hospitals in Taiyuan, Shanxi, China, with a total of 1,281 hemodialysis patients recruited as participants. Data were collected using Pittsburgh Sleep Quality Index, Connor-Davidson Resilience Scale, The Social Support Rate Scale, Post-dialysis fatigue Questionnaire, The Simplified Nutritional Appetite Questionnaire, The Rome IV constipation diagnostic criteria.

Transcriptome Analysis of Individual Ovine Oocytes and Preimplantation Embryos From In Vitro Fertilization Source.

In this study, we examine the transcriptional profiles of eight stages of preimplantation embryo development, from germinal vesicle (GV) oocytes to blastocysts, in in vitro fertilized sheep embryos using RNA sequencing. Between 12,744 and 15,539 genes were detected from the GV moving forward to blastocyst, with cluster analysis revealing two distinct clusters related to developmental stage. The largest change for differentially expressed genes (DEGs) numbers took place between 2- to 4-cell comparison and 4- to 8-cell comparison, with a c.

[Trajectory planning and tracking control for upper limb traction rehabilitation training].

To solve the safety problems caused by the restriction of interaction space and the singular configuration of rehabilitation robot in terminal traction upper limb rehabilitation training, a trajectory planning and tracking control scheme for rehabilitation training is proposed. The human-robot safe interaction space was obtained based on kinematics modeling and rehabilitation theory, and the training trajectory was planned based on the occupational therapy in rehabilitation medicine. The singular configuration of the rehabilitation robot in the interaction space was avoided by exponential adaptive damped least square method.

exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulation.

() has emerged as a potential contributor to ulcerative colitis (UC) pathogenesis, although the specific mechanisms remain incompletely understood. This study demonstrates that promotes colitis by disrupting intestinal barrier integrity, inducing apoptosis in epithelial cells, and modulating inflammatory pathways. Furthermore, we demonstrate that promotes STAT3 acetylation at K685, followed by phosphorylation at Y705, thereby enhancing its transcriptional activity and exacerbating colitis severity.

Cryo-EM Reveals Structural Diversity in Prolate-headed Mycobacteriophage Mycofy1.

Mycobacteriophages show promise in treating antibiotic-resistant mycobacterial infections. Here, we isolated Mycofy1, a mycobacteriophage, using M. smegmatis as a host.

Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production.

Background And Aims: While metformin has been shown to alleviate dextran sulfate sodium (DSS)-induced colitis in murine models, the mechanisms underlying its anti-inflammatory and barrier-restorative effects remain poorly defined. This study investigates the role of acetyl coenzyme A (acetyl-CoA)-dependent STAT3 acetylation in mediating metformin's therapeutic actions, with the goal of identifying novel molecular targets for ulcerative colitis (UC) treatment.

Methods: Acute colitis was induced in wild-type C57BL/6J mice via oral DSS administration, followed by daily intraperitoneal metformin treatment.

Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites.

Background: Inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), is a chronic inflammatory disorder characterized by an unclear etiology, often linked to gut microbiota dysbiosis and immune dysregulation. Existing UC therapies are constrained by suboptimal efficacy and adverse effects, underscoring the necessity for novel therapeutic strategies. Diosmin (DIO), a naturally occurring flavonoid, has demonstrated anti-inflammatory and antioxidant potential, yet its precise mechanisms and therapeutic role in colitis remain poorly understood.

Effects of exogenous GnRH administration at insemination on pregnancy rates of estrus-synchronized seven ewe populations during the breeding season.

The objective of this study was to investigate the effects of GnRH at insemination on pregnancy and lambing in seven ewe populations during the breeding season. Estrus was synchronized in 1560 adult ewes using an intravaginal sponge impregnated with flurogestone acetate. The sponge was left in the vagina for 12 days followed by an injection of 330 IU of eCG at sponge removal.

Effects of repeated low-level red-light therapy on myopia control in children with intermittent exotropia.

Background: The optimal myopia control measures for children with intermittent exotropia (IXT) have yet to be determined. This study evaluates the impact of Repeated low-level red-light therapy (RLRL) on myopia control in this population.

Methods: This retrospective study included 94 participants divided into three groups: Myopic children without strabismus receiving RLRL treatment (RLRL Group).

Lon protease 1-mediated metabolic reprogramming promotes the progression of prostate cancer.

Lon protease 1 (LONP1) is an ATP-dependent protease located in the mitochondrial matrix and plays a crucial role in regulating mitochondrial proteostasis, metabolism, and cellular stress responses et al. Aberrant LONP1 expression has been found in the progression of various tumors; however, the role and molecular mechanisms of LONP1 in prostate cancer (PCa) remain poorly understood. Here we show that overexpression of LONP1 is closely related to adverse clinic pathological features and poor prognosis in PCa patients.

Differences in catheter-related complications to insertion site selection for long peripheral intravenous catheters in antimicrobial therapy: a randomized controlled trial.

Background: The long peripheral intravenous catheter (long PIVC), a type of PIVC, has an indwelling time of 5-14 days and is one of the options for antibacterial therapy. However, there is no consensus regarding the impact of insertion site selection on the complications associated with long PIVCs.

Methods: This randomized controlled trial included 90 participants randomly assigned to either the control or experimental group, with 45 patients in each group.

Design of ROS-Triggered Sesquiterpene Lactone SC Prodrugs as TrxR1 Covalent Inhibitors for the Treatment of Non-Small Cell Lung Cancer.

Thioredoxin reductase 1 (TrxR1) is an important therapeutic target for nonsmall cell lung cancer (NSCLC) treatment due to its overexpression in NSCLC cells. In this work, to address the deficiency that sesquiterpene lactone containing α-methylene-γ-lactone moiety was rapidly metabolized by endogenous nucleophiles, series of novel thioether derivatives were designed and synthesized based on a reactive oxygen species (ROS)-triggered prodrug strategy. Among them, prodrug exhibited potent cytotoxicity against NSCLC cells and better release rates in response to ROS.

Asynchronous Embryo Transfer in Ewes.

The aim of the present study was to evaluate the effects of spatially and/or temporally asynchronous transfer of in vivo embryos at different stages in ewes during the breeding season. Four experiments were carried out. In Experiment 1, 207 blastocysts that had been frozen and thawed were transferred into the oviducts of 43 day two recipients, the oviducts of 23 day six recipients, and the uteri of 141 day six recipients, respectively.

Comparison of Two-Point Versus Three-Point Fixation in Treatment of Zygomaticomaxillary Complex Fractures: An Updated Meta-Analysis.

Purpose: Zygomaticomaxillary complex (ZMC) fractures are a prevalent form of craniofacial trauma. However, no universally accepted fixation method has been established to prevent postreduction displacement in ZMC fractures.

Methods: Computerized and additional manual searches of the Medline, Embase, Chinese National Knowledge Infrastructure, and Cochrane Central database for potential studies, published from inception to May 2024, were performed.

Electroacupuncture promotes resolution of inflammation by modulating SPMs via vagus nerve activation in LPS-induced ALI.

During the process of acute lung injury (ALI) associated with sepsis, the α7nAChR in the cholinergic anti-inflammatory pathway (CAP) plays a crucial role. However, the roles of electroacupuncture (EA) and specialized pro-resolving mediators (SPMs) in this context remain unclear. In this study, we demonstrated that EA activates CAP via α7nAChR, reducing lung permeability and inflammatory cytokine release.

A hybrid network using transformer with modified locally linear embedding and sliding window convolution for EEG decoding.

. Brain-computer interface(BCI) is leveraged by artificial intelligence in EEG signal decoding, which makes it possible to become a new means of human-machine interaction. However, the performance of current EEG decoding methods is still insufficient for clinical applications because of inadequate EEG information extraction and limited computational resources in hospitals.