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Article Abstract
Efficient photocatalytic tumor therapy relies on deep tissue penetration via near-infrared (NIR) light absorption and potent oxidative stress induced by efficient photogenerated hole (h) migration. Herein, we report a supramolecular donor-acceptor (D-A) structure fabricated by integrating self-assembled tetra-(4-carboxyphenyl) porphyrin (SA-TCPP) with amino-functionalized graphene quantum dots (GQDs-NH). The D-A configuration significantly narrowed the band gap for extended NIR absorption and amplified the interfacial electric field 6.2 times. This facilitated efficient h migration with a 5.3-fold enhancement, generating highly oxidation holes. Under 700 nm irradiation, this system induced potent oxidative cell apoptosis, leading to 100% tumor elimination . This study presents a dual-promotion strategy involving NIR responsiveness and charge migration, advancing the efficiency of photocatalytic cancer therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308412 | PMC |
| http://dx.doi.org/10.1021/jacsau.5c00535 | DOI Listing |
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