Teniposide Triggers DNA Repair Inhibition by Binding and Ubiquitination of Apurinic/Apyrimidinic Endonuclease 1 to Boost Oxidative DNA Damage for Lung Cancer Destruction.

Teniposide (Ten/VM-26) is low in toxicity and has proven to be effective in destroying malignant cells at low doses. However, the target and molecular mechanism of Ten/VM-26 are poorly understood, which limits its clinical application against solid malignant cancers. Apurinic/apyrimidinic endonuclease 1 (APEX1) expression is upregulated in lung cancer, which could effectively suppress DNA damage.

Greenhouse gas emissions in a microbial fuel cell-assisted composting system: Microbial insights into bacterial structures and genetic functions.

Greenhouse gas emissions, including methane (CH), carbon dioxide (CO), and nitrous oxide (NO), have significant environmental impacts during the composting process. Herein, a microbial fuel cell (MFC)-assisted composting system was employed to investigate the emission profiles of these gases. CH and CO emissions were peaked during the temperature-heating phase, while NO emission showed maximum levels during the temperature-heating and maturation phases.

Early versus late pancreatic stent placement for preventing post-ERCP pancreatitis: protocol of a multicenter randomized clinical trial.

Background: Pancreatic stenting has been shown to effectively lower the occurrence of post-ERCP pancreatitis (PEP) and reduce its severity. To date, no evidence exists to determine the optimal timing for pancreatic stent placement in prospective trials. Our aim is to compare early versus late pancreatic stent placement in preventing PEP among patients with naive papilla.

Artificial intelligence alert system based on intraluminal view for colonoscopy intubation.

Mucosal contact of the tip of colonoscopy causes red-out views, and more pressure may result in perforation. There is still a lack of quantitative analysis methods for red-out views. We aimed to develop an artificial intelligence (AI)-based system to assess red-out views during intubation in colonoscopy.

Mechanisms of reactive intermediates formation in saline-alkali agricultural waters.

Reactive intermediates (RIs) are critical in nutrient cycling and pollution mitigation, yet their behavior in salinized agricultural waters remains underexplored. This study investigates RIs formation in rice cultivation water from a typical saline-alkali region in China. Singlet oxygen was more pH-sensitive than hydroxyl radical (•OH), while triplet excited-state dissolved organic matter were more influenced by salinity.

Enhanced removal of sulfonamide antibiotics in water using high-performance S-nZVI/BC derived from rice straw.

Sulfonamide antibiotics (SAs) are widely used in the biomedical field but pose an environmental risk as ecotoxic pollutants. Developing eco-friendly methods to degrade SAs into harmless compounds is crucial. In this work, biochar (BC) was prepared from rice straw via pyrolysis and used to support S-nZVI, thereby forming the S-nZVI/BC composites.

Microbial fuel cell-assisted composting yields higher performance on metals passivation, antibiotics degradation, and resistance genes removal.

Little scientific evidence on metal passivation, antibiotic degradation and resistance genes removal, is available under autogenetic electrochemical reactions during composting process. This study established microbial fuel cell (MFC)-assisted composting procedure to ascertain the removal performance and detoxification mechanisms involving metals, antibiotics and their resistance genes. Compared to control treatment, the bioavailability of zinc (Zn) and copper (Cu) in MFC-assisted treatment decreased by 7.

From winter dormancy to spring bloom: Regulatory mechanisms in Microcystis aeruginosa post-overwintering recovery.

Cyanobacterial blooms pose a significant environmental threat in freshwater ecosystems. These cyanobacteria exhibit resilience to cold and dark conditions during winter and flourish as temperature rise in warmer seasons. However, there is a limited understanding of the dynamic growth recovery process and regulatory signaling mechanisms in cyanobacteria after overwintering.

Redistribution of phosphorus fraction driven by organic carbon and microbial community during composting.

Available information on the coupling relationship between phosphorus fraction and organic carbon during composting remains limited. Thus, this research investigated the changes of phosphorus fraction, dissolved organic carbon fluorescent components and microbial community in swine manure composting with different carbon sources including the maize straw (MS), garden waste (GW) and distillers' grains (DG), in order to investigate whether the distribution and availability of phosphorus are influenced by different carbon sources used in the composting of swine manure. The result showed that different carbon sources changed phosphorus availability variously mainly by altering the succession of fungal communities and phosphorus functional genes.

Microbial fuel cell-assisted composting shows stronger capacity to immobilize phosphorus: Emphasized on bacterial structures and functional enzymes.

Limited scientific evidence exists on phosphorus immobilization under autogenetic electrochemical reactions in composting systems. This study exploited a composting procedure using microbial fuel cell (MFC) to ascertain phosphorus redistribution during composting process. Compared to the control without MFC equipment, MFC-assisted treatment yielded a 13 % decrease in phosphorus availability due to the transformation of exchangeable fraction (Ex-P) to aluminum-bound (Al-P) and calcium-bound (Ca-P) fractions.

Greenhouse gases emissions and carbon budget estimation in horizontal subsurface flow constructed wetlands with different plant species.

Constructed wetlands (CWs) are pivotal for wastewater treatment due to their high efficiency and numerous advantages. The impact of plant species and diversity on greenhouse gas (GHG) emissions from CWs requires a more comprehensive evaluation. Moreover, controversial perspectives persist about whether CWs function as carbon sinks or sources.

Spatiotemporal dual-periodic soliton pulsation in a multimode fiber laser.

Spatiotemporal mode-locked (STML) fiber lasers have become a new platform for investigating nonlinear phenomena. In this work, spatiotemporal dual-periodic soliton pulsation (SDSP) is firstly observed in an STML fiber laser. It is found that in the SDSP, the long-period pulsations (LPPs) of different transverse modes are synchronous, while the short-period pulsations (SPPs) exhibit asynchronous modulations.

Soil amendments reduce CH and CO but increase NO and NH emissions in saline-alkali paddy fields.

Limited research has been conducted on ammonia (NH) volatilization and greenhouse gases (GHGs) emissions in saline-alkali paddy fields, along with complex interaction involving various genes (16sRNA, amoA, narG, nirK, nosZ, and nifH). This study employed mesocosm-scale experiment to investigate NH volatilization and GHGs emissions, focusing on bacterial communities and genic abundance, in saline-alkali paddy fields with desulfurized gypsum (DG) and organic fertilizer (OF) amendments. Compared to the control (CK) treatment, DG and OF treatments reduced methane (CH) and carbon dioxide (CO) emissions by 78.

Periodically tunable multimode soliton pulsation in a spatiotemporal mode-locked fiber laser.

Multimode fiber lasers have become a new platform for investigating nonlinear phenomena since the report on spatiotemporal mode-locking. In this work, the multimode soliton pulsation with a tunable period is achieved in a spatiotemporal mode-locked fiber laser. It demonstrates that the pulsation period drops while increasing the pump power.

Soil aggregate-driven changes in nutrient redistribution and microbial communities after 10-year organic fertilization.

Research studies on nutrient content and microbial communities after the application of organic manure have been reported, while available information about multi-interaction mechanisms of nutrient stoichiometry and microbial succession in soil aggregates remains limited. This work conducted a 10-year field experiment amended with cow manure (1.5 t/ha), during which the application of organic manure stimulated the fragmentation of soil macro-aggregates (>5 mm) and the agglomeration of soil micro-aggregates (<0.

FeCa-based layered double hydroxide, a high-performance phosphorus adsorbent in constructed wetlands and ecological dams - A pilot scale study.

Research studies have modified traditional substances to seek fast-acting removal of phosphorus in constructed wetlands (CWs) and ecological dams, rather than develop a brand-new nano-adsorbent. This work synthesized FeCa-based layered double hydroxide (FeCa-LDH) with a chemical co-precipitation method, and the performance, mechanism and factors of phosphorus removal were investigated. FeCa-LDH showed a marked ability to adsorb phosphorus from waste water, with a removal efficiency of 94.

Exercise Exertion Levels Prediction Based on Real-Time Wearable Physiological Signal Monitoring.

The real-time revolutions per minute (RPM) data, ECG signal, pulse rate, and oxygen saturation levels were collected during 16-minute cycling exercises. In parallel, ratings of perceived exertion (RPE) were collected each minute from the study participants. A 2-minute moving window, with one minute shift, was applied to each 16-minute exercise session to divide it into a total of fifteen 2-minute windows.

Dissipative soliton resonance in a figure-eight multimode fiber laser.

We report, for the first time to the best of our knowledge, a spatiotemporal mode-locked (STML) multimode fiber laser based on nonlinear amplifying loop mirror (NALM), generating dissipative soliton resonance (DSR) pulses. Due to the complex filtering characteristics caused by the inherent multimode interference filtering structure and NALM in the cavity, the STML DSR pulse has wavelength tunable function. What's more, kinds of DSR pulses are also achieved, including multiple DSR pulses, and the period doubling bifurcations of single DSR pulse and multiple DSR pulses.