Oyster farming acts as a marine carbon dioxide removal (mCDR) hotspot for climate change mitigation.

Bivalve farming, a vital component of global aquaculture, has been proposed as a potential marine carbon dioxide removal (mCDR) strategy, yet its role remains contentious. Using field mesocosms, we demonstrate that oyster filter-feeding enhances mCDR by accelerating the formation of particulate and dissolved organic carbon in the water column and promoting organic carbon deposition in sediments. This process shifts the water column toward a more autotrophic and alkaline state, effectively sequestering CO from the atmosphere.

Neuropsychiatric symptom trajectories across cognitive spectrums of Alzheimer's disease: Joint probabilities with cognitive and functional decline.

Objectives: Neuropsychiatric symptoms (NPSs), cognitive and functional decline developed heterogeneously in Alzheimer's disease (AD). We aimed to compare distinct NPS burden trajectories across cognitive spectrums, and their joint probabilities with cognition and function.

Methods: Data were from the Alzheimer's Disease Neuroimaging Initiative cohort.

Precision prediction of intervertebral disc degeneration in ankylosing spondylitis using a nomogram model reveals the pivotal role of Th2-type immune dysregulation.

Background: Ankylosing spondylitis (AS) is an immune-mediated chronic inflammatory disease. When AS is complicated by intervertebral disc degeneration (IVDD), disease complexity increases substantially, often resulting in poor long-term outcomes. Although previous studies have explored the mechanisms linking AS and IVDD, reliable tools for precise risk prediction and early intervention remain scarce.

[Research Progress for the Toxic Effects of Microplastics on Soil Animals and Plants].

Terrestrial ecosystems represent the most direct and principal reservoirs of plastic contamination on Earth. The toxic effects of microplastic exposure on terrestrial plants have been analyzed from the perspectives of direct toxicity, indirect toxicity, and combined toxicity with other pollutants. By investigating the impacts on the growth, behavior, and oxidative stress responses of soil animals, the toxicological patterns of microplastics have been elucidated.

Clinical Analysis and Imaging Study of Lateral Lumbar Intervertebral Fusion in the Treatment of Degenerative Lumbar Scoliosis.

Objective: As the population ages and technology advances, lateral lumbar intervertebral fusion (LLIF) is gaining popularity for the treatment of degenerative lumbar scoliosis (DLS). This study investigated the feasibility, minimally invasive concept, and benefits of LLIF for the treatment of DLS by observing and assessing the clinical efficacy, imaging changes, and complications following the procedure.

Methods: A retrospective analysis was performed for 52 DLS patients (12 men and 40 women, aged 65.

Reg2 treatment is protective but the induced Reg2 autoantibody is destructive to the islets in NOD mice.

Regenerating family protein 2 (Reg2) is a trophic factor which stimulates β-cell replication and resists islet destruction. However, Reg2 also serves as an islet autoantigen, which makes it complicated to judge the effectiveness in treating diabetes. How Reg2 treatment behaves in non-obese diabetic (NOD) mice is to be investigated.

[Age estimation model for individual tree in natural forest based on random forest model].

To accurately estimate the age of individual tree and to achieve full-cycle sustainable management of natural forest in Great Xing'an Mountains of northeastern China, we constructed individual tree age prediction model using stepwise regression and random forest algorithms based on 44 fixed plots data and 280 stan-dard tree cores obtained from the Pangu Forest Farm. We analyzed the influence of stand structure, site conditions, and competition index on the accuracy of model prediction. The model was evaluated by the coefficient of determination (), root mean square error (RMSE), and mean absolute error (MAE).

Hidden diversity and potential ecological function of phosphorus acquisition genes in widespread terrestrial bacteriophages.

Phosphorus (P) limitation of ecosystem processes is widespread in terrestrial habitats. While a few auxiliary metabolic genes (AMGs) in bacteriophages from aquatic habitats are reported to have the potential to enhance P-acquisition ability of their hosts, little is known about the diversity and potential ecological function of P-acquisition genes encoded by terrestrial bacteriophages. Here, we analyze 333 soil metagenomes from five terrestrial habitat types across China and identify 75 viral operational taxonomic units (vOTUs) that encode 105 P-acquisition AMGs.

Lumbar Intradural Disc Herniation Caused by Injury: A Case Report and Literature Review.

Background: Intradural disc herniation(IDH) caused by trauma is a rare type of disease，which is difficult to diagnose clinically and is easily misdiagnosed. We received a patient with the disease, reported the case to share the process of diagnosis and treatment and put forward our own opinions, so as to increase the probability of correct diagnosis.

Case Presentation: We report the case of a 48-year-old male who fell from a scaffold at a height of 2 m.

Clinical Efficacy Analysis of the New PRUNUS Spine Plate System for Anterior Cervical Spine Surgery.

Objective: Although the role of anterior cervical titanium plate system in stabilizing the spine sequence and promoting bone graft fusion has been widely recognized, more and more attention has been paid to the design of the plate itself and the complications caused by it. In order to solve the problems of poor stability of internal fixation, plate displacement and screw looseness, we designed the new PRUNUS spine plate system. Hence, the present study was conducted to describe observe and evaluate the clinical efficacy of a new type of three-leaf reinforced cervical anterior screw plate system (PRUNUS nailing system) developed for anterior cervical surgery.

Ecotoxicity stress and bioaccumulation in Eisenia fetida earthworms exposed to vanadium pentoxide in soil.

As an important commercial form of vanadium, vanadium pentoxide (VO) is widely used in various modern industries, and its environmental impacts and ecotoxicity have been extensively studied. In this research, the ecotoxicity of VO to earthworms (Eisenia fetida) in soil was tested by exposure to VO at a series of doses, and biochemical response indices, such as the superoxide dismutase (SOD) and catalase (CAT) enzyme activity and malondialdehyde (MDA) content, were analysed to determine the mechanism by which antioxidant enzymes respond to VO exposure. The bioaccumulation factor (BAF) of vanadium pentoxide in the earthworms and soil was also measured to explore the bioaccumulation process of VO in the test period.

[Effect Factors and Model Prediction of Soil Heavy Metal Bioaccessibility].

The soil environmental pollution situation has been severe in recent years, but studies on evaluating with bioavailability testing and prediction models are lacking, which makes it difficult to accurately assess the ecological risks of contaminated soil. As an important indicator of bioavailability, the bioaccessibility of cadmium (Cd), arsenic (As), copper (Cu), zinc (Zn), and lead (Pb) in the soil was analyzed in this study. The bioaccessibility content and their corresponding soil property data were screened and systematically analyzed to explore the relationship between bioaccessibility content and soil properties.

LncRNA FIRRE stimulates PTBP1-induced Smurf2 decay, stabilizes B-cell receptor, and promotes the development of diffuse large B-cell lymphoma.

Sustained expression of B-cell receptor (BCR) critically contributes to the development of diffuse large B-cell lymphoma (DLBCL). However, little is known on the mechanism regulating BCR expression. In the present study, we explored the biological significance of functional intergenic repeating RNA element (FIRRE) in DLBCL and its regulation on BCR.

The Correlation between Microalbuminuria and Thyroid Nodules in Type 2 Diabetic Mellitus.

Objective: To investigate the correlation between thyroid nodules and microalbuminuria in type 2 diabetic mellitus.

Methods: A total of 270 patients with type 2 diabetes at Tongzhou Branch of Dongzhimen Hospital were enrolled in this retrospective study. Data were collected from the inpatient electronic files between January 2018 and January 2020.

CDK12 activates MYC to repress miR-28-5p/EZH2 and amplifies tonic BCR signaling to promote the development of diffuse large B-cell lymphoma.

Cyclin-dependent kinase 12 (CDK12) is a transcription-associated kinase that participates in various cellular processes. However, its regulatory role in the progression of diffuse large B-cell lymphoma (DLBCL), which is the most prevalent subtype of non-Hodgkin lymphoma (NHL), is still elusive and controversial.The expression of CDK12 was detected by immunohistochemistry (IHC), RT-qPCR was performed to detect miR-28-5p expression of OCI-LY3 and SU-DHL-4 cells.

Correlation Analysis for Selection of Microtitanium Plates with Different Specifications for Use in a Cervical Vertebral Dome Expansion Laminoplasty.

Objective: To analyze correlations between the selection of microtitanium plates with different specifications for use in a cervical vertebral dome expansion laminoplasty.

Methods: Sixteen patients that underwent the cervical vertebral dome expansion laminoplasty with a cervical spinal stenosis angioplasty procedure for treatment of their cervical spinal cords were recruited at our hospital. From February 2017 to September 2018, medical records confirmed that all patients underwent cervical CT and MRI tests pre- and postsurgery.

Wuzhi capsule increased systemic exposure to methotrexate by inhibiting the expression of OAT1/3 and P-gp.

Background: Methotrexate (MTX) is an important anticancer agent and immunosuppressant with a narrow therapeutic window. Wuzhi capsule (WZC) is an extract of Schisandra which is widely used to treat liver diseases. Co-administration of MTX and WZC is common in the clinical setting, but research on the interaction between WZC and MTX is limited.

Evaluation of influence of telmisartan on the pharmacokinetics and tissue distribution of canagliflozin in rats and mice.

Background: Canagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, is widely used for the treatment of type 2 diabetes mellitus. However, drug interactions with canagliflozin can affect its glucoselowering therapeutic effects or exacerbate its adverse effects. Telmisartan, an angiotensin receptor blocker (ARB), has been approved for the treatment of diabetic kidney disease.

Depression and myocardial injury in ST-segment elevation myocardial infarction: A cardiac magnetic resonance imaging study.

Background: Depression is common in patients with myocardial infarction and has been independently associated with adverse outcomes. However, the association between depression and myocardial injury on cardiac magnetic resonance (CMR) in patients with ST-segment elevation myocardial infarction (STEMI) has still not been assessed.

Aim: To assess the association between depression and myocardial injury on CMR in patients with STEMI.

Development and Biomechanical Study of a New Open Dynamic Anterior Cervical Nail Plate System.

Objective: To develop a new type of open dynamic cervical spine system and study its biomechanical properties.

Methods: Ten fresh goat spine specimens were used in this study. Using high precision digital display grating displacement sensor system, a new type of open dynamic nail plate fixation was compared with Atlantis nail plate fixation in terms of the stability of cervical vertebrae, pull-out strength, and fatigue strength.

Development and Clinical Application of a New Open-Powered Nail Anterior Cervical Plate System.

Objective: To observe and evaluate the clinical curative effect of a new type of open-powered cervical spine system developed for anterior cervical surgery.

Methods: A retrospective analysis was performed in our hospital in 2015-2017 of 329 orthopaedic patients treated with cervical anterior decompression, cage or titanium mesh graft fusion, new open-powered nail plate or traditional cervical anterior screw plate. A total of 154 (control group) and 175 (observation group) cases were fixed with conventional cervical- and new open-powered nail plates, respectively.