Nomogram-based risk stratification to analyze the value of receiving postoperative adjuvant therapy after neoadjuvant immunochemotherapy for patients with locally advanced esophageal squamous carcinoma.

Purpose: To develop a prognosis nomogram for locally advanced esophageal squamous cell carcinoma (LA-ESCC) patients after neoadjuvant immunochemotherapy (NICT) and assess postoperative adjuvant therapy (PAT) value through survival risk stratification.

Methods: We retrospectively analyzed 297 LA-ESCC patients (2019-2023) receiving NICT with or without PAT, randomly divided into the training and validation cohorts. Independent prognostic factors were determined by Least Absolute Shrinkage and Selection Operator (Lasso) regression and multivariate Cox analysis.

Bioremediation strategies for hexavalent chromium: Development and safety assessment of recombinant Escherichia coli strain 3458.

Incidents of periodic water pollution and damage to aquatic organisms resulting from the mismanagement of hexavalent chromium emissions have been documented. Utilizing environmentally friendly bioremediation strategies has effectively controlled chromium pollution. The ChrA gene, responsible for hexavalent chromium remediation and sourced from Sporosarcina saromensis M52, was introduced into Escherichia coli to develop recombinant strain 3458.

Influence of microplastics on antibiotic resistance genes across diverse environments: A comprehensive meta and machine-learning analysis.

The coexistence of microplastics (MPs) and antibiotic resistance genes (ARGs) in various environments presents significant ecological risks. However, the influence of MPs properties and environmental conditions shaping ARG dynamics remain unclear. This study utilized meta- and interaction analysis to elucidate how MPs properties (size, concentration, type, and age) and exposure environments drive ARGs fluctuations.

Effects of different size polylactic acid on arsenic migration and rhizosphere microorganisms in soil-rice system.

The impact of microplastics on arsenic biogeochemical cycles within the plant-soil system holds critical importance for food safety and public health, yet remains largely underexplored, particularly concerning biodegradable microplastics. This study investigated the influence of polylactic acid (PLA), a representative biodegradable microplastic, on arsenic migration and transformation in rice-soil systems. Our findings indicated that PLA enhanced arsenic bioavailability in soil through acidification and increased dissolution of iron and manganese minerals.

The impact of radiation-related lymphocyte recovery on the prognosis of locally advanced esophageal squamous cell carcinoma patients: a retrospective analysis.

Background: The impact of radiation-related lymphocyte recovery on prognosis in locally advanced esophageal squamous cell carcinoma (LA-ESCC) remains unclear.

Methods: Patients with stage II-IVa ESCC who received definitive RT were screened. Collect absolute lymphocyte counts (ALCs) before, during, and after RT.

Patterns of recurrence after esophagectomy following neoadjuvant immunochemotherapy in patients with thoracic esophageal squamous cell carcinoma.

Purpose: To explore the recurrence pattern and risk factors associated with the relapse of thoracic esophageal squamous cell carcinoma (TESCC) among patients who received esophagectomy following neoadjuvant immunochemotherapy (NICT).

Methods: A total of 191 TESCC patients who received esophagectomy following NICT were retrospectively reviewed from 2019 to 2022. The first recurrence patterns were assessed.

Meta-analysis reveals the combined effects of microplastics and heavy metal on plants.

The combined pollution of microplastics and heavy metals is becoming increasingly serious, and its effects on toxicology and heavy metal accumulation of plants are closely related to crop yield and population health. Here, we collected 57 studies to investigate the effect of microplastics on heavy metal accumulation in plants and their combined toxicity. An assessment was conducted to discover the primary pollutant responsible for the toxicity of combined pollution on plants.

Integrating subjective feelings into the evaluation of ecological restoration outcomes of urban green space: Indicator framework from bibliometrics analysis and evidence synthesis.

Despite much progress has been made in the evaluation of ecological restoration outcomes, there is still a lack of a suitable framework for evaluating the ecological restoration outcomes of urban green space. In view of this, this study systematically analyzed the characteristics and differences between the evaluation index systems of ecological restoration outcome and urban green space quality evaluation, and then discussed the relationship between objective elements of landscape and people's subjective feelings. On this basis, an ecological restoration outcome evaluation framework was developed for urban green space considering people's subjective feelings.

Meta-analysis unravels the complex combined toxicity of microplastics and antibiotics in aquatic ecosystems.

The aquatic ecosystem, a repository for various pollutants, has been identified as a crucial zone where microplastics (MPs) serve as vectors for antibiotics, facilitating their spread. Despite this, the influence of MPs on the toxicity of antibiotics remains a topic of debate. In this study, we conduct a global meta-analysis, examining 730 datasets from 29 laboratory studies.

Effects of biodegradable microplastics on arsenic migration and transformation in paddy soils: a comparative analysis with conventional microplastics.

The combined pollution of microplastics (MPs) and arsenic (As) in paddy soils has attracted more attention worldwide. However, there are few comparative studies on the effects of biodegradable and conventional MPs on As migration and transformation. Therefore, conventional (polystyrene, polyethylene, polyvinyl chloride) and biodegradable (polybutadiene styrene, polylactic acid, polybutylene adipate terephthalate) MPs were selected to explore and demonstrate their influences and mechanism on As migration from paddy soils to overlying water and As speciation transformation through microcosmic experiment with measuring the changes of As chemical distribution, physicochemical indexes and microbial community in paddy soils.

Exploration of risk analysis and elimination methods for a Cr(VI)-removal recombinant strain through a biosafety assessment in mice.

Though recombinant strains are increasingly recognized for their potential in heavy metal remediation, few studies have evaluated their safety. Moreover, biosafety assessments of fecal-oral pathway exposure at country as well as global level have seldom analyzed the health risks of exposure to microorganisms from a microscopic perspective. The present study aimed to predict the long-term toxic effects of recombinant strains by conducting a subacute toxicity test on the chromium-removal recombinant strain 3458 and analyzing the gut microbiome.

Phytoremediation for antibiotics removal from aqueous solutions: A meta-analysis.

Antibiotics are widely used as drugs and enter water bodies through various routes, leading to environmental pollution. As a green in-situ remediation technology, phytoremediation has been proven to be highly effective in removing antibiotics present in the aqueous phase. However, these data are distributed in various studies and lack systematic analysis, which could provide a more comprehensive understanding of the current status and trends in the research field.

The effects of microplastics on heavy metals bioavailability in soils: a meta-analysis.

The combined pollution of heavy metals and microplastics is common in natural soil environments. Here, we collected 790 data sets from 39 studies to investigate the effects of microplastics on heavy metal bioavailability. The results showed that microplastics could increase the bioavailability of Cu, Pb, Cd, Fe, and Mn.

Aerobic Degradation Characteristics of Decabromodiphenyl ether through TAW-CT127 and Its Preliminary Genome Analysis.

Decabromodiphenyl ether (BDE-209), a polybrominated diphenyl ether (PBDE) homolog, seriously threatens human health. In this study, a strain with high BDE-209 degradation activity, named TAW-CT127, was isolated from Tong'an Bay, Xiamen. Under laboratory conditions, the strain's optimal growth temperature, pH, and salinity are 45 °C, 7.

Cr(VI) Removal by Recombinant Harboring the Main Functional Genes of M52.

Hexavalent chromium [Cr(VI)], a recognized heavy metal pollutant, has attracted much attention because of its negative impact on the ecological environment and human health. A chromium-resistant strain, M52, was discovered, and the functional genes orf2987, orf3015, orf0415, and orf3237 were identified in the strain by genomics. With the advancement of DNA recombination and gene-splicing technology, genetic engineering technology was used to produce recombinant strains 2987, 3015, 0415, and 3237.

Exploring the Cr(VI) removal mechanism of Sporosarcina saromensis M52 from a genomic perspective.

Serious hexavalent chromium [Cr(VI)] pollution has continuously threatened ecological security and public health. Microorganism-assisted remediation technology has strong potential in the treatment of environmental Cr(VI) pollution due to its advantages of high efficiency, low cost, and low secondary pollution. Sporosarcina saromensis M52, a strain with strong Cr(VI) removal ability, isolated from coastal intertidal zone was used in this study.