Ultrasound-guided platelet-rich plasma injection improves pain, function and symmetry in lumbar myofascial pain syndrome: A case report.

Background: Myofascial pain syndrome (MPS) is a common musculoskeletal disease associated with myofascial trigger point (MTrP). Muscle injury is one of the common causes of MPS. Currently, there is no effective treatment for MPS.

Comparison of the Predictive Roles of CT- and MRI-Based Pedicle Regional Osteoporosis Status Measurements for Pedicle Screw Loosening After Posterior Lumbar Interbody Fusion.

Study DesignRetrospective Study.ObjectivesTo compare the efficacy of pedicle Hounsfield unit (HU) values and pedicle bone quality (PBQ) scores in predicting pedicle screw loosening (PSL) after posterior lumbar interbody fusion (PLIF) in elderly patients and to identify the most discriminative bone mineral density (BMD) assessment indicator.MethodsThis retrospective analysis included 275 consecutive patients who underwent PLIF.

Mismatch Between Perceived and Actual Dietary Nutrition in Hospitalized Cardiovascular Patients and Clinicians: A Cross-Sectional Assessment and Recommendations for Improvement.

Multiple studies demonstrated that nutritional risk and malnutrition were associated with prolonged hospitalization, extended rehabilitation duration, and increased mortality among patients with cardiovascular diseases (CVD). However, current research on dietary behaviors and nutritional status in hospitalized CVD patients remains insufficient. This study systematically evaluated the concordance between cardiology inpatients' and clinicians' subjective nutritional status assessments and objective energy and protein intake achievement rates, while comprehensively investigating the multidimensional associations among Nutritional Risk Screening 2002 (NRS 2002), Global Leadership Initiative on Malnutrition (GLIM), blood parameters, and dietary intake.

Mannan-Containing Polymers from Hadal Bacterium : Preparation, Structural Analysis, Immunological Activity and Antitumor Effects.

Microbial exopolysaccharides from extreme environments are increasingly becoming valuable candidates for drug development. In this study, four fractions named XL-1, XMRS-1, XL-1-D, and XMRS-1-D were isolated and purified from the hadal bacterium by column chromatography. The structural features of these fractions were characterized by molecular weight, monosaccharide composition, Fourier transform infrared (FTIR) spectrum, amino acid analysis and NMR.

Anti-photoaging activity of cod peptides: structural characterisation and clinical validation.

The role of collagen peptides in anti-photoaging has attracted considerable research attention; however, the structure-activity relationship between their specific structural characteristics and biological efficacy remains poorly defined. In this study, collagen peptides from five sources, cod skin (CP), tilapia skin (TP), cowhide (BP), pig skin (PP), and chicken bone (JP), were selected to systematically compare their anti-photoaging activities in a UVA-induced L929 cell model and to investigate the mechanisms underlying their effects through analysis of molecular weight distributions, amino acid compositions, and sequence features. The results showed that CP, TP, and BP had stronger activities in increasing cell viability, enhancing the expression of , , and HAS-1/2/3, and inhibiting ROS generation and over-activation of MMP-1/3 in UVA-damaged cells, with CP having the most significant effect.

Fungal-fungal cocultivation alters secondary metabolites of marine fungi mediated by reactive oxygen species (ROS).

Unlabelled: Microorganisms form complex ecological networks of interactions, with secondary metabolites (SMs) playing a crucial role in microbial communication. This study explored the cocultivation of marine fungi and , uncovering significant SM production changes. The biosynthetic gene clusters (BGCs) and transcription factor in marine were activated, leading to enhanced production of alternariol (AOH), a compound inhibiting fungal competitors, whereas the activation was not present in the coculture of terrestrial strains of .

Maribacter luteocoastalis sp. nov., a novel marine bacterium isolated from the tidal flat sediments of the East China Sea.

A Gram-stain-negative, halophilic, rod-shaped, aerobic bacterial strain, designated as CXY002, was isolated from intertidal seawater of the East China Sea. Strain CXY002 exhibited growth at 4-33 °C (optimum 28 °C), pH 5.5-10 (optimum pH 6-7), and 2-10% (w/v) NaCl (optimum 6%).

Integration of Electrical Heating and Infrared-Reflection with Connected Ag Network for Personal Thermal Management.

Fabrics for keeping warm are essential for comfort and protection in extremely cold climates, yet integrating active heating and passive insulation remains challenging. Therefore, we propose an effective and facile methodology to fabricate Nomex/silver (Ag) nanofibrous membranes with electrical heating and infrared-reflecting capacity. We prepared Nomex nanofibrous membranes by first electrospinning, further employed dip-coating with dispersed Ag nanoparticles, and finally performed hot-pressing for constructing a connected Ag network.

The HOG signal pathway contributes to survival strategies of the piezo-tolerant fungus DM1 in hadal sediments.

Unlabelled: The hadal zone, one of Earth's most extreme ecosystems, harbors diverse and unique microbial communities adapted to its harsh environmental conditions, including high hydrostatic pressure (HHP) and low temperatures. Within these communities, deep-sea fungi play a critical role in geochemical cycling and marine ecosystem functioning; however, research on their cultivable strains and adaptation mechanism remains scarce. In this study, the piezo-tolerant fungus DM1, isolated from the Mariana Trench sediments (10,898 m), was selected as a representative strain.

Stability of gut microbiota in non-small cell lung cancer patients during chemoradiotherapy and its association with radiation pneumonitis.

To assess the intra-patient stability of gut microbiota across longitudinal samples in non-small cell lung cancer (NSCLC) patients treated with chemoradiotherapy (CCRT), its association with radiation pneumonitis (RP), and the factors driving such stability. Intra-patient gut microbial stability between consecutive time points was quantified by stability coefficients (mS scores) using iteratively growing-partitioned clustering. Patients with G0 RP exhibited higher mS scores compared with those with G2+ RP.

Large-Scale Roll-to-Roll Manufacturing of Flexible, Hydrophobic, and Fire-Resistant Mica/SiO Nanofiber Aerogel Paper.

Oxide ceramic aerogels offer exceptional thermal insulation and chemical stability but face limitations due to brittleness, moisture sensitivity, and costly, complex manufacturing. Here, we present a roll-to-roll method for producing flexible, hydrophobic, and fire-resistant silica/mica hybrid aerogel paper. The process bypasses the need for expensive polymer sacrificial templates and high temperature sintering, instead forming aerogels directly through electrospinning stabilized tetraethyl orthosilicate and a synthetic fluorophlogopite sol.

Urate-lowering and renal-protective effects of sugarcane polyphenols in hyperuricemia: mechanisms and key components.

Hyperuricemia (HUA) is a metabolic disorder characterized by abnormally elevated levels of uric acid (UA) in the blood, often accompanied by renal damage. The continuous rise in HUA incidence necessitates the development of safe, efficient natural urate-lowering pathways. This study combined network pharmacology prediction with rat model experiments to systematically evaluate the urate-lowering potential of sugarcane polyphenols (SP), a byproduct of the sugarcane sugar industry.

Evaluating the Performance of State-of-the-Art Artificial Intelligence Chatbots Based on the WHO Global Guidelines for the Prevention of Surgical Site Infection: Cross-Sectional Study.

Background: Surgical site infection (SSI) is the most prevalent type of health care-associated infection that leads to increased morbidity and mortality and a significant economic burden. Effective prevention of SSI relies on surgeons strictly following the latest clinical guidelines and implementing standardized and multilevel intervention strategies. However, the frequent updates to clinical guidelines render the processes of acquisition and interpretation quite time-consuming and intricate.

Protective role of natural saccharides in frozen animal food formulations: Enhancing cryopreservation during cold treatment.

Animal food formulations, particularly meat and related products, are essential components of the global food supply. However, their quality is highly vulnerable to deterioration during frozen storage due to ice crystal formation, protein denaturation, and moisture loss. This review outlines the key challenges associated with freezing preservation and highlights the increasing interest in naturally derived saccharides as safe and effective alternatives to conventional cryoprotectants such as glycerol and dimethyl sulfoxide.

C7ORF41 Alleviates Ferroptosis Via the Keap1/Nrf2/HO-1 Axis in Endotoxin-Associated Acute Kidney Injury.

Endotoxin-associated acute kidney injury (EA-AKI) is a critical complication in intensive care units. Ferroptosis, an iron-dependent form of cell death characterized by lipid peroxidation, has been implicated in EA-AKI; however, its regulatory mechanisms remain unclear. Prior research links C7ORF41 to anti-inflammatory effects and cellular stress regulation.

Deep Learning-Based Prediction for Bone Cement Leakage During Percutaneous Kyphoplasty Using Preoperative Computed Tomography: MODEL Development and Validation.

Study Design: Retrospective study.

Objective: To develop a deep learning (DL) model to predict bone cement leakage (BCL) subtypes during percutaneous kyphoplasty (PKP) using preoperative computed tomography (CT) as well as employing multicenter data to evaluate the effectiveness and generalizability of the model.

Summary Of Background Data: DL excels at automatically extracting features from medical images.

Randomized trial on the impact of card Game-Based teaching on learning and memory retention of neurological syndromes.

Background: Learning about neurological syndromes is an essential component of medical education, but traditional teaching methods often lack interactivity and practical engagement. This study investigates the impact of an innovative teaching approach using the Neurological Syndrome Card Game (NSCG) on students' learning outcomes.

Methods: A randomized controlled trial design was implemented, with participants divided into an experimental group and a control group.

KIF23 inhibition protects against perioperative neurocognitive disorders by hindering ROS/caspase-3/GSDME-mediated pyroptosis.

The activation of caspase-3 and gasdermin E (GSDME)-mediated pyroptosis is a key driver of perioperative neurocognitive disorders (PND). Kinesin family member 23 (KIF23), a constituent of the kinesin superfamily of microtubule-associated motor proteins, governs NLRP3 inflammasome-mediated pyroptosis and is essential for dendritic differentiation and development. This study sought to ascertain whether KIF23 influences PND by affecting caspase-3/GSDME-dependent pyroptosis.

A Multi-view Open-access Dataset of Paired Knee MRI for Motion Artifact Removal.

Magnetic resonance imaging (MRI) has become a standard examination method for the knee, facilitating the identification of a range of knee-related issues, including injuries, arthritis, and other conditions. The lengthy image acquisition time inherent to MRI results in the generation of motion artifacts, which in turn impairs the efficiency of MRI applications. To address this challenge, we present a multi-view, multi-sequence knee joint paired MRI dataset (image with motion artifact vs.

Ultrasound-guided injection of platelet-rich plasma alleviated pain and improved function for individuals with myofascial pain syndrome: a retrospective case series study.

Background: Myofascial pain syndrome (MPS) is a regional musculoskeletal pain associated with myofascial trigger point (MTrP), lacks therapies with sustained efficacy. Current modalities offer short-term relief but fail to address underlying tissue degeneration.

Objectives: This study aimed to evaluate the 3-month safety and efficacy of ultrasound-guided platelet-rich plasma (PRP) injections in alleviating MPS-related pain and function.

A novel deep learning system for automated diagnosis and grading of lumbar spinal stenosis based on spine MRI: model development and validation.

Objective: The study aimed to develop a single-stage deep learning (DL) screening system for automated binary and multiclass grading of lumbar central stenosis (LCS), lateral recess stenosis (LRS), and lumbar foraminal stenosis (LFS).

Methods: Consecutive inpatients who underwent lumbar MRI at our center were retrospectively reviewed for the internal dataset. Axial and sagittal lumbar MRI scans were collected.

Career adaptability and job burnout of pediatric residents: the role of psychological resilience and insomnia.

Background: Pediatric residents face significant occupational stress due to the demanding work environment, which often leads to high levels of job burnout. The study examined the internal mechanisms by which career adaptability could influence job burnout, focusing on the mediating role of psychological resilience and the moderating effect of insomnia.

Methods: A cross-sectional survey was conducted from March to May, 2024, among 866 pediatric residents in the Pearl River Delta region, using a convenience sampling.

A Deep Learning-Based De-Artifact Diffusion Model for Removing Motion Artifacts in Knee MRI.

Background: Motion artifacts are common for knee MRI, which usually lead to rescanning. Effective removal of motion artifacts would be clinically useful.

Purpose: To construct an effective deep learning-based model to remove motion artifacts for knee MRI using real-world data.

Experience with transarterial embolization for large symptomatic renal angiomyolipomas in patients with a solitary kidney: long-term outcomes.

Background: Treatment of large symptomatic renal angiomyolipomas (AMLs) in patients with a solitary kidney poses a challenge in controlling the tumor while preserving renal function. This retrospective research examines the safety and long-term effects of transarterial embolization (TAE) using iodized oil-bleomycin emulsion plus N-Butyl cyanoacrylate (NBCA) for treating large symptomatic AMLs in patients with a solitary kidney.

Methods: Over 20 years, 12 female patients, who had a solitary kidney due to a previous radical nephrectomy for AMLs, underwent TAE.