Successful cure of a patient with tracheoesophageal fistula in cervical esophageal cancer: A case report and review of literature.

Background: Tracheoesophageal fistula (TEF) is a life-threatening complication of advanced esophageal squamous cell carcinoma (ESCC). Cervical ESCC is rare and frequently diagnosed at an advanced stage. Managing cervical esophageal cancer (CEC) is challenging, requiring intervention by a multidisciplinary team (MDT) and innovative surgical management.

Mismatch Between Perceived and Actual Dietary Nutrition in Hospitalized Cardiovascular Patients and Clinicians: A Cross-Sectional Assessment and Recommendations for Improvement.

Multiple studies demonstrated that nutritional risk and malnutrition were associated with prolonged hospitalization, extended rehabilitation duration, and increased mortality among patients with cardiovascular diseases (CVD). However, current research on dietary behaviors and nutritional status in hospitalized CVD patients remains insufficient. This study systematically evaluated the concordance between cardiology inpatients' and clinicians' subjective nutritional status assessments and objective energy and protein intake achievement rates, while comprehensively investigating the multidimensional associations among Nutritional Risk Screening 2002 (NRS 2002), Global Leadership Initiative on Malnutrition (GLIM), blood parameters, and dietary intake.

Prognostic comparison between LNM and MaVI of hepatocellular carcinoma: a multicenter population-based propensity scores matching study.

Background: Hepatocellular carcinoma (HCC) with lymph node metastases (LNM) is an uncommon neoplasm and has an ambivalent prognosis compared to the common type of HCC with macrovascular invasion (MaVI).

Methods: In this study, the clinical data of patients were extracted from Surveillance, Epidemiology, and End Results (SEER) and Southeast Big Data Institute of Hepatobiliary Health, Mengchao Hepatobiliary Hospital of Fujian Medical University. The K-M survival curve described overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) between LNM and MaVI.

Utility of novel composite index in predicting the prognosis of total neoadjuvant therapy for locally advanced rectal cancer: A multicenter real-world cohort study.

Objective: C-reactive protein-albumin-lymphocyte (CALLY) is a novel composite index. Total neoadjuvant therapy (TNT) has become one of the standard treatments for locally advanced rectal cancer (LARC). It remains unclear whether CALLY can predict the prognosis for LARC patients.

Pocket Electronic Nose Integrating an Ultra-Compact Sensor Array Chip and Spatiotemporal Network Enables Highly Selective Gas Sensing.

Accurately distinguishing gases with nearly identical molecular structures─such as nitric oxide (NO) and nitrogen dioxide (NO)─remains challenging for conventional sensors. We report a palm-sized (5 cm × 5 cm) electronic nose that integrates an ultralow-power microelectro-mechanical systems (MEMS) sensor array with a spatiotemporal deep-learning model (STNet), for trace-level detection and quantification of NO and NO. The array contains nine carbon-based nanocomposite sensors monolithically fabricated on a 3 mm × 3 mm chip; each sensor operates at room temperature, consumes <2 mW, and achieves detection limits below 0.

PLK1 inhibitors for the treatment of colorectal cancer.

Polo-like kinase 1 (PLK1) is a key regulator in mitosis and a highly potent target for anti-cancer therapies. Several PLK1 inhibitors have been developed and evaluated for cancer treatment. However, none of them has yet been approved for clinical usage, mostly due to their low response rates in cancer patients.

GRK2 Orchestrates VSMC Phenotypic Modulation via DNMT1-Mediated DNA Methylation Reprogramming.

Background: Vascular smooth muscle cell (VSMC) phenotypic modulation is responsible for the pathogenesis of hyper-muscularized arterial diseases. Recent studies have highlighted the critical role of epigenetic regulation in VSMC fate. However, the mechanisms underlying the precise regulation of the epigenetic machinery in VSMC remain unclear.

Stabilization of sesame oil-in-water emulsions by synergistic complexation of tea saponin and gum arabic: Stability and rheological characterization.

This work aimed at developing a stable oil-in-water microemulsion by electrostatically assembling tea saponin (TS) with varying concentrations of gum arabic (AG). Particular emphasis has been given to rheology, droplet size distribution, ζ-potential measurements, and microscopy to investigate their underlying relationship with emulsion properties. A small concentration (0.

Permethrin Stimulates Fat Accumulation via Regulating Gut Microbiota and Its Metabolites in Mice.

Permethrin, a commonly used type I pyrethroid insecticide, has been shown to induce insulin resistance and adipogenesis, however the molecular mechanisms driving these effects remain unclear. This research demonstrated that permethrin disrupts the balance of gut microbiota, particularly altering and ratios, leading to increased adipogenesis and metabolic disorders. Antibiotic treatment significantly alleviated the effects of permethrin, highlighting the potential role of gut microbiota in obesity and insulin resistance.

A differential diagnostic model based on immunological evaluation and routine laboratory tests: distinguishing multiple myeloma from other disorders with aberrant immunoglobulin elevation.

Objective: Develop a diagnostic model using common hematological and immunological indicators to assist in the early screening and differential diagnosis of Multiple Myeloma (MM) in clinical settings, reducing the risk of misdiagnosis.

Methods: A retrospective analysis was conducted on 274 newly diagnosed and treated MM patients and 137 connective tissue disease patients treated at Zhejiang Provincial People's Hospital from January 2008 to August 2023. Laboratory indicators, including complete blood count, biochemistry, coagulation function, and immunoglobulin markers, were collected.

Nature-Inspired Upward Hanging Evaporator with Photothermal 3D Spacer Fabric for Zero-Liquid-Discharge Desalination.

While desalination is a key solution for global freshwater scarcity, its implementation faces environmental challenges due to concentrated brine byproducts mainly disposed of via coastal discharge systems. Solar interfacial evaporation offers sustainable management potential, yet inevitable salt nucleation at evaporation interfaces degrades photothermal conversion and operational stability via light scattering and pathway blockage. Inspired by the mangrove leaf, we propose a photothermal 3D polydopamine and polypyrrole polymerized spacer fabric (PPSF)-based upward hanging model evaporation configuration with a reverse water feeding mechanism.

Spike RBD drives sustained Parkinson's disease progression via microglia-neuron crosstalk-mediated RTP801 upregulation.

Introduction: Emerging evidence highlights the exacerbation and sustained Parkinson's disease (PD) progression following COVID-19. The SARS-CoV-2 spike receptor-binding domain (RBD), which can persist in the brain post-infection, is a likely contributor, but how it drives this neuropathology is unclear.

Objectives: To elucidate the underlying mechanisms of long COVID's impact on PD and identify mechanism that contribute to the continuous progression of PD.

Dual-Action Tocilizumab-Conjugated Cisplatin Nanoparticles Overcome Chemoresistance and Metastasis in Non-Small-Cell Lung Cancer.

Cisplatin remains a cornerstone chemotherapeutic agent for non-small-cell lung cancer (NSCLC) treatment, yet its clinical utility is substantially limited by acquired resistance and the inadequate suppression of tumor metastasis. Emerging evidence implicates interleukin 6 (IL-6) as a critical mediator of chemoresistance through cancer stem cell (CSC) enrichment and metastasis promotion via epithelial-mesenchymal transition (EMT) induction, ultimately contributing to cisplatin therapy failure. This study sought to address these challenges by designing a nanoplatform with two innovative aims: (1) to achieve active tumor targeting through binding to the IL-6 receptor (IL-6R), and (2) to concurrently inhibit IL-6-mediated chemoresistance signaling pathways.

Evolutionary legacy of the "living fossil" genus Parrotia (Hamamelidaceae): genomic insights into species divergence and polygenic adaptation.

Despite their long evolutionary history, the genomic basis of adaptation and speciation in "living fossil" plants remain largely unexplored. Parrotia, a Tertiary relict tree genus with two extant species, P. subaequalis and P.

Integrated multi-omics preliminarily reveals sex-biased gene networks controlling dormancy release in Asparagus officinalis.

Understanding dormancy regulation in Asparagus (Asparagus officinalis L.), a globally valued dioecious vegetable, is critical for optimizing uniform spear emergence and yield. This study integrates transcriptomic, proteomic, and endogenous hormone analyses across key dormancy and sprouting stages in male and female plants to elucidate the underlying molecular mechanisms.

MLN0905 effectively kills gemcitabine-resistant pancreatic cancer cells by targeting PLK1.

Background: Polo-like kinase 1 (PLK1) functionally mediates tumorigenesis of pancreatic cancer (PC) and associates with its drug resistance to gemcitabine, but related inhibitor therapies were poorly explored. MLN0905 is a novel small molecule inhibitor targeting PLK1. Here we investigate the therapeutic capacity for gemcitabine-resistant pancreatic cancer and related molecular mechanism of MLN0905.

Added value of dual-phase Tc-HYNIC-FAPI-04 SPECT/CT in postoperative follow-up of colorectal cancer.

Objective: To assess the added value of dual-phase Tc-HYNIC-FAPI-04 single-photon emission computed tomography/computed tomography (SPECT/CT) compared with single-phase imaging in postoperative follow-up of colorectal cancer (CRC).

Methods: Early and delayed Tc-HYNIC-FAPI-04 SPECT/CT imaging were undertaken in 21 patients with CRC after surgery. The mean radioactivity count of the lesion site and abdominal aorta in secondary imaging was delineated and measured.

Parthenolide reverses cisplatin-resistant in ovarian cancer: An observational network pharmacology and molecular docking study.

Background: Ovarian cancer (OV) is the most prevalent and lethal gynecologic malignancy globally. Cisplatin remains the first-line chemotherapeutic regimen for OV; however, chemotherapy resistance poses a persistent clinical challenge in gynecologic oncology. Parthenolide, a naturally derived phytochemical, exhibits broad-spectrum antitumor activity.

Global, regional, and national burden of endometriosis among women of childbearing age from 1990 to 2021: a cross-sectional analysis from the 2021 global burden of disease study.

Background: Endometriosis is a major contributor to infertility and pelvic pain, which brings a significant burden on family and society. Although the data of endometriosis in Global Burden of Disease (GBD) 2019 was reviewed, no updated analysis has been conducted using GBD 2021, and the disease burden across different age groups has not been analyzed. The aim of this cross-sectional analysis was to provide an up-to-date assessment of the prevalence, incidence, and disability-adjusted life-years (DALYs) of endometriosis from 1990 to 2021 at the global, national, and regional levels.

Porous PLGA microspheres loaded with PTH peptide for long-term treatment of OA.

Background: Osteoarthritis (OA) is a chronic disease characterized by degeneration of articular cartilage, affecting over 530 million patients worldwide. Current oral medications such as non-steroidal anti-inflammatory drugs (NSAIDs) can only alleviate symptoms and are associated with numerous adverse effects. Although teriparatide (PTH) exhibits dual functions of chondroprotection and osteogenic effects, its clinical application is significantly limited by its short biological half-life (30-60 min) and accelerated degradation within the inflammatory microenvironment of joint cavities.

Independent tuning of free spectral range in thin-film lithium niobate microring resonators.

In conventional traveling-wave optical cavities, the free spectral range (FSR) and the resonance frequencies are inherently linked, limiting the ability to control the FSR independently. This work presents a systematic investigation of techniques to tune the waveguide dispersion in thin-film lithium niobate (TFLN) microring resonators (MRRs), enabling independent control of the FSR without affecting a specific resonance. We experimentally characterize and compare the effects of electro-optic and thermo-optic tuning on the FSR and resonance wavelengths, revealing the difference in tuning waveguide mode dispersion between distinct mechanisms.

Atroposelective Suzuki-Miyaura Coupling Reaction with Benzoxaboroles.

The asymmetric ring-opening Suzuki-Miyaura cross-coupling (SMC) reaction of -disubstituted aryl bromides with cyclic benzoxaboroles has been developed for the first time by using a commercially available Et-AntPhos as the chiral ligand, offering general access to diverse axial chiral biaryl benzyl alcohols in high enantioselectivity (up to 97:3 er). This protocol also features mild reaction conditions and a broad substrate scope, demonstrating the potential of benzoxaboroles in asymmetric transformations.

Alcohol-induced bone loss driven by dysregulated spatial distribution of gut microbiota and PGD2-IL17 pathway-mediated osteoclast activation.

Introduction: Alcohol-induced damage to bone microstructure leads to alcoholic osteoporosis (AOP). While prior studies have demonstrated alcohol's negative impact on bone density, the mechanisms by which alcohol induces osteoporosis through immune pathways, gut microbiota dysbiosis, and metabolic alterations remain insufficiently characterized. Given that alcohol is primarily absorbed in the upper gastrointestinal tract, in this research, we aimed to elucidate the role of spatial distribution disorders in gut microbiota and metabolites in the pathogenesis of alcohol-induced osteoporosis.

RETRACTED: Shi et al. Surface Hydrophilic Modification for Chip of Centrifugal Microfluidic Immunoassay System. 2022, , 831.

The journal retracts the article titled "Surface Hydrophilic Modification for Chip of Centrifugal Microfluidic Immunoassay System" [...

Structural optimization of biodegradable tracheal stent based on mechanical properties of trachea.

Tracheal stent implantation serves as a critical intervention for tracheal stenosis, where biodegradable magnesium (Mg) alloy stents have emerged as promising alternatives due to their ability to eliminate long-term complications associated with permanent stents. However, the uneven stress distribution on the stent often leads to premature failure through localized rapid degradation and structural collapse. This study systematically investigated the biomechanical interactions between biodegradable stents and tracheal tissues to guide optimized stent design.