Publications by authors named "Kevin Gramajo-Aponte"
A Single-center Experience of Coccidioides Meningitis in Immunocompetent Patients: Case Series and Literature Review.
Open Forum Infect Dis
November 2024
Article Synopsis
- The California Department of Public Health has raised concerns about a significant increase in Coccidioidomycosis cases, linking it to climate change and rapid housing development.
- Many believe Coccidioidal meningitis (CM) only affects immunocompromised patients, but a recent study highlights 12 cases in immunocompetent individuals, all of whom faced severe complications.
- The majority required surgical interventions, including shunting, and the condition proved fatal for three patients, emphasizing the critical need for early recognition and diagnosis of CM to prevent life-threatening outcomes.
We describe a case of a young patient with a recurrent pleomorphic xanthoastrocytoma (PXA) showing unusual cell-in-cell (CiC) phenomena. We observed mostly viable but also necrotic neutrophils engulfed within tumor cells. The recurrent tumor was immunopositive for BRAFV600E mutant protein and showed CDKN2 homozygous deletions typical of PXA.
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