Efficacy of digital interventions for smoking cessation by type and method: a systematic review and network meta-analysis.

Smoking cessation is the only evidence-based approach to reducing tobacco-related health risks, yet traditional interventions suffer from limited coverage. Although digital interventions show promise, their comparative efficacy across methodological frameworks and technology types remains unclear. Here we assessed digital interventions versus standard care via frequentist random-effects network meta-analysis of 152 randomized controlled trials (48.

Hydrazine-Mediated Thermally Assisted Photocatalytic Ammonia Decomposition Over Layered Protonated Perovskites.

Photocatalytic ammonia decomposition offers a sustainable route for hydrogen production, but its development is limited by low catalytic efficiency and poorly understood mechanisms. Here, a protonated layered perovskite, HPrNbO (HPNO), is reported as an efficient catalyst for ammonia decomposition under mild photo-thermal conditions. Upon exposure to NH at elevated temperatures, HPNO promotes the in situ formation and intercalation of hydrazine intermediates within its interlayer galleries, enabled by thermally generated oxygen vacancies and hydrogen bonding.

A study exploring predictors of cell phone use while walking among adolescents based on theory of planned behavior.

Background: Walking is a complex activity that requires high levels of perception and cognitive abilities. Healthy pedestrians who use mobile phones while walking will have their decision-making process affected to varying degrees and may be at greater risk of injury. Previous studies have shown that using mobile phones while walking is becoming increasingly common.

Response of rapeseed growth to soil salinity content and its improvement effect on coastal saline soil.

Coastal saline soil is considered an important land source due to their abundant thermal and light conditions, irrigation resources, and relatively low reclamation difficulty. However, it is crucial to establish effective strategies for ameliorating saline soil to render it suitable for crop growth and development. As an economic crop with strong salt tolerance, rapeseed ( L.

Toti-N-glycan Recognition Enables Universal Multiplexed Single-Nucleus RNA Sequencing.

Sample barcoding-based multiplex single-cell and single-nucleus sequencing (sc/sn-seq) offers substantial advantages by reducing costs, minimizing batch effects, and identifying artifacts, thereby advancing biological and biomedical research. Despite these benefits, universal sample barcoding has been hindered by challenges such as inhomogeneous expression of tagged biomolecules, limited tagging affinity, and insufficient genetic insertion. To overcome these limitations, we developed Toti-N-Seq, a universal sample multiplex method, by tagging Toti-N-glycan on cell surfaces or nuclear membranes via our engineered streptavidin-Fbs1 GYR variant fusion protein, which could be used not only for sc-seq but also for sn-seq.

Polymer-engineered PROTAC nanovehicles amplify synergistic effects with temozolomide by BRD4 degradation.

As the most aggressive primary brain tumor, glioblastoma (GBM) remains therapeutically challenging. Proteolysis-targeting chimeras (PROTACs), capable of degrading target proteins like BRD4, offer a promising strategy for GBM therapy. However, their clinical application is limited by poor solubility, stability, and bioavailability.

The First Complete Mitogenome Characterization and Phylogenetic Implications of (Teleostei: Elopiformes: Elopidae).

This study presents the first complete mitochondrial genome characterization of (Teleostei: Elopiformes: Elopidae), a basal teleost lineage critical for understanding early actinopterygian evolution. The assembled mitogenome, deposited under GenBank accession number PV294982, spans 16,712 bp and exhibits the canonical vertebrate mitochondrial gene organization, comprising 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and a control region. Base composition analysis revealed 22.

The Long Noncoding RNA TUG1 Is Down-Regulated in Osteonecrosis of the Femoral Head and Enhances the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Stimulating the Wnt/β-Catenin Pathway.

Osteonecrosis of the femoral head (ONFH) is an orthopaedic disease with multifaceted pathogenesis. The role of long noncoding RNA (lncRNA) taurine-up-regulated gene 1 (TUG1) in ONFH remains unexplored. Thus, lncRNA expression profiles in subchondral bone from patients with ONFH and healthy controls were analyzed using microarray analysis, RT-qPCR, and bioinformatics.

[Short-term effectiveness of minimally invasive treatment for posterolateral depressed tibial plateau fractures assisted by robots and arthroscopy].

Objective: To investigate short-term effectiveness of robot-assisted fracture reduction and fixation combined with arthroscopic exploration for posterolateral depressed tibial plateau fractures.

Methods: Between January 2022 and January 2024, 8 patients with posterolateral depressed tibial plateau fractures (Schatzker type Ⅲ) were treated using robot-assisted fracture reduction and fixation combined with arthroscopic exploration, with simultaneous treatment of concomitant ligament or meniscus tears. There were 3 males and 5 females with an average age of 54.

Transfersome enhances nail penetration of antifungal drug and photosensitizer for chemo-photodynamic therapy of onychomycosis in a novel rat model.

Onychomycosis is a prevalent nail infection caused by fungi, presenting significant treatment challenges due to poor drug penetration and high recurrence rates. Current treatments, including oral and topical antifungals, often have limited efficacy and can lead to resistance. Transfersomes are lipid vesicles that can penetrate skin for transdermal drug delivery.

Acupuncture Alleviates Blood-Brain Barrier Damage After Delayed rtPA Thrombolysis for Acute Ischemic Stroke by Regulating Ferroptosis.

Background: Acute ischemic stroke (AIS) is the second leading cause of death and disability worldwide. Recombinant tissue plasminogen activator (rtPA) was the first FDA-approved thrombolytic drug for AIS. However, delayed administration of rtPA exacerbates brain injury and increases the risk of hemorrhagic transformation (HT) and mortality.

Personality typology, emotional needs, and romantic relationship stability in Chinese college students: A cultural perspective on MBTI dynamics.

This study investigates the relationship between MBTI personality types, emotional needs, and relationship stability among college students from a university in Northwest China. A total of 110 participants were surveyed, and the MBTI type distribution (with INFJ, ENFP, and ISFP being most prevalent) is reported as a descriptive feature of this specific sample. The findings reveal significant differences in emotional needs across MBTI types: NT types in this sample demonstrate a greater focus on intellectual connection, while NF types prioritize emotional intimacy and psychological support.

Stress hyperglycemia ratio and its correlation with long-term prognosis in ACS patients with chronic kidney disease: a retrospective study.

Background: The Stress Hyperglycemia Ratio (SHR), which serves as an indicator of blood glucose variability in response to acute illness or injury, has been established as a predictor of long-term prognosis for various diseases, particularly those affecting cardiovascular health. However, the relationship between SHR and patients presenting with acute coronary syndrome (ACS) in conjunction with chronic kidney disease (CKD) remains to be fully elucidated.

Methods: From January 2013 to December 2019, this study enrolled a total of 465 patients with ACS complicated by CKD at the First Affiliated Hospital of Wenzhou Medical University.

Engineered-Macrophage-Escorted Rotaxane Nanoscavengers for Precise Diquat Detoxification.

This study proposes a bioinspired on-demand detoxification strategy addressing the critical need for efficient toxin poisoning therapies. Focusing on the high-mortality herbicide diquat, an active toxin-hunting paradigm is developed, diverging from passive methods like hemodialysis. Charge-neutralizing carboxymethyl α-cyclodextrin (CCD) is computationally designed to recognize, sequester, and detoxify diquat by counteracting its positive charge and suppressing ROS generation.

CoC/CoC heterostructure towards polysulfide capture/conversion for advanced lithium-sulfur batteries.

The slow redox kinetics and intractable shuttle effect of lithium polysulfides (LiPSs) significantly hinder the practical usage of lithium-sulfur batteries (LSBs). Here, the nanostructured material combining doped nitrogen, cobalt carbides with high intrinsic activity, and electronically conductive carbon black (CoC/CoC/NEC) is prepared by a hydrothermal method and subsequent heat treatment. CoC/CoC heterostructure is comprised of CoC exhibiting a high adsorption capacity for LiPSs and CoC electrocatalyst demonstrating a mighty catalytic activity on LiPSs.

In-depth analysis of the first complete mitochondrial genome of the rare shrimp Alpheus euphrosyne, with comparative phylogenetic genomics insights into the Alpheus species.

Background: Mitochondrial genomes, with their maternal inheritance, rapid evolution, and compact organization, are ideal for phylogenetic analysis.

Aim: This study presents the first comprehensive mitochondrial genome analysis of the rare shrimp Alpheus euphrosyne, a species known for its unique morphological traits and ecological niche.

Methods And Results: By sequencing and annotating its entire mitochondrial genome, we provide a detailed genetic blueprint that informs future studies on its evolutionary trajectory, population genetics, and conservation status.

Global warming exacerbates the risk of habitat loss for regional mangrove species.

Mangroves, as a salt-tolerant evergreen broad-leaved vegetation ecosystem, are widely distributed along the coastlines of tropical and subtropical regions. In the field of ecology, scholars generally agree that climatic drivers, particularly temperature and precipitation patterns, play a crucial role in regulating the global distribution, structure, and functions of mangroves. However, there are still significant challenges in research exploring the relationship between climate and mangrove distribution.

Efficacy and Safety of Neoadjuvant Immunotherapy plus Chemotherapy versus Neoadjuvant Chemotherapy in Non-Small Cell Lung Cancer Treatment: A Mixed Method Meta-Analysis Based on Global Randomized Controlled Trials.

This study explores the efficacy and safety of combining immunotherapy with chemotherapy for neoadjuvant non-small cell lung cancer (NSCLC) treatment. Despite the rapid advancement of immunotherapy, direct evidence comparing it with chemotherapy alone is limited. Following PRISMA guidelines, we analyzed global phase II and III randomized controlled trials data.

Modeling habitat distribution and niche overlap of Asian horseshoe crabs: Implications for conservation.

Asian horseshoe crabs are ancient organisms essential for the balance of marine ecosystems. However, detailed information on their ecology and the environmental factors influencing their distribution remains limited. In this study, we analyzed habitat characteristics, potential distribution, and niche overlap for three species: Tachypleus tridentatus, Carcinoscorpius rotundicauda, and Tachypleus gigas.

Comparative analysis of sexual function and psychological health in infertile patients with different ovarian dysfunctions.

Background: Premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS) are common reproductive disorders that negatively affect women's sexual and psychological health.

Aim: This study aims to compare sexual function and psychological well-being in women with POI, PCOS, and healthy controls.

Methods: A total of 340 women were recruited: 68 with POI, 104 with PCOS, and 168 healthy controls.

Panoramic lead-immune system interactome reveals diversified mechanisms of immunotoxicity upon chronic lead exposure.

Lead exposure is of high prevalence, and over a billion people are chronically exposed to alarming level of lead. Human immune system is highly vulnerable to lead, but the underlying mechanism remains unknown. Using single-cell mass cytometry and mass spectrometry-based proteomics, we performed a panoramic survey of lead targets at both cellular and molecular levels in murine immune system upon chronic lead exposure.

Untangling the Mechanisms in Magneto-Electrocatalytic Oxygen Evolution.

External magnetic fields emerge as a promising method for enhancing the electrocatalytic oxygen evolution reaction (OER), yet the underlying magneto-electric (ME) mechanisms are not well understood. The slow kinetics of OER make it a key challenge in electrocatalytic water-splitting, a promising technique for sustainable H fuel production. Herein, a systematic approach is presented to analyzing the ME mechanisms governing OER, using metallic-plate (Ni foam, Ni sheet, and Pt sheet) and powder-based (CoO/BaFeO on carbon paper) electrodes.

Synthesis of Thienoacenes via Cascade Copper-Catalyzed C-S Coupling and Thienannulation Reactions and Their Thermoelectric Properties.

Thienoacenes are a prominent class of fused-ring conjugated organic compounds and have attracted considerable attention due to their high coplanarity, good stability, high charge-carrier mobility, etc. However, most current synthetic methods toward thienoacenes require costly starting materials and reagents, as well as a lengthy synthetic procedure with low overall yields. Herein, a nonprecious copper-catalyzed system without additional ligands was developed to facilitate C-S coupling and 5-endo-dig thienannulation reaction, leading to the synthesis of a range of thienoacenes including dithieno[3,2-:2',3'-]thiophenes (DTTs) and thieno[2',3':4,5]thieno[3,2-]thiophene[2,3-]thiophene (TTAs) with yields of up to 90% (for single-sided thienannulation reactions) and 65% (for double-sided thienannulation reactions).

Solid Polymer Electrolytes for All-Solid-State Lithium-Sulfur Batteries: Different Designs Dependent on Their Interaction with Sulfur Cathodes.

Nonflammable and flexible solid polymer electrolytes (SPEs) are widely studied to improve the safety of lithium-sulfur batteries (LSBs). Studies on SPE-based LSBs primarily focus on addressing issues stemming from poor SPE properties, Li dendrites, and "shuttle effect" of polysulfides. Currently, strategies from SPE-based lithium batteries (without sulfur cathodes) and liquid electrolyte (LE)-based LSBs (without SPEs) are the most commonly employed approaches to tackle above issues.