Dual surface modification strategies for enhanced osteogenesis of titanium through the biomimetic Haversian osteon with deposited CaP to assemble salidroside.

Titanium (Ti) and Ti alloy are the most widely used implant metals, but the limited bioactivity hinders the further clinical application. Aiming to enhance their osteogenesis, dual biomimetic strategies were utilized to decorate the surface of Ti by topological and biochemical cues. Firstly, a series of concentric circles with TiO nanotubes on Ti were fabricated by photolithography and anodic oxidation.

Reversible shear stress-mediated mechanoregulation of endothelial cell function in thixotropic hydrogels via L-type Ca channel and focal adhesion molecules for accelerated vascularization.

Developing functional vascular networks in engineered tissues is crucial for regenerative medicine. Recently, thixotropic hydrogel has emerged as a promising approach due to their 3D-printability and force-responsive dynamics. However, their gel-sol transitions under physiological loading and subsequent mechanoregulation mechanism on vascularization remains inadequately explored.

Polyphenol Conductive Nanozyme-Enhanced Redox Hydrogel Coupled with Vagus Nerve Electrical Stimulation for Diabetic Wound Repair.

Diabetic wound repair is complicated by excessive oxidative reactions, bacterial infection, and persistent inflammation. Nanozyme-incorporated hydrogels have shown potential to facilitate diabetic wound repair. This study developed a polyphenol-conductive nanozyme-enhanced redox hydrogel composed of dopamine-grafted fish gelatin, methacrylated silk fibroin, and dopamine-mediated poly(3,4-ethylenedioxythiophene) (PDA-Fe-PEDOT) conductive nanozymes.

Polyphenol-Mediated Electroactive Hydrogel with Armored Exosomes Delivery for Bone Regeneration.

Prolonged oxidative stress and reduced activity of mesenchymal stem cells are significant barriers to effective bone repair. Current therapeutic approaches often suffer from limited long-term efficacy due to inefficient exosome delivery and the degradation of biological materials. Here, we present an electroactive gelatin methacryloyl hydrogel incorporating a tannic acid-mediated conductive polypyrrole microfiber network and exosomes armored with a metal-polyphenol network, designed to mitigate chronic inflammation and enhance bone healing.

Polyphenol-Mediated Multifunctional Human-Machine Interface Hydrogel Electrodes in Bioelectronics.

Human-machine interface (HMI) electrodes enable interactions between humans and bioelectronic devices by facilitating electrical stimulation and recording neural activity. However, reconciling the soft, hydrated nature of living human tissues with the rigid, dry properties of synthetic electronic systems is inherently challenging. Overcoming these significant differences, which is critical for developing compatible, effective, and stable interfaces, has become a key research area in materials science and technology.

Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy.

Rheumatoid arthritis (RA) is a common chronic autoimmune condition accompanied by lubrication dysfunction, inflammatory infiltration, and cartilage wear. Long-term improvements in joint lubrication, inflammation elimination, and worn cartilage repair are crucial for effective RA treatment. Herein, we present an injectable bioadhesive and lubricating hydrogel containing a dopamine-modified hyaluronic acid (DA-HA) network, sulfonated hyaluronic acid (SO-HA) network, and kartogenin (KGN)-grafted dopamine-hybridized graphene quantum dot-supported Cu single-atom nanozyme (DAGQD@Cu@KGN SAN) designed to restore cartilage lubrication and repair worn cartilage in RA.

A Bio-Adaptive Janus-Adhesive Dressing with Dynamic Lubrication Overlayer for Prevention of Postoperative Infection and Adhesion.

Wound postoperative infection and adhesion are prevalent clinical conditions resulting from surgical trauma. However, integrating intraoperative repair and postoperative management into a dressing suitable for wounds with unpredictable surface shapes and surroundings remains a formidable challenge. Here, we attempt to introduce a dynamic antifouling surface as wound protective covering and report an in situ formation of slippery-adhesive Janus gel (SAJG) by assembling hydrogel (N-hydrosuccinimide ester-activated powders) and elastomer (Silicon oil-infused polydimethylsiloxane).

Polyphenol Microneedles for Dermatological Therapy.

Dermatological diseases represent one of the most prevalent health concerns globally, with associated care and treatment costs having consistently increased over the past decade. Current therapeutic modalities, including topical medications, oral pharmaceuticals, and physical therapies, frequently face challenges such as inadequate drug absorption and substantial adverse effects. Microneedles, recognized as minimally invasive drug delivery systems, effectively penetrate the cutaneous barrier to enhance drug permeability and therapeutic efficacy.

Smart self-healing hydrogel wound dressings for diabetic wound treatment.

Diabetic wounds are difficult to treat clinically because they heal poorly, often leading to severe complications such as infections and amputations. Hydrogels with smart self-healing properties show great promise for treating diabetic wounds. These hydrogels are capable of continuously and dynamically responding to changes in the wound environment, feature improved mechanical qualities and the capacity to self-heal damage.

Injectable Chondroitin Sulfate Microspheres with Gallic Acid-Magnesium MOF for Anti-Inflammatory and Cartilage Degeneration Alleviation in Osteoarthritis Treatment.

Inflammation and cartilage degeneration are critical challenges in osteoarthritis (OA) treatment. Achieving sustained drug efficacy while mitigating the adverse effects of inflammation and reactive oxygen species remains a significant challenge. This study synthesizes a gallic acid-magnesium (GA-Mg) metal-organic framework (MOF) as a drug carrier for puerarin (PA).

Polydopamine-Mediated Nanofillers Reinforced Zwitterion Hydrogel Electrodes for Supercapacitors in Bioelectronics.

Supercapacitors that can function when in direct contact with human tissue are of paramount importance for wearable bioelectronics but face mismatching with biological tissue and its movement. Herein, we developed a zwitterion hydrogel elastomer electrode-based all-hydrogel supercapacitor (AHSC) characterized by good energy storage properties, bioadhesion, body movement-matching mechanical properties, and biocompatibility. These functions were realized by integrating a [2-(methacryloyloxy)ethyl]dimethyl-(3-propylsulfonate)ammonium hydroxide (DMAPS) and hydroxyethyl acrylate (HEA)-copolymerized zwitterion hydrogel electrode (DMAPS-HEA) with redox-active nanofillers.

Enhanced piezoelectric sensor to distinguish real-time arrhythmia for predicting heart failure.

Monitoring cardiac rhythm is crucial for diagnosis of heart failure. However, the deficient sensitivity of polyvinylidene fluoride (PVDF) sensors impede their application in monitoring of cardiac rhythm due to the limited piezoelectricity. Here, doping of CoFeO and aligning fibers were jointly adopted to enhance the piezoelectricity of PVDF, attributed to the transformation of α-PVDF to β-PVDF from 51.

Adhesive and Conductive Hydrogels for the Treatment of Myocardial Infarction.

Myocardial infarction (MI) is a leading cause of mortality among cardiovascular diseases. Following MI, the damaged myocardium is progressively being replaced by fibrous scar tissue, which exhibits poor electrical conductivity, ultimately resulting in arrhythmias and adverse cardiac remodeling. Due to their extracellular matrix-like structure and excellent biocompatibility, hydrogels are emerging as a focal point in cardiac tissue engineering.

Polyphenols and Functionalized Hydrogels for Osteoporotic Bone Regeneration.

Osteoporosis induces severe oxidative stress and disrupts bone metabolism, complicating the treatment of bone defects. Current therapies often have side effects and require lengthy bone regeneration periods. Hydrogels, known for their flexible mechanical properties and degradability, are promising carriers for drugs and bioactive factors in bone tissue engineering.

Conductive polyphenol microneedles coupled with electroacupuncture to accelerate wound healing and alleviate depressive-like behaviors in diabetes.

Inflammation and depression are serious complications of diabetes that interact to form a feedback loop and may hinder diabetic wound healing. They share a common pathophysiological basis of abnormal interactions between diabetic wounds and the brain. Here, we propose a strategy combining electroacupuncture (EA) stimulation of the Dazhui acupoint (GV14) with polyphenol-mediated conductive hydrogel microneedles to promote diabetic wound healing and alleviate depression through local wound-brain interactions.

Polyphenol-mediated redox-active hydrogel with HS gaseous-bioelectric coupling for periodontal bone healing in diabetes.

Excessive oxidative response, unbalanced immunomodulation, and impaired mesenchymal stem cell function in periodontitis in diabetes makes it a great challenge to achieve integrated periodontal tissue regeneration. Here, a polyphenol-mediated redox-active algin/gelatin hydrogel encapsulating a conductive poly(3,4-ethylenedioxythiopene)-assembled polydopamine-mediated silk microfiber network and a hydrogen sulfide sustained-release system utilizing bovine serum albumin nanoparticles is developed. This hydrogel is found to reverse the hyperglycemic inflammatory microenvironment and enhance functional tissue regeneration in diabetic periodontitis.

Oxygen-Propelled Dual-Modular Microneedles with Dopamine-Enhanced RNA Delivery for Regulating Each Stage of Diabetic Wounds.

Diabetic wounds are characterized by the disruption and cessation of essential healing stages, which include hemostasis, inflammation, proliferation, and remodeling. However, traditional treatments for diabetic wounds concentrate on individual stages of the healing process. Herein, this study utilizes mask-mediated sequential polymerization and varied cross-linking techniques to develop dual-modular microneedles (MNs) with fast- and slow-module, exhibiting varying degradation rates tailored for the full spectrum of diabetic wound healing.

Injectable bioadhesive hydrogel as a local nanomedicine depot for targeted regulation of inflammation and ferroptosis in rheumatoid arthritis.

Medicine intervention is the major clinical treatment used to relieve the symptoms and delay the progression of rheumatoid arthritis (RA), but is limited by its poor targeted delivery and short therapeutic duration. Herein, we developed an injectable and bioadhesive gelatin-based (Gel) hydrogel as a local depot of leonurine (Leon)-loaded and folate-functionalized polydopamine (FA-PDA@Leon) nanoparticles for anti-inflammation and chondroprotection in RA. The nanoparticles could protect Leon and facilitate its entry into the M1 phenotype macrophage for intracellular delivery of Leon, while the hydrogel tightly adhered to the tissues in the joint cavity and prolonged the retention of FA-PDA@Leon nanoparticles, thus achieving higher availability and therapeutic efficiency of Leon.

Glycocalyx-inspired dynamic antifouling surfaces for temporary intravascular devices.

Protein and cell adhesion on temporary intravascular devices can lead to thrombosis and tissue embedment, significantly increasing complications and device retrieval difficulties. Here, we propose an endothelial glycocalyx-inspired dynamic antifouling surface strategy for indwelling catheters and retrievable vascular filters to prevent thrombosis and suppress intimal embedment. This strategy is realized on the surfaces of substrates by the intensely dense grafting of hydrolyzable endothelial polysaccharide hyaluronic acid (HA), assisted by an amine-rich phenol-polyamine universal platform.

Smart Hydrogels for Tissue Regeneration.

The rapid growth in the portion of the aging population has led to a consequent increase in demand for biomedical hydrogels, together with an assortment of challenges that need to be overcome in this field. Smart hydrogels can autonomously sense and respond to the physiological/pathological changes of the tissue microenvironment and continuously adapt the response according to the dynamic spatiotemporal shifts in conditions. This along with other favorable properties, make smart hydrogels excellent materials for employing toward improving the precision of treatment for age-related diseases.

Not in black or white, encryption of grayscale images by donor-acceptor Stenhouse adducts.

Invisible inks have been applied for the secrecy of texts, symbols and binary images. Based on the photochromism of donor-acceptor Stenhouse adducts (DASAs) in the solid-state promoted by ester-containing molecules, we report the encryption of grayscale information by controlling the kinetics of photoisomerization.

Electroactive Hydrogels with Photothermal/Photodynamic Effects for Effective Wound Healing Assisted by Polydopamine-Modified Graphene Oxide.

Antibacterial hydrogel wound dressings have attracted considerable attention in recent years. However, bacterial infections can occur at any point during the wound-healing process. There is a demand for hydrogels that possess on-demand antibacterial and excellent wound repair properties.

Polydopamine-Mediated Immunomodulatory Patch for Diabetic Periodontal Tissue Regeneration Assisted by Metformin-ZIF System.

An essential challenge in diabetic periodontal regeneration is achieving the transition from a hyperglycemic inflammatory microenvironment to a regenerative one. Here, we describe a polydopamine (PDA)-mediated ultralong silk microfiber (PDA-mSF) and metformin (Met)-loaded zeolitic imidazolate framework (ZIF) incorporated into a silk fibroin/gelatin (SG) patch to promote periodontal soft and hard tissue regeneration by regulating the immunomodulatory microenvironment. The PDA-mSF endows the patch with a reactive oxygen species (ROS)-scavenging ability and anti-inflammatory activity, reducing the inflammatory response by suppressing M1 macrophage polarization.

Oral polyphenol-armored nanomedicine for targeted modulation of gut microbiota-brain interactions in colitis.

Developing oral nanomedicines that suppress intestinal inflammation while modulating gut microbiota and brain interactions is essential for effectively treating inflammatory bowel disease. Here, we report an oral polyphenol-armored nanomedicine based on tumor necrosis factor-α (TNF-α)-small interfering RNA and gallic acid-mediated graphene quantum dot (GAGQD)-encapsulated bovine serum albumin nanoparticle, with a chitosan and tannin acid (CHI/TA) multilayer. Referred to "armor," the CHI/TA multilayer resists the harsh environment of the gastrointestinal tract and adheres to inflamed colon sites in a targeted manner.

Hybrid Dry Powders for Rapid Sealing of Gastric Perforations under an Endoscope.

Effective wound sealing is key to prevent postoperative complications arising from gastric endoscopic submucosal dissection (ESD). Accurate delivery of the adhesive to wet and dynamic tissues and rapid action of the adhesive onsite should be considered for endoscopic operation. A hybrid dry powder (HDP) strategy, characterized by decoupling of powder gelation and tissue adhesion, for rapid sealing of wet tissues is presented.