Role of Ferroptosis in the Redox Biology of Mycotoxins.

Ferroptosis, an iron-dependent regulated cell death process driven by lipid peroxidation, has emerged as a pivotal mechanism in mycotoxin-induced redox pathology. This review synthesizes the molecular interplay between fungal secondary metabolites (e.g.

Sleep Deprivation Activates a Conserved Lactate-H3K18la-RORα Axis Driving Neutrophilic Inflammation Across Species.

Sleep deprivation critically disrupts physiological homeostasis, impairing development, metabolic balance, and immune regulation, with excessive neutrophil activation being a hallmark consequence. However, the molecular mechanisms underlying sleep deprivation-induced neutrophilic inflammation remain elusive. Here, it is shown that acute sleep deprivation in mice triggers neutrophil hyperactivation, resulting in aberrant peripheral accumulation and a systemic cytokine storm.

Polyphenol-Mediated Electroactive Hydrogel with Armored Exosomes Delivery for Bone Regeneration.

Prolonged oxidative stress and reduced activity of mesenchymal stem cells are significant barriers to effective bone repair. Current therapeutic approaches often suffer from limited long-term efficacy due to inefficient exosome delivery and the degradation of biological materials. Here, we present an electroactive gelatin methacryloyl hydrogel incorporating a tannic acid-mediated conductive polypyrrole microfiber network and exosomes armored with a metal-polyphenol network, designed to mitigate chronic inflammation and enhance bone healing.

Dihydromyricetin improving myocardial function in the mice induced by CCl.

Objective: To study the role and underlying mechanisms of dihydromyricetin on the myocardial function in mice induced by CCl.

Methods: Eighteen C57BL/6 mice (6-8 W, female) were randomly divided into the following three groups: control group, CCl-induced positive group (CCl group), dihydromyricetin group, six mice/group. NLRP3-deficient (NLRP3) C57BL/6 mice used the same age, gender, and modeling method.

Injectable Chondroitin Sulfate Microspheres with Gallic Acid-Magnesium MOF for Anti-Inflammatory and Cartilage Degeneration Alleviation in Osteoarthritis Treatment.

Inflammation and cartilage degeneration are critical challenges in osteoarthritis (OA) treatment. Achieving sustained drug efficacy while mitigating the adverse effects of inflammation and reactive oxygen species remains a significant challenge. This study synthesizes a gallic acid-magnesium (GA-Mg) metal-organic framework (MOF) as a drug carrier for puerarin (PA).

ROS regulates circadian rhythms by modulating Ezh2 interactions with clock proteins.

Redox imbalance induced by the accumulation of reactive oxygen species (ROS) accelerates age-related processes, often accompanied by a decrease in circadian rhythm amplitude. However, the underlying mechanisms by which ROS modulate circadian rhythms remain poorly understood. In this study, we found that ROS disrupt circadian rhythms in both zebrafish, as indicated by changes in diurnal behavior and clock gene expression, and in a human cell model.

Dynamic assessment of dust hazard risk in the reconstruction of old industrial buildings: coupling effects of dust distribution and personnel trajectories.

Since the old industrial buildings bear many functions of industrial production and storage in the service stage, the dust generated by the regeneration construction is often accompanied by industrial pollutants, causing irreversible damage to the personal safety of construction workers. However, little consideration has been given to the uncertainty of dust emissions and the dynamics of construction personnel movement. Therefore, reducing the risk of dust hazards during the regeneration of old industrial buildings is imperative.

Unveiling the Electrocatalytic Activity of the GdBaSrCoCuO ( ≥ 1) Oxygen Electrodes for Solid Oxide Cells.

The A-site cation-ordered GdBaSrCoCuO (GBSCC) double perovskites are evaluated regarding the development of high-performance oxygen electrodes for reversible solid oxide cells (rSOCs). The aims are to maximally decrease the content of toxic and expensive cobalt by substitution with copper while at the same time improving or maintaining the required thermomechanical and electrocatalytic properties. Studies reveal that compositions with 1 ≤ ≤ 1.

Health damage assessment of reconstruction dust from old industrial buildings under multi-process.

The regeneration of old industrial buildings produces considerable construction dust, thereby seriously threatening the occupational health of construction workers. The existing articles concerning the exposure and health impacts of reconstruction dust in enclosed spaces are limited, but this research field has received increasing attention. In this study, multi-process during the demolition and reinforcement stages of a reconstruction project were monitored to determine the respirable dust concentration distribution.

NLRP3 Inflammasome: A key contributor to the inflammation formation.

Inflammation is an important part of the development of various organ diseases. The inflammasome, as an innate immune receptor, plays an important role in the formation of inflammation. Among various inflammasomes, the NLRP3 inflammasome is the most well studied.

The hepatocyte in the innate immunity.

The hepatocytes, as the main cells in the liver, exert liver functions by expressing innate immune receptors. The innate immune receptors include Toll-like receptors (TLRs), RIG-like receptors (retinoic acid inducible gene I-like receptors, RLRs) and NOD-like receptors (nucleotide binding oligomerization domain-like receptors, NLRs). The hepatocytes, recognize extracellular pathogen-associated molecular patterns (PAMPs) and intracellular damage-associated molecular patterns (DAMPs) through the above receptors.

Enhancing electrochemical detection of dopamine via dumbbell-like FePt-FeO nanoparticles.

We synthesize dumbbell-like FePt-FeO nanoparticles (NPs) and study their electrocatalytic oxidation and sensing of dopamine (DA). The FePt and FeO NPs are strongly coupled in the dumbbell structure and as a result, the dumbbell FePt-FeO NPs show the best activity for DA oxidation with the DA detection limit reaching 1 nM. They are used successfully to monitor the DA concentration increase induced by K-stimulation of PC12 cells.