Genetically predicted maternal prepregnancy BMI increased risk of childhood intestinal malformation: evidence from a Mendelian randomization study.

The study aimed to explore the causal effect of maternal prepregnancy body mass index (BMI) on congenital malformations of intestine (CMI). The genome-wide association data of BMI and CMI were obtained via the Mendelian randomization (MR) base platform. Single nucleotide polymorphisms (SNPs) significantly associated with BMI in females were identified and used as instrumental variables, and the causal relationship between BMI in females and CMI was examined using the bidirectional two-sample MR analyses research method.

Effective of high-intensity interval training and moderate-intensity continuous training on body composition, glycolipid metabolism, and cardiopulmonary function in patients with pre-diabetes: a randomized controlled trial.

Aims: The aim of this study is to compare the effectiveness of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on body composition, cardiovascular function, glycolipid metabolism, and cardiopulmonary function in patients with pre-diabetes.

Methods: Seventy-one participants were randomly assigned to the HIIT (10 × 1-min at 75%-90% HR, intersperse with 1-min active recovery at 50% HR) or MICT (50 min at 55%-70% HR) for a 12-week (three times per week) program. The outcome measured was the change in body composition, cardiovascular index, glycolipid metabolism, and cardiopulmonary.

Risk factors analysis for significant liver fibrosis of prenatally diagnosed choledochal cysts: a retrospective case-control study.

Background: The severity of liver fibrosis and optimal surgical timing in infants with prenatally diagnosed choledochal cysts (CDCs) remain contentious. This study aims to identify risk factors for significant liver fibrosis in prenatally diagnosed CDCs and guide optimal surgical timing.

Methods: This retrospective case-control study reviewed infants with prenatally diagnosed CDCs between January 2016 and January 2024.