Prenatal Ultrasound Features of Biliary Atresia: Diagnostic Significance of Abnormal Gallbladder Size and Hepatic Hilar Cyst.

Objective: To explore the predictive potential of prenatal ultrasound features and their capacity to differentiate biliary atresia (BA) in fetuses exhibiting biliary abnormalities.

Methods: Data of pregnant women who underwent routine fetal ultrasound screening during the second trimester (18-27 weeks) were retrospectively analyzed in the 2018-2022 period. Fetuses with suspected biliary abnormalities in the second trimester were identified, and the cases were categorized into 5 groups: enlarged fetal gallbladder, small fetal gallbladder, non-visualized fetal gallbladder, hepatic hilar cyst, and fetal duplicated gallbladder.

Prenatal ultrasound diagnosis and prognosis of ductal-dependent congenital heart disease: A single-center study in China.

Objective: To investigate the prenatal ultrasound features of fetal ductal-dependent congenital heart disease (DDCHD), analyze their association with chromosomal abnormalities, and summarize clinical outcomes.

Method: A retrospective analysis was conducted on the clinical and ultrasound data of 308 fetuses diagnosed with DDCHD at our center over the past 10 years. The ultrasound characteristics of each DDCHD type during early pregnancy were systematically summarized.

Rib-indexed quantitative lung ultrasound versus chest X-ray for lung recruitment assessment in neonates with moderate-severe ARDS on surfactant therapy combined with prone position: a prospective observational study.

Serial lung recruitment assessment in neonates with moderate-to-severe neonatal acute respiratory distress syndrome (NARDS) is crucial. However, current methods involve ionizing radiation or invasiveness, which limits their serial use in neonates. This study evaluated the feasibility of rib-indexed quantitative lung ultrasound (LUS) as a radiation-free alternative for monitoring lung aeration in neonates with moderate-to-severe NARDS on surfactant therapy combined with prone position.

Proximal and Distal Impairments in Runners With Achilles Tendinopathy Compared With Matched Controls.

Rathod, V, Oh, C, Ling, W, and Rao, S. Proximal and distal impairments in runners with Achilles tendinopathy compared with matched controls. J Strength Cond Res XX(X): 000-000, 2025-This study investigated drop countermovement jump (DCMJ) performance in runners with midportion Achilles tendinopathy (AT).

Multimodal model for the diagnosis of biliary atresia based on sonographic images and clinical parameters.

It is still challenging to diagnose biliary atresia (BA) in current clinical practice. The study aimed to develop a multimodal model incorporated with uncertainty estimation by integrating sonographic images and clinical information to help diagnose BA. Multiple models were trained on 384 infants and validated externally on 156 infants.

Altered mesenchymal and endothelial subsets in interstitial bone marrow and focal lesions in myeloma patients and SCID-hu mice.

In myeloma, the bone marrow (BM) stroma mediates tumor growth directly and indirectly through the alteration of BM niches. The mesenchymal and endothelial cell subsets altered in the interstitial BM and focal lesions (FLs) of patients newly diagnosed with myeloma, as well as in the myelomasupportive human bone of the SCID-hu mouse model, were identified using single-cell atlases and gene expression profiling. The mesenchymal compartment showed enriched cells reflecting matrix cancer-associated fibroblasts (CAFs) and vascular CAFs/pericytes in FLs compared to interstitial BM and in myeloma interstitial BM compared to healthy donors.

Correlation analyses of ultrasonographic and histopathological characteristics of porta hepatis lymph nodes in biliary atresia.

Background: To perform correlation analyses between the ultrasonographic characteristics of porta hepatis lymph nodes (PHLNs) and the pathological features of PHLNs and the liver in biliary atresia (BA).

Methods: We analyzed the clinical ultrasonographic characteristics of PHLNs in 27 patients with BA, along with specific pathological features, including pathological size, the number of bile granules, the number of germinal centers, the proportion of lymphocytes, and the analysis of liver biopsy specimens. A series of correlation analyses were then performed between ultrasonography data, pathological features, and prognosis.

Prenatal diagnosis of pulmonary atresia with intact ventricular septum: a single-center study in China.

Objectives: To evaluate the efficacy of prenatal ultrasound in diagnosing pulmonary atresia with intact ventricular septum (PA/IVS).

Methods: This retrospective study analyzed 48 cases of PA/IVS at the Fujian Maternity and Child Health Hospital between January 2013 and December 2023. Prenatal ultrasound was used to characterize and classify the features of PA/IVS.

Prognostic factors in pediatrics TAPVC: a 10-year retrospective study.

Total anomalous pulmonary venous connection (TAPVC) is a rare congenital heart defect where the pulmonary veins abnormally connect to the systemic venous circulation, rather than the left atrium (LA). This study retrospectively analyzed 48 children diagnosed with TAPVC from January 2014 to January 2024 to investigate how specific echocardiographic and morphological characteristics impact prognosis. Perioperative records, including echocardiography, computed tomography angiography (CTA) images, surgical details, and patient outcomes, were reviewed.

Comprehensive Two-Dimensional Gas Chromatography-Mass Spectrometry for the Analysis of Atmospheric Particulate Matter.

Background: Atmospheric particulate matter (PM) is a complex mixture with a wide range of sources, but only a limited proportion can be identified by existing analytical techniques. Comprehensive two-dimensional gas chromatography-mass spectrometry (GC × GC-MS) couples the advantages on high resolution, sensitivity, and peak capacity on gas chromatography, together with the high mass accuracy and acquisition frequency of time-of-flight mass spectrometry (TOFMS). GC × GC-MS has been gradually applied on the analysis of environmental organic pollutants.

Enhanced Delivery of Photothermal Gelatin Nanoparticle for Redox Balanced Nanocatalytic Tumor Chemotherapy.

Nanocatalytic platforms are promising in cancer therapeutics via combining multiple treatments, which can be leveraged through the metabolic dysfunction in cancer progression. However, the lack of effective tumor delivery platforms hampers this approach. Here, a gelatin-based platform is designed that is preloaded with gold nanoparticles and photothermal polypyrrole (GNPs@AuNPs-PPy) with an acid-induced doping enhancement.

Application of point-of-care ultrasound-guided tip navigation combined with visualised directional high-frequency linear array probe compression to improve the success rate of umbilical venous catheterisation in critical neonates: protocol of a multicentre randomised controlled trial in neonatal units.

Introduction: Conventional umbilical venous catheterisation (UVC) relies on 'blind' insertion without ultrasound guidance, resulting in low success and high complication rates. While point-of-care ultrasound (POCUS)-based tip navigation and location has improved this scenario by enabling real-time visualisation of the catheter tip during UVC, challenges remain when the catheter is inadvertently inserted into an incorrect vessel. Selecting effective intervention methods to correct the catheter direction has become a key research focus.

Can Fetal Heterotaxy Syndrome Be Diagnosed Through Prenatal Ultrasound in the First Trimester (GA 11-13 Weeks)?

Objective: To investigate the value of prenatal ultrasonography in the diagnosis and classification of fetal heterotaxy syndrome (HS) in the first trimester (gestational age 11-13 weeks).

Methods: A retrospective analysis of data from 31 HS fetuses prenatally diagnosed with HS. Diagnoses were confirmed by follow-up prenatal ultrasound and in some cases postnatal ultrasound or autopsy.

Unravelling riverine dissolved organic matter sources using molecular fingerprints and FEAST model in a multi-tributary mountain river basin.

Revealing the sources, composition and fate of riverine dissolved organic matter (DOM) is fundamental to understanding the biogeochemical cycles of aquatic ecosystems. This study aimed to reveal the impact of land uses and wastewater treatment plants (WWTPs) on riverine DOM. Spatiotemporal variations in molecular characteristics of riverine DOM in the river network containing 15 tributaries in the mainstream of upper Hanjiang River were studied.

Countermovement Jump Inefficiency Is Mostly Independent of Quadriceps Weakness in Athletes Returning to Sport After Anterior Cruciate Ligament Reconstruction.

Orishimo, KF, Fukunaga, T, Kremenic, IJ, Rao, S, Magill, R, Ling, WK, McHugh, MP, and Nicholas, SJ. Countermovement jump inefficiency is mostly independent of quadriceps weakness in athletes returning to sport after anterior cruciate ligament reconstruction. J Strength Cond Res 39(5): 562-569, 2025-After anterior cruciate ligament reconstruction (ACLR), comparing ground reaction force (GRF) metrics during countermovement jumps (CMJs) and isokinetic quadriceps strength testing may aid in return-to-sport decision-making.

Prenatal ultrasound diagnosis, associated anomalies and pregnancy outcomes of fetal right aortic arch.

Objective: The aim was to summarise the prenatal ultrasound characteristics, associated anomalies and pregnancy outcomes of fetal right aortic arch (RAA) and to discuss the value of prenatal ultrasound diagnosis and prognostic analysis.

Methods: We retrospectively analysed 157 cases of fetal RAA diagnosed via prenatal ultrasound in our hospital from October 2017 to October 2022. RAA features were characterised by comparing prenatal ultrasound data with anatomical casting results after pregnancy termination or postnatal imaging and surgical intervention to analyse the prognosis and misdiagnoses of fetal RAA.

Intraocular lens calculation formula selection for short eyes: based on axial length and anterior chamber depth.

Purpose: To evaluate the predictive accuracy of 11 intraocular lens (IOL) calculation formulas in eyes with an axial length (AL) less than 22.00 mm.

Methods: New-generation formulas (Barrett Universal II [BUII], Emmetropia Verifying Optical [EVO] 2.

Circular RNA circ-CARD8 regulates alveolar macrophage pyroptosis through the miR-580-3p/CARD8 pathway in acute lung injury.

Pyroptosis is linked to the development of acute lung injury (ALI), and circular RNAs (circRNAs) play a role in ALI-related inflammation. However, the mechanisms by which circRNAs contribute to macrophage pyroptosis in ALI remain unclear. This study constructed an in vitro ALI model by inducing THP-1 cells with phorbol 12-myristate 13-acetate (PMA) and lipopolysaccharide (LPS).

Artificial intelligence-based rapid brain volumetry substantially improves differential diagnosis in dementia.

Introduction: This study evaluates the clinical value of a deep learning-based artificial intelligence (AI) system that performs rapid brain volumetry with automatic lobe segmentation and age- and sex-adjusted percentile comparisons.

Methods: Fifty-five patients-17 with Alzheimer's disease (AD), 18 with frontotemporal dementia (FTD), and 20 healthy controls-underwent cranial magnetic resonance imaging scans. Two board-certified neuroradiologists (BCNR), two board-certified radiologists (BCR), and three radiology residents (RR) assessed the scans twice: first without AI support and then with AI assistance.

Evaluation of tracheal diameter and angles in fetuses with double aortic arch using prenatal ultrasound: implications for postnatal management.

Objective: This study aims to analyze the value of prenatal ultrasound in the screening, diagnosis, and treatment of double aortic arch (DAA) malformations.

Methods: A retrospective analysis was conducted on 31 fetal cases with double aortic arch anomalies over a 12-year period from June 1, 2011 to June 1, 2023. The assessment included combined measurements of fetal tracheal internal diameter Z-score and DAA pinch angle, along with ultrasonographic findings, associated anomalies, genetic abnormalities, postnatal CTA images, and long-term postnatal outcomes.

Optimized liquid chromatography-tandem mass spectrometry protocol for enhanced detection of 45 pesticides in water and soil samples.

Rationale: The development of analytical screening techniques for pesticides is crucial for preventing and mitigating environmental contamination. Mass spectrometry-based screening methods differ based on the complexity of the sample matrix and the diversity of the target compounds. One of the major challenges is balancing cost reduction in the extraction process with the optimization of analytical results.

Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice.

Objectives: The mitochondrial deacetylase sirtuin-3 (SIRT3) is necessary for the increased bone resorption and enhanced function of mitochondria in osteoclasts that occur with advancing age; how SIRT3 drives bone resorption remains elusive.

Methods: To determine the role of SIRT3 in osteoclast mitochondria, we used mice with conditional loss of Sirt3 in osteoclast lineage and mice with germline deletion of either Sirt3 or its known target Pink1.

Results: SIRT3 stimulates mitochondrial quality in osteoclasts in a PINK1-independent manner, promoting mitochondrial activity and osteoclast maturation and function, thereby contributing to bone loss in female but not male mice.