Implementation of Early Mobilization in Post-CABG Patients: A Constructivist Grounded Theory Study.

Purpose: Coronary artery bypass grafting (CABG) is an essential intervention for treating coronary artery disease. However, the effectiveness of postoperative rehabilitation often depends on the implementation of early mobilization by patients. In practice, adherence to early mobilization post-CABG is frequently suboptimal.

NF1-depleted ER breast cancers are differentially sensitive to CDK4/6 inhibitors.

Neurofibromin/NF1 is a RAS (rat sarcoma virus) GTPase-activating protein and estrogen receptor (ER) transcriptional corepressor. NF1 status, identified by copy number loss or low mRNA/protein expression, is associated with endocrine therapy resistance in ~20% of ER/HER2 (human epidermal growth factor receptor 2) early-stage breast cancers. The identification of targeted treatments for NF1 ER/HER2 breast cancer is therefore a priority.

MetaSage: Machine Learning-Based Prioritization of Metabolic Regulators from Multi-Omics Data.

Dysregulation of metabolites is a hallmark of cancer, yet the underlying regulatory mechanisms remain poorly understood. To systematically explore metabolic regulation across cancers, we developed an XGBoost-based machine learning pipeline, MetaSage, that integrates context-agnostic knowledge graph with multi-omics datasets. Using harmonized data from 15 cohorts spanning 11 cancer types, we identified 442 variable metabolites and found that both genes and upstream metabolites showed comparable regulatory influence.

Proteogenomic characterization unveils biomarkers associated with chemoresistance in muscle-invasive bladder cancer.

To explore potential chemoresistance mechanisms and identify therapeutic opportunities in muscle-invasive bladder cancer (MIBC), we conduct comprehensive proteogenomic characterization of 46 pre- and 14 post-treatment MIBC tumors incorporating genomics, transcriptomics, proteomics, and phosphoproteomics. Multi-omics clustering not only recapitulated established molecular subtypes but also revealed subtypes associated with chemotherapy sensitivity. Protein isoform level analysis identifies protein abundance of a short isoform of ATAD1 and RAF family proteins as biomarkers of chemosensitivity.

A retrospective cohort study of gastrografin in the management of adhesive small bowel obstruction during pregnancy.

Adhesive small bowel obstruction (ASBO) during pregnancy is a critical condition that remains understudied. This study aimed to address management challenges of ASBO in pregnancy by evaluating the dual diagnostic and therapeutic role of gastrografin. We retrospectively analyzed medical records of pregnant patients with ASBO admitted between September 2018 and September 2023.

Anatomical mapping of GFAP-immunoreactive astrocytes in the tree shrew brain.

Astrocytes are associated with varying brain size between rodents and primates. As a close evolutionary relative of primates, the tree shrew ( ) provides a valuable comparative model for investigating glial architecture. However, the anatomical distribution and morphological characteristics of astrocytes in the tree shrew brain remain poorly characterized.

Perceptions of shared decision-making participation during cardiac rehabilitation in coronary heart disease patients after coronary artery bypass surgery grafting: a qualitative study.

Background: Cardiac rehabilitation is a widely adopted approach for postoperative recovery in coronary heart disease patients undergoing coronary artery bypass grafting (CABG). However, in China, patients tend to be highly dependent on medical staff and less expressive of their personal wishes in medical decision-making due to the influence of traditional concepts. This study aims to investigate the current status of CABG postoperative patients' perceptions of shared decision-making during cardiac rehabilitation.

Improving Laser Powder Bed Fusion IN718 Process Development Efficiency by Eliminating Pore Defects of Specified Size.

The rapid identification of process windows in laser powder bed fusion (L-PBF) additive manufacturing garnered significant attention for its ability to reduce upfront engineering costs. This study focuses on accelerating the development of process windows by targeting the elimination of specific-size pore defects in L-PBF IN718. A novel relative density-porosity similarity evaluation method (DPSEM) is introduced to evaluate the reliability of porosity data derived from computed tomography (CT).

Double Swords in One: Novel Selective PI3/110β PROTAC Degraders for the Treatment of Multidrug-Resistant Cancer by Activating ERS and Inhibiting P-gp.

The p110β isoform of the PI3 kinase (PI3K) family plays a key role in tumorigenesis and PTEN loss-driven multidrug resistance (MDR). Herein, we describe the design, synthesis, and structure-activity relationship studies of a series of small-molecule PI3/110β PROTACs degraders by combining the selective inhibitor TGX221 of PI3/110β with VHL ligands. Among them, and exhibited rapid and efficient degradation ability for the target proteins in MDR cells.

Defect detection method based on sparse scanning with laser ultrasonics.

The rapid development of metal additive manufacturing (AM) technology has led to its widespread application across various industries, with quality control of AM components being a current focal point of research. To enable on-line defect detection during the metal AM process using laser ultrasonic technology, this paper proposes a defect detection method based on sparse scanning. By employing sparse scanning to collect data, the method significantly improves detection efficiency while accurately characterizing the position and morphology of defects.

Defect detection in EBSM components through selective box fusion of modern object detection.

Additive Manufacturing (AM) technology has gained widespread application across various industries due to its capability to directly produce products from computer-aided design models. Among AM techniques, the Electron Beam Selective Melting (EBSM) process has attracted significant attention, particularly in aerospace and automotive industries, owing to its high precision, speed, and excellent material properties. However, various defects, especially internal defects that inevitably arise during the manufacturing process, significantly limit the performance of EBSM parts.

A Rapid Heat-Enhanced Golgi-Cox Staining Method for Detailed Neuroanatomical Analysis Coupled With Immunostaining.

The Golgi-Cox staining technique is renowned for its ability to delineate neuronal architecture with remarkable precision. However, the traditional protocol's lengthy processing timeline and limited compatibility with immunostaining and transgenic labeling have hindered its widespread adoption in modern neuroscience research. In the current study, we found that adjusting the incubation temperature to 55°C significantly reduced the staining duration to a mere 24 h for 100 µm-thick sections of mouse brain tissue.

Adipose progenitor cell-derived extracellular vesicles suppress macrophage M1 program to alleviate midlife obesity.

Among different age groups, middle-aged individuals are particularly susceptible to obesity, with a 22% higher risk of all-cause mortality. However, the underlying mechanisms remain unclear. In this study, we identify adipose progenitor cells (APCs) in the white adipose tissue (WAT) of middle-aged subjects as potential causes of midlife obesity.

Magnetar emergence in a peculiar gamma-ray burst from a compact star merger.

The central engine that powers gamma-ray bursts (GRBs), the most powerful explosions in the universe, is still not identified. Besides hyper-accreting black holes, rapidly spinning and highly magnetized neutron stars, known as millisecond magnetars, have been suggested to power both long and short GRBs. The presence of a magnetar engine following compact star mergers is of particular interest as it would provide essential constraints on the poorly understood equation of state for neutron stars.

Analysis and Management of Perivenous Tissue Pain in the Outflow Tract of Arteriovenous Fistulas During Dialysis.

Background: Pain is a prevalent cause of medical consultation among dialysis patients, severely impacting both treatment outcomes and quality of life. This study focuses on a specific yet underexplored type of pain-delayed and progressive perivenous tissue pain in the outflow tract of arteriovenous fistulas (AV fistula) during dialysis. The aim is to summarize its clinical features, investigate its underlying mechanisms, and evaluate the effectiveness of various treatments, ultimately providing new insights into pain management.

Crash risk prediction and analysis from the perspective of alignment and environment features: A study on an expressway in a hilly area.

Objective: Expressways in hilly areas feature complex alignment and environments constrained by terrain conditions, significantly threatening life and property safety. This study aims to investigate crash risk prediction of expressways in hilly areas through alignment and environment features and identify determinants of the high risk for safety improvement.

Methods: Based on 5 years of crash data on casualties and property damage of an expressway in southwestern China, the order technique and five clustering algorithms were employed to determine and classify risk levels.

Jiawei Danxuan Koukang and its key component Quercetin intervened in OSF carcinogenesis by inhibiting the AR/eIF5A2 signaling pathway-mediated EMT.

Objective: This work aims to investigate the mechanism of Jiawei Danxuan Koukang (JDK) and Quercetin in oral submucous fibrosis (OSF) carcinogenesis.

Design: We established an OSF model for rats by injecting Arecoline into the oral mucosa of rats to study the impact of JDK and Quercetin on the progression of OSF and OSCC. Then, the viability, proliferation, and migration ability of Arecoline-induced hOMF, CAL27 and SCC-25 cells in JDK and quercetin intervention were detected.

Summary of the Best Evidence for Non-Pharmacological Management of Sleep Disturbances in Intensive Care Unit Patients.

Aim: To retrieve, evaluate and summarise the best evidence for non-pharmacological management of sleep disturbances in ICU patients, and to provide basis for clinical nursing practice.

Design: This study was an evidence summary followed by the evidence summary reporting standard of Fudan University Center for Evidence-based Nursing.

Methods: All evidence on non-pharmacological management of sleep disturbances in ICU patients from both domestic and international databases and relevant websites was systematically searched, including guidelines, expert consensuses, best practice, clinical decision-making, evidence summaries and systematic review.

Alterations of amino acids in older adults with Alzheimer's Disease and Vascular Dementia.

Metabolomics provide a promising tool for understanding dementia pathogenesis and identifying novel biomarkers. This study aimed to identify amino acid biomarkers for Alzheimer's Disease (AD) and Vascular Dementia (VD). By amino acid metabolomics, the concentrations of amino acids were determined in the serum of AD and VD patients as well as age-matched healthy controls.

Quantitative Detection Method for Surface Angled Cracks Based on Laser Ultrasonic Full-Field Scanning Data.

Surface angled cracks on critical components in high-speed machinery can lead to fractures under stress and pressure, posing a significant threat to the operational safety of equipment. To detect surface angled cracks on critical components, this paper proposes a "Quantitative Detection Method for Surface Angled Cracks Based on Full-field Scanning Data". By analyzing different ultrasonic signals in the full-field scanning data from laser ultrasonics, the width, angle, and length of surface angled cracks can be determined.

Prognosis predictors of hepatocellular carcinoma after hepatectomy following conversion therapy.

Background: Hepatectomy is the optimal treatment for less than 20 % patients with hepatocellular carcinoma (HCC). A combination of hepatic artery infusion chemotherapy and systemic therapy-based conversion therapy provides a chance of resection for those with unresectable HCC. Yet, the prognosis for those successfully conversion resection is still unknown.

Driving risk identification of urban arterial and collector roads based on multi-scale data.

Urban arterial and collector roads, while interconnected within the urban transportation network, serve distinct purposes, leading to different driving risk profiles. Investigating these differences using advanced methods is of paramount significance. This study aims to achieve this by primarily collecting and processing relevant vehicle trajectory data alongside driver-vehicle-road-environment data.

Proteomics Meets Dose Response: A New Paradigm for Deciphering Drug Effects.

In a groundbreaking study, Eckert and colleagues introduce DecryptE, an innovative approach to dose-resolved proteomics that significantly advances our understanding of drug effects at the proteomic level. This method integrates cutting edge sample preparation and mass spectrometry technologies, establishing a robust platform for high-throughput proteome analysis. DecryptE enables the quantification of more than 7,000 proteins per hour and was employed to study 144 clinical drugs and research compounds, generating more than 1 million dose-response curves using Jurkat acute T-cell leukemia cells as a model system.