Jiawei Danxuan Koukang and its key component Quercetin intervened in OSF carcinogenesis by inhibiting the AR/eIF5A2 signaling pathway-mediated EMT.

Objective: This work aims to investigate the mechanism of Jiawei Danxuan Koukang (JDK) and Quercetin in oral submucous fibrosis (OSF) carcinogenesis.

Design: We established an OSF model for rats by injecting Arecoline into the oral mucosa of rats to study the impact of JDK and Quercetin on the progression of OSF and OSCC. Then, the viability, proliferation, and migration ability of Arecoline-induced hOMF, CAL27 and SCC-25 cells in JDK and quercetin intervention were detected.

m6A-Mediated Regulates the Development of Oral Squamous Cell Carcinoma through p53/Line-1 Signaling.

Background: The importance of N6-methyladenosine (m6A) modification in tumorigenesis and progression have been highlighted. This study aimed to investigate the modification of insulin receptor substrate 1 () by m6A and its role in oral squamous cell carcinoma (OSCC).

Methods: Bioinformatics was employed to predict differential genes related to epithelial-mesenchymal transition (EMT) in OSCC.

Jiawei Danxuan Koukang Alleviates Arecoline Induced Oral Mucosal Lesions: Network Pharmacology and the Combined Ultra-High Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS).

Purpose: Arecoline is one of the main toxic components of arecoline to cause oral mucosal lesions or canceration, which seriously affects the survival and life quality of patients. This study analyzed the mechanism of Jiawei Danxuan Koukang (JDK) in alleviating arecoline induced oral mucosal lesions, to provide new insights for the treatment of oral submucosal fibrosis (OSF) or cancerosis.

Methods: Metabolomics was applied to analyze the composition of JDK and serum metabolites.

Role of hyaluronan mediated motility receptor gene in oral squamous cell carcinoma and clinical prognosis.

Objectives: To screen genes related to the prognosis of oral squamous cell carcinoma (OSCC), and to explore its role and mechanism in the occurrence and development of OSCC.

Methods: The data and the biological information in 330 OSCC tumor samples with head and neck squamous cell carcinoma (HNSCC) (OSCC group) and 37 normal samples (normal sample group) were screened and included, which came from the cancer genome atlas (TCGA) database. The differentially expressed genes were screened out by biological information analysis between the 2 groups.

Proline-Serine-Threonine Phosphatase-Interacting Protein 2 Alleviates Diabetes Mellitus-Osteoarthritis in Rats through Attenuating Synovial Inflammation and Cartilage Injury.

Objective: To explore the possible way of proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2) influencing diabetes mellitus-osteoarthritis (DM-OA) progression.

Methods: In vivo, eight-week-old male Sprague Dawley rats were induced with DM-OA by intraperitoneal injection of streptozotocin with high-fat diet feeding and intra-articular injection of monoiodoacetate. PSTPIP2 overexpression was achieved by intra-articular injection of lentivirus vectors.

Etiology of Spontaneous Extensor Tendon Injury in Northern-China Rice Farmers.

Background: Spontaneous extensor tendon injury is caused by repeated finger flexion and wrist movement. This rare disease has a relatively high incidence in northern China, mostly among rice farmers. This study aimed to elucidate the etiology of spontaneous extensor tendon injury in rice farmers.

[Concentration of Phosphorus in Sediments Interstitial Water as Affected by Distribution of Aquatic Plants in Dianchi Lake].

In order to reveal the effect of aquatic plants distribution on the mass concentration of phosphorus in sediment interstitial water, the mass concentrations of Dissolved Total Phosphorus (DTP), Soluble Reactive Phosphorus (SRP) and Dissolved Organic Phosphorus (DOP) in the sediment interstitial water and overlying water from areas with or without plants in the same site of Dianchi were studied. The vertical variation characteristics of phosphorus forms in sediment interstitial water were analyzed to explore the effect of aquatic plants on the phosphorus forms in sediment interstitial water. The results showed: ①Aquatic plants had an significant effect on the phosphorus mass concentration of the sediment interstitial water in different Dianchi lakes.

[Characteristics of nitrogen pollution and the potential mineralization in surface sediments of Dianchi Lake].

The nitrogen content, its different forms and their spatial distribution were studied by using the 53 sediment samples from different sites in Dianchi Lake. Thereafter, the potential nitrogen mineralization ability of the sediments and their pollution characteristics were also explored to understand the influencing factors of nitrogen pollution and its release risk from the sediment surface to the overlying water of Dianchi. The results showed: (1) the average total nitrogen content of surface sediment in Dianchi Lake was 3 515.

[Comparison of agronomic traits of Panax notoginseng between traditional cultivated fields and new cultivated fields].

Objective: In order to provide scientific basis for introduction breeding and production regionalization of Panax notoginseng, the environment of producing area, agronomic traits and medicinal material output were investigated.

Method: Using field survey sampling at harvest time, agronomic traits indicators of leaf segment, stem segment and roots segment etc. of commodity P.

[Effects of balanced fertilization and soil amendment on growth and yield of sanqi in continuous cropping].

Objective: To explore the solution of continuous cropping obstacle of Panax notoginseng.

Method: The effects of balanced fertilization and soil amendment on the emergence rate, survival rate, growth and yield of P. notoginseng were studied with a pot culture experiment in 3-year-interval continuous cropping soil.

[Status and prospective on nutritional physiology and fertilization of Panax notoginseng].

Sanqi, Panax notoginseng, is a famous traditional Chinese herb, which has more than 400 years cultivation history in China. This paper has reviewed the studies on the suitable growing soil conditions for Sanqi, mineral nutrition effects on Sanqi, and the effects of nutrients uptake on the yield and quality of Sanqi by applying fertilizer. Thereafter, research needed to be put further efforts in the future has raised for discussion, and outlined the following topics for further research like the mechanism of mineral nutrition, methods of nutrients deficiency diagnosis on site, suitable cultivated soil grading special fertizer development, disease resistance, and fertilization recommended by soil testing.

[Epidemiological study of betel nut chewing among elementary and middle school students in Loudi city, Hunan province].

Objective: To investigate the prevalence of betel nut chewing and oral submucous fibrosis (OSF) among elementary and middle school students in Loudi city, Hunan province.

Methods: According to the standard of the third national oral health epidemiological investigation, the subjects were selected through a two-stage random sampling procedure. A face to face questionnaire survey was conducted among students by random sampling from 6 schools, and oral examination was performed to find the prevalence of OSF.

[PRB technology in situ remediation of groundwater polluted by landfill leachate].

In this paper three reaction media zero valent iron (ZVI), a mixture of ZVI and activated carbon, a mixture of the ZVI and zeolites were used to design three kinds of permeable reactive barrier (PRB), viz. reactors A, B and C and to study the feasibility and the efficiency of the PRB technology in the remediation of leachate-polluted groundwater. The designs of the reactors took into account the relation of the permeability of the reactor with the permeability of the aquifer.