Ultra-Fast Self-Powered Heterojunction Blue-Light Photodetector Based on Boronate-Ester-Linked COF-5.

Covalent organic framework materials have recently garnered significant interest from the scientific community due to their fascinating properties that include highly ordered porosity, structural versatility, high chemical and thermal stabilities, and facile surface modification. Herein, for the first time, we present the design and fabrication of a self-powered blue-light photodetector based on boronate-ester-linked 2D covalent organic framework (COF-5) film, synthesized using hexahydroxytriphenylene and 1,4-phenylenediboronic acid organic linkers. Specifically, we have developed a COF-5/n-Si photodetector that exhibits an ultra-short rise response time of 41 µs and a decay response time of 222 µs under 0 V bias.

Multi-defect type beam bridge dataset: GYU-DET.

This paper proposes the GYU-DET dataset for bridge surface defect detection, aiming to address the limitations of existing datasets in terms of scale, annotation accuracy, and environmental diversity. The GYU-DET dataset includes six types of defects: cracks, spalling, seepage, honeycomb surface, exposed rebar, and holes, with a total of 11,123 high-resolution images. It covers a variety of lighting and environmental conditions, comprehensively reflecting the diversity and complexity of bridge defects.

2D Triazine Covalent Organic Frameworks for Ultrafast Self-Powered Green-Light Photodetection.

Covalent organic frameworks (COFs) are crystalline porous materials constructed by covalently linking organic monomers, offering advantages such as lightweight, high thermal stability, and tunable bandgaps. In this study, p-type Tp-TTA COF films with a covalent triazine backbone are synthesized via an interfacial synthesis method and integrated with n-type silicon (n-Si) to form a 2D Triazine COF-based photodetectors. The p-type Tp-TTA COF/n-Si green light self-powered photodetector exhibits ultrafast response times (rise time of 60 µs, decay time of 47 µs).

Redefining value assessment and healthcare funding priorities for medicines: the journey to patient-centric decision making in APAC - a systematic literature review.

Objectives: This study explored patient involvement in healthcare decision-making in the Asia Pacific region (APAC) by identifying roles and factors influencing differences between healthcare systems. Proposed recommendations to enhance patient engagement were made.

Methods: This systematic literature review was conducted using studies from Australia, China, Japan, Malaysia, New Zealand, the Philippines, South Korea, Singapore, Taiwan, and Thailand.

A systematic review and meta-analysis on the efficacy of fecal microbiome transplantation in patients with severe alcohol-associated hepatitis.

Background: Severe alcohol-associated hepatitis (sAH) has a high short-term mortality, with limited treatment options. Fecal microbiota transplantation (FMT) has shown benefits in small, uncontrolled studies.

Aim: Perform a systematic review and meta-analysis to provide updated evidence on the efficacy and safety of FMT in sAH patients.

Cardiovascular Medication and Health Service Use in Individuals With Cancer: A Retrospective Population-Based Cohort Study.

Background: Cancer and cardiovascular disease (CVD) frequently coexist, but little is known about CVD medication use in cancer survivors. The aim of this study was to compare CVD medication and medical service use between individuals with and without cancer.

Methods: Retrospective cohort study linking Australian National Health Survey 2020-2021 data from participants aged ≥ 25 years to medication dispensing, medical services, and death registry data via the Multi-Agency Data Integration Project.

Combined effect of fasting blood glucose and serum uric acid on nonalcoholic fatty liver disease.

Background: This study sought to investigate the independent and synergistic impacts of fasting blood glucose (FBG) and serum uric acid (SUA) levels on non-alcoholic fatty liver disease (NAFLD) in participants with and without type 2 diabetes mellitus (T2DM).

Method: A total of 12,430 participants (mean age: 54.34 ± 15.

Long-term survival was achieved through multidisciplinary treatment of a patient with gallbladder carcinosarcoma accompanied by KRAS mutation: a case report and literature review.

Carcinosarcoma of the gallbladder (CSGB) is an extremely rare subtype of primary gallbladder malignancy, which with a high rate of preoperative misdiagnosis due to its nonspecific clinical symptoms and imaging findings, as well as a high rate of recurrence within a short period of time after surgery, resulting in a very poor prognosis. Through a search of the medical literature, we found that there are few reports of CSGB receiving comprehensive treatments and achieving relatively good outcomes. Here, we report a rare case of CSGB with KRAS G12V mutation that achieved survival time of 32 months after receiving a combination of treatments including surgery, chemotherapy, radiotherapy, and immunotherapy, and we conducted a literature review for the disease with the aim of raising awareness of the disease.

Is Southeast Asia and the Western Pacific ready for potential monkeypox virus outbreaks?

The new variant of the monkeypox virus (MPXV) clade Ib has recently spread to other African countries outside the Democratic Republic of the Congo (DRC), prompting the World Health Organisation to declare the outbreak as a public health emergency of international concern (PHEIC). This comes just two years after the initial PHEIC that was issued for the clade IIb outbreaks. Compared to the clade IIb outbreaks, clade Ib shows a demographic shift, including higher case fatality rates for younger individuals, indicating a possibility of additional transmission pathways through heterosexual and household contacts.

Development and validation of a novel self-assessment tool for breastfeeding mothers.

Background: Difficulties with breastfeeding can lead to early breastfeeding cessation. Empowering mothers through self-assessment and education of breastfeeding skills can help support them. We aimed to develop and validate a tool for self-screening and education on breastfeeding skills.

Turning Zn(PO)-Enriched Inorganic/Organic Hybrid Interfacial Chemistry with Chelating Ligands toward Robust Aqueous Zn Anodes.

Due to the inherent redox potential of the zinc metal anode (ZMA), it is susceptible to corrosion and dendrite formation in aqueous electrolytes. These issues compromise the electroplating-stripping process at the electrolyte-electrode interface, adversely affecting the reversibility of aqueous zinc-ion batteries (AZIBs). Here, we propose a chelating-ligand additive (i.

Endoscopists' knowledge, perceptions, and attitudes toward the use of artificial intelligence in endoscopy: a systematic review.

Background And Aims: Artificial intelligence (AI) is rapidly evolving in the field of GI endoscopy. This systematic review aims to summarize the current perspectives of endoscopists on AI in endoscopy and to identify its challenges.

Methods: Electronic databases were searched to identify studies conducted on endoscopists' opinions on the use of AI in endoscopy.

Leaf adaptation strategy of non-tree plants altered by community structure implies vegetation degradation risk in alpine rocky desertification areas.

In alpine rocky desertification areas, environmental stress poses challenges to vegetation restoration and protection. Merely observing the changes in specific leaf area driven by environmental factors may overlook the risk of non-tree vegetation degradation. The leaf resource allocation strategies of non-tree plants need to be focused on.

gdf11 is required for pronephros/cloaca development through targeting TGF-β signaling.

The kidney is a vital organ responsible for removing toxins, producing urine, and regulating homeostasis. Developmental defects in the kidney lead to various congenital abnormalities that impair renal function. Gdf11, a member of the transforming growth factor β family, is associated with numerous renal abnormalities.

ChatGPT performance in assessing musculoskeletal MRI scan appropriateness based on ACR appropriateness criteria.

Large Language Models (LLMs) hold potential as clinical decision support tools, particularly when integrated with domain-specific knowledge. In radiology, there is limited research on LLMs for assessing imaging appropriateness. This study evaluates a contextualized GPT-4-based LLM's performance in assessing the appropriateness of musculoskeletal MRI scan requests with standard models and different versions of optimization.

Extracts from petal of the Crocus sativus (saffron) possesses detoxification effects on acetaminophen induced liver injury by inhibiting hepatocyte apoptosis via regulating Nrf2/HO-1 signaling.

The purpose of this study was to investigate the detoxification effect of extracts from the petal of Crocus sativus L. (PCSE) on acetaminophen (APAP) induced liver injury in mice and its related mechanisms. LC-MS/MS analysis was used to identify the main components in PCSE, and an APAP-induced acute liver injury model in mice was constructed to evaluate the detoxification effect of PCSE.

Jiawei Danxuan Koukang and its key component Quercetin intervened in OSF carcinogenesis by inhibiting the AR/eIF5A2 signaling pathway-mediated EMT.

Objective: This work aims to investigate the mechanism of Jiawei Danxuan Koukang (JDK) and Quercetin in oral submucous fibrosis (OSF) carcinogenesis.

Design: We established an OSF model for rats by injecting Arecoline into the oral mucosa of rats to study the impact of JDK and Quercetin on the progression of OSF and OSCC. Then, the viability, proliferation, and migration ability of Arecoline-induced hOMF, CAL27 and SCC-25 cells in JDK and quercetin intervention were detected.

The structures of two polysaccharides from Fructus Corni and their protective effect on insulin resistance.

Type 2 diabetes mellitus (T2DM) is characterized by impaired cellular or organ responsiveness to insulin, which results in ineffective glucose disposal and lacks a definitive treatment. Previous studies suggest that polysaccharides hold promise as natural agents for the prevention and treatment of T2DM. In this study, we identified two polysaccharides from Fructus Corni, PFC-CI and PFC-CII, with molecular weights of 59.

Structure characteristics of a novel pectic polysaccharide from Fructus Corni and its protective effect on alcoholic fatty liver.

Alcoholic fatty liver disease (AFLD) is characterized by the accumulation of hepatic lipid and has no effective treatment yet. Fructus Corni is a traditional Chinese medicinal herb, and its extractions have demonstrated hepatoprotective properties. We hypothesize that the polysaccharides in Fructus Corni might have therapeutic effects on AFLD.

Persistence of advanced therapies in patients with inflammatory bowel disease: retrospective cohort study using a large healthcare claims database in Japan.

Background/aims: There are few studies that comprehensively report real-world persistence for first-line advanced therapies used to treat inflammatory bowel disease. We aimed to describe persistence of first-line advanced therapies among incident biologic or Janus kinase inhibitor users with inflammatory bowel disease.

Methods: Retrospective cohort study using the Japan Medical Data Center database from January 1, 2010, until September 30, 2022.

Effects of the transtheoretical model-based self-management program on behavioral change in persons with epilepsy: Study protocol for a randomized controlled trial.

Introduction: Self-management applications are cost-effective and scalable for epilepsy treatment. However, there is a limited long-term quantitative evidence regarding their effectiveness. The Transtheoretical Model (TTM) offers a psychological framework that tailors self-management plans to the individual's stage of behavioral change.

C1 Functionalization of β-Carboline via Knochel-Hauser Base-Directed Metalation and Negishi Coupling.

The synthesis of C1-functionalized β-carbolines from -Boc norharman is described. Substitution is realized by employing the Knochel-Hauser base (TMPMgCl·LiCl) followed by transmetalation with ZnCl and subsequent Negishi cross-coupling of the resulting organozinc species. A variety of aryl or heteroaryl bromides participated in this one-pot reaction sequence, allowing for rapid diversification of the β-carboline scaffold in moderate to excellent yields.

Giant Cell Tumour of the Spine.

Giant cell tumour (GCT) is a benign bone tumour characterised by osteoclastic-like multinucleated cells. This tumour predominantly occurs in adults during the third decade of life, commonly in the distal femur, proximal tibia, distal radius, and sacrum. Treatment options include wide local excision with possible adjuvant therapy depending on tumour size and site.

Discovery of New Cyclic Lipodepsipeptide Orfamide N via Partnership with Middle School Students from the Boys and Girls Club.

We established a university-community partnership with the Boys and Girls Clubs of Chicago (BGCC)-named b-to involve middle school students in antibiotic discovery research. In the course of working with a cohort of students from the BGCC, one student isolated a bacterium from a goose feces sample that produced a new cyclic lipodepsipeptide, which was characterized as orfamide N. Orfamide N is composed of ten mixed D/L-amino acids and a ()-3-hydroxyhexadec-9-enoic acid residue.