Magnetic separation-integrated electrochemical biosensor with synergy of photo-electronic cascading for high-reproducibility detection of miRNA biomarker in tumor tissue.

Electrochemical detection of microRNA biomarkers in tumor interstitial fluid is promising for accurately assessing tumor burden, but remains challenging due to interference and reproducibility limitations. Here, a magnetic separation-integrated electrochemical biosensor utilizing the synergy of photo-electronic cascading was developed for anti-interference and highly reproductive detection of miRNA-21. Polydopamine-coated FeO magnetic nanoparticles were adopted as electroactive probe carriers and photoactivatable electron donors.

Targeting microglial NAAA-regulated PEA signaling counters inflammatory damage and symptom progression of post-stroke anxiety.

Post-stroke anxiety (PSA) manifests as anxiety symptoms after stroke, with unclear mechanisms and limited treatment strategies. Endocannabinoids, reported to mitigate fear, anxiety, and stress, undergo dynamic alterations after stroke linked to prognosis intricately. However, endocannabinoid metabolism in ischemic microenvironment and their associations with post-stroke anxiety-like behavior remain largely uncovered.

Effects of Fospropofol Disodium and Propofol on the Postoperative Recovery of Elderly Patients Who Underwent Total Hip Arthroplasty: A Retrospective Study.

Purpose: Propofol is widely used for general anesthesia in elderly patients. Fospropofol disodium, a precursor of propofol, may reduce the incidence of postoperative nausea and vomiting (PONV). However, the effects of these two drugs on patients' postoperative recovery quality are unclear.

FeP/ZnS Heterostructures Supported on N-Doped Porous Carbon as Efficient Oxygen Reduction Electrocatalysts for High-Performance Zinc-Air Batteries.

The development of oxygen reduction reaction (ORR) catalysts with high catalytic activity, high stability, and low cost is of great significance for the development of rechargeable zinc-air batteries (ZABs). Designing heterostructures within the catalyst can regulate the charge distribution to enhance the electron transfer rate during the catalytic process, and optimize the adsorption of oxygen-containing intermediates, resulting in high-performance ORR catalysts. In this study, FeP/ZnS heterostructures supported on N-doped porous carbon (FeP/ZnS@NC) are designed and fabricated through one-step synthesis via high-temperature pyrolysis.

Low CD4 count was characterized in recent HIV CRF01_AE infection and it rapidly increased to reach a peak in the first year since ART initiation.

Background: Currently, most people living with HIV (PLWH) in China have a strong awareness of diagnosis and treatment in the early stage of HIV infection. Subtype-specific virological and immunological features of recently infected PLWH have not yet been elucidated.

Methods: Data including CD4 count and viral load (VL) of 1508 anti-retroviral therapy (ART) -naïve PLWH were obtained from the HIV Database and comparatively analyzed among PLWH with different HIV subtypes.

Recent Progress in the Design and Application of Strong Metal-Support Interactions in Electrocatalysis.

The strong metal-support interaction (SMSI) in supported metal catalysts represents a crucial factor in the design of highly efficient heterogeneous catalysts. This interaction can modify the surface adsorption state, electronic structure, and coordination environment of the supported metal, altering the interface structure of the catalyst. These changes serve to enhance the catalyst's activity, stability, and reaction selectivity.

Extracts from petal of the Crocus sativus (saffron) possesses detoxification effects on acetaminophen induced liver injury by inhibiting hepatocyte apoptosis via regulating Nrf2/HO-1 signaling.

The purpose of this study was to investigate the detoxification effect of extracts from the petal of Crocus sativus L. (PCSE) on acetaminophen (APAP) induced liver injury in mice and its related mechanisms. LC-MS/MS analysis was used to identify the main components in PCSE, and an APAP-induced acute liver injury model in mice was constructed to evaluate the detoxification effect of PCSE.

Ni Single Atoms/FeN Nanoparticles Supported by N-Doped Carbon Hollow Nanododecahedras with Nanotubes on the Surface for Efficient Electro-Reduction of CO to CO.

The transition metal single atoms (SAs)-based catalysts with M-N coordination environment have shown excellent performance in electrocatalytic reduction of CO, and they have received extensive attention in recent years. However, the presence of SAs makes it very difficult to efficiently improve the coordination environment. In this paper, a method of direct high-temperature pyrolysis carbonization of ZIF-8 adsorbed with Ni and Fe ions is reported for the synthesis of Ni SAs and FeN nanoparticles (NPs) supported by the N-doped carbon (NC) hollow nanododecahedras (HNDs) with nanotubes (NTs) on the surface (Ni SAs/FeN NPs@NC-HNDs-NTs).

The Asymmetrical Fe-O-Se Bonds in FeO(SeO) Boosting Bifunctional Oxygen Electrocatalytic Performance for Zinc-Air Battery.

Zinc-air batteries (ZABs) have the advantages of high energy density and rich zinc raw materials. It is a low-cost, green and sustainable energy storage device. At present, one of the key technologies that hinder the large-scale application of ZABs is the design and fabrication oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) bifunctional catalysts with excellent performance, especially the non-platinum-based catalysts.

Neuronal HIPK2-HDAC3 axis regulates mitochondrial fragmentation to participate in stroke injury and post-stroke anxiety like behavior.

Post-stroke anxiety (PSA) seriously affects the prognosis of patients, which is an urgent clinical problem to be addressed. However, the pathological mechanism of PSA is largely unclear. Here, we found that neuronal HIPK2 expression was upregulated in the ischemic lesion after stroke.

Sponge-derived alkaloid AP-7 as a sensitizer to cisplatin in the treatment of multidrug-resistant NSCLC via Chk1-dependent mechanisms.

Multidrug resistance is a substantial obstacle in treating non-small cell lung cancer (NSCLC) with therapies like cisplatin (DDP)-based adjuvant chemotherapy and EGFR-tyrosine kinase inhibitors (TKIs). Aaptamine-7 (AP-7), a benzonaphthyridine alkaloid extracted from sponge, has been shown to exhibit a broad spectrum of anti-tumor activity. However, the anti-cancer activity of AP-7 in combination with DDP and its molecular mechanisms in multidrug-resistant NSCLC are not yet clear.

Macrophage WNK1 senses intracellular hypo-chlorine to regulate vulnerability to sepsis attack during hypochloremia.

Sepsis is one of the leading causes of death in critical patients worldwide and its occurrence is related to the excessive activation of macrophages. Chloride loss worsens the prognosis of patients with sepsis but the underlying mechanism is currently unclear. In this study, we founded that macrophages deficient in intracellular Cl secrete more inflammatory cytokines such as IL-1β, IL-6 and TNF-α compared with control group.

Amorphous P-CoO Promotes the Formation of Hypervalent Ni Species in NiFe LDHs by Amorphous/Crystalline Interfaces for Excellent Catalytic Performance of Oxygen Evolution Reaction.

Water electrolysis has become an attractive hydrogen production method. Oxygen evolution reaction (OER) is a bottleneck of water splitting as its four-electron transfer procedure presents sluggish reaction kinetics. Designing composite catalysts with high performance for efficient OER still remains a huge challenge.

The association between proactive personality and interprofessional learning readiness in nursing students: The chain medication effects of perceived social support and professional identity.

Background: Interprofessional education (IPE) has been advocated for all healthcare students, and readiness for interprofessional learning significantly influences its effectiveness. It is essential to explore the antecedent factors of readiness for interprofessional learning among nursing students to promote IPE. While a proactive personality might impact readiness for interprofessional learning, its specific role has remained unspecified.

Fe-Doped NiP/NiSe Composite Catalysts for Urea Oxidation Reaction (UOR) for Energy-Saving Hydrogen Production by UOR-Assisted Water Splitting.

The development of efficient urea oxidation reaction (UOR) catalysts helps UOR replace the oxygen evolution reaction (OER) in hydrogen production from water electrolysis. Here, we prepared Fe-doped NiP/NiSe composite catalyst (Fe-NiP/NiSe-12) by using phosphating-selenizating and acid etching to increase the intrinsic activity and active areas. Spectral characterization and theoretical calculations demonstrated that electrons flowed through the Ni-P-Fe-interface-Ni-Se-Fe, thus conferring high UOR activity to Fe-NiP/NiSe-12, which only needed 1.

Precursor-Directed Biosynthesis of Neoantimycin Derivatives with Selective Cytotoxicity.

A precursor-directed biosynthesis approach led to the accumulation of seven new neoantimycin derivatives (-) from RJ2. Structure elucidation was conducted using NMR and HRESIMS analysis, and the absolute configuration was determined by advanced Marfey's method, Mosher's analysis, and ECD analysis. The obtained compounds revealed selective and significant cytotoxicity, specifically against colorectal cancer cells bearing the K-ras mutation, with IC values ranging from 40 nM to 3.

Physiological and pathological effects of phase separation in the central nervous system.

Phase separation, also known as biomolecule condensate, participates in physiological processes such as transcriptional regulation, signal transduction, gene expression, and DNA damage repair by creating a membrane-free compartment. Phase separation is primarily caused by the interaction of multivalent non-covalent bonds between proteins and/or nucleic acids. The strength of molecular multivalent interaction can be modified by component concentration, the potential of hydrogen, posttranslational modification, and other factors.

Remifentanil is Superior to Propofol for Treating Emergence Agitation in Adults After General Anesthesia.

Background: Emergence agitation (EA) is one of the most common complications in clinical general anesthesia during recovery in adults. Remifentanil and propofol can reduce the incidence of EA, but with no randomized controlled trial to evaluate their effectiveness for treating EA. This study aims to compare the effectiveness of remifentanil and propofol for treating EA following general anesthesia.

Co/CoO Heterojunctions Encased in Porous N-Doped Carbon Nanocapsules for High-Performance Cathode of Rechargeable Zinc-Air Batteries.

A long-term goal of rechargeable zinc-air batteries (ZABs) has always been to design bifunctional electrocatalysts that are robust, effective, and affordable for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). It has become a feasible method to construct metal/metal oxide interfaces to achieve superior electrocatalytic performance for ORR and OER by enhanced charge transfer. In this study, Co/CoO heterojunctions were successfully prepared and encased in porous N-doped mesoporous carbon (Co/CoO@NC) via a simple condensation-carbonization-etching method.

A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer.

Modulating Tankyrases (TNKS), interactions with USP25 to promote TNKS degradation, rather than inhibiting their enzymatic activities, is emerging as an alternative/specific approach to inhibit the Wnt/-catenin pathway. Here, we identified UAT-B, a novel neoantimycin analog isolated from , as a small-molecule inhibitor of TNKS-USP25 protein-protein interaction (PPI) to overcome multi-drug resistance in colorectal cancer (CRC). The disruption of TNKS-USP25 complex formation by UAT-B led to a significant decrease in TNKS levels, triggering cell apoptosis through modulation of the Wnt/-catenin pathway.

HDAC3 Contributes to Ischemic Stroke by Regulating Interferon Pathway.

Background: The inflammation and immune response contribute to ischemic stroke pathology. Damaged brain cells release inflammatory substances to activate the immune system in the acute phase of stroke, including altering the interferon signaling pathway. However, the involvement of histone deacetylation in stroke remains unclear.