Loss and Recovery of Effective Lithium in Anode-Free Solid-State Lithium Metal Batteries.

Anode-free solid-state lithium (Li) metal batteries (AFSSLMBs), with anticipated high energy density and cost-effectiveness, high safety, and simplicity of fabrication, are considered to have great potential in becoming promising alternatives for next-generation electrochemical energy storage devices. Unfortunately, the inefficiency of Li plating/stripping and the rapid capacity decay during cycling have severely hindered the further development of AFSSLMBs. Accordingly, to cope with these faced challenges, enormous efforts have been made in the most recent years.

The Multiomics Landscape of Plasma-Derived Small Extracellular Vesicles during the Development of HPV Cervical Cancer.

The transition from HPV infection to cervical cancer (CC) remains unclear, especially concerning small extracellular vesicles (sEVs). We analyzed plasma-sEVs from HPV-negative individuals (HPVN-sEVs), HPV-positive individuals (HPVP-sEVs), and HPV-positive CC patients (HPVC-sEVs) via proteomics (n = 5/5/9) and transcriptomics (n = 3/3/4). Multiomics revealed HPVP-sEVs harbor antiviral and pro-inflammatory signals early in infection, whereas HPVC-sEVs shift toward immunosuppression to sustain persistent infection.

Fat embolism syndrome: Never give up - A case report and literature review.

Rationale: Fat embolism syndrome (FES) is a complex syndrome with high in-hospital mortality and the diagnosis and treatment of FES remain challenging. In this article, we present a case report as well as a comprehensive review of trauma-related cases to enhance the understanding of FES.

Patient Concerns: An 18-year-old young man developed a fever, tachycardia, and dyspnea about 58 hours after the trauma.

Diagnostic Accuracy and Chromosomal Microarray and Karyotype Analysis with Different Clinical Biomarkers for Prenatal Diagnosis of Fetal Genetic Diseases.

Background: We compared the diagnostic accuracy and application value of chromosome microarray (CMA) technique and karyotype analysis for prenatal diagnosis of fetal genetic diseases using different clinical markers.

Methods: This is a prospective clinical study involving 1587 pregnant women who underwent amniocentesis for prenatal diagnosis due to various abnormal clinical indications in China between May 2018 and Nov 2021. Both chromosome microarray and karyotype analysis were applied.

Microenvironment Regulation Unlocks High Li⁺ Conduction in Polyether Electrolytes for High-Performance Quasi-Solid-State Batteries.

Polyether electrolytes (PEs) have attracted significant research and industrial interest for high-performance lithium metal batteries (LMBs). However, traditional PEs are limited by their low lithium-ion (Li) conductivity primary due to strong Li⁺-polymer interactions (i.e.

Liposomal all-trans retinoic acid boosts anti-tumor immunity of radiotherapy via mitigating cancer stemness and remedying tumor microenvironment.

Radiotherapy (RT) induces immunogenic cell death but also promotes immunosuppression, cancer stemness and immune evasion, thus compromising anti-tumor immune response and leading to cancer recurrence and metastasis. Here, we developed liposomal all-trans retinoic acid nanoparticles (LATRA) to simultaneously mitigate cancer stemness and remedy suppressive tumor microenvironment, which on one hand decreases tumorigenicity and sensitizes tumors to RT and on the other hand stimulates dendritic cell maturation and reprograms macrophages toward a pro-inflammatory M1 phenotype. In murine colorectal tumor model, RT combined with LATRA essentially reduces tumor burden, prevents recurrence and induces a durable immune response with memory effects.

Rationale and protocol for a longitudinal cohort study of children with cerebral palsy in China assessing functional developmental trends, genetic aetiology and imaging.

Introduction: Cerebral palsy (CP), the most common physical disability in children, imposes substantial economic and psychological burdens on families and society. The clinical management of CP remains challenging due to the limited efficacy of current treatments and the heterogeneity of its aetiologies and clinical presentations. This study aims to investigate the functional changes and identify influencing factors in Chinese children with CP.

Bulky Ligand-Induced Hindrance in Photocatalytic CO Reduction over Various Tris(bipyridine)cobalt(II) Chloride Complexes.

Photocatalytic CO conversion is one of the ideal approaches to address both topics of solar energy shortage and carbon neutrality. Cobalt(II) centers coordinated with bipyridines have been designed and evaluated as catalysts for CO conversion under light irradiation. Herein, we report a series of pyridine-based cobalt complexes with alkyl substituents as molecular photocatalysts, aiming to elucidate the effects of alkyl type and substitution position on catalytic performance through spectroscopic and electrochemical measurements.

Molecular Engineering Enabled In Situ 3D Cross-Linked and Thermo-Electrochemically Stable Poly(1,3-dioxolane) Solid Polymer Electrolyte.

The narrow electrochemical stability window (ESW) and poor thermal stability of poly(1,3-dioxolane) (PDOL) solid polymer electrolyte severely restrict its application. In this study, poly(1,3-dioxolane) dimethacrylate (PDOL-DMA) is designed and synthesized to replace the unstable terminal hydroxyl groups with unsaturated C═C double bond. The cross-linked quasi-solid electrolyte (CPDOL-DMA QSE) demonstrates a wide ESW of 4.

A New Classification System for Alveolar Bone Morphology around Maxillary Incisors in Adult Patients with Maxillary Protrusion.

Objective: To develop a new alveolar bone morphology classification for maxillary incisors in patients with maxillary protrusion, and to investigate the association of alveolar morphology with skeletal patterns and alveolar bone defects following retraction.

Methods: A retrospective study of CBCT scans was performed for 250 patients with maxillary protrusion. The morphology of alveolar bone around maxillary incisors was classified into four types: A1 (upright maxillary incisor in thin alveolar bone), A2 (lingually inclined maxillary incisor in thin alveolar bone), B1 (upright maxillary incisor in thick alveolar bone) and B2 (lingually inclined maxillary incisor in thick alveolar bone).

"Gene-Editing" Design Upgrades Eutectic-Polymer Electrolytes with Ultra-High Li Conductivity.

Deep eutectic polymer electrolytes (DEPEs) have emerged as highly promising next-generation electrolytes, offering unparalleled electrochemical performance and safety. Their excellence stems from a synergistic blend of the robust mechanical stability of solid polymer electrolytes and the exceptional interfacial wettability and superior thermal resilience of deep eutectic electrolytes. However, conventional DEPEs frequently exhibit suboptimal Li conductivity due to strong coordination between Li and oxygen-containing polymer moieties.

"Rigid Exterior, Soft Interior" Design Enables High-Voltage Polyether Electrolytes for Quasi-Solid-State Batteries.

Polyether electrolytes with high Li conductivity and excellent interfacial contact have garnered significant attention. Yet further applications of such electrolytes in high-voltage lithium metal batteries are severely hindered by the instability of the electrolyte and electrolyte/electrodes interphases. Here, we report a novel high-voltage polyether electrolyte with a "rigid exterior, soft interior" design, which involves a 3D F-contained network as a rigid exterior framework, and a unique solvation structure with intensified Li-anion coordination as a soft interior within the framework.

A comparison of arthroscopy combined with continuous irrigation, arthroscopic debridement alone, and open arthrotomy for the treatment of septic arthritis of the native knee.

Background: The optimal surgical treatment for septic arthritis of the knee remains debatable, with few studies comparing different arthroscopic techniques. Furthermore, no study has simultaneously compared arthroscopy combined with continuous irrigation, arthroscopic debridement alone, and open arthrotomy. This study compared the efficacy and success rates of these three surgical methods and analyzed the risk factors for failure following initial surgery.

Rational Dual-Atom Design to Boost Oxygen Reduction Reaction on Iron-Based Electrocatalysts.

The oxygen reduction reaction (ORR) is critical for energy conversion technologies like fuel cells and metal-air batteries. However, advancing efficient and stable ORR catalysts remains a significant challenge. Iron-based single-atom catalysts (Fe SACs) have emerged as promising alternatives to precious metals.

Infection characteristics and risk factors in ovarian cancer patients with concomitant vaginitis.

Objective: To investigate the infection characteristics in ovarian cancer (OC) patients with concomitant vaginitis and identify the risk factors for the patients.

Methods: A retrospective analysis was conducted on the clinical data from 100 OC patients treated at the Yiwu Central Hospital from July 2019 to July 2024. Patients were assigned to the infection group (n=34) or non-infection group (n=66) based on the presence of vaginitis.

PRIMA1 participates in the inhibition of inflammation and acetylcholinesterase activity in goose fatty liver formation.

Goose fatty liver, a product of short-term overfeeding, is notable for its high nutritional value and unique tolerance to severe steatosis without inflammation, in contrast to human nonalcoholic fatty liver disease (NAFLD). It is known that choline can alleviate nonalcoholic steatohepatitis and liver cirrhosis, inhibit cell apoptosis, promote lecithin synthesis and fat transportation out of the liver, and relieve cardiovascular disease-related symptoms (e.g.

Functional connectivity across multi-frequency bands in patients with tension-type headache: a resting-state fMRI retrospective study.

Objectives: Tension-type headache (TTH) is the most common nervous system disorder worldwide. This study aimed to examine abnormal network-level brain functional connectivity (FC) alterations in patients with TTH across multi-frequency bands.

Methods: The study enrolled 63 subjects, comprising 32 patients with TTH and 31 healthy controls (HC).

Dynamics of small RNAs in a red-fruited wine grape cultivar infected with Grapevine red blotch virus.

Background: Red blotch disease, caused by Grapevine red blotch virus (GRBV, genus Grablovirus, family Geminiviridae), negatively impacts vine health, fruit yield, and quality, leading to substantial economic losses to growers. While recent studies have enhanced our understanding of the epidemiology of GRBV and its effects, little is known about the molecular basis of the host-virus interactions. Since small RNAs (sRNAs) are known to play a central role in host-virus interactions, this study was undertaken to investigate sRNA dynamics in leaves and berries at two phenological stages (asymptomatic pre- and symptomatic post-véraison) of GRBV-infected grapevines (Vitis vinifera cv.

[Perception of Mandarin aspirated/unaspirated consonants in children with cochlear implants].

This study aims to investigate the perception of Mandarin aspirated and unaspirated consonants by children with cochlear implants （CIs） under quiet and noisy conditions. It also examines factors that may affect their acquisition, such as auditory conditions, place of articulation, manner of articulation, chronological age, age at implantation, and non-verbal intelligence. Twenty-eight CI children aged 3 to 5 years who received implantation from 2018 to 2023 were recruited.

Nanoparticle Delivery of Antisense miR162 Inhibits Invasive Habitat Adaption of Alternanthera Philoxeroides.

Phenotypic flexibility in adaptive traits is crucial for organisms to thrive in changing environments. Alternanthera philoxeroides, native to South America, has become an invasive weed in Asia. The mechanism by which invasive capacity is achieved remains unknown.

Near-Infrared Light-Responsive Immunomodulator Prodrugs Rejuvenating Immune Microenvironment for "Cold" Tumor Photoimmunotherapy.

Light-activatable prodrugs have been applied in precision cancer therapy because of their spatiotemporal controllability and minimal toxic side effects. However, the reported prodrugs were limited by the ultraviolet and visible light regions, which seriously restricted their application in deep tissues. Developing a near-infrared (NIR) light-activatable release system remains a great challenge.

Recent advances in 2D MXene-based heterostructures for gas sensing: mechanisms and applications in environmental and biomedical fields.

MXenes, a unique class of 2D transition metal carbides, have gained attention for gas sensing applications due to their distinctive properties. Since the synthesis of TiCT MXene in 2011, significant progress has been made in using MXenes as chemiresistive sensors. Their layered structure, abundant surface groups, hydrophilicity, tunable conductivity, and excellent thermal properties make MXenes ideal for low-power, flexible, room temperature gas sensors, fostering scalable and reproducible applications in portable devices.

Skin-interfaced sweat monitoring patch constructed by flexible microfluidic capillary pump and Cu-MOF sensitized electrochemical sensor.

The limitations of skin-interfaced sweat monitoring are mainly reflected in the effective collection of sweat and the high sensitivity of the detection. This work proposes a new type of sweat monitoring patch based on a flexible microfluidic chip fabricated by a capillary pump and a copper-based metal-based organic framework (Cu-MOF) sensitized electrochemical sensor. The sweat in the microchannel is driven by a capillary pump to ensure the smooth collection and transportation.

Efficacy of platelet-rich plasma use as an adjunctive treatment in autologous osteochondral transplantation for patients with osteochondral lesions of the talus accompanied by chronic lateral ankle instability.

Background: Autologous osteochondral transplantation (AOT) combined with biological agents is an advanced technique for treating osteochondral lesions. Therefore, this study aimed to explore the effect of combining platelet-rich plasma (PRP) treatment with AOT on postoperative functional and magnetic resonance imaging (MRI) outcomes in patients with osteochondral lesions of the talus (OLTs) accompanied by chronic lateral ankle instability (CLAI).

Methods: This retrospective study had a minimum follow-up period of 1 year.

Tumor-Adhesive Chitosan-Derived Multi-Immune Agonist Unleashes Strong and Durable Anti-Cancer Immunity.

The immunomodulation of the tumor microenvironment is critical for effective cancer immunotherapy, particularly for tumors that exhibit limited responses to conventional treatments. However, current immune agonists developed for tumor immunomodulation face several challenges, such as poor intratumoral retention, inadequate biocompatibility, and restricted cellular targets, which ultimately hamper their therapeutic efficacy and clinical application. In this study, a tumor-adhesive chitosan-tethered immune agonist construct (TACTIC) is introduced, which demonstrates good biocompatibility and robust immunostimulatory effects, enhancing the immunogenicity of tumor cells while simultaneously stimulating pro-inflammatory responses in various immune cell populations.