Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objectives: Tension-type headache (TTH) is the most common nervous system disorder worldwide. This study aimed to examine abnormal network-level brain functional connectivity (FC) alterations in patients with TTH across multi-frequency bands.
Methods: The study enrolled 63 subjects, comprising 32 patients with TTH and 31 healthy controls (HC). According to our team's previous research, the brain regions with abnormal ReHo in the conventional frequency band (0.01-0.08 Hz) and the slow-5 band (0.01-0.027 Hz) were chosen as seed regions of interest (ROIs). Subsequently, the FC between ROIs and the entire brain analysis across various frequency bands was calculated to evaluate network-level alterations, and differences between the TTH and HC were analyzed. Pearson's correlation analysis was conducted to assess the relationship between significantly altered FC values in two frequency bands and visual analog score (VAS) in TTH patients.
Results: In the slow-5 band (0.01-0.027 Hz), FC between right medial superior frontal gyrus and right medial temporal pole/right inferior temporal gyrus as well as right middle frontal gyrus and left supramarginal gyrus of TTH patients exhibited significantly higher, compared to the HC group, while FC between right middle frontal gyrus and right lateral occipital cortex reduced. For the correlation results, there was no correlation between abnormal brain regions of FC and VAS score.
Conclusions: Changes in FC within brain regions associated with TTH are linked to pain processing. And the altered FC in TTH patients were frequency dependent. These initial observations could enhance our understanding of TTH's pathophysiological mechanism and offer insights for its future diagnosis and treatment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046950 | PMC |
| http://dx.doi.org/10.1186/s12880-025-01599-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evidence for cognitive compensation mechanism in the postoperative delirium: a prospective multi-modal neuroimaging cohort study.
Brain Imaging Behav
September 2025
Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, South 4th Ring West Road 119, Fengtai District, Beijing, 100070, China.
To explore the effect of brain cognitive compensation on the pathogenesis of postoperative delirium (POD) in the frontal glioma patients. Eighty-four adult patients with unilateral frontal glioma who underwent elective craniotomy and 37 healthy controls were recruited. Primary outcomes were POD during postoperative 1-7 days, as assessed by Confusion Assessment Method.
View Article and Find Full Text PDFUnraveling the Molecular Basis of Extracranial Glioblastoma Metastasis: A Case Report and Literature Review.
Neuropathology
October 2025
Pathology Department, Complejo Hospitalario Universitario de Toledo, Toledo, Spain.
Glioblastoma (GB), IDH-wildtype (IDH-wt), is the most prevalent primary malignant brain neoplasm in adults. Despite adjuvant therapy, the prognosis for these tumors remains dismal, with a median survival of around 15-18 months. Although rare, extracranial metastases from GB are reported with increasing frequency, likely due to advancements in follow-up, treatments, and improved patient survival.
View Article and Find Full Text PDFLaser Interstitial Thermal Therapy (LITT) in pediatric neurosurgery: Single center retrospective analysis of 41 consecutive procedures.
Neurochirurgie
September 2025
Necker Hospital, Departments of Pediatric Neurosurgery, Radiology, Pediatric Neurology and Anesthesiology; Reference Center for Rare Epilepsies CRéER, Member of ERN Epicare; APHP, Paris, France; Université de Paris Cité, Paris, France; Institut Imagine, INSERM U1163, Paris, France; Paris Kids Can
Introduction: Laser Interstitial Thermal Therapy under MRI control has emerged as a safe and efficient alternative to microsurgery in epilepsy and neurooncology procedures. Yet it has been used only recently in seldom European centers. Here, we report our 4 years' experience with LITT in children (complications, epileptic and oncologic outcomes).
View Article and Find Full Text PDFGratitude increases the sharing willingness to micro-charity information: An fNIRS study.
Behav Brain Res
September 2025
School of Psychology, Zhejiang Normal University, Jinhua, China, 321004; College of Economics and Management, Zhejiang Normal University, Jinhua, China, 321004. Electronic address:
Micro-charity, with its ease of dissemination, is an effective way to support public welfare. Gratitude has been shown to promote prosocial behavior. However, its specific role in driving micro-charity sharing, particularly the underlying neural correlates, remains unclear.
View Article and Find Full Text PDFEndoplasmic Reticulum Stress Modulation by Alpha-Pinene in a Rotenone-Induced Rat Model of Parkinson's Disease.
Eur J Pharmacol
September 2025
Faculty of Medicine, Department of Histology and Embryology, İzmir Katip Çelebi University, İzmir, Turkiye.
Age is the most significant risk factor for Parkinson's disease, a common and progressive neurodegenerative disorder; however, exposure to toxic substances is also strongly implicated. Rotenone, an organic pesticide, induces neuropathological features of Parkinson's disease, and is widely used to create rodent models of the condition. Although the molecular mechanisms involved in the onset and progression of the disease are still unknown, neurodegenerative diseases due to protein accumulation in certain areas of the brain, have been associated with endoplasmic reticulum stress.
View Article and Find Full Text PDF