Decoding Multi-Electron Redox Pathways in Carbon-Free Iron Selenide Cathodes: Enabling Energy-Dense All-Solid-State Lithium Batteries Across Extreme Temperatures.

Conversion-type iron chalcogen cathodes, characterized by the multi-electron redox reaction and cost-effectiveness, represent an alternative pathway for next-generation all-solid-state lithium batteries (ASSLBs). In this study, α-FeSe as a cathode is identified that operates stably through a Fe/Fe redox reaction in a sulfide solid-state system at 30 C, without the need for any carbon additives. This carbon-free α-FeSe cathode exhibits rapid Li/e transfer properties and limited volume change, thus yielding high reversible capacity (564.

Staged Construction of Pluripotent Stem Cell Lung Models for Assessing Respiratory Toxicity of Environmental Pollutants.

Due to factors such as smoking, air pollution, and an aging population, the prevention and control of chronic respiratory diseases in China are becoming more severe. Combining current epidemiological investigations, exposure to environmental pollutants such as atmospheric pollutants, persistent organic pollutants, and heavy metals may have adverse effects on lung development. Lung differentiation models are crucial tools for elucidating the process of lung development.

Analysis of the immune microenvironment in colorectal cancer with different KRAS gene subtypes.

Background: To explore the differences in tumor immune microenvironment between different KRAS mutation subtypes, and to provide a new direction for clinical immunotherapy of different subtypes of colorectal cancer.

Methods: We examined the spatial distribution of common inflammatory cell markers of CD8 + T cells, CD4 + T cells, natural killer cells, and B cells and macrophages in 55 colorectal cancer patients with different KRAS gene phenotypes using immunohistochemistry and panoramic scanning. We analyzed the relationship between inflammatory cells and clinical information.

Axial Growth and Meridian Modulation of Cornea Power in Children Wearing Orthokeratology Lenses of Different Back Optic Zone Diameters.

Purpose: To evaluate the effect of orthokeratology lenses with different back optical zone diameters (BOZD) on relative corneal refraction power shift (RCRPS) and explore its association with axial length growth (ALG).

Design: A randomized, double-blinded, controlled clinical trial.

Methods: Subjects aged between 8 and 15 years, with the refraction of -1.

Exploring the role of monocarboxylate transporter 4 in diverse KRAS mutation subtypes of colorectal Cancer.

This study explored the therapeutic potential of monocarboxylate transporter 4 (MCT4/SLC16A3) in KRAS-mutant colorectal cancer (CRC). By integrating immunohistochemistry with UCSC Xena database analysis, we identified a distinct MCT4 expression pattern in KRAS-mutant CRC. Cytoplasmic MCT4 expression was positively correlated with KRAS mutation status and mismatch repair (MMR) proficiency, but negatively associated with sex and tumor differentiation.

Abnormal Static and Dynamic Functional Connectivity in Tension-Type Headache: A Support Vector Machine Analysis.

Tension-type headache (TTH) is a primary headache with the highest prevalence. Previous studies have revealed the local brain abnormalities of TTH patients. However, little is known about its brain connectivity disruption.

Valproic acid induces ferroptosis and suppresses the proliferation of MDA-MB-231 cells by targeting FDFT1.

Introduction: Valproic acid (VPA) constitutes a branched-chain, short-chain fatty acid that serves as an antiepileptic medication. It has been increasingly recognized that VPA has presented potential anti-tumor properties, including breast cancer. However, the exploration of novel breast cancer treatment methods necessitates a more comprehensive and in-depth understanding of the novel mechanism of VPA inhibition of breast cancer.

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis.

Anatomically modern humans (AMHs) exhibit a significant increase in basal metabolic rate (BMR) and height compared to non-human apes. This study investigates the genetic basis underlying these traits. Our analyses reveal a strong genetic correlation between height and BMR.

"Two-in-One" DPP Building Blocks for Ambipolar Conjugated Polymers in Flexible Transistors.

Advancements in conjugated donor-acceptor (D-A) polymers with superior semiconducting performance and reliability are pivotal to the evolution of flexible electronics. However, the development of electron-accepting building blocks has lagged far behind that of electron-donating ones, hindering the progression of ambipolar and n-type semiconductor polymers-especially ambipolar types-and thereby limiting the construction of logic circuits and p-n heterojunctions. In this study, we introduce a new electron-accepting building block, , meticulously engineered for semiconducting polymers tailored to flexible electronics applications.

Functional connectivity across multi-frequency bands in patients with tension-type headache: a resting-state fMRI retrospective study.

Objectives: Tension-type headache (TTH) is the most common nervous system disorder worldwide. This study aimed to examine abnormal network-level brain functional connectivity (FC) alterations in patients with TTH across multi-frequency bands.

Methods: The study enrolled 63 subjects, comprising 32 patients with TTH and 31 healthy controls (HC).

Host selection and nutrient status jointly drive algal and bacterial interactions in epiphytic biofilms of submerged macrophytes: Structural and functional insights.

Epiphytic biofilms play a crucial role in aquatic biogeochemical cycles but are simultaneously influenced by host selection and eutrophication. However, the compositional structure and interaction mechanisms of these factors on algal and bacterial communities remain poorly understood. In this study, we employed Confocal Laser Scanning Microscopy (CLSM), Scanning Electron Microscopy (SEM), and high-throughput sequencing to investigate the physicochemical properties, algal and bacterial diversity, and community structure of epiphytic biofilms on two submerged macrophytes - Vallisneria natans (VN) and Hydrilla verticillata (HV) - across three urban shallow lakes with varying trophic levels in the Yangtze River Basin.

Developmental toxicity and skin sensitization potential of synthetic phenolic antioxidants and butylated hydroxytoluene transformation products: Insights from human embryonic stem cell models.

Synthetic phenolic antioxidants (SPAs) are commonly used in food, cosmetics, and other products for their antioxidant properties and stability. However, increasing evidence links excessive SPA use to adverse effects, including developmental issues in animals. Given the widespread use of SPAs in cosmetics, there is a growing need to assess their potential health risks, particularly whether safe to be used during pregnancy.

Improving the stability of myofibrillar proteins undergoing hemoglobin-mediated oxidation by rosmarinic acid or chlorogenic acid: Insights into the underlying mechanisms.

In this study, rosmarinic acid (RA) and chlorogenic acid (CGA) were used to improve the stability of myofibrillar protein (MP) undergoing hemoglobin (Hb)-mediated oxidation. Hb-mediated oxidation caused changes in MP's secondary and tertiary structures. RA or CGA suppressed effectively Hb-induced MP oxidation, and maintained MP's spatial conformational stability through interacting with MP's amino acid side chains to form phenolic-protein complexes.

Innovative dopamine-modified carbon quantum dot fluorescence sensor meets affinity chromatography: A breakthrough in Tyrosinase inhibitor screening in food.

Tyrosinase (TYR), a polyphenol oxidase crucial for melanin synthesis, plays various biological functions, and its inhibitors are widely used in the cosmetics and food industries for skin-lightening and anti-browning applications. Here, an innovative method that integrates biosensing with affinity chromatography was developed, enabling the rapid and precise identification of TYR inhibitors in food. The biosensing segment used a dopamine-modified carbon quantum dot fluorescence sensor for quick detection of TYR inhibitors in complex food samples.

Frequency-specific modulation of motor cortical excitability by transcranial alternating current stimulation.

Background: Transcranial alternating current stimulation (tACS) is a non-invasive technique that modulates neural oscillations, yet its specific effects on cortical excitability are not well-understood. This study investigated the effects of tACS on neuroplasticity in the primary motor cortex (M1) across different frequencies.

Methods: In this randomized, sham-controlled, crossover study, 18 healthy young adults received β-tACS γ-tACS, and sham stimulation over the M1.

Intermittent Theta Burst Stimulation Over Cerebellum Facilitates Neurological Recovery in Poststroke Depression via the cAMP/PKA/CREB Pathway.

Background: Stroke causes somatic dysfunction and psychological disorders, leading to poststroke depression (PSD). This study investigates mood alterations in PSD models via cerebellar intermittent theta burst stimulation (iTBS).

Methods: PSD animal models were developed using middle cerebral artery occlusion and chronic unpredictable mild stress procedures.

Melt-Infusion-Induced Electrolyte Surface Coating Stabilized Sulfide-Based All-Solid-State Lithium Metal Batteries.

Sulfide-based all-solid-state lithium metal batteries (ASSLBs) are a potentially safe and high-energy electrochemical storage technology. The continuous interfacial degradation within sulfide solid-state electrolytes (SSEs) and Li metal however hinders Li transport and induces inhomogeneous Li deposition. Herein, we propose a melt-infusion method to introduce lithium trifluorosulfonylimide (LiTFSI) on LiPSCl (LPSCl) particles as an artificial coating.

Precise Identification of Inhibitors for Coagulation Reactions from Complex Extracts through Monitoring of Biological Aggregates Combined with a Targeted Fishing Technique.

Biological aggregates play a crucial role in the pathogenesis of thrombotic diseases, especially thrombin-induced biological aggregates. Therefore, the efficient discovery of thrombin inhibitors is of great significance for the prevention and treatment of thrombotic diseases. In this study, the aggregation precursor protein fluorescent probe was successfully prepared for monitoring the production of biological aggregates induced by thrombin.

Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy.

Dry eye disease (DED) is a prevalent and intractable ocular disease induced by a variety of causes. Elevated sphingomyelin (SM) levels and pro-inflammatory cytokines were detected on the ocular surface of DED patients, particularly in the meibomian glands. Sphingomyelin synthase 2 (SMS2), one of the proteins involved in SM synthesis, would light a novel way of developing a DED therapy strategy.

Research advances in : Nutrients, bioactive compounds, and functional properties benefitting livestock.

Growth retardation affects the health and production of livestock, while overexertion can cause sudden cardiac arrest. Both cases are considered to be metabolic disorders and are detrimental to livestock production. Effective measures for relieving or treating these disorders are scarce.

Fluorescence paper sensor meets magnetic affinity chromatography: discovering potent neuraminidase inhibitors in herbal medicines.

Given the inherent complexity of natural medicines, finding a straightforward and efficient method for identifying active ingredients remains a significant challenge, yet it is of paramount importance. Influenza virus neuraminidase (NA), a primary target for anti-influenza drug development, plays a crucial role in the infection process, making it essential to develop rapid and facile methods for screening NA inhibitors. Herein, we developed a novel and efficient analytical technique for the identification of NA inhibitors from complex herbal medicines by integrating dual sensing with affinity chromatography.

Investigating the role of the metabolic score for visceral Fat in assessing the prevalence of chronic kidney disease from the NHANES 1999-2018.

This study investigates the association between the Metabolic Score for Visceral Fat (METS-VF) and chronic kidney disease (CKD), assessing METS-VF as a potential predictor of CKD risk. Utilizing data from the 1999-2018 National Health and Nutrition Examination Survey (NHANES), this cross-sectional study included 24,387 adult participants. Multivariable logistic regression, restricted cubic spline models, and threshold effect analyses were employed to explore the relationship.

Altered brain functional connectivity in patients with tension-type headache.

Objective: To evaluate whether patients with tension-type headache (TTH) exhibit abnormal brain functional connectivity compared to healthy controls.

Background: TTH is one of the most prevalent headache disorders throughout the world. The present study delves into brain functional connectivity in patients with TTH to enhance the understanding of its underlying pathophysiology.

Integration of paper-based colorimetric microdevice and magnetic nanoparticles affinity for high-throughput capture of antimicrobial resistance-reversing agent from complex natural products.

Efficient analysis of active ingredient in complex natural products is crucial for drug discovery, but developing a simple method for this is challenging. The discovery of drugs against bacterial resistance is urgent because drug-resistant bacteria produce β-lactamases, which inactivate antibiotics and increase infection risks, particularly the AmpC β-lactamase. Here, an integrated analytical model based on colorimetric sensing and magnetic nanoparticles (MNPs) affinity chromatography was developed for screening AmpC β-lactamase inhibitors.