A retrospective cohort study of gastrografin in the management of adhesive small bowel obstruction during pregnancy.

Sci Rep

Department of General Surgery, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, NO.745 Wuluo Road, Hongshan District, Wuhan City, Hubei Province, P.R. China, 430070.

Published: July 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Adhesive small bowel obstruction (ASBO) during pregnancy is a critical condition that remains understudied. This study aimed to address management challenges of ASBO in pregnancy by evaluating the dual diagnostic and therapeutic role of gastrografin. We retrospectively analyzed medical records of pregnant patients with ASBO admitted between September 2018 and September 2023. Patients were categorized into conventional treatment or gastrografin groups based on received therapy. The groups showed no significant differences in demographics, baseline characteristics, or adverse events. However, the gastrografin group demonstrated superior outcomes, including a higher conservative treatment success rate, reduced need for surgery, shorter hospital stays, lower medical costs, and enhanced diagnostic utility. Gastrografin appears relatively safe in pregnancy, with its effective therapeutic action and precise diagnostic capability proving instrumental in managing ASBO.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297560PMC
http://dx.doi.org/10.1038/s41598-025-11777-2DOI Listing

Publication Analysis

Top Keywords

adhesive small
8
small bowel
8
bowel obstruction
8
asbo pregnancy
8
gastrografin
5
retrospective cohort
4
cohort study
4
study gastrografin
4
gastrografin management
4
management adhesive
4

Similar Publications

Synthetic cathinones (SCs) are drugs of abuse that act on the central nervous system, producing psychoactive effects similar to those of amphetamines. Their greater accessibility compared with the traditional amphetamine-type stimulants has contributed to their increasing popularity in recent years. The analysis of SCs in biological samples is essential for documenting their consumption.

View Article and Find Full Text PDF

The emergence of special scenarios involving small-sized penetrating wounds has imposed stricter performance requirements on shape-recovery hemostatic materials, particularly regarding their shape fixity and water-triggered shape recovery efficiency. Herein, an efficient shape-recovery sponge dressing with high shape fixity and high-speed liquid absorption, designated as CQT, was developed by integrating a sieve structure with the rough surface coating. The sieve structure, characterized by microporous structures on macroporous walls, enhanced the multi-level and connectivity of the overall pore network, which could improve compressive fixity via enhancing the energy dissipation required for rebound and enabled efficient shape recovery through augmented capillary action during fluid absorption.

View Article and Find Full Text PDF

Background: Endometrial damage is a critical factor contributing to infertility, particularly in women with refractory thin endometrium or intrauterine adhesions. Therefore, developing innovative therapeutic strategies for endometrial regeneration is essential. This study evaluates the regenerative potential of endometrial stromal cell (EMSC) injection and EMSC-loaded patch application in a mouse model with ethanol-induced endometrial damage.

View Article and Find Full Text PDF

Strategic Timing of Gene Silencing: Cellular Kinetics-Based Administration of siRNA for Optimized Photothermal Cancer Treatment.

Adv Sci (Weinh)

September 2025

Department of Biomedical Engineering, College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, 210023, China.

Heat shock protein 70 (HSP70) represents a critical barrier to effective mild-temperature photothermal therapy (MPTT), limiting its clinical utility in aggressive cancers like triple-negative breast cancer (TNBC). While small interfering RNA (siRNA)-mediated HSP70 suppression offers a promising solution, optimal timing for this therapeutic combination remains unexplored. Here, it is demonstrated that precisely timed administration significantly enhances MPTT efficacy through systematic temporal characterization of HSP70 expression dynamics.

View Article and Find Full Text PDF

Background: Endothelial inflammation is involved in cerebral small vessel disease (CSVD) pathogenesis. Vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) are biomarkers of endothelial inflammation.

Aims: This study investigated association of VCAM-1 and ICAM-1 with presence of CSVD and CSVD burden.

View Article and Find Full Text PDF