Publications by authors named "Yuyu Ping"
Unlabelled: Infectious bursal disease virus (IBDV) causes a highly contagious and immunosuppressive disease that severely impacts the poultry industry. However, the molecular basis of IBDV-induced immunosuppression remains poorly understood. In this study, we investigate key genes implicated in this process, focusing on the interplay between metabolism and immune regulation.
View Article and Find Full Text PDFUnlabelled: Avian leukosis virus subgroup J (ALV-J) poses a significant threat to the poultry industry; yet, our understanding of its replication and pathogenic mechanisms is limited. The Ten-Eleven Translocation 2 (TET2) is an indispensable regulatory factor in active DNA demethylation and immune response regulation. This study reports a significant and time-dependent decrease in TET2 levels following ALV-J infection and shows that the reduction of TET2 protein is mediated by the autophagy pathway.
View Article and Find Full Text PDFArticle Synopsis
- Avian leukosis virus subgroup J (ALV-J) is a chicken virus that causes immunosuppression and significant economic losses in the poultry industry due to reduced production performance and tumor formation.
- The study investigates the TRIM45 gene in chickens, finding that its expression increases during ALV-J infection, suggesting a potential role in controlling the virus.
- Overexpression of TRIM45, regardless of its RING domain, reduces ALV-J replication by inducing cell death (apoptosis) in infected cells, while silencing the gene enhances viral replication.
Article Synopsis
- Cadmium (Cd) is an environmental pollutant that primarily harms the kidneys and may disrupt iron metabolism, potentially leading to a type of cell death called ferroptosis.
- In experiments with rats, exposure to Cd resulted in renal damage, mitochondrial disruption, and changes in iron-related gene expressions, indicating Cd's impact on iron metabolism.
- The study concludes that Cd induces chronic kidney injury through iron deficiency rather than traditional ferroptosis, suggesting that addressing abnormal iron metabolism could be key in preventing kidney disease.