Metabolomics-Based Characterization of Fungal Ball Sinusitis.

This study used nontargeted metabolomics to characterize metabolic alterations in fungal ball sinusitis (FBS), identify differential metabolites, and explore their roles in fungal infection, immune dysregulation, and histopathological mechanisms. This study prospectively enrolled 30 patients with FBS and 29 controls with isolated nasal septum deviation who underwent surgery at Beijing Tongren Hospital between February 2023 and April 2024. Specimens of collected fungal balls and secretions of the middle meatus were analyzed for metabolites.

Innovative surgical approaches for chronic rhinitis: nasal neurectomy mechanisms, techniques, and clinical outcomes.

Introduction: Chronic rhinitis (CR) represents a prevalent, persistent inflammatory condition of the nasal mucosa, substantially impacting patients' quality of life. Despite standard pharmacotherapy, many patients with refractory symptoms do not achieve adequate relief, highlighting the need for alternative interventions such as nasal neurectomy.

Areas Covered: Literature was reviewed on the PubMed, EMBASE, and Web of Science databases published from March 1961 to April 2025.

Analysis of Sinus Inflammation Associated With Maxillary Sinus Fungal Ball Based on CT Imaging.

Paranasal sinus fungal balls usually occur unilaterally, and the maxillary sinus is most commonly involved. However, other sinuses could be concomitantly inflammed, and this phenomenon is rarely discussed. To evaluate the severity of maxillary sinus fungal ball (MSFB) and the occurrence of sinus inflammation in paranasal sinuses according to the image findings and analyze the potential correlations.

Value of Opening the Middle Meatus in Patients With Nasal Airway Obstruction.

Objectives: While surgeries to correct the anatomical malformations that cause nasal airway obstruction (NAO) are generally successful, the outcomes of such procedures are often unsatisfactory. The aim of the present study was to assess the value of opening the middle meatus in patients with NAO.

Methods: Thirty-four patients with nasal obstruction due to nasal septal deviation were included in this study.

Differential expression profile of plasma exosomal microRNAs in chronic rhinosinusitis with nasal polyps.

Exosomes mediate inflammation and immune responses. The aim of the study was to examine the expression profiles of plasma exosomal microRNAs (miRNAs) and analyze their target gene functions in participants with chronic rhinosinusitis with nasal polyps (CRSwNP). We measured plasma exosomal miRNAs in five patients with CRSwNP and five controls.

[Correlation between nasal mucosal temperature change and nasal airflow perception].

The mechanism of nasal airflow perception remains little known. It is currently believed that the main mechanism for perceiving nasal patency is to activate transient receptor potential melastatin subtype 8. Computer fluent dynamics show that increased airflow and heat flux are associated with higher subjective scores.

The values of (1,3)-β-D-glucan and galactomannan in cases of invasive fungal rhinosinusitis.

Objective: The purpose of the present study was to investigate the values of the serum (1,3)-β-D-glucan test (G test) alone, the galactomannan test (GM test) alone, and their combination in the diagnosis of invasive fungal rhinosinusitis (IFRS).

Methods: The present study retrospectively analysed the clinical data of 98 patients who were preliminarily diagnosed with "space-occupying lesions in nose". Of these 98 patients, 88 received the G test, 55 received the GM test, and 45 received both.

A retrospective analysis of 1,717 paranasal sinus fungus ball cases from 2008 to 2017.

Objectives/hypothesis: To analyze the epidemiological characteristics, clinical features, and the outcomes of histopathology and microbiology for fungus ball (FB) in the last 10 years in our department.

Study Design: Database review.

Methods: In total, 1,717 cases of FB were reviewed from the case database of Beijing Tongren Hospital (between 2008 and 2017).

Distinguishing the dominant species of pathogen in ethmoidal sinusitis by sequencing DNA dataset analysis.

Identifying the predominant microbial species in patients with ethmoidal sinusitis is conducive to its successful treatment. The aim of the present study was to determine the microbial composition and the predominant fungal and bacterial species in patients with ethmoidal sinusitis. A sample was obtained from 3 patients with ethmoidal sinusitis and from the ethmoid sinus of 2 healthy volunteers.

The microbiology of chronic rhinosinusitis with and without nasal polyps.

Objective: To compare the microbiological features in middle meatus samples from chronic rhinosinusitis (CRS) patients with nasal polyps (CRSwNP) and those without nasal polyps (CRSsNP), and control subjects.

Methods: A total of 136 CRSwNP patients, 66 CRSsNP patients, and 49 control subjects who underwent endoscopic surgery in Beijing TongRen Hospital were enrolled between January 2014 and January 2016. Swab samples were obtained from the middle meatus during surgery and processed for the presence of aerobic and non-aerobic bacteria and fungi.