Stapokibart for Severe Uncontrolled Chronic Rhinosinusitis With Nasal Polyps: The CROWNS-2 Randomized Clinical Trial.

Importance: Chronic rhinosinusitis with nasal polyps causes severe symptoms and impaired quality of life. Stapokibart is a novel monoclonal antibody that targets interleukin 4Rα.

Objective: To assess the efficacy and safety of stapokibart as an add-on treatment to intranasal corticosteroids in patients with severe uncontrolled chronic rhinosinusitis with nasal polyps.

TLR4group 2 innate lymphoid cells contribute to persistent type 2 immunity in airway diseases.

Group 2 innate lymphoid cells (ILC2s) directly contribute to local inflammation in type 2 inflammatory airway diseases. Here, we identify ILC2 subsets by single cell RNA sequencing in chronic rhinosinusitis with nasal polyps (CRSwNP) and in a memory inflammatory mouse model. We find that toll-like receptor 4 (TLR4)ILC2s, with similar markers to their human counterparts, expresse memory cell markers, persist over time, and respond more vigorously to a secondary unrelated antigen challenge in the mouse model.

Effects of external diaphragm pacing combined with repetitive peripheral magnetic stimulation of the phrenic nerve on respiratory function in stroke patients.

Objectives: To investigate the effects of external diaphragmatic pacing (EDP) and repetitive peripheral magnetic stimulation (rPMS) of the phrenic nerve on respiratory function in stroke patients.

Methods: Fifty-four stroke patients were randomly assigned to three groups: an EDP group ( = 18), an rPMS group ( = 18), and a combined treatment group ( = 18). All groups received routine breathing training.

Predictive significance of 15(S)-hydroxyeicosatetraenoic acid for eosinophilic chronic rhinosinusitis with nasal polyps.

Background: Among the different endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP), eosinophilic CRSwNP (ECRSwNP) exhibits more severe symptoms and a higher rate of recurrence compared with noneosinophilic CRSwNP (non-ECRSwNP), as well as distinct metabolic alterations. Hence, early identification of metabolic alterations in polyps is crucial for the prediction and selection of personalized treatment for patients with CRSwNP, especially ECRSwNP. However, clinical practice faces a deficiency in readily accessible and expedited predictive diagnostics of metabolic changes.

Effects of long-term very high-altitude exposure on cardiopulmonary function of healthy adults in plain areas.

Due to the unique plateau climate, such as low atmospheric pressure, hypoxia, cold, and dryness, people in plain areas will have a series of physiological and pathological changes after entering the plateau. This observational study was designed to assess the effects of long-term very high-altitude (HA) exposure on the cardiopulmonary function of healthy adults in plain areas through cardiopulmonary exercise testing (CPET). We tracked and observed 45 healthy adult men or women from the plain area (Beijing, with an altitude of approximately 40 m).

Nasal-Specific Immunoglobulin E to Total Immunoglobulin E Ratio Mediates the Effect of Natural Pollen Exposure on Symptom Severity in Patients With Seasonal Allergic Rhinitis.

Daily pollen concentration was associated with symptom severity of SAR. Nasal sIgE showed a similar trend of variation with pollen concentrations. Nasal sIgE to tIgE ratio mediated the influence of pollen concertation on symptom severity.

Association between metabolic health indicators and cardiorespiratory fitness in urban young and middle-aged population: a retrospective cross-sectional study.

Background: Cardiorespiratory fitness (CRF) is an established risk factor for cardiovascular diseases (CVD). Compared with traditional clinical risk factors for CVD, CRF can better predict health status and possible adverse events. However, few studies have reported the association between multiple metabolic health indicators and CRF as an indicator of CVD risk.

Preoperative prediction of malignant transformation in sinonasal inverted papilloma: a novel MRI-based deep learning approach.

Objective: To develop a novel MRI-based deep learning (DL) diagnostic model, utilizing multicenter large-sample data, for the preoperative differentiation of sinonasal inverted papilloma (SIP) from SIP-transformed squamous cell carcinoma (SIP-SCC).

Methods: This study included 568 patients from four centers with confirmed SIP (n = 421) and SIP-SCC (n = 147). Deep learning models were built using T1WI, T2WI, and CE-T1WI.

Amphiregulin Mediates Epithelial Cell-Eosinophil Interactions and Amplifies Inflammation in Chronic Rhinosinusitis With Nasal Polyps.

Background: Eosinophils easily accumulate in the intra-epithelial layer and subepithelial regions in eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). While several factors influence the migration of eosinophils from peripheral blood to extravascular tissues, the triggers and role of eosinophils near the epithelial layer in CRSwNP remain unclear.

Methods: We examined interactions between eosinophils and epithelial cells using co-culture systems.

Innovative surgical approaches for chronic rhinitis: nasal neurectomy mechanisms, techniques, and clinical outcomes.

Introduction: Chronic rhinitis (CR) represents a prevalent, persistent inflammatory condition of the nasal mucosa, substantially impacting patients' quality of life. Despite standard pharmacotherapy, many patients with refractory symptoms do not achieve adequate relief, highlighting the need for alternative interventions such as nasal neurectomy.

Areas Covered: Literature was reviewed on the PubMed, EMBASE, and Web of Science databases published from March 1961 to April 2025.

Chinese Expert Consensus on the Impact of Ambient Air Pollution on Allergic Rhinitis and Recommendations for Mitigation Strategies.

Ambient air pollution poses a significant yet manageable threat to human health. The growing consensus on the impact of ambient air pollutants on allergic rhinitis (AR) emphasizes the importance of prevention, control, and treatment strategies. A multidisciplinary consensus development group was established to further standardize management strategies for AR in the presence of exposure to ambient air pollutants.

Stapokibart for moderate-to-severe seasonal allergic rhinitis: a randomized phase 3 trial.

Seasonal allergic rhinitis (SAR) places a significant socioeconomic burden, particularly on individuals with poorly managed recurrent and severe symptoms despite standard-of-care treatment. Stapokibart, a humanized monoclonal antibody that targets the interleukin (IL)-4 receptor subunit alpha, inhibits its interaction with both IL-4 and IL-13 in type 2 inflammation. Here we aim to assess the efficacy and safety of stapokibart as an add-on therapy in adults with moderate-to-severe SAR.

Efficacy and Safety of Combined Pharmacotherapies in Moderate-to-Severe Allergic Rhinitis: A Network Meta-Analysis.

Background: Combination pharmacotherapies are often selected for moderate-to-severe allergic rhinitis (AR), particularly when monotherapies do not control symptoms effectively. However, few studies have compared the efficacy and safety of different combination regimens. Therefore, we performed this study to investigate the clinical benefits of different combination strategies for moderate-to-severe AR.

Shared genetic investigation of asthma and blood eosinophils in relation to chronic rhinosinusitis.

Background: An epidemiological association among asthma, blood eosinophil level and chronic rhinosinusitis (CRS) is well established, but whether consistent genetic relationships exist, and whether this reflects a shared genetic etiology between CRS and asthma or blood eosinophil level remains unclear.

Methods: Data from CRS patients (N = 1,255) and healthy controls (N = 1,032) were reviewed retrospectively to investigate associations between clinical characteristics and CRS. Data from white blood cells in the UK biobank (N = 173,480), asthma in the Trans-National Asthma Genetic Consortium (127,669) and CRS (N = 272,922) or nasal polyps (N = 264,107) in the FinnGen consortium were used to conduct genetic study, including linkage disequilibrium score regression analysis to detect genetic associations between aforementioned variables, Mendelian randomization (MR) analysis to investigate causal relationships of asthma and blood eosinophil levels on CRS, and Bayesian co-localization to consolidate MR findings and to identify shared genetic signals.

Stapokibart (CM310) in patients with uncontrolled seasonal allergic rhinitis (PHECDA): Rationale and design of a multicentre, randomized, double-blind, placebo-controlled study.

Background: Seasonal allergic rhinitis (SAR) is a global health issue, and the current standard of care (SoC) has limited effectiveness in controlling the disease. There is a need for innovative treatments to better manage uncontrolled SAR and advance beyond the uniform SoC, and biologics targeting type 2 inflammation driving allergic rhinitis is promising.

Objective: To evaluate the efficacy and safety of Stapokibart, a humanized monoclonal antibody targeting interleukin-4 receptor subunit alpha, as an add-on therapy in patients with uncontrolled SAR.

Efficacy and safety of azelastine hydrochloride and fluticasone propionate nasal spray in treating allergic rhinitis: A randomized controlled trial.

Background: MP-AzeFlu (Dymista; Meda Pharma GmbH & Co., KG), a formulation combining azelastine hydrochloride and fluticasone propionate in a single spray, is superior to fluticasone propionate alone in relieving symptoms and improving the quality of life of patients with allergic rhinitis.

Objectives: In this study, we evaluated whether the effect of AzeFlu, a generic drug manufactured from China, is equivalent to that of MP-AzeFlu.

Chinese Position Paper on Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps.

Emerging biologics that selectively target key cytokines present a promising therapeutic alternative for patients suffering from severe, uncontrollable chronic rhinosinusitis with nasal polyps (CRSwNP). Despite the limited availability of registered biologics for CRSwNP treatment in China, the country is experiencing rapid development in this field. It is imperative to standardize the application of biologic agents in CRSwNP management in preparation for their future integration into the CRSwNP care pathway.

New insights into the endotypes of chronic rhinosinusitis in the biologic era.

Chronic rhinosinusitis (CRS) exhibits significant heterogeneity and has been generally classified as type 1 (T1), T2, and T3 endotypes according to the histopathologic and inflammatory features of the nasal mucosa. T2 inflammation has been regarded as the predominant endotype of CRS linked to disease severity and refractory conditions. The development of biological agents that specifically target key molecules involved in T2 inflammation offers a highly effective and promising therapeutic approach for CRS.

Efficacy and safety of GR1802 in uncontrolled chronic rhinosinusitis with nasal polyps: Placebo-controlled phase 2 trial.

Background: Anti-IL-4 receptor subunit alpha (IL-4Rα) treatments can effectively treat eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). However, their impact on the overall population of patients with uncontrolled CRSwNP remains unclear.

Objectives: We evaluated the safety and efficacy of GR1802, a novel anti-IL-4Rα monoclonal antibody, in patients with uncontrolled CRSwNP.

Biological therapy in chronic rhinosinusitis with nasal polyps.

Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease. High proportions of patients with CRSwNP characterized by type 2 inflammation fail to gain adequate control with conventional treatment. The application of biologics in clinics and assessments of novel biologics in clinical trials are blooming in expectations to fulfill the unmet medical needs of patients with CRSwNP with type 2 inflammation.

Effects of functional strength training on pain, function, and lower extremity biomechanics in patients with patellofemoral pain syndrome: a randomized clinical trial.

Background: Patellofemoral pain syndrome (PFPS) is a common disorder affecting the lower extremity. This study aimed to compare the effects of functional strength training (FST) and standard strength training (SST) in PFPS patients.

Methods: Forty college students (aged 18-30 years) with PFPS and no exercise habits were randomized into FST group (n = 20) and SST group (n = 20).

GZMK-expressing CD8 T cells promote recurrent airway inflammatory diseases.

Inflammatory diseases are often chronic and recurrent, and current treatments do not typically remove underlying disease drivers. T cells participate in a wide range of inflammatory diseases such as psoriasis, Crohn's disease, oesophagitis and multiple sclerosis, and clonally expanded antigen-specific T cells may contribute to disease chronicity and recurrence, in part by forming persistent pathogenic memory. Chronic rhinosinusitis and asthma are inflammatory airway diseases that often present as comorbidities.

Total immunoglobulin E levels in induced sputum reflect asthma control status.

Background: Most patients with severe asthma are sensitized to at least one allergen. Whether local immunoglobulin E (IgE) in induced sputum reflects asthma control status has not been investigated.

Methods: Patients with asthma were classified as well controlled, partly controlled, and uncontrolled asthma (UCA) according to Global Initiative for Asthma 2022 guidelines.

M2 macrophage derived HMOX1 defines chronic rhinosinusitis with nasal polyps.

Background: Molecular signatures of chronic rhinosinusitis with nasal polyps (CRSwNP) related to macrophages remain unclear. This study aimed to develop a macrophage-associated diagnostic signature for CRSwNP.

Methods: Transcriptome data from 54 patients with CRSwNP and 37 healthy controls across GSE136825, GSE36830, and GSE72713 were used to identify differentially expressed genes (DEGs) between two groups.