Inflammatory factor CCL2 enhances the interaction between monocyte-macrophage cells and liver parenchymal cells to promote liver inflammation and fibrosis in biliary atresia.

Background: Liver fibrosis in biliary atresia (BA) progresses rapidly and has distinct characteristics; however, current studies have not identified effective prevention or treatment strategies to address this issue.

Methods: BA liver tissues with different degrees of liver fibrosis (n = 4), liver tissues of choledochal cyst (n = 2), and liver tissues of the normal control (NC) group (n = 2) were selected. Single-cell RNA sequencing (scRNA-seq), spatial transcriptomics (ST), and Mendelian randomization (MR) were integrated for analysis.

[Textual research on the editions of ].

() is composed of the empirical prescriptions, dictated by , the medical master of acupuncture in the Qing Dynasty, recorded and drawn in detail by . There are 5 existing editions of this book preserved, and stored in library of Shanghai University of TCM, bookstore of Nanjing Ancient Classics, library of Heilongjiang Provincial Institute of TCM, library of Beijing University of CM, and China Academy of Chinese Medicine Sciences, respectively. Different from the official canonical book, this book provides a simplified and easily understandable contents, including 3 sections, named illustrations, prescriptions, and medicinal properties.

Curcumin-alendronate carbon dots: A dual-logic strategy for precision treatment of periodontitis.

Periodontitis, a multifaceted chronic inflammatory disorder affecting the oral cavity, with its etiology intricately linked to oxidative stress. Existing pharmacotherapies for periodontitis often suffer from a lack of target specificity and are challenged by the double demands of mitigating oxidative stress and promoting tissue regeneration in a coordinated, multi-pronged strategy. To address the challenges of "where" and "how", this study synthesizes both guidance and therapeutic dual logic-based Curcumin-Alendronate carbon dots (Cur-Alen CDs).

Differences in responses of invasive and native plants to climate change: a case study of () from China.

Global warming has emerged as one of the most pressing environmental challenges. Concurrently, plant invasion has been exacerbated by ongoing climate change, posing a severe ecological threat. This study investigates the distribution patterns of both invasive and native species within the genus and their responses to projected climate change.

Changes in the Distribution Range of the Genus in China Under Climate Change and Human Activities.

are perennial herbaceous plants of the Liliaceae family with high ornamental, nutritional, and medicinal value. However, critical knowledge gaps remain regarding the following: (1) the fine-scale habitat preferences of ; (2) the key ecological drivers influencing their growth and distribution. The MaxEnt software 3.

MaxEnt Modeling of the Impacts of Human Activities and Climate Change on the Potential Distribution of in China.

Human activities exert both beneficial and detrimental impacts on the ecosystem. In recent years, greenhouse gas emissions have significantly increased due to global climate change, causing profound alterations in ecosystem distribution and productivity. The synergistic interplay between climatic shifts and anthropogenic activities is intensifying ecological transformations and disturbances, and accelerating biodiversity depletion.

Scar-associated macrophages and biliary epithelial cells interaction exacerbates hepatic fibrosis in biliary atresia.

Background: Biliary atresia (BA) is a severe pediatric biliary disorder characterized by the progressive obstruction of liver bile ducts. In the absence of treatment, fibrosis advances rapidly in most affected children. Despite the identification of various factors contributing to fibrosis progression, comprehensive investigations into the microenvironmental alterations within the liver are still scarce.

Amphiregulin Mediates Epithelial Cell-Eosinophil Interactions and Amplifies Inflammation in Chronic Rhinosinusitis With Nasal Polyps.

Background: Eosinophils easily accumulate in the intra-epithelial layer and subepithelial regions in eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). While several factors influence the migration of eosinophils from peripheral blood to extravascular tissues, the triggers and role of eosinophils near the epithelial layer in CRSwNP remain unclear.

Methods: We examined interactions between eosinophils and epithelial cells using co-culture systems.

Role of CD44CCR2CD64monocyte-derived macrophage in chronic rhinosinusitis with nasal polyps.

Heterogeneity of monocyte-derived macrophages (MDMs) is gradually recognized in polyp tissue of chronic rhinosinusitis with nasal polyps (CRSwNP). However, the contributions of MDM subsets for sustaining inflammation remain unclear. This study therefore aimed to characterize MDM subsets in polyp tissues and estimate their functions.

[Investigation on the versions, herbal compositions of moxa stick, indications and treatment of ].

The paper introduces the investigation on the versions, herbal composition, indications and treatment of (). , written by in the Qing Dynasty, is the special book with this moxibustion technique recorded in the earliest time. But this book did not record the related herbal composition.

[Seeking the spirit of the ancients].

) traces the historical origin for the development of the theories of visceral manifestation and meridians and in terms of the guiding principles and cultural background of these theories structured by the ancients. It chains the clues of the related knowledge development in () based on the rich historic literature. By interpreting the classics through history and in view of the specific humanistic perspective, the book exhibits the non-linear evolution track of the theoretical knowledge of visceral manifestation and meridians in the pre-Qin and Han dynasties.

Butyrate inhibits histone deacetylase 2 expression to alleviate liver fibrosis in biliary atresia.

Background: Previous studies have found a reduction in butyrate-producing bacteria in the gut microbiota of infants with biliary atresia (BA). Butyrate is also an important inhibitor of histone deacetylase 2 (HDAC2). This study aims to explore how butyrate alleviates liver fibrosis in BA through HDAC2.

Correlation between Occupational Noise Exposure and Renal Dysfunction in Male Workers.

Objective: This study aimed to explore the relationship between occupational noise exposure and renal dysfunction in male workers.

Methods: A total of 160 male workers (the number of people who met the inclusion criteria) who underwent health examinations in Qingdao Municipal Hospital from January 2023 to December 2023 were grouped into a noise group (80 cases) and a control group (80 cases) based on whether they engaged in noise work. We compared the differences in creatinine (CREA), cystatin C (CysC) and blood urea nitrogen (BUN) levels between the two groups.

Identification of linear B cell epitopes on the E146L protein of African swine fever virus with monoclonal antibodies.

The outbreak and spread of African swine fever virus (ASFV) have caused considerable economic losses to the pig industry worldwide. Currently, to promote the development of effective ASF vaccines, especially subunit vaccines, more antigenic protein targets are urgently needed. In this work, six transmembrane proteins (I329L, E146L, C257L, EP153R, I177L, and F165R) were expressed in mammalian cell lines and screened with pig anti-ASFV serum.

Identification of Two Linear Epitopes on MGF_110-13L Protein of African Swine Fever Virus with Monoclonal Antibodies.

African swine fever caused by African swine fever virus (ASFV) is an acute, highly contagious swine disease with high mortality. To facilitate effective vaccine development and find more serodiagnostic targets, fully exploring the ASFV antigenic proteins is urgently needed. In this study, the MGF_110-13L was identified as an immunodominant antigen among the seven transmembrane proteins.

[Acupuncture theory in and launching the natural history of body].

Chinese traditional medicine is long in the natural history, which focuses on herbal medicine, but has less discussion on acupuncture. On the basis of exploring the body knowledge in (') from the perspective of the natural history, especially through the investigation of the evolution of acupoint knowledge, the route of the natural history of body in have been detected in the aspects of observation, record, nomination and classification. In , the natural history of body is characterized by the object annotation, the interaction between the nature and things, and the practicability.

Exploration of the body from the perspective of acupuncturists: based on the classification of body terms in .

There is a rich record on body terms in (). The authors classify them into 4 dimensions, including "structure of human body", "constant concern of human body", "symptoms" of disease and "sites" of acupuncture, which corresponds to anatomy, physiology, pathology (including diagnosis) and treatment from the perspective of acupuncture. It is based on the knowledge described by these 4 categories of body terms, acupuncturists recognize the body in treatment.

Knocking out FAM20C in pre-osteoblasts leads to up-regulation of osteoclast differentiation to affect long bone development.

Family with sequence similarity 20 member C (FAM20C) is a Golgi casein kinase that phosphorylates extracellularly-secreted regulatory proteins involved in bone development and mineralization, but its specific role in bone development is still largely unknown. In this study, to examine the specific mechanisms that FAM20C influences bone development, we cross-bred Osx-Cre with FAM20C mice to establish a Osx-Cre; FAM20C knockout (oKO) mouse model; FAM20C was KO in pre-osteoblasts. oKO development was examined at 1-10 weeks, in which compared to control FAM20C, they had lower body weights and bone tissue mineralization.

Standardization studies of acupuncture prescriptions: a new approach to translational medicine in acupuncture.

This paper explores the relationship between the standardization studies of acupuncture prescriptions and translational medicine, elucidating the translational medical concepts in the standardization of acupuncture prescriptions. It emphasizes that the standardization of acupuncture prescriptions is a pivotal link in the transformation of foundational acupuncture research. Considering the current clinical status of acupuncture prescriptions, the paper proposes the elements for standardizing prescriptions to promote the translation of foundational acupuncture research into clinical practice.

Diagnostic and prognostic value of the gut microbiota and its metabolite butyrate in children with biliary atresia.

Purpose: To determine the prevalent microbiological profile of biliary atresia (BA) patients at the time of its occurrence by studying their intestinal flora.

Methods: A total of 118 gut microbiota samples from three groups of 43 BA patients, 33 disease controls (DC) with other cholestatic diseases and 42 healthy controls (HC), were analyzed by deep mining of public data. Subsequently, a total of 23 fecal samples from three groups of clinically collected patients (11 BA, 6 DC and 6 HC) were sequenced for 16S rRNA gene amplification and analyzed for serum butyrate (BU) level by liquid chromatography.

Development and post-Kasai procedure prognostic relevance of histological features for biliary atresia.

Objectives: To validate an appropriate evaluation method of liver fibrosis assessment based on the unique pathological features of biliary atresia (BA) that could well predict its prognosis.

Methods: A total of 68 patients with BA who underwent Kasai procedure (KP) and an intraoperative liver biopsy, followed up from January 2019 to December 2021, were recruited in a retrospective analysis. Ishak, Metavir, and BA-specific staging systems in relation to outcomes were analyzed using logistic regression, COX proportional hazard regression, Kaplan-Meier analysis, etc.

[Cognitive differences between Taoism and medical science in the location of "Jiaji"].

The differences in the cognition on the location of "Jiaji" between Taoism and medical science are summarized through literature searching. In the medical field, "Jiaji" is generally described as "Jiaji (point)", which is considered as EX-B 2, while, in Taoism, it is expressed as "Jiaji (pass)", focusing on the crucial parts of the body. Medical scholars lay their attention to the distance of "Jiaji" lateral to the spine, in which "" (place on both sides) is mostly considered.

Epithelial-specific deletion of FAM20A leads to short root defects.

Short Root Defects defined by a reduced ratio of root to crown, may culminate in root resorption and subsequent tooth loss, in spite of the absence of apparent symptoms. Such defects present considerable impediments to orthodontic treatment and restoration. Recent identification of Fam20a, an emergent pseudokinase, has been associated with enamel development and tooth eruption, yet its definitive role in root formation and eruption remains ambiguous.

Dynamic changes of nasal tight junctions in patients with convalescent COVID-19 with allergic rhinitis.

Nasal tight junction module score correlates negatively to allergy module score in COVID-19. Omicron variant may slow-down tight junction restoration in patients with AR.