Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis.

Allergic rhinitis (AR), a globally prevalent immune-mediated inflammatory condition, is still an incurable disease. In the present study, we have validated the impact of the Kelch-like ECH associated protein 1 (Keap1)-related oxidative stress and inflammatory response in clinical AR patient peripheral blood and nasal swab samples, emphasizing the biological relevance of Keap1 and AR. Targeting Keap1 -nuclear factor erythroid 2-related factor 2 (Nrf2) related anti-oxidative stress may be effective for AR intervention.

Dosage and duration of ursodeoxycholic acid therapy Post-Kasai portoenterostomy in biliary atresia: a multicenter cross-sectional study with age stratification.

Purpose: Evaluate clinical efficacy of ursodeoxycholic acid (UDCA) in biliary atresia (BA) infants post-Kasai portoenterostomy (KPE) using real-world data.

Methods: Retrospective analysis of 698 BA patients from eight Chinese pediatric centers (2020-2025). Age-stratified analyses used propensity score matching (PSM) and inverse probability treatment weighting (IPTW) to adjust baseline differences.

Inflammatory factor CCL2 enhances the interaction between monocyte-macrophage cells and liver parenchymal cells to promote liver inflammation and fibrosis in biliary atresia.

Background: Liver fibrosis in biliary atresia (BA) progresses rapidly and has distinct characteristics; however, current studies have not identified effective prevention or treatment strategies to address this issue.

Methods: BA liver tissues with different degrees of liver fibrosis (n = 4), liver tissues of choledochal cyst (n = 2), and liver tissues of the normal control (NC) group (n = 2) were selected. Single-cell RNA sequencing (scRNA-seq), spatial transcriptomics (ST), and Mendelian randomization (MR) were integrated for analysis.

Interpretable machine learning integrates multi-source biomarkers for osteoarthritis diagnosis and mechanistic insights: A temporomandibular joint model.

Objective: Osteoarthritis (OA) is a pan-joint degenerative disorder characterized by cartilage degradation and subchondral bone remodeling. The temporomandibular joint (TMJ) offers a unique model for early OA due to its anatomy and early-onset disease. Current diagnostics rely on late-stage changes, underscoring the need for biomarker integration.

High-Resolution C-arm Computed Tomography for Evaluation of Stent Expansion and Apposition after Intracranial Stent Implantation.

Objective: C-arm computed tomography (CT) has always played an important role in neurointerventional surgery, in this study, we aimed to investigate the value of high-resolution C-arm CT in evaluating stent expansion and apposition in carotid arteries of Guangxi Bama piglets.

Methods: Twenty-four stents were implanted in the carotid arteries of 24 Guangxi Bama piglets. High-resolution C-arm CT was performed to evaluate stent expansion and the quality of processed images, followed by three-dimensional digital subtraction angiography (3D-DSA).

Deep Learning-Enhanced CTA for Noninvasive Prediction of First Variceal Haemorrhage in Cirrhosis: A Multi-Centre Study.

Background And Aims: The first variceal haemorrhage (FVH) is a life-threatening complication of liver cirrhosis that requires timely intervention; however, noninvasive tools for accurately predicting FVH remain limited. This study aimed to develop noninvasive, deep learning-enhanced computed tomographic angiography (CTA) models for early and accurate FVH prediction.

Methods: This multi-centre retrospective study included 184 cirrhotic patients (FVH: n = 107, non-FVH: n = 77) enrolled from December 2014 to May 2022.

Gut microbiota maturation and early behavioral and cognitive development.

The presence of gut microbiota-brain-axis has been widely reported. However, few studies have focused on uncovering the potential associations during a time-period that our brain and gut microbiota undergo rapid maturation. We evaluated the potential associations between characteristics of gut microbiota and cognition and temperament using an accelerated longitudinal design in typically developing children over 0-3 years of age.

Integrated Omics and Multi-Cohort Analyses Identify an Enhancer Variant Linking Ferroptosis to Precision Therapy in Prostate Cancer.

Prostate cancer is the most prevalent cancer among men worldwide and exhibits significant genetic heritability. In this study, we performed an integrative analysis combining chromatin accessibility profiling, transcriptomics, and two-stage case-control studies, alongside an unbiased phenome-wide exploration in the FinnGen cohort. This comprehensive approach identified the enhancer-associated single-nucleotide polymorphism rs7077830 at chromosome 10q11 as a critical modulator of prostate cancer susceptibility.

Towards a low-carbon economy: How can green technological innovation affect carbon productivity in China?

Green technological innovation (GTI) has emerged as a central mechanism for advancing energy efficiency, mitigating carbon emissions, and facilitating the broader shift toward sustainable economic development in China. Utilizing panel data encompassing 269 prefecture-level Chinese cities from 2008 to 2021, we systematically investigate how GTI affects carbon productivity. Our findings reveal that GTI contributes positively to local carbon productivity while simultaneously exerting a positive influence on adjacent regions.

A nomogram model based on routine serum markers for predicting the occurrence of primary cholangitis after Kasai operation for biliary atresia.

Background: The Kasai procedure is still considered the optimal therapeutic approach for biliary atresia (BA). Nevertheless, the onset of postoperative cholangitis can impede the resolution of jaundice and significantly affect the overall prognosis of the disease. This study aims to develop a nomogram model that precisely forecasted the incidence of cholangitis after the Kasai procedure.

Network analysis of the association between depression and quality of life in the elderly.

The worsening global aging population and the rising prevalence of depression occur simultaneously. However, the mechanisms through which depression affects quality of life (QOL) in different domains remain poorly understood, particularly in older adults. Data for this research were sourced from the Healthy Aging Cross-Sectional Data.

Synergistic effect on sludge disintegration and antibiotic resistance genes removal during sludge treatment by combined plasma-calcium peroxide.

Excess sludge generated during wastewater treatment serves as a major reservoir of antibiotic resistance genes (ARGs), posing environmental and public health risks. In this study, a combined plasma-calcium peroxide (Plasma-CaO) treatment was proposed to simultaneously enhance sludge disintegration and ARGs removal. Compared with solo treatment, Plasma-CaO significantly improved sludge disintegration, as evidenced by a higher disintegration rate (9.

ZIF-8 modified Citrus reticulata peel carbon aerogel as solid-phase microextraction coating for the determination of organochlorine pesticides.

A novel CRPCA@ZIF-8 biomass composite was synthesized by in situ growth of zeolite imidazoline frameworks on the Citrus reticulata peel carbon aerogel (CRPCA) surface to enhance the adsorption capacity. CRPCA@ZIF-8 was employed as a headspace solid-phase microextraction (HS-SPME) coating in conjunction with gas chromatography (GC) for detecting 12 organochlorine pesticides (OCPs). The effects of different adsorption and desorption conditions on the extraction efficiency were investigated.

The trans T-tube cholangial drainage versus percutaneous transhepatic cholangial drainage for the treatment of bile leakage at the biliary-enteric anastomosis: a retrospective study.

Background: The trans T-tube cholangial drainage (TTCD) is a novel approach that is first reported in this study for the treatment of bile leakage at the biliary-enteric anastomosis. However, no researchers have compared it with percutaneous transhepatic cholangial drainage (PTCD) as yet.

Methods: The clinical and imaging data of patients with bile leakage at the biliary-enteric anastomosis treated with TTCD (TTCD group) or PTCD (PTCD group) at three centers were retrospectively evaluated.

Amplified narrowband perovskite photodetectors enabled by independent multiplication layers for anti-interference light detection.

Metal-halide perovskite narrowband photodetectors offer a low-cost opportunity to detect specific signals covering a broad spectrum directly. However, the thickness of charge collection narrowing mechanism photodetectors increases recombination, resulting in performance bottlenecks. Here, we demonstrate amplified narrowband photodetectors that combine perovskite single-crystal absorbers and organic multiplication layers.

Association of intrinsic capacity with ADL and IADL trajectories: Evidence from a nationwide longitudinal study.

Background: With global aging, functional decline in older adults is a major public health concern. The WHO introduced Intrinsic Capacity (IC) as a key indicator of healthy aging, yet longitudinal evidence on its association with Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) trajectories remains limited.

Methods: Data were drawn from the China Health and Retirement Longitudinal Study (CHARLS, 2015-2020), including 4368 participants aged ≥60 years.

[Determination of 18 polychlorinated biphenyls in milk by dispersive solid-phase extraction based on zeolitic- imidazolate-framework composite microspheres prior to gas chromatography-mass spectrometry].

Polychlorinated biphenyls （PCBs） are hazardous， persistent organic pollutants that are widely used industrially. Although the use of PCBs is banned in many countries， they are still present at trace levels in food and the environment. PCBs are highly chemically stable and lipophilic； hence， they are easily enriched and accumulate in the human body through milk and dairy products.

Deuterating Narrow-Bandgap Organic Semiconductors for Sensitive Short-Wave Infrared Photodetection.

Organic semiconductors exhibit significant potential for next-generation optoelectronic technologies owing to their structural tunability and solution processability; nevertheless, as their bandgap decreases, the nonradiative recombination for either exciton or photogenerated charge-carriers increases, limiting short-wave infrared (SWIR) photoresponse, as governed by energy gap law. Here, a deuteration strategy is employed to universally reduce the nonradiative decay pathways of SWIR organic semiconductors, enhancing photodetector sensitivity. Compared to protonated L4, the rational deuterated molecule (BT-12D) maintains SWIR photoresponse to ∼1.

Should Joint Deformity, which is More Common Than Swelling or Tenderness, be Assessed in all Rheumatoid Arthritis Patients and Databases?

Objective: We analyzed 28 joint counts in 173 contemporary routine care patients with rheumatoid arthritis (RA), who had disease duration of 10 years and were examined in 2021, for swollen joint count (SJC), tender joint count (TJC)/pain on motion, and deformity joint count (DJC)/limited motion. In addition, we computed DJC according to Disease Activity Score in 28 joints (DA28), Clinical Disease Activity Index (CDAI), and Routine Assessment of Patient Index Data 3 (RAPID3) as remission/low or moderate/high activity or severity.

Methods: This report presents a retrospective analyses of a cross-sectional Australian database for medians and prevalences of SJC, TJC, and DJC, including in RA index categories.

Scar-associated macrophages and biliary epithelial cells interaction exacerbates hepatic fibrosis in biliary atresia.

Background: Biliary atresia (BA) is a severe pediatric biliary disorder characterized by the progressive obstruction of liver bile ducts. In the absence of treatment, fibrosis advances rapidly in most affected children. Despite the identification of various factors contributing to fibrosis progression, comprehensive investigations into the microenvironmental alterations within the liver are still scarce.

Early life phthalate exposure impacts gray matter and white matter volume in infants and young children.

Objective: Prenatal phthalate exposure is associated with adverse neurodevelopmental outcomes, yet data on impacts of early life exposure remains limited. We investigated phthalate and replacement plasticizer exposures from 2 weeks to 7 years of age in relation to brain anatomical attributes, using serial structural magnetic resonance imaging (sMRI).

Material And Methods: Children were enrolled after birth into the UNC Baby Connectome Project, a longitudinal neuroimaging study (North Carolina, USA; 2017-2020).

HCDPD: A Heterogeneous Causal Framework for Disease Pattern Detection in Medical Imaging.

Understanding the causal effects of diseases on body organs through medical imaging is crucial for advancing research and improving clinical outcomes. This paper introduces a novel causal inference framework, Heterogeneous Causal Disease Pattern Detection (HCDPD), designed to map the complex causal pathways from early-stage diseases to latent disease patterns and their manifestation in organs as observed in later-stage medical images. HCDPD serves as a potential outcome framework for multivariate responses.

Quantitative Evaluation of Incomplete Stent Apposition in Intracranial Aneurysms Using Optical Coherence Tomography: a Porcine Model Study.

Incomplete stent apposition (ISA) of intracranial stents is recognized as a significant issue in aneurysm treatment leading to in-stent thrombosis and aneurysm recurrence. Traditional imaging techniques like DSA have limitations in accurately assessing stent apposition. This study aimed to explore the efficacy of optical coherence tomography (OCT) in the detection of ISA after stent-assisted coiling (SAC) and its impact on stent endothelialization and aneurysm healing in a porcine model.

Research progress and future opportunities of pediatric cow milk protein allergy: a bibliometric overview and evidence mapping.

Introduction: This study employs bibliometric methods to reveal research trends, hot topics, and development trajectories in the field of cow milk protein allergy (CMPA) in children.

Methods: We retrieved and downloaded literature on CMPA in children from the Web of Science Core Collection database on the basis of specific search strategies and screening criteria. Using VOSviewer software, we analyzed the collaboration networks among countries, institutions, and authors, as well as the co-occurrence of keywords.

Polycyclic aromatics in the Chang'E 5 lunar soils.

Polycyclic aromatics are ubiquitous in the interstellar medium and meteorites, yet the search for lunar polycyclic aromatics remains a significant challenge. Here, we analyze Chang'E-5 lunar soil samples, revealing polycyclic aromatic concentrations of 5.0-9.