ATF6 Alleviates Endothelial Inflammation Following Extended Hepatectomy Through Inhibition of TRIM10/NF-κB Signaling.

The inflammatory response in liver sinusoidal endothelial cells (LSECs) is crucial to the pathophysiology of postoperative hepatic failure. The unfolded protein response (UPR) in LSECs following surgical stress exerts an important mechanism for resolving endothelial inflammation and re-establishing liver homeostasis. We employed 80% hepatectomy in mice to simulate extended hepatectomy and verified the gene expression in the patients who underwent marginal hepatectomy.

High-Resolution C-arm Computed Tomography for Evaluation of Stent Expansion and Apposition after Intracranial Stent Implantation.

Objective: C-arm computed tomography (CT) has always played an important role in neurointerventional surgery, in this study, we aimed to investigate the value of high-resolution C-arm CT in evaluating stent expansion and apposition in carotid arteries of Guangxi Bama piglets.

Methods: Twenty-four stents were implanted in the carotid arteries of 24 Guangxi Bama piglets. High-resolution C-arm CT was performed to evaluate stent expansion and the quality of processed images, followed by three-dimensional digital subtraction angiography (3D-DSA).

Copper-catalyzed C(sp)-H amination and etherification of unactivated hydrocarbons via photoelectrochemical pathway.

C(sp)-H activation and functionalization of unactivated hydrocarbons has provided enormous opportunities for the construction of diverse organic molecules, which facilitates the structural modification of pharmaceutical molecules. To achieve this goal, the direct hydrogen atom transfer (HAT) via radical pathway has become an attractive strategy. Taking the advantage of photo/electrochemistry, we herein describe oxidative C(sp)-H amination and etherification reactions via a photoelectrochemical pathway, which could directly transform easily available hydrocarbons into N-heterocycle and ether products under mild conditions.

Point-of-Care Monitoring for Lung Cancer from Exhaled Breath Formaldehyde via Luminescent Metal-Organic Frameworks.

The identification of specific markers in exhaled gas from individuals with lung cancer has significantly enhanced the feasibility of early lung cancer screening. This paper presents the synthesis of a 2D Cu-BDC-NH nanosheet at room temperature, which has been applied for the noninvasive diagnosis and point-of-care test (POCT) of lung cancer. During this approach, the hydrazine group in the ligand molecule was employed to enhance the intrinsic fluorescence of Cu-BDC-NH through a Schiff base reaction with formaldehyde (HCHO), thereby reducing the detection limits of HCHO gas and aqueous solution (25 ppb and 0.

Uncovering Mitochondrial Defects Induced by Chemicals: A Case Study of Low-Dose Medium-Chain Chlorinated Paraffin Exposure.

Given the susceptibility of mitochondria to environmental pollutants, mitochondrial defects are critical end points for chemical safety evaluation. In this study, we present a comprehensive strategy for assessing mitochondrial toxicity, exemplified through a case study on medium-chain chlorinated paraffins (MCCPs, CHCl with 14-17 carbon atoms), one of the most abundant organic pollutants in the human body. Our results demonstrate that MCCP exposure at levels commonly found in humans significantly reduces cellular ATP content by impairing mitochondrial respiration rather than glycolysis.

Porous TiPO/nitrogen-doped carbon composite with tailored crystal orientation as diffusion-controlled high-rate anode for lithium-ion batteries.

TiPO is a lithium-ion batteries anode material with outstanding stability and high safety due to its strong polyanion three-dimensional frame structure. However, poor electrical conductivity severely represses the rate capability of TiPO anode. Herein, a porous TiPO/nitrogen-doped carbon (CN) composite with tailored (630) and (600) preferential crystallographic orientation is achieved by the ball-milling and thermal treatment strategy.

Medium-Chain Chlorinated Paraffins Induced Reproductive Toxicity in Female Rats by Interfering with Oocyte Meiosis and Triggering DNA Damage.

Medium-chain chlorinated paraffins (MCCPs) are among the most prevalent chemicals detected in human serum. As an emerging persistent organic pollutant, their toxicity mechanisms, particularly concerning the female reproductive system, remain poorly understood. In this study, we present both and evidence of ovarian toxicity induced by MCCPs and insights into their underlying molecular mechanisms.

Menin inhibitor MI-503 exhibits potent anti-cancer activity in osteosarcoma.

Small molecule Menin inhibitor recently has emerged as a new therapeutic by targeting the interaction of histone methyltransferase MLL1 (KMT2A) with Menin. MLL1 is associated with aggressive osteosarcoma (OS) in young adults. The purpose of the study is to explore whether Menin inhibitors have therapeutic effects in OS.

Unveiling the conserved nature of chloroplast genomes: insights from the assembly and analysis of four complete chloroplast genomes.

Introduction: , a genus within the Zingiberales order, is renowned for its diverse morphology, suggesting a rich genetic reservoir. However, genetic research on plants within the family has primarily focused on taxonomy and phylogenetics, with limited exploration into other genetic aspects, particularly the chloroplast genome. Given the significance of chloroplast genomes in evolutionary studies, a deeper understanding of their structure and diversity within Heliconia is essential.

Light-Driven N-Heterocyclic Carbene-Catalyzed Multi-Component Reaction for the Synthesis of β-Amino Ketones.

A N-heterocyclic carbene-catalyzed (NHC) three-component reaction involving -aminopyridinium salts, alkenes, and aldehydes for the synthesis of β-amino ketones is described. In this reaction, -aminopyridinium salts and the Breslow intermediate, which is generated from NHC and aldehydes, are utilized to undergo a single-electron transfer process, forming a ketyl radical intermediate and amidyl radicals. Subsequent to the formation of the amidyl radical, it undergoes selective capture by alkenes, followed by radical cross-coupling to yield the desired β-amino ketones.

Occurrence and fate of atmospheric short/medium chain chlorinated paraffins: Size distribution and inhalation exposure.

Chlorinated paraffins (CPs) are intricate industrial compounds synthesized through alkane chlorination. Researches on the size distribution of short-chain (SCCPs) and medium-chain chlorinated paraffins (MCCPs) in atmospheric particulate matter (PM) are limited. Here, we conducted a thorough investigation on the size-dependent distribution characteristics, deposition behavior in respiratory tract, and health risks associated with CPs in atmospheric PM.

Taxonomic composition and functional potentials of gastrointestinal microbiota in 12 wild-stranded cetaceans.

Cetaceans play a crucial role in marine ecosystems; however, research on their gastrointestinal microbiota remains limited due to sampling constraints. In this study, we collected hindgut samples from 12 stranded cetaceans and performed 16S rRNA gene amplicon sequencing to investigate microbial composition and functional potentials. Analysis of ZOTUs profiles revealed that the phyla Firmicutes, Proteobacteria, and Bacteroidetes dominated all hindgut samples.

Expression and Functional Analysis of Two Cytochrome P450 Monooxygenase Genes and a UDP-Glycosyltransferase Gene Linked with Thiamethoxam Resistance in the Colorado Potato Beetle.

Cytochrome P450 monooxygenases (P450s) and UDP-glycosyltransferases (UGTs) are involved in the evolution of insecticide resistance. (Say), the Colorado potato beetle (CPB), is a notorious insect that has developed resistance to various insecticides including neonicotinoids. This study investigated whether the differentially expressed P450 genes and and UGT gene , found in our transcriptome results, conferred resistance to thiamethoxam in .

Datasets of fungal diversity and pseudo-chromosomal genomes of mangrove rhizosphere soil in China.

With climate change and anthropic influence on the coastal ecosystems, mangrove ecosystems are disappearing at an alarming rate. Accordingly, it becomes important to track, study, record and store the mangrove microbial community considering their ecological importance and potential for biotechnological applications. Here, we provide information on mangrove fungal community composition and diversity in mangrove ecosystems with different plant species and from various locations differing in relation to anthropic influences.

Horizontal gene transfer and symbiotic microorganisms regulate the adaptive evolution of intertidal algae, Porphyra sense lato.

Intertidal algae may adapt to environmental challenges by acquiring genes from other organisms and relying on symbiotic microorganisms. Here, we obtained a symbiont-free and chromosome-level genome of Pyropia haitanensis (47.2 Mb), a type of intertidal algae, by using multiple symbiont screening methods.

Biocatalytic Synthesis of Ruxolitinib Intermediate via Engineered Imine Reductase.

An enzyme catalyzed strategy for the synthesis of a chiral hydrazine from 3-cyclopentyl-3-oxopropanenitrile and hydrazine hydrate is presented. An imine reductase (IRED) from was identified to catalyze the reaction between 3-cyclopentyl-3-oxopropanenitrile and hydrazine hydrate to produce trace amounts of ()-3-cyclopentyl-3-hydrazineylpropanenitrile . We employed a 2-fold approach to optimize the catalytic performance of this enzyme.

Multi-omics integration analysis: Tools and applications in environmental toxicology.

Nowadays, traditional single-omics study is not enough to explain the causality between molecular alterations and toxicity endpoints for environmental pollutants. With the development of high-throughput sequencing technology and high-resolution mass spectrometry technology, the integrative analysis of multi-omics has become an efficient strategy to understand holistic biological mechanisms and to uncover the regulation network in specific biological processes. This review summarized sample preparation methods, integration analysis tools and the application of multi-omics integration analyses in environmental toxicology field.

Achieving Equiaxed Transition and Excellent Mechanical Properties in a Novel Near-β Titanium Alloy by Regulating the Volume Energy Density of Selective Laser Melting.

This research investigated the relationship between volume energy density and the microstructure, density, and mechanical properties of the Ti-5Al-5Mo-3V-1Cr-1Fe alloy fabricated via the SLM process. The results indicate that an increase in volume energy density can promote a transition from a columnar to an equiaxed grain structure and suppress the anisotropy of mechanical properties. Specifically, at a volume energy density of 83.

Microstructure Evolution and Mechanical Properties of 7A52 Aluminum Alloy Thin Sheet Repaired with Friction Stir Surfacing.

A solid-state repair technique based on surface friction welding is investigated in depth to achieve excellent mechanical properties of damaged 7A52 aluminum alloy. The results show that the yield strength and tensile strength along the repair direction are 436 MPa and 502 MPa, respectively, at a rotational speed of 1400 rpm and a travel speed of 300 mm/min, which are about 157.9% and 129.

Diluted contrast media combined with high-resolution C-arm CT for evaluating apposition of flow diversions in a porcine model.

Background: In intracranial stenting, good stent apposition is crucial, and high-resolution C-arm computer tomography (CT) is utilized to assess whether stent apposition is complete. This study was aimed at finding optimal hypertonic or isotonic contrast media injection concentration for high-resolution C-arm CT to assess apposition of flow diversion (FD) after carotid artery stenting in swine.

Methods: Twelve FD stents were implanted into the left carotid artery of Bama swine through the endovascular method.

Cicer super-pangenome provides insights into species evolution and agronomic trait loci for crop improvement in chickpea.

Chickpea (Cicer arietinum L.)-an important legume crop cultivated in arid and semiarid regions-has limited genetic diversity. Efforts are being undertaken to broaden its diversity by utilizing its wild relatives, which remain largely unexplored.

Deficiency of betaine-homocysteine methyltransferase activates glucose-6-phosphate dehydrogenase (G6PD) by decreasing arginine methylation of G6PD in hepatocellular carcinogenesis.

Betaine-homocysteine methyltransferase (BHMT) regulates protein methylation and is correlated with tumorigenesis; however, the effects and regulation of BHMT in hepatocarcinogenesis remain largely unexplored. Here, we determined the clinical significance of BHMT in the occurrence and progression of hepatocellular carcinoma (HCC) using tissue samples from 198 patients. BHMT was to be frequently found (86.