Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis.

Allergic rhinitis (AR), a globally prevalent immune-mediated inflammatory condition, is still an incurable disease. In the present study, we have validated the impact of the Kelch-like ECH associated protein 1 (Keap1)-related oxidative stress and inflammatory response in clinical AR patient peripheral blood and nasal swab samples, emphasizing the biological relevance of Keap1 and AR. Targeting Keap1 -nuclear factor erythroid 2-related factor 2 (Nrf2) related anti-oxidative stress may be effective for AR intervention.

Bevacizumab-associated glomerular microangiopathy: a case report and literature review.

Here we present a case of bevacizumab-associated glomerular microangiopathy (Bmab-GMA), a rare and distinct glomerular pathology, in a middle-aged male patient who developed progressive renal impairment following adjuvant chemotherapy with bevacizumab for surgically resected lung adenocarcinoma. The patient presented with new-onset hypertension and mild elevation in serum creatinine. Renal biopsy revealed characteristic histopathological features, including pseudothrombotic deposits of periodic acid-Schiff (PAS)-positive hyaline material within glomerular capillaries on light microscopy, and subendothelial and mesangial electron-dense deposits with segmental widening of the subendothelial space on electron microscopy.

Electrochemical Determination of Creatinine Based on Multienzyme Cascade-Modified Nafion/Gold Nanoparticles/Screen-Printed Carbon Composite Biosensors.

Creatinine serves as a crucial diagnostic biomarker for assessing kidney disease. This work developed portable non-enzymatic and multienzyme-modified electrochemical biosensors for the detection of creatinine based on commercial screen-printed carbon electrodes (SPCEs). The non-enzymatic creatinine sensor was constructed by the electrochemical deposition of AuNPs onto the surface of a pre-activated SPCE by electrochemical activation, followed by the surface modification of a Nafion membrane.

Enhancing Ion Transport at Primary Interparticle Boundaries of Polycrystalline Lithium-Rich Oxide in All-Solid-State Batteries.

Polycrystalline lithium-rich oxide (PLRO) is a promising high-capacity cathode for next-generation all-solid-state batteries (ASSBs). However, its full potential is hindered by sluggish Li+ transport at primary interparticle boundaries, mainly due to the limited flowability of inorganic solid-state electrolytes (SEs). Additionally, infiltrating conventional SEs into PLRO can lead to severe interfacial side reactions because of high melting points.

Design of spiro-heterocyclic substituted diaminonaphthalene Keap1-Nrf2 protein-protein interaction inhibitors as novel anti-depressant agents.

Oxidative stress, inflammation and the Keap1-Nrf2 pathway are validated to be related to depression. Theoretically, modulating Keap1 and Nrf2 protein-protein interaction (PPI) should be an effective method to activate Nrf2 for the treatment of major depressive disorders. We previously reported NXPZ-2, a 1,4-diaminonaphthalene, as a Keap1-Nrf2 PPI inhibitor that exhibited promising effects in an Alzheimer's disease (AD) mouse model.

Renal arteriolosclerosis impact on clinicopathological features and outcomes of idiopathic membranous nephropathy: a retrospective cohort analysis.

Background: To investigate the clinicopathological features and prognostic factors of idiopathic membranous nephropathy (IMN) patients with renal arteriolosclerosis, providing evidence for individualized clinical management.

Methods: A retrospective analysis was conducted on 597 biopsy-confirmed IMN patients at Guangdong Provincial Hospital of Chinese Medicine from January 1, 2012, to December 31, 2022. Patients were stratified into two groups based on the presence of renal arteriolosclerosis.

Simultaneously Modulating Li Transport Kinetics and Structural Stability in Li-Rich Mn-Based All-Solid-State Electrodes by Dual-Scale Particle Engineering.

Li-rich Mn-based oxides (LRMOs) are promising cathodes for all-solid-state lithium batteries (ASSLBs) due to their high theoretical capacity. However, their practical application is hindered by sluggish Li transport and interfacial instability. Herein, it is demonstrated that primary and secondary particle sizes of LRMOs play crucial roles in influencing Li transport kinetics and interfacial stability.

Hyperbranched Polyborophosphate towards Transparent Epoxy Resin with Ultrahigh Toughness and Fire Safety.

Inherent transparency makes epoxy resins ideal for aircraft windows, yet their brittleness and flammability remain challenges. Existing strategies for these issues often compromise transparency, with limited research on the mechanisms involved. Herein, a novel strategy is proposed for fabricating transparent epoxy resin by tuning the electrostatic potential distribution via hyperbranched polyborophosphate.

Design of anti-depressant phosphodiester amino acidic Keap1-Nrf2 protein-protein interaction inhibitors.

Inhibiting the protein-protein interaction (PPI) between Keap1 and Nrf2 is theoretically an effective and safe strategy for activation of Nrf2 pathway to treat major depressive disorder (MDD). In this study, through bioinformatic analysis of the brain tissues and peripheral blood of MDD patients and depressive mice, we confirmed the involvement of oxidative stress, inflammation, and the Keap1-Nrf2 pathway in depression. Subsequently, we developed a series of phosphodiester amino acidic diaminonaphthalene compounds as Keap1-Nrf2 PPI inhibitors for the first time.

Alloying Strategy Balances the Adsorption-Reduction-Oxidation Process of Sulfur Species Across Wide Temperature Ranges.

Transition metal-based catalysts have been demonstrated to effectively anchor and utilize lithium polysulfides (LiPSs), thereby enhancing the capacity of lithium-sulfur batteries (LSBs). However, the immobilized d-band electronic structure of a single transition metal is inadequate for achieving satisfactory adsorption and catalytic conversion. In this study, an alloying strategy is employed to modulate the d-band structure with the aim of achieving the optimal adsorption capacity for LiPSs.

Encapsulation of FeS within N/S-Doped bamboo-like carbon nanotubes for facilitated rapid catalytic conversion of polysulfides in high-performance lithium-sulfur batteries.

Lithium-sulfur batteries (LSBs) are considered to be competitive next-generation electrochemical energy storage devices, but their practical application is severely hampered by the shuttle effect and slow redox kinetics of soluble lithium polysulfides (LiPSs). To address this challenge, FeS encapsulated within N/S co-doped bamboo-like carbon nanotubes (FeS/NSC) is synthesized via a pyrolysis sulfidation process, and act as a coating separator for LSBs. The 1-dimensional (1D) S and N co-doped carbon substrate materials can act as conductive networks, exposing more adsorption sites and enhancing the capture of LiPSs.

Electrochemical Exfoliation of Layered Non-van der Waals Crystals into 2D Nanosheets: MAX Phases and Beyond.

2D materials have rapidly gained attention due to their exceptional properties like high surface area, flexibility, and tunable electronic characteristics. These attributes make them highly versatile for applications in energy storage, electronics, and biomedicine. Inspired by graphene's success, researchers are exploring other 2D materials from bulk crystals.

Labeled and Label-Free Target Identifications of Natural Products.

Target identification, employing chemical proteomics, constitutes a continuous challenging endeavor in the drug development of natural products (NPs). Understanding their targets is crucial for deciphering their mechanisms and developing potential probes or drugs. Identifications fall into two main categories: labeled and label-free techniques.

Extremely Durable K-Ion Batteries Enabled by Heteroatom Co-Doped Highly-Ordered Porous Carbon Spheres with Nearly 100% Capacity Retention up to 11,000 Cycles.

Currently, one major target for exploring K-ion batteries (KIBs) is enhancing their cycle stability due to the intrinsically sluggish kinetics of large-radius K ions. Herein, we report a rationally designed electrode, the S/O co-doped hard carbon spheres with highly ordered porous characteristics (SPC), for extremely durable KIBs. Experimental results and theory calculations confirm that this structure offers exceptional advantages for high-performance KIBs, facilitating rapid K diffusion and (de)-intercalation, efficient electrolyte penetration and transport, improved K storage sites, and enhanced redox reaction kinetics, thus ensuring the long-term cycle stability.

"Bottom-up" and "top-down" strategies toward strong cellulose-based materials.

Cellulose, as the most abundant natural polymer on Earth, has long captured researchers' attention due to its high strength and modulus. Nevertheless, transferring its exceptional mechanical properties to macroscopic 2D and 3D materials poses numerous challenges. This review provides an overview of the research progress in the development of strong cellulose-based materials using both the "bottom-up" and "top-down" approaches.

Synergistic electrochemical catalysis by high-entropy metal phosphide in lithium-sulfur batteries.

The shuttle effect and sluggish redox kinetics of polysulfides have hindered the development of lithium-sulfur batteries (LSBs) as premier energy storage devices. To address these issues, a high-entropy metal phosphide (NiCoMnFeCrP) was synthesized using the sol-gel method. NiCoMnFeCrP, with its rich metal species, exhibits strong synergistic effects and provides numerous catalytic active sites for the conversion of polysulfides.

Reaction Mechanism and Performance of Innovative 2D Germanane-Silicane Alloys: SiGe H Electrodes in Lithium-Ion Batteries.

The adjustable structures and remarkable physicochemical properties of 2D monoelemental materials, such as silicene and germanene, have attracted significant attention in recent years. They can be transformed into silicane (SiH) and germanane (GeH) through covalent functionalization via hydrogen atom termination. However, synthesizing these materials with a scalable and low-cost fabrication process to achieve high-quality 2D SiH and GeH poses challenges.

Enabling Rapid and Stable Sodium Storage via a P2-Type Layered Cathode with High-Voltage Zero-Phase Transition Behavior.

Currently, a major target in the development of Na-ion batteries is the concurrent attainment of high-rate capacity and long cycling stability. Herein, an advanced Na-ion battery with high-rate capability and long cycle stability based on Li/Ti co-doped P2-type NaMnNiO, a host material with high-voltage zero-phase transition behavior and fast Na migration/conductivity during dynamic de-embedding process, is constructed. Experimental results and theoretical calculations reveal that the two-element doping strategy promotes a mutually reinforcing effect, which greatly facilitates the transfer capability of Na.

Hyperbranched Dynamic Crosslinking Networks Enable Degradable, Reconfigurable, and Multifunctional Epoxy Vitrimer.

Degradation and reprocessing of thermoset polymers have long been intractable challenges to meet a sustainable future. Star strategies via dynamic cross-linking hydrogen bonds and/or covalent bonds can afford reprocessable thermosets, but often at the cost of properties or even their functions. Herein, a simple strategy coined as hyperbranched dynamic crosslinking networks (HDCNs) toward in-practice engineering a petroleum-based epoxy thermoset into degradable, reconfigurable, and multifunctional vitrimer is provided.

MoO/t-CN Heterogeneous Materials with Bidirectional Catalysis for the Rapid Conversion of S Species in Li-S Batteries.

Li-S batteries have drawn a lot of attention for their high theoretical specific capacity and significant economic benefits. However, the shuttle effect of polysulfides prevents them from being used widely. To tackle this difficulty, a heterogeneous structure based on tubular carbon nitride with evenly dispersed molybdenum dioxide nanoparticles (MoO/t-CN) as the S host is constructed in this work.

Practical Application of Li-Rich Materials in Halide All-Solid-State Batteries and Interfacial Reactions between Cathodes and Electrolytes.

Benefiting from the advanced solid-state electrolytes (SSEs), conventional cathodes have been widely applied in all-solid-state lithium batteries (ASSLBs). However, Li-rich Mn-based (LRM) cathodes, which possess enhanced discharge capacities beyond 250 mA h g, have not yet been studied in ASSLBs. In this work, the practical application of LRM cathodes in ASSLBs using a high-voltage-stability halide SSE (LiInCl, LIC) is reported for the first time.

Manipulating Charge-Transfer Kinetics of Lithium-Rich Layered Oxide Cathodes in Halide All-Solid-State Batteries.

Employing lithium-rich layered oxide (LLO) as the cathode of all-solid-state batteries (ASSBs) is highly desired for realizing high energy density. However, the poor kinetics of LLO, caused by its low electronic conductivity and significant oxygen-redox-induced structural degradation, has impeded its application in ASSBs. Here, the charge transfer kinetics of LLO is enhanced by constructing high-efficiency electron transport networks within solid-state electrodes, which considerably minimizes electron transfer resistance.

Tellurium Surface Doping to Enhance the Structural Stability and Electrochemical Performance of Layered Ni-Rich Cathodes.

The Ni-rich layered oxides are considered as a candidate of next-generation cathode materials for high energy density lithium-ion batteries; however, the finite cyclic life and poor thermostability impede their practical applications. There is often a tradeoff between structure stability and high capacity because the intrinsical instability of oxygen framework will lead to the structural transformation of Ni-rich materials. Because of the strong binding energy between the Te atom and O atom, herein a new technology of surface tellurium (Te) doping in the Ni-rich layered oxide (LiNiCoAlO) is proposed to settle the above predicament.

Preparation and Performance of the Heterostructured Material with a Ni-Rich Layered Oxide Core and a LiNiMnO-like Spinel Shell.

The LiNiCo Al O (NCA)-layered materials are regarded as a research focus of power lithium-ion batteries (LIBs) because of their high capacity. However, NCA materials are still up against the defects of cation mixing and surface erosion of electrolytes. Herein, a novel design strategy is proposed to obtain a heterostructured cathode material with a high-capacity LiNiCoAlO layer ( R3̅ m) core and a stable LiNiMnO-like spinel ( Fd3̅ m) shell, which is prepared through spontaneous redox reaction of the precursor with KMnO in an alkaline solution and subsequent calcination procedure.