Effects of endoscopic minimally invasive surgery on olfactory function and quality of life in patients with chronic rhinosinusitis and nasal polyps.

Objective: To evaluate the efficacy of endoscopic minimally invasive surgery (EMIS) in improving olfactory function and quality of life among patients with chronic rhinosinusitis with nasal polyps (CRSwNP).

Methods: A cohort of 117 patients diagnosed with CRSwNP between January 2020 and June 2024 were included in this retrospective study. Patients were assigned to either a control group (n=50, treated with conventional endoscopic sinus surgery [ESS]) or a research group (n=67, treated with EMIS).

Characterization and enzymatic function of thioredoxin glutathione reductase in Orientobilharzia turkestanicum isolated from Xizang.

Unlabelled: Orientobilharziasis, caused by , is a zoonotic parasitic disease that leads to significant economic losses in livestock and cercarial dermatitis in humans. This study focuses on the molecular characterization and functional analysis of thioredoxin glutathione reductase (TGR) from , a key enzyme involved in the parasite’s antioxidant defense system. The full-length thioredoxin glutathione reductase (OtTGR) cDNA and thioredoxin glutathione reductase with selenocysteine (OtTGRsec) were cloned and expressed as recombinant proteins in .

Real-time monitoring of water states in large-diameter aqueducts - learning from distributed acoustic sensing signals.

Large-diameter gravity aqueducts are essential for water supply systems but face performance and safety risks from complex flow conditions. Effective flow-state monitoring is critical for hydraulic performance and infrastructure safety. However, conventional monitoring techniques like closed-circuit television (CCTV) inspection and ultrasonic sensing have limited real-time accuracy in distinguishing flow states.

Prognostic Value of Peripheral Blood nCD64 Index, mHLA-DR, and CD14monocyte Percentage in Different Infection Status in COVID-19 Patients.

Objective: To explore the value of the neutrophil CD64 (nCD64) index, monocytic HLA-DR (mHLA-DR), and the percentage of CD14 monocytes in the prognosis of Coronavirus disease 2019 (COVID-19).

Methods: Fifty-seven COVID-19 patients from December 2022 to November 2023 were divided into two groups: non-severe group (mild or moderate cases) and severe group (severe or critical cases). Among them, 17 patients were deceased.

Comparison of the efficacy of unilateral versus bilateral pedicle approach vertebroplasty in the treatment of osteoporotic thoracic and lumbar vertebral compression fractures: A retrospective cohort study.

Osteoporotic vertebral compression fractures (OVCFs) are prevalent among the elderly and significantly impact quality of life. Percutaneous kyphoplasty (PKP) offers effective, minimally invasive treatment. However, the choice between unilateral and bilateral transpedicular approaches remains debated due to differing surgical outcomes and complication risks.

VTCN1 emerges as a biomarker of immune tolerance in osimertinib-resistant lung cancer.

Osimertinib is an effective strategy for nonsmall-cell lung cancer (NSCLC). However, the acquired resistance neutralizes the efficacy of osimertinib. Herein, we investigated the potential biomarkers of osimertinib-resistant lung cancer.

The causal relationship between immune cells and rheumatoid arthritis: A dual sample Mendelian randomization study.

The etiology of rheumatoid arthritis (RA) is still unclear, but it has been shown to be genetically related. While previous studies have shown a causal relationship between immune cells and RA, there has been no systematic evaluation of the causal relationship between immune cell characteristics and RA in terms of genetic variation. For this study, a comprehensive Mendelian randomization analysis was performed to determine the causal relationship between immune cell characteristics and RA.

Prevalence and relative-risks of pasteurella in yaks of Xizang, China.

Pasteurella multocida-induced hemorrhagic septicemia is an important bacterial disease of buffaloes and cattle, especially in resource-constrained and high-altitude regions. Although its economic and health implications are of vital interest, there has not been much studied about its occurrence among yaks. Pasteurella multocida, the pathogen causing hemorrhagic septicemia in cattle, was investigated in 922 yak serum samples collected from Lhasa, Nagqu, and Shigatse regions of Xizang from 2021 to 2024.

Subcellular redistribution of Rhein from whole cellular to single mitochondria for enhancing anti-hepatoma efficacy.

Background: RECQL4 is a critical factor in DNA repair and serves as a significant biomarker for liver cancer. Inhibiting RECQL4 induces apoptosis in liver cancer cells. Given the role of mitochondria in regulating apoptosis and the dual localization of RECQL4 in both the mitochondria and nucleus, targeting mitochondrial RECQL4 may induce mitochondrial dysfunction, thereby enhancing the therapeutic efficacy of liver cancer treatments.

Neuromuscular adaptations to resistance training in elite versus recreational athletes.

Neuromuscular adaptations to resistance training drive strength and performance improvements, but differences between elite and recreational athletes remain underexplored. Understanding the underlying mechanisms can refine training approaches and enhance athletic development. This review synthesized findings from the past decade regarding how training status, age, sex, and genetics influence neuromuscular adaptations to resistance training, identified key gaps in the literature, and provided practical recommendations for tailoring training to different athletic levels.

Comparative study of Chinese herbal enema combined with Mesalazine versus Mesalazine alone in the treatment of ulcerative colitis: A randomized controlled trial.

Background: Mesalazine is a standard treatment for ulcerative colitis (UC). However, it is unclear whether the efficacy of mesalazine combined with traditional Chinese medicine (TCM) enemas is superior to that of mesalazine alone. Therefore, this study aimed to evaluate the clinical effectiveness of TCM enema hydrotherapy combined with mesalazine for active UC.

Extrachromosomal circular DNA drives dynamic genome plasticity: emerging roles in disease progression and clinical potential.

Extrachromosomal circular DNA (eccDNA) has emerged as a dynamic and versatile genomic element with key roles in physiological regulation and disease pathology. This review synthesizes current knowledge on eccDNA, covering its classification, biogenesis, detection methods, biological functions, and clinical implications. Once considered rare anomalies, eccDNAs are now recognized as major drivers of oncogene amplification, genomic plasticity, and therapeutic resistance, particularly in cancer.

Non-invasive characterization of cascaded SOAs on InP-based photonic integrated circuits.

Semiconductor optical amplifiers (SOAs) are widely used as active elements in optical switching networks for their features of loss compensation and fast reconfiguration time. To optimize the SOA chain operation, it is essential to know the gain response of each SOA. However, the performance of the individual SOA in an on-chip network is challenging to characterize without additional splitters, which increases path insertion losses and, therefore, power consumption.

End-to-End Abnormal Subgraph Detection via Subgraph-Level Contrastive Learning.

Abnormal subgraph (AS) detection plays a significant role in ensuring the security of many high-impact domains. Unlike node anomaly detection, identifying subgraph anomalies is extremely challenging due to the exponentially large subgraph space caused by various combinations of nodes and edges. Moreover, in the absence of supervisory signals, how to quantify the abnormality of subgraphs poses another pressing challenge.

Pulse Wave and Rock Fracturing Characteristics of Composite Energetic Materials Ignited by Underwater Wire Electrical Explosion.

In this study, experiments were conducted to investigate the electric explosion initiation of composite energetic materials (CEMs) by using Cu and NiCr wires in water. The composite energetic material is composed of Al powder and a heater, and there are three formulations after mixing according to the mass ratio (1:1, 1:2, and 1:4). Metal wires with a diameter of 0.

Ultra-Soluble 1-Azaphenothiazine Additive Stabilizes High-Voltage LiCoO₂ for 500 Wh Kg Lithium Metal Pouch Cells.

High-voltage LiCoO is a promising cathode candidate for achieving high-energy lithium metal pouch cells. However, further application is still hindered by irreversible structural degradation and severe interfacial side reactions that accelerate capacity decay. Herein, 1-Azaphenothiazine (1-APT) is incorporated as a cathode slurry additive (1 g mL in N-methyl-2-pyrrolidone) to promote the optimization of the LiCoO interface during the electrode coating process.

Tailoring Dual High-Valence Cu-O-Mn Active Sites to Enhance VOC Catalytic Oxidation.

Advancing the catalytic oxidation of volatile organic compounds (VOCs) requires ongoingly boosting of both low-temperature activity and durability. Our strategy was to tailor suitable Cu-O-Mn coordination environments across numerous types of widely used CuMn bimetallic oxides. Unexpectedly, Cu-O-Mn sites within the CuO phase ignited greater catalytic activity toward alkanes like cyclohexane under 5.

EccDNA-Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation.

Genotoxic therapies such as ionizing radiation eliminate cancer cells by inducing extensive DNA damage but often cause normal tissue toxicity, including cutaneous injury. Extrachromosomal circular DNA (eccDNA) refers to circular DNA fragments outside the chromosomal context, with their formation and persistence linked to DNA damage repair and genomic instability. Despite growing recognition of eccDNA in oncogenesis, its role under genotoxic stress in normal tissues remains poorly understood.

Active futures: combating youth sedentary lifestyles in Pakistan through smart use of fragmented time.

Sedentary behavior among adolescents is a growing concern globally, including in Pakistan, due to its association with negative physical and psychological health outcomes. Fragmented time agility training has arisen as a prospective solution to tackle these challenges. The proposed work evaluates the impact of a structured six-week agility training protocol on sedentary behavior, mood, and stress among adolescents aged 12-18 in Pakistan.

Associations of exposure to arsenic species and endogenous sex hormones with oral cancer: a hospital-based study in Southeastern China.

The effects of arsenic species and endogenous sex hormones on oral cancer risk, particularly their molecular interactions, have been infrequently reported. This study aimed to assess the individual and combined effects of arsenic species and endogenous sex hormones on oral cancer risk and elucidate the association between hormones, arsenic species, and arsenic metabolism. A case-control study (comprising 144 cases and 144 controls) was conducted from January 2020 to January 2024 in Southeastern China.

Hospitalization costs of oral cancer patients in Southeast of China: a quantile regression analysis.

Background: Scant research has systematically examined the hospitalization costs of oral cancer patients in China. Therefore, this study aims to systematically analyze the hospitalization costs and identify the factors influencing these costs among oral cancer inpatients.

Methods: Basic information and cost data for oral cancer patients who were admitted to the hospital for the first time between July 2015 and May 2022 were collected from one grade-A tertiary hospital in Fuzhou city of Southeastern China.

Enhancing lower-limb motor imagery using a paradigm with visual and spatiotemporal tactile synchronized stimulation.

Vibrotactile stimulation (VS) has been widely used as an appropriate motor imagery (MI) guidance strategy to improve MI performance. However, most VS induced by a single vibrator cannot provide spatiotemporal information of tactile sensation associated with the visual guidance of the imagined motion process, not vividly providing MI guidance for subjects.This paper proposed a paradigm with visual and spatiotemporal tactile synchronized stimulation (VSTSS) to provide vivid MI guidance to help subjects perform lower-limb MI tasks and improve MI-based brain-computer interface (MI-BCI) performance, with a focus on poorly performing subjects.

Automatic identification of hard and soft tissue landmarks in cone-beam computed tomography via deep learning with diversity datasets: a methodological study.

Background: Manual landmark detection in cone beam computed tomography (CBCT) for evaluating craniofacial structures relies on medical expertise and is time-consuming. This study aimed to apply a new deep learning method to predict and locate soft and hard tissue craniofacial landmarks on CBCT in patients with various types of malocclusion.

Methods: A total of 498 CBCT images were collected.

Nanocomposite Hydrogels and Micro/Nanostructures for Printing Organoids.

Organoids are 3D artificial miniature organs composed of a cluster of self-renewing and self-organizing cells , which mimic the functions of real organs. Nanotechnologies, including the preparation of nanomaterials and the fabrication of micro/nanostructures, have been proven to promote cell proliferation, guide cell differentiation, and regulate cell self-organization, showing great promise in engineering organoids. In this Perspective, different types of nanocomposite hydrogels for organoid culture are summarized, the effects of micro/nanostructures on organoid growth and development are discussed, and 3D bioprinting technologies for constructing organoid models are introduced.

Prevalence and Molecular Characterization of Parasitic Lice in Tibetan Yaks, Pigs and Sheep.

The infestation of ectoparasites poses a severe problem in animal breeding, severely affecting animal health and causing substantial economic losses. However, limited information is available regarding lice infestations in plateau livestock. To address this, we collected and examined lice samples from Tibetan yaks, pigs and sheep, amplifying the and genes for evolutionary analysis.