Glia maturation factor-β deficiency improves insulin resistance by promoting CARM1-mediated lipid turnover.

Insulin resistance (IR) is a major factor for obesity-associated type 2 diabetes. The molecular mechanisms of IR and its systemic control remain poorly understood, and pharmacological drugs to ameliorate IR are an unmet need. So finding new therapeutic targets and drugs is important.

The fabrication of N, S co-doped carbon dots and cascade sensing Hg and bovine serum albumin in food with reversible strategy.

High-performance effective and precise detection of Hg possesses great significance for ensuring environmental, food safety and public health, but still a great challenge. Here, efficient fabrication of NS-doped carbon dots (NS-CDs) were achieved and applied as fluorescent probe for cascade sensing Hg and BSA. NS-CDs emitted green emission at 500 nm under 355 nm excitation.

Integrative intratumoral and peritumoral radiomic model for predicting endometrial cancer grade.

Non-invasive preoperative assessment of tumor grade serves an important role for clinical management. The aim of the present study was to assess the value of an intratumoral and an peritumoral radiomic model in predicting the histological grade of endometrial cancer (EC). A total of 107 patients with EC were retrospectively enrolled and randomly divided into the training (n=74) and test cohorts (n=33).

Mechanisms of pyroptosis in vitiligo.

Vitiligo is a common depigmentation disorder characterized by the loss of skin pigmentation, resulting in white patches on the skin. The pathogenesis of vitiligo involves complex interactions between genetic, immunological and environmental factors. Recent studies have implicated pyroptosis, a form of programmed cell death, in the development and progression of vitiligo.

Beyond the water activity and T: water usability can govern xerophilic fungal and bacterial proliferation in sucrose/whey protein isolate solid matrices.

High-solid food matrices are often unstable; how water behaves in them dictates molecule mobility and microbial proliferation. Here, we employ lyophilized sucrose/whey protein isolate (WPI) mixtures as a model system to link water sorption isotherms, glass-transition temperatures (T), structural relaxation dynamics, and relaxation times to microbial growth of Aspergillus flavus and Bacillus subtilis. Although the sorption isotherms, T, and relaxation processes of the studied matrices were affected by a and WPI, the microbial growth showed a high dependence on water mobility rather than a (0.

Glycoconjugated Metallohelices Eliminate Cancer Stem-Like Cells via Modulating G-Quadruplex Surrounding Transcriptional Start Site of Sox2 Gene.

As an important pluripotency transcription factor, Sox2 plays key roles in the stemness maintenance of cancer stem-like cells (CSCs). Here, we found that a highly conserved G-rich region surrounding transcriptional start sites (TSSs) of Sox2 gene can form G-quadruplex (Sox2G4) both in vitro and in cells. More intriguingly, the glycoconjugated triplex metallohelice [FeL ] (Δ-f) can enantioselectively stabilize Sox2G4.

Construction of Microsphere Culture System for Human Mesenchymal Stem Cell Aggregates.

Stem cells cultured in cell aggregates exhibit higher cell survival rates and enhanced anti-inflammatory and angiogenic effects compared to single cells, constructing a stable and economical cell aggregate culture system that can accurately adjust the mass transfer distance of nutrients, which contributes to improving the therapeutic effects of stem cell aggregates. In this study, an alginate hydrogel microsphere culture system (Alg-HM) was prepared using electrostatic spraying technology and refined by optimizing the electrostatic spraying technology parameters, such as the sodium alginate concentration, voltage, electrospray injection speed, and nozzle inner diameter. Furthermore, by setting the Tip-dropped culture system (Tip-D culture system, created by dropping the resuspended hMSC aggregate-hydrogel solution with a tip to form the hydrogel microsphere) and Matrigel culture system (created by dropping the resuspended hMSC aggregates-Matrigel solution with a tip to form the Matrigel culture system) as the control group and Alg-HM as the experimental group, the culture effect of hMSC aggregates in the optimized Alg-HM culture system was tested; CCK-8 detection and Ki-67 immunofluorescence staining showed that the Alg-HM culture system significantly enhanced the cell proliferation activity of hMSC aggregates after 7 and 14 days of culture.

Solvent Performance Evaluation of Heavy Oil in Coal-Oil Co-Liquefaction.

In this study, we investigated the solvent performance of six heavy oils from Xinjiang, China, for coal-oil co-liquefaction (COCL). Autoclave experiments revealed that shale oil vacuum residue (SOVR) provided the best liquefaction performance. The oils were characterized using FT-IR, C-NMR, H-NMR, and column chromatography, which revealed that they were mainly composed of aliphatic compounds, with minor aromatic and substituted aromatic compounds.

Deep learning-based risk stratification of ductal carcinoma using mammography and abbreviated breast magnetic resonance imaging.

Background: Current management of ductal carcinoma in situ lacks robust risk stratification tools, leading to universal surgical and radiotherapy interventions despite heterogeneous progression risks. Optimizing therapeutic balance remains a critical unmet clinical need.

Materials And Methods: We retrospectively analyzed two patient cohorts.

Oncogenic Potential of Epstein-Barr Virus in NK and NKT Cells Contribute to the Rapid Deterioration of Hemophagocytic Lymphohistiocytosis.

The rapid deterioration and fatal outcomes in Epstein-Barr virus (EBV)-related hemophagocytic lymphohistiocytosis (HLH) remain poorly understood. This study aimed to elucidate the key factors contributing to the progression of EBV-HLH by comparing EBV cellular tropism and host immune responses between survivors and deceased patients. Compared to healthy individuals, acute HLH patients exhibited impaired natural killer (NK) cell activity, which improved during the recovery phase.

Synergistic mechanisms of Banxia Xiexin decoction in overcoming chemoresistance and enhancing chemosensitivity in colorectal cancer.

Contract: Banxia Xiexin decoction (BXD), a classic formula clinically applied for gastroenteritis, possesses anti-tumor properties in Colorectal cancer (CRC). However, the exact molecular mechanism remains obscure.

Objective: To explore the effectiveness of BXD in reversing 5-FU resistance in CRC and elucidate its mechanism of action.

Delayed Viral Clearance Accompanied by Early Impaired Humoral and Virus-Specific T-Cell Response in Patients with Coronavirus Disease 2019 and Interstitial Lung Disease.

Objectives: Patients with interstitial lung disease (ILD) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are at high risk of severe coronavirus disease 2019. It is unclear whether anti-viral cellular and humoral immunity is impacted in patients with ILD in the presence of immune disorders and immunosuppressive therapy. This results in poor control of viral infections following SARS-CoV-2 infection.

Microwave Pretreatment-Induced Significant Nutrient and Metabolite Changes in Sea Cucumber .

The body wall of sea cucumbers is rich in nutrients and small-molecule metabolites; however, traditional hot water pretreatment often leads to nutrient loss. To optimise processing techniques, this study compared the effects of microwave pretreatment and conventional hot water pretreatment on nutrient retention and metabolite profiles. Untreated sea cucumber body wall samples served as controls.

Naphthalene Metabolites From Long-Term Environmental Tobacco Smoke Induce the Aging of Retinal Pigment Epithelium.

Tobacco use is the main source of indoor air pollution and contains a variety of toxic components. The smoke from burning cigarettes is a key environmental risk factor that leads to accelerated aging and the occurrence of numerous diseases. Meanwhile, cigarette smoke and aging are both prominent risk factors for age-related macular degeneration (AMD).

Spatial-temporal radiogenomics in predicting neoadjuvant chemotherapy efficacy for breast cancer: a comprehensive review.

Radiomics is undergoing a paradigm shift from single-omics to multi-omics, from single-temporal to multi-temporal analysis, and from global to subregional analysis. These transformations have shown great potential in addressing key challenges related to imaging changes before and after neoadjuvant chemotherapy (NAC) in breast cancer. Furthermore, radiomics has achieved remarkable progress in tasks such as exploring tumor heterogeneity and uncovering underlying biological mechanisms.

Enhanced Monitoring of Urethral and Bladder Mobility in Postpartum Stress Urinary Incontinence Using Combined Ultrasound Techniques.

Objective: This study aimed to compare the consistency between smart pelvic floor ultrasound and biplanar transrectal ultrasound in detecting early stress urinary incontinence (SUI) by assessing urethral dilation and bladder structure.

Methods: We selected 40 multiparas who went through prenatal assessment after delivery and had standard pelvic floor ultrasounds at 6 weeks after childbirth, spanning from June 2022 to September 2022. The Bland-Altman method was employed to evaluate the consistency between biplanar transrectal ultrasound and transperineal pelvic floor ultrasound in assessing the mobility of the bladder neck and the posterior bladder wall in women.

Current evidence for Banxia Xiexin decoction in gastrointestinal tumors and future research perspectives.

Unlabelled: Gastrointestinal malignancies constitute a leading contributor to global cancer-related mortality, with an annually increasing incidence rate. More therapy techniques are urgently needed to improve clinical efficacy and patient quality of life. In the therapeutic treatment of digestive tract malignancies, Banxia Xiexin Decoction (BXD), a traditional Chinese medicine prescription, offers benefits such enhancing postoperative and post-chemotherapy unpleasant reactions, decreasing postoperative recurrence and enhancing the synergistic effect of combined chemotherapy medications.

3D-bioprinted multifunctional artificial skin patches with synergistic antimicrobial-mechanoadaptive functions for accelerating infected wound healing.

This study employs advanced 3D bioprinting to molecularly integrate polycaprolactone (PCL), carboxymethyl chitosan (CMCS), and curcumin (CCM), formulating an artificial skin patch with dual antibacterial and regenerative functionalities. The patch employs directional hydrogen bonding between CMCS and bioactive CCM to reduce the contact angle of the PCL matrix from 107.5° to 57.

Bacterial colonization contributes to pathological scar formation via the regulation of inflammatory response.

Background: It has been established that inflammatory factors are involved in the formation of pathological scars. Therefore, pathological scars are regarded to be highly associated with chronic inflammation, whereas what factors contribute to this inflammation remains unclear.

Objective: To confirm that bacterial colonization is involved in the formation of pathological scars, and to reveal that the persistent inflammatory response mediated by macrophages due to bacterial colonization promotes scar formation.

Addressing challenges and advancing solutions: Enhancing semi-coking wastewater treatment for a sustainable prospect.

During the semi-coke process, the semi-coking wastewater (SCWW) produced contains high concentrations of organic pollutants. This wastewater has the characteristics of abundant coal tar, high ammonia nitrogen content, high phenol concentration, high chemical oxygen demand (COD), and a low B/C ratio. These features make its treatment extremely difficult and bring significant environmental risks.

Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation.

One of the histopathological hallmarks of neuroinflammatory diseases such as multiple sclerosis (MS) is the emergence of astrocyte reactivity. Accumulating evidence suggests that excessive glycolysis may lead to astrocyte reactivity and contribute to neuroinflammatory responses. However, the intricate mechanisms underlying astrocyte metabolic reprogramming towards glycolysis remain largely unknown.

A pH/STEAP Cascade-Responsive Nanomedicine with Self-Supplied Peroxide for Precise Chemodynamic Therapy.

Self-supply of peroxo compounds has been regarded as a promising strategy to enhance Fenton chemistry-based chemodynamic therapy (CDT). However, the inherent selectivity of CDT will be affected after introducing peroxide-supplementing functionality into chemodynamic agents due to the lack of ability to distinguish cancer cells from normal cells. Here, an intelligent CDT nanomedicine is reported with both cascade-responsive and peroxide self-supplying performances for specific and efficient cancer treatment.

Structural characterization of a novel fucoidan from Sargassum horneri for anticancer drug delivery.

A fucoidan SHF from Sargassum horneri was obtained. Nanoparticles were prepared using SHF (F) and chitosan (Cs) at F/Cs mass ratios of 1.0/3.

pH-Dependent Structural Engineering of Sulfonate-Carboxylate Cu-MOFs for High Proton Conductivity.

Metal-organic frameworks (MOFs) with free carboxylic acid (COOH) groups are promising for solid-state proton-conducting materials, owing to the Brønsted acidity, polarity, and the hydrogen-bonding ability of COOH groups. In this work, two Cu-MOFs with different dimensions were synthesized by adjusting the pH of the reaction solution using disodium-2,2'-disulfonate-4,4'-oxidibenzoic acid (NaHDSOA) and 4,4'-bipyridine (4,4'-bpy) as ligands to coordinate with Cu(II). The resulting compounds, (([Cu(4,4'-bpy)(HO)][Cu(HDSOA)(4,4'-bpy)(HO)]·12HO)) and ([Cu(DSOA)(4,4'-bpy)(HO)]·4HO), have distinct dimensionalities and structures, mainly due to the pH's effect on carboxylic acid deprotonation.

Coblation-Assisted Transoral Endoscopic Excision of Lingual Thyroglossal Duct Cysts.

ImportanceLingual thyroglossal duct cysts (LTGDCs) are rare congenital anomalies that necessitate proactive surgical intervention due to their potential for life-threatening airway obstruction. The challenging anatomical location of LTGDCs complicates their surgical management, and there are currently no standardized surgical modalities in place.ObjectiveTo analyze the clinical features of LTGDCs and evaluate the feasibility, safety, and efficacy of coblation-assisted transoral endoscopic excision of LTGDCs.