A pH/STEAP Cascade-Responsive Nanomedicine with Self-Supplied Peroxide for Precise Chemodynamic Therapy.

Self-supply of peroxo compounds has been regarded as a promising strategy to enhance Fenton chemistry-based chemodynamic therapy (CDT). However, the inherent selectivity of CDT will be affected after introducing peroxide-supplementing functionality into chemodynamic agents due to the lack of ability to distinguish cancer cells from normal cells. Here, an intelligent CDT nanomedicine is reported with both cascade-responsive and peroxide self-supplying performances for specific and efficient cancer treatment.