Clinical significance and gene prediction of a novel classification system based on tacrolimus concentration-to-dose ratio in the early post-liver transplant period.

Background And Aims: Classification system of tacrolimus elimination and its clinical significance has not been well described in liver transplantation. This study aimed to present a novel tacrolimus clearance clinical-FIS (Fast-Intermediate-Slow) classification and its gene prediction system.

Methods: Patients from 3 transplant centers were enrolled in this study.

Ultrasound-assisted starch succinylation (C8-C14): Balancing side-chain lengths and degree of substitution for optimal amphiphilicity and emulsification.

In this study, rice starch was ultrasound-assisted (power = 0 W, 200 W, and 450 W) succinylated with C8-C14 anhydrides under controlled conditions, with the major aim of balancing side-chain lengths and degree of substitution (DS) for superior amphiphilicity and emulsification. A bell-shaped relationship between chain lengths and functionality was observed, peaking at decenyl succinic anhydride (DSA, C10)-modified starch, particularly DSA-450 W achieved optimal amphiphilicity (θ = 86.3°), emulsification performance (EAI = 34.

Correlation analysis of pharmacokinetic parameters of docetaxel AUC and adverse reactions in breast cancer patients.

Background: Docetaxel is commonly used in breast cancer chemotherapy. The previous drug dose is generally calculated based on body surface area (BSA). However, the metabolism varies greatly among different patients.

Comparison of a novel endoscopic approach versus laparoscopic deroofing for symptomatic simple hepatic cysts.

Background: Laparoscopic hepatic cyst deroofing (LHCD) stands as the preferred treatment modality for simple hepatic cysts (SHCs), but it has limitations. This study aimed to introduce endoscopic transgastric hepatic cyst deroofing (ETGHCD) as a minimally invasive alternative and to compare its safety and efficacy with LHCD in treating SHCs.

Methods: We retrospectively enrolled 10 patients with 15 symptomatic SHCs treated by ETGHCD and 53 patients with 72 SHCs treated by LHCD at Shanghai General Hospital from June 2021 to August 2024.

[Preparation and physicochemical properties of double aldehyde starch microcapsules loaded with tea polyphenols].

Objective: To achieve high-value and functional applications of Mongolian oak starch resources.

Methods: Dialdehyde Mongolian oak starch was prepared by modifying Mongolian oak starch with NaIO_4, using the degree of aldehyde substitution as an indicator to study the oxidation conditions. The dialdehyde Mongolian oak starch was then combined with gum arabic to create a composite wall material for encapsulating tea polyphenols, and the reaction conditions were optimized through PB tests and response surface analysis to investigate the encapsulation efficiency and sustained release properties of the polyphenols.

Porcine plasma protein cold-set hydrogel crosslinked by genipin and the immunomodulatory, proliferation promoting and scar-remodeling in wound healing.

Addressing the critical need for biocompatible and multifunctional wound dressings for chronic and non-healing wounds, cold-set hydrogel using natural biomacromolecules are potential candidates. This study developed a novel cold-set hydrogel of porcine plasma protein (PPP) through genipin (GP) as crosslinker and glucono delta-lactone (GDL) as acidifier. GP promoted hardness, springiness, water holding capacity (WHC) and modulus in a dose-dependent manner in the presence of GDL, and significantly enhanced microstructural density, integrity and anti-degradation, critical as wound dressing, achieving the optimal performance at 0.

Stability assessment of surrounding rock in downward mining route supported by slab-wall backfill structure.

Characteristic of ground pressure in surrounding rock is generally considered as the theoretical basis of parameter optimization for stope structure and technology. To explore the feasibility of efficient method for the second-step downward route backfill stopes in Shanjin gold mine, various numerical simulation methods were used to investigate the effect of slab-wall backfill structure on stability of surrounding rock in downward route mining system. The maximum principal stress, artificial false roof stress, and displacement were analyzed to evaluate the level of ground pressure in different mining areas.

Ultrasound-assisted acid/enzymatic hydrolysis preparation of loquat kernel porous starch: A carrier with efficient palladium loading capacity.

Porous starch, with excellent renewal and thermodynamic stability characteristics, could be utilized as a novel carrier for metals. In this research, starch was obtained from wasted loquat kernel (LKS) and converted into loquat kernel porous starch (LKPS) through ultrasound-assisted acid/enzymatic hydrolysis. Then, LKS and LKPS were utilized for loading with palladium.

Interrelation among one-carbon metabolic (OCM) pathway-related indicators and its impact on the occurence of pregnancy-induced hypertension disease in pregnant women supplemented with folate and vitamin B12: Real-world data analysis.

Background And Objective: A considerable number of pregnant women who were supplemented with folate and vitamin B12 were selected as major participants in studying the one-carbon metabolic (OCM) pathway. Our study aimed to explore the effects of OCM-related indicators on pregnancy-induced hypertension (PIH) and preeclampsia (PE) in pregnant women with folate and vitamin B12 supplementation.

Subjects And Methods: A total of 1,178 pregnant women who took multivitamin tablets containing 800 μg folate and 4 μg vitamin B12 daily from 3 months before pregnancy to 3 months after pregnancy were enrolled in this study.

HCC: RNA-Sequencing in Cirrhosis.

Hepatocellular carcinoma (HCC) ranks the most common types of cancer worldwide. As the fourth leading cause of cancer-related deaths, its prognosis remains poor. Most patients developed HCC on the basis of chronic liver disease.

Genotype-guided model significantly improves accuracy of tacrolimus initial dosing after liver transplantation.

Background: The initial dose of tacrolimus after liver transplantation (LT) is critical for rapidly achieving the steady state of the drug concentration, minimizing the potential adverse reactions and warranting long-term patient prognosis. We aimed to develop and validate a genotype-guided model for determining personalized initial dose of tacrolimus.

Methods: By combining pharmacokinetic modeling, pharmacogenomic analysis and multiple statistical methods, we developed a genotype-guided model to predict individualized tacrolimus initial dose after LT in the discovery (n = 150) and validation cohorts (n = 97) respectively.

Genetic factors underlying tacrolimus intolerance after liver transplantation.

Background: Tacrolimus (FK506) is the cornerstone of immunosuppression after liver transplantation (LT), however, clinically, switching from FK506 to cyclosporine (SFTC) is common in LT patients with tacrolimus intolerance. The aim of this study was to investigate the genetic risk of patients with tacrolimus intolerance.

Methods: A total of 114 LT patients were enrolled in this retrospective study.

Influencing Mechanism of Nod-Like Receptor Protein 3 Inflammasome Activation in A375 Cell Activity in Human Cutaneous Malignant Melanoma.

This work was to investigate mechanism by which mir-22 targeting nod-like receptor protein 3 (NLRP3) inflammasome affected activity of human skin malignant melanoma (MM) A375 cells. Twenty-four mice were rolled into a control group (Group X) and an experimental group (Group Y) randomly. Without treatment in Group X, Group Y established MM model.

Risk Factors for New-Onset Diabetes Mellitus After Heart Transplantation: A Nomogram Approach.

Background: New-onset diabetes mellitus after transplantation (NODAT) is a leading cause of morbidity and mortality after heart transplantation (HT), which still remains a clinical challenge.

Methods: In this study, 522,708 follow-up records of HT were reviewed. After screening, 14,452 patients were analyzed when combined with immunosuppression records.

Administration of rTMS Alleviates Stroke-Induced Cognitive Deficits by Modulating miR-409-3p/CTRP3/AMPK/Sirt1 Axis.

Cognitive deficit is a typical complication induced by stroke injuries. Repetitive transcranial magnetic stimulation (rTMS) is a technique that can both attenuate neuropsychiatric disorders and influence miR levels. We attempted to assess effects of rTMS on post-stroke cognitive deficit (PSCD) by focusing on the activity of miR-409-3p/CTRP3/AMPK/Sirt1 axis.

Postoperative serum triglyceride levels in predicting risk of new-onset diabetes mellitus in patients following liver transplantation.

To investigate the postoperative serum triglyceride (TG) levels in predicting the risk of new-onset diabetes mellitus (NODM) in patients following allogeneic liver transplantation. One hundred and forty three patients undergoing allogeneic liver transplantation in Shanghai General Hospital from July 2007 to July 2014 were enrolled in this study. The NODM developed in 33 patients after liver transplantation.

Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside.

There are rarely systematic studies to analyze the prognostic factors among non-surgical liver cancer patients. Whether there is a gender difference in the survival of non-surgical liver cancer patients and what may cause this difference is still unclear. A total of 12,312 non-surgical liver cancer patients were enrolled in this study.

The influence of recipient SLCO1B1 rs2291075 polymorphism on tacrolimus dose-corrected trough concentration in the early period after liver transplantation.

Purpose: To explore the relationship between rs2291075 polymorphism in SLCO1B1 gene, which encodes an influx transmembrane protein transporter, and tacrolimus dose-corrected trough concentration (C/D, ng ml mg kg) in the early period after liver transplantation.

Methods: CYP3A5 rs776746 and SLCO1B1 rs2291075 polymorphisms of 210 liver transplantation patients and their corresponding donor livers were assessed by PCR amplification and DNA sequencing. The influence of gene polymorphisms on C/D values of tacrolimus was analyzed.

Corrigendum to "Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer".

[This corrects the article DOI: 10.1155/2017/1202710.].