Uncovering common disease mechanisms and critical biomarkers in Crohn's disease with concurrent psoriasis and exploring potential therapeutic agents.

Introduction: Research findings show a substantial correlation between Crohn's disease and psoriasis. However, the exact cause or pathogenesis of the concurrent manifestations of these two conditions in the same individuals remains uncertain. This research aimed to scrutinize the important molecules and mechanisms responsible for the concomitance of Crohn's disease and Psoriasis by using quantitative bioinformatics utilizing a publicly available RNA sequencing repository.

Physiological and metabolic responses of Limnoperna fortunei to KMnO and NaClO exposure.

Biofouling of Limnoperna fortunei causes increment on water conveyance energy and deteriorates concrete during freshwater transportation process. Apart from application of chemical oxidants such as KMnO and NaClO, few other strategies can control L. fortunei.

Anatomical significance of the vestibular aqueduct in posterior wall of the internal auditory canal drilling through the retrosigmoid approach: a study utilizing 3D reconstruction technology.

The anatomical importance of the vestibular aqueduct and posterior semicircular canal is explored in this study, which utilizes three-dimensional(3D) image reconstruction and registration fusion technology through the retrosigmoid approach for drilling the posterior wall of the internal auditory canal. A total of 200 temporal bone high-resolution computed tomography (HRCT) scans were collected from 100 patients without inner ear diseases at the Central Hospital of the PLA's Neurosurgery and Radiology Department between 2016 and 2024. Additionally, temporal bone HRCT and brain MRI imaging data were also collected concurrently from 32 patients diagnosed with vestibular schwannomas.

3DSlicer software-assisted neuroendoscopic surgery compared with traditional surgery on surgical effects, complications, and safety evaluation in patients with intracerebral hemorrhage: A systematic review and meta-analysis.

Objective: This study aims to comprehensively evaluate the complications, effectiveness, and safety of neuroendoscopic surgery (NS) assisted by 3DSlicer software, compared to traditional surgery in patients with intracerebral hemorrhage (IH).

Methods: We searched for case-control trials from the Chinese Biomedical Literature data (CBM) online database, Wanfang Database, EMBASE, VIP Full-text Database, China National Knowledge Infrastructure (CNKI), Science Direct, Cochrane Library, and PubMed. The studies, published since January 2010, involved NS or traditional surgery for IH patients assisted by 3DSlicer software.

Assessment of traumatic brain injury treatment guided by continuous monitoring of intracranial pressure and brain tissue oxygen partial pressure: A single-center pilot study.

Severe traumatic brain injury (TBI) is a leading cause of death and disability. Monitoring intracranial pressure (ICP) is recommended, but the data on the outcomes are conflicting. Adding continuous brain tissue oxygen partial pressure (PbtO2) monitoring may have some benefit but the OXY-TC suggested it did not improve 6-month neurological outcomes.

Intracranial peak pressure as a predictor for perioperative mortality after spontaneous intracerebral hemorrhage evacuation and decompressive craniectomy.

Background: An optimal intracranial pressure (ICP) management target is not well defined in patients with spontaneous intracerebral hemorrhage. The aim of this study was to explore the association between perioperative ICP monitoring parameters and mortality of patients with spontaneous intracerebral hematoma undergoing emergency hematoma removal and decompressive craniectomy (DC), to provide evidence for a target-oriented ICP management.

Methods: The clinical and radiological features of 176 consecutive patients with spontaneous intracerebral hemorrhage that underwent emergent hematoma evacuation and DC were reviewed.

Effects and mechanism of ultrasound treatment on Chironomus kiiensis eggs.

Chironomids are abundant insects in freshwater ecosystems and lay in still or slow-moving water. The walls of sedimentation tanks in drinking water treatment plants (DWTP) provide such laying habitat, which can lead to larval outbreaks in plant effluent. While chironomid larvae are often associated with poor hygiene, effective methods to control outbreaks are needed.

Microbial composition and nitrogen removal pathways in a novel sequencing batch reactor integrated with semi-fixed biofilm carrier: evidence from a pilot study for low- and high-strength sewage treatment.

The sequencing batch reactor (SBR) activated sludge process is a well-established technology for sewage treatment. One of the drawbacks of SBRs, however, total nitrogen (TN) removals is insufficient. By means of introducing four improvements, including semi-fixed biofilm carrier, sludge elevation mixing and change for the mode of influent and effluent, compliant standard for TN discharge was obtained in this novel SBR configuration during low- and high-strength sewage load.

Integrated Analysis of Mutations, miRNA and mRNA Expression in Glioblastoma.

Background: Glioblastoma multiforme (GBM) is a common, malignant brain tumor in adults, with a median survival of only 15-23 months. Organisms respond to disease stress through sophisticated mechanisms at the physiological, transcriptional and metabolic levels. However, the molecular regulatory networks responsible for occurrence, progression and recurrence of glioma have yet to be elucidated.

Geometrical and Hemodynamic Characteristic Changes of Small Anterior Communicating Artery Aneurysms during Follow-ups in a Retrospective Analysis.

Background: Small intracranial aneurysms have a low risk of rupture. However, ruptured anterior communicating artery (ACoA) aneurysms are usually smaller in clinical practice. The retrospective study aimed to investigate the geometrical and hemodynamic changes of small unruptured ACoA aneurysms during serial follow-ups.

[Application of continuous monitoring of intracranial pressure and brain oxygen partial pressure in the treatment of patients with severe craniocerebral injury].

Objective: To investigate the effects of continuous monitoring intracranial pressure (ICP) and brain oxygen partial pressure (PbtO) on the prognosis of patients with severe craniocerebral injury.

Methods: A prospective randomized controlled trial was conducted. Seventy patients with severe craniocerebral injury with a Glasgow coma score (GCS) 4-8 admitted to the neurosurgical intensive care unit (NICU) of the People's Hospital of Inner Mongolia Autonomous Region from January 2017 to May 2020 were enrolled, and they were divided into ICP monitoring group and ICP+PbtO monitoring group by random number table.

LncRNA NEAT1 promotes glioma cancer progression via regulation of miR-98-5p/BZW1.

Background: Glioma is the most common malignant tumor in the human central nervous system. Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) promotes oncogenesis in various tumors. In the present study, we aimed to examine the role of NEAT1 in altering the properties of gliomas.

Effects of ultrasound on invasive golden mussel Limnoperna fortunei mortality and tissue lesions.

Biofouling by the invasive golden mussel Limnoperna fortunei deleteriously affects artificial water systems, but few effective, environmentally friendly antifouling strategies exist. We propose ultrasound for control of this invasive mussel and report minimum exposure times to kill juveniles and adults at ultrasonic powers ranging 300-600 W from a fixed distance of 8.5 cm.

UV dose effects on the revival characteristics of microorganisms in darkness after UV disinfection: Evidence from a pilot study.

Ultraviolet (UV) disinfection during water supply treatment aims to reduce the number of bacteria. Although UV disinfection is effective at inactivating most microorganisms, some microbe species may be entirely impervious. A pilot study was conducted to compare the quantity and community component of bacteria in surface water collected from filtration effluent before UV disinfection with different doses of UV, and those 1 and 2 days afterwards, in darkness.

Inhibition of Glioblastoma Cell Growth In Vitro and In Vivo by Brucine, a Component of Chinese Medicine.

Glioblastoma multiforme (GBM) is one of the most common glial cell tumors and has drawn more and more attention in the clinic in recent years. Brucine has been reported to significantly suppress gastric cancer, lung cancer, and prostate cancer growth in vivo by inducing cell apoptosis. Here, the effects of brucine on U251 human glioma cell growth were investigated in vitro by cell proliferation assay, FACs, and qPCR in a xenograft tumor model.

A novel endovenous laser ablation strategy of treatment of greater saphenous vein varicosities with difficult wire placement.

Aim: To investigate the efficacy and early postoperative morbidity of a novel endovenous laser ablation (IEVLA) strategy of treatment of the great saphenous vein (GSV) with difficulty of wire placement.

Methods: Sixty patients with serious GSV incompetence in 73 limbs were randomized into two treatment groups: Group 1 underwent traditional endovenous laser ablation (TEVLA) surgery and group 2 received IEVLA. Local pain, ecchymosis, induration, paraesthesia in treated regions, thrombotic diseases, vein diameter, treated vein length, delivered energy, operation duration, success rate in placement of the laser fiber and venous clinical severity (VCS) scores were recorded for both group.

Inhibition of autophagy using 3-methyladenine increases cisplatin-induced apoptosis by increasing endoplasmic reticulum stress in U251 human glioma cells.

Cisplatin is one of the most widely used chemotherapeutic drugs; however, the side effects and drug resistance limit its usage. Previous findings have demonstrated that cisplatin kills tumor cells through endoplasmic reticulum (ER) stress, which provides a novel method to minimize cisplatin toxicity and circumvent cisplatin resistance. ER stress induces cell autophagy, cell apoptosis and the complicated regulatory network between them.

Improved productivity of poly (3-hydroxybutyrate) (PHB) in thermophilic Chelatococcus daeguensis TAD1 using glycerol as the growth substrate in a fed-batch culture.

A particularly successful polyhydroxyalkanoate (PHA) in industrial applications is poly (3-hydroxybutyrate) (PHB). However, one of the major obstacles for wider application of PHB is the cost of its production and purification. Therefore, it is desirable to discover a method for producing PHB in large quantities at a competitive price.

Algae consumption and nitrate removal in a raw water transport system by Limnoperna fortunei and its associated microorganisms.

This laboratory-scale study investigated the effect of Limnoperna fortunei on chlorophyll a, phosphates, ammonia, and nitrates in a simulated raw water transport system, with a special focus on the isolation and identification of microbes in the biofilm attached to the shell surface. These microbes appear to be involved in the decreased concentration of nitrates observed in the water. The microbial communities in the raw water and on the surface of the mussel's shell were investigated through various methods, including a 16S rRNA phylogenetic analysis, which revealed significant diversity in terms of the structure and abundance of microbial species present.

Degradation of forchlorfenuron by nitrification and denitrification reactions in the gut and shell biofilm of Limnoperna fortunei.

The capacity and mechanism of Limnoperna fortunei to reduce the concentration of forchlorfenuron [or 1-(2-chloropyridin-4-yl)-3-phenylurea (CPPU)] in water has been studied under laboratory conditions. Firstly, the evasive response of mussels to CPPU (10, 20, 40 and 60 mg L(-1)) was evaluated, and a toxicity test was carried out at these concentrations. Secondly, the effect of two different sizes of mussels on CPPU concentrations was investigated in a 24-day experiment.

Downregulation of Ezh2 expression by RNA interference induces cell cycle arrest in the G0/G1 phase and apoptosis in U87 human glioma cells.

The Ezh2 gene is an important member of the polycomb-group (PcG) family. As a newly identified oncogene, the expression of Ezh2 has been shown to be significantly increased in prostate cancer, breast cancer, renal cell carcinoma and hepatic cancer; however, a role for Ezh2 in the occurrence of glioma has not yet been reported. In this study, we found that the Ezh2 gene is highly expressed in U87 human glioma cells.

[Antibody detection in sera of patients with Schistosomiasis japonica by dot immunogold filtration assay].

Serum antibody of schistosomiasis patients was detected by dot immunogold filtration method (DIGFA) in laboratory and field, and F-ELISA was used as control. The results showed that there was no significant difference between these two assays in sensitivity and specificity (P > 0.05), with a high coincidence.