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Silicon carbide (SiC) is a critical semiconductor material extensively used in high-performance electronic power devices. However, achieving high-efficiency, low-loss SiC substrates remains a significant challenge. This study introduces an innovative dual-focus, double-layer laser slicing technique for SiC, incorporating spherical aberration correction into the traditional weighted Gerchberg-Saxton (GSW) approach. The corrected method generates controllable dual-focus beams, which form double-layer cracks within the SiC, significantly enhancing slicing efficiency. The proposed method achieves a slicing speed twice as fast as conventional techniques. Using this approach, a 10 × 10 × 1.4mm SiC sample was successfully sliced into three chips with thicknesses ranging from 400 m to 550 m. The resulting wafers demonstrate tensile strengths of 1.07 MPa and 1.40 MPa, with surface roughness values of 0.9 m and 0.55 m, respectively. Raman analysis further indicates the presence of SiC structures in the processed regions using the double method. This technique showcases significant potential for broader applications in processing other transparent and brittle materials, providing what we believe to be a new pathway for high-precision laser slicing.
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http://dx.doi.org/10.1364/OE.553210 | DOI Listing |
eNeuro
September 2025
NMD Laboratory at the Department of Biomedical Engineering, Florida International University, Miami, FL, 33174, USA.
Understanding the roles of astrocytic calcium signaling in multiple brain regulatory mechanisms including metabolism, blood flow, neuromodulation and neuroinflammation has remained one of the enduring challenges in glial biology. To delineate astrocytic contribution from concurrent neuronal activity, it is vital to establish robust control and manipulate astrocytes using a technique like optogenetics due to its high cellular specificity and temporal resolution. The lack of an experimental paradigm to induce controlled calcium signaling in astrocytes has hindered progress in the field.
View Article and Find Full Text PDFNeurosci Lett
August 2025
Department of Biology, University of Crete, Greece; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Greece. Electronic address:
The hippocampus, including the cornu ammonis (CA) and dentate gyrus (DG) subregions, is a brain area highly susceptible to seizure-like activity (SLA). Most studies conducted in vivo have been performed in a single hippocampal subregion. In our study, we used the high [K] (HK) model of SLA to investigate the role of oscillatory activity in predicting SLA and in its modulation by anti-epileptic drugs in the three hippocampal subregions (CA1, CA3 and DG).
View Article and Find Full Text PDFMicromachines (Basel)
August 2025
The Institute of Technological Sciences, Wuhan University, Wuhan 430072, China.
Silicon carbide (SiC), a wide-bandgap semiconductor, is renowned for its exceptional performance in power electronics and extreme-temperature environments. However, precision low-loss laser slicing of SiC is impeded by energy divergence and crack delamination induced by refractive-index-mismatch interfacial aberrations. This study presents an integrated laser slicing system based on a liquid crystal on silicon spatial light modulator (LCOS-SLM) to address aberration-induced focal elongation and energy inhomogeneity.
View Article and Find Full Text PDFCell Rep
August 2025
Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32611, USA. Electronic a
The loss of insulin secretory function associated with type 1 diabetes (T1D) is attributed to the immune-mediated destruction of beta cells. Yet, at onset of T1D, patients often retain a substantial beta cell mass, and T cell infiltration of pancreatic islets is typically sporadic. Here, we investigate the hypothesis that the remaining beta cells in T1D are dysfunctional, using live pancreas slices from organ donors recently diagnosed with T1D.
View Article and Find Full Text PDFAm J Physiol Cell Physiol
August 2025
Department of Neurophysiology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Belgrade, Republic of Serbia.
Astrocytes are abundant glial cells organized in a meshwork in which each cell is in contact with both neuronal and vascular elements. They receive and respond to neuronal signals and modulate synaptic activity and diameter of blood vessels through changes in their intracellular Ca. Norepinephrine plays an important role in both of these astrocytic functions, however, it remains unclear whether norepinephrine-induced intracellular Ca increase leads to further cellular adjustments in astrocyte activity.
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