Challenges in the diagnosis of esophageal cancer with intramural gastric metastasis: Two case reports.

Background: Esophageal squamous cell carcinoma (ESCC) is a prevalent gastrointestinal malignancy associated with significant morbidity and mortality rates. Tumor metastasis leads to a poor prognosis for patients. Intramural gastric metastasis (IGM), is an uncommon pathway of ESCC metastasis, and is more likely to occur when tumor cells show deep infiltration.

Intracellular Glutathione Cleaved Long-Targeting Chains of Cancer Cells and Macrophages to Exposedly Activate Mitochondria Delivery of Liposomes for Enhancing Antitumor Efficacy by Metabolic Reprogramming.

Considering that M2-tumor associated macrophages (TAMs) performing immunosuppressive function in tumor microenvironment (TME) rely on oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) metabolic pathways for energy supply, whereas M1 TAMs with antitumor effect and cancer cells mainly rely on glycolysis as energy source, so targeting the vital subcellular organelles of mitochondria for metabolic reprogramming of TAMs and cancer cells by nanocarriers could be expected as promising approaches for enhancing antitumor efficacy. Herein, two kinds of liposomes with M2 TAMs/mitochondria-targeting co-delivered the OXPHOS inhibitor atractyloside (ATR) and curcumin (CUR) for lipid intervention (MST@A/C), and tumor/mitochondria-targeting liposomes encapsulated 2-DG (BST@2-DG) were fabricated. MST@A/C located in mitochondria of M2 TAMs could inhibit OXPHOS and lipid uptake by downregulating CD36 expression, killing M2 TAMs and induced the transformation of M2 to M1 TAMs.

Association between postpartum depression and components of the metabolic syndrome: A bidirectional Mendelian randomization study.

Objective: To investigate the causality between metabolic syndrome (MetS) components and postpartum depression (PPD) using Mendelian randomization (MR) analysis.

Methods: Genetic instruments for MetS components including hypertension, fasting blood glucose (FBG), waist circumference (WC), high-density lipoprotein cholesterol (HDL-C), and triglycerides were obtained from public genome-wide association studies. The datasets for PPD data were sourced from the FinnGen study.

Mitigating Cadmium Stress in Soybean Plants: Seed Priming with Nanoscale TiO and ZnO for Safer Crop Production.

This study investigates the effects of soybean seed priming with titanium dioxide nanoparticles (TiO NPs) or zinc oxide nanoparticles (ZnO NPs) on germination and plant growth under cadmium (Cd) stress. Soybean seeds were primed with TiO NPs (50, 100, 200, or 400 mg/L) or ZnO NPs (50, 100, 300, or 500 mg/L) followed by Cd exposure during the germination (7 days) and plant (35 days) stages. The results demonstrate that priming with 100 mg/L ZnO NPs significantly enhanced soybean germination energy by 22.

Predicting peripartum depression using elastic net regression and machine learning: the role of remnant cholesterol.

Background: Traditional statistical methods have dominated research on peripartum depression (PPD), but innovative approaches may provide deeper insights. This study aims to predict the impact factors of PPD using elastic net regression (ENR) combined with machine learning (ML) model.

Methods: This longitudinal study was conducted from June 2020 to May 2023, involving healthy pregnant women in the first trimester, followed up until the completion of the assessment in the second trimester.

Recombinant adenovirus expressing pdhβ-pdhD fusion protein produces robust immune responses and partial protection against Mycoplasma Synoviae challenge in chickens.

Mycoplasma synoviae (MS) stands as a pivotal pathogen, responsible for triggering arthritis and airsacculitis in both chickens and turkeys. Given the pressing need for safe and efficacious vaccine candidates, we engineered recombinant adenoviruses expressing a fusion antigen. This antigen consisted of the pyruvate dehydrogenase E1 subunit beta (pdhβ) and dihydrolipoyl dehydrogenase (pdhD) of MS.

Effects of Hot Night Exposure on Human Semen Quality: A Multicenter Population-Based Study.

Objective: To explore and quantify the association of hot night exposure during the sperm development period (0-90 lag days) with semen quality.

Methods: A total of 6,640 male sperm donors from 6 human sperm banks in China during 2014-2020 were recruited in this multicenter study. Two indices (i.

CuO nanoparticles facilitate soybean suppression of Fusarium root rot by regulating antioxidant enzymes, isoflavone genes, and rhizosphere microbiome.

Background: Fusarium root rot is a widespread soil-borne disease severely impacting soybean yield and quality. Compared to traditional fertilizers' biological and environmental toxicity, CuO nanoparticles (NPs) hold promise for disease control in a low dose and high efficiency manner.

Methods: We conducted both greenhouse and field experiments, employing enzymatic assays, elemental analysis, qRT-PCR, and microbial sequencing (16S rRNA, ITS) to explore the potential of CuO NPs for sustainable controlling Fusarium-induced soybean disease.

FeO nanoparticles enhance soybean resistance to root rot by modulating metabolic pathways and defense response.

Four doses of FeO NPs suspension (10, 50, 100, and 500 mg/L) and one dose of EDTA-FeNa solution (10 mg/L) were foliar applied to two soybean (Glycine max) varieties (ND12 and C103) with Fusarium oxysporum. Notably, soybean disease indices were significantly reduced following foliar application of FeO NPs. At 50 mg/L FeO NPs, disease indices were reduced by 60.

Design, Synthesis, and Biological Evaluation of Chiral-Proline Derivatives as Novel HSP90 Inhibitors.

Heat shock protein 90 (HSP90) is a promising target for oncology therapeutics. Over the past decades, several small molecule inhibitors have demonstrated significant antitumor activity in clinical trials. However, nearly all HSP90 inhibitors in clinical trials have failed due to toxicity or insufficient efficacy.

Biochar-derived dissolved organic matter enhanced the release of residual ciprofloxacin from the soil solid phase.

Biochar has been utilized to reduce ciprofloxacin (CIP) residues in soil. However, little is known about the effect of biochar-derived dissolved organic matter (DOM) on residual CIP transformation. Thus, we analyzed the residual soil CIP as influenced by biochar generated from rice straw (RS3 and RS6), pig manure (PM3 and PM6), and cockroach shell (CS3 and CS6) at 300 °C and 600 °C.

Sarm1 Controls the MYD88-Mediated Inflammatory Responses in Inflammatory Bowel Disease via the Regulation of TRAF3 Recruitment.

Background: Sterile alpha and TIR motif-containing 1 (Sarm1) is known as a negative regulator of inflammatory responses. However, its role in inflammatory bowel disease (IBD) is still unclear.

Objective: This study aimed to explore the function of Sarm1 in IBD and its underlying mechanisms.

COVID-19-Induced Automation: An Exploratory Study of Critical Occupations.

The COVID-19 pandemic may have spurred automation, especially in critical occupations. This article explores the potential of each detailed Standard Occupational Classification System (SOC) occupation being automated due to COVID-19. The authors explore two key elements of each occupation: its exposure to diseases such as COVID-19 and the probability of that occupation being automated.

The impact of SARS-Cov-2 Omicron infection on short-term outcomes after elective surgery in patients with gastrointestinal cancer.

With the emergence of novel variants, Omicron variant caused a different clinical picture than the previous variants and little evidence was reported regarding perioperative outcomes after Omicron variants. The aim of the study was to evaluate the postoperative outcomes of gastrointestinal cancer patients following Omicron variants infection and also to determine the timing of surgery after infection recovery. A total of 124 patients who underwent gastrointestinal cancer surgery with prior SARS-CoV-2 infection between December 2022 and February 2023 were retrospectively reviewed.

Macrocycles and macrocyclization in anticancer drug discovery: Important pieces of the puzzle.

Increasing disease-related proteins have been identified as novel therapeutic targets. Macrocycles are emerging as potential solutions, bridging the gap between conventional small molecules and biomacromolecules in drug discovery. Inspired by successful macrocyclic drugs of natural origins, macrocycles are attracting more attention for enhanced binding affinity and target selectivity.

IRHB3 assemblies beneficial microbes and activates JA-mediated resistance to promote nutrient utilization and inhibit pathogen attack.

Introduction: The rhizosphere microbiome is critical to plant health and resistance. PGPR are well known as plant-beneficial bacteria and generally regulate nutrient utilization as well as plant responses to environmental stimuli. In our previous work, one typical PGPR strain, IRHB3, isolated from the soybean rhizosphere, had positive impacts on soil-borne disease suppression and growth promotion in the greenhouse, but its biocontrol mechanism and application in the field are not unclear.

Assessment of molybdenum application on soybean physiological characteristics in maize-soybean intercropping.

Soybean is a leguminous crop known for its efficient nitrogen utilization and ease of cultivation. However, its intercropping with maize may lead to severe reduction in its growth and yield due to shading effect of maize. This issue can be resolved by the appropriate application of essential plant nutrient such as molybdenum (Mo).

Impact of feeding dried distillers' grains with solubles diet on microbiome and metabolome of ruminal and cecal contents in Guanling yellow cattle.

Dried distillers' grains with solubles (DDGS) are rich in nutrients, and partially alternative feeding of DDGS effectively reduces cost of feed and improves animals' growth. We used 16S rDNA gene sequencing and LC/MS-based metabolomics to explore the effect of feeding cattle with a basal diet (BD) and a Jiang-flavor DDGS diet (replaces 25% concentrate of the diet) on microbiome and metabolome of ruminal and cecal contents in Guanling yellow cattle. The results showed that the ruminal and cecal contents shared the same dominance of , and in two groups.

Maize-legume intercropping achieves yield advantages by improving leaf functions and dry matter partition.

Intercropping can obtain yield advantages, but the mechanism of yield advantages of maize-legume intercropping is still unclear. Then, we explored the effects of cropping systems and N input on yield advantages in a two-year experiment. Cropping systems included monoculture maize (Zea mays L.

Remediation of cadmium contaminated soil using KFeO modified vinasse biochar.

The remediation of cadmium (Cd) contaminated soil is challenging for agricultural practices. In this study, a novel vinasse biochar modified by potassium ferrate (KFeO) was synthesized to immobilize Cd in agricultural soil. Three biochars [i.

Application of a New Retraction Method in Laparoscopic Gastrectomy for Gastric Cancer.

Background: Better exposition is important for lymph node dissection in the suprapancreatic region and lesser curvature region of the stomach, and digestive tract reconstruction, especially without excellent assistants.

Patients And Methods: We developed a new laparoscopic retraction method with the use of two internal retractors (TIRs) punctured along with suture. Clinicopathological data, surgical data, and postoperative outcomes were assessed.

Improvement of cadmium immobilization in contaminated paddy soil by using ureolytic bacteria and rice straw.

Cadmium (Cd) in paddy soil can be immobilized via microbially induced carbonate precipitation (MICP), but it poses a risk to the properties and eco-function of the soil. In this study, rice straw coupled with Sporosarcina pasteurii (S. pasteurii) was used to treat Cd-contaminated paddy soil with minimizing the detrimental effects of MICP.

Assessment of Autologous Blood marker localIzation and intraoperative coLonoscopy localIzation in laparoscopic colorecTal cancer surgery (ABILITY): a randomized controlled trial.

Background: Laparoscopic colorectal surgery has been proved to have similar oncological outcomes with open surgery. Due to the lack of tactile perception, surgeons may have misjudgments in laparoscopic colorectal surgery. Therefore, the accurate localization of a tumor before surgery is important, especially in the early stages of cancer.