Associations Between Lymphopenia and the Development/Recovery of Acute Kidney Injury Among Patients Hospitalized With Respiratory Virus Infections.

Rationale & Objective: Lymphopenia may have a potential mechanism on the development of acute kidney injury (AKI) after respiratory virus infection but has never been revealed. We aimed to investigate the relationship between lymphopenia and AKI in patients hospitalized with respiratory virus infections.

Study & Design: A single-center and retrospective cohort study.

Impact of prophylactic anticoagulation on hospitalized COVID-19 patients aged over 80 years: a multicenter prospective cohort study.

Background: Individuals aged 80 and older face a notably increased risk of venous thromboembolism (VTE) and mortality after SARS-CoV-2 infection. Clinical guidelines recommend routine pharmacological thromboprophylaxis, yet its application in oldest-old patients remains insufficiently studied.

Aims: To assess the efficacy and safety of low-molecular-weight heparin (LMWH) thromboprophylaxis in hospitalized COVID-19 patients aged 80 years and older.

Real-world practices of low-molecular-weight heparin for venous thromboembolism prophylaxis in patients hospitalized with COVID-19: a multicenter prospective study from China.

Background: Effective thromboprophylaxis is critical to reducing mortality and improving clinical outcomes in COVID-19 patients. Despite guidelines recommending prophylactic anticoagulation, particularly for those in intensive care, real-world adherence and optimal venous thromboembolism (VTE) prevention strategies remain challenging, particularly in populations with complex comorbidities.

Methods: A prospective study was conducted on patients hospitalized with moderate, severe, and critical COVID-19 in six Chinese hospitals during the Omicron pandemic (December 2022-January 2023).

Giant and Anisotropic Spin Relaxation Time in van der Waals GeSe With Gate-Tunability.

The 2D materials are promising channel materials for spin transistors due to their natural spatial-confined carrier transport character. Nonetheless, electrical spin injection and detection in 2D semiconductors used to be challenging. This study reports high-efficient spin injection and transport in 2D GeSe, which exhibits moderate spin-orbit coupling (SOC) and extended spin diffusion lengths due to the van der Waals structure.

The association between prolonged lymphopenia and in-hospital venous thromboembolism among different respiratory virus infections: a retrospective cohort study.

Background: Lymphopenia, a marker of prolonged clearance of virus, has unclear association with venous thromboembolism (VTE) in respiratory virus infection.

Objectives: This study aims to explore the correlation between prolonged lymphopenia and the risk of in-hospital VTE in patients with respiratory virus infection.

Methods: Adult patients with laboratory-confirmed COVID-19 influenza and other respiratory virus infection from January 1, 2016, to December 31, 2023, were retrospectively recruited.

Age-adjusted cut-off values of natriuretic peptides for right ventricular dysfunction in acute pulmonary embolism: Post-hoc analysis from CURES.

Background: Cut-off values of natriuretic peptides [NPs, including B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP)] for right ventricular dysfunction (RVD) in acute pulmonary embolism (PE) are not standardized.

Methods: Patients with acute PE enrolled between 2016 and 2021 were selected from a large prospective nationwide cohort in China. Patients with available values of NPs were included.

Rapid penetrating inactivation and disinfection through ice layers by light-condensed deep ultraviolet LED irradiation.

The longer survival of virus and bacteria under low temperature greatly accelerates the infection risk and duration. How to effectively and rapidly inactivate them beneath ice layer in cold chain logistics has been an important issue never being well studied. Here, we demonstrate a novel light condenser design of high power UVC-LED device for rapid penetrating inactivation through ice layers.

Polarization-Field-Induced Inequivalent Exciton Dynamics in Janus MoSeS/MoSe Heterostructures.

The interplay between excitons and physical fields emerges as a forefront research topic within the domain of condensed matter physics, harboring significant impact for unraveling material properties. Herein, we investigate the valley exciton behaviors in Janus MoSeS/MoSe heterostructures with 2H- or 3R-stacking configurations. We ascertain that the intrinsic polarized electric field in Janus materials can markedly enhance the valley polarization.

The efficacy comparison on femoral vein hemodynamics and morphology between two types of graduated elastic compression stockings among patients undergoing knee replacement: a single center, double-blind, randomized trial.

Background: Venous thromboembolism is a significant complication after knee replacement. The short-term efficacy disparities between different types of graduated elastic compression stockings (GCS) among patients undergoing total/unicompartmental knee replacement remain unclear.

Objective: The aim of the trial was to compare the efficacies on hemodynamics and morphology of femoral vein between two types of GCS, providing more evidence on GCS prophylaxis among patients undergoing total/unicompartmental knee replacement.

External Validation of the IMPROVE Risk Score for Predicting Bleeding in Hospitalized COVID-19 Patients.

Background: COVID-19 patients are at increased risk of thrombosis and bleeding, but no standardized bleeding risk assessment tool has been recommended.

Objective: This study evaluates the predictive value of the IMPROVE Bleeding Risk Score (BRS) in hospitalized COVID-19 patients.

Design: A multicenter, prospective cohort of 3,886 hospitalized COVID-19 patients across six tertiary hospitals in China between December 1, 2022, and January 31, 2023.

Van der Waals GeSe with Strain- and Gate-Tunable Linear Dichroism for Wearable Electronics.

The direct detection of light polarization poses a crucial challenge in the field of optoelectronics and photonics. Herein, the tunable linear dichroism (LD) in GeSe-based polarized photodetectors is presented through electronic and structural asymmetry modulation, and demonstrate their application prospects in wearable electronics. An improvement in the dichroic ratio up to 34% is achieved under a gate voltage of 20 V, and the improvement reaches 44% by applying a tensile strain along the zigzag direction.

Multivariate growth analysis on D0-phase MnGa kagome-based topological antiferromagnets.

The combination of antiferromagnetism and topological properties in MnX (X = Sn,Ge,Ga) offers a unique platform to explore novel spin-dependent phenomena and develop innovative spintronic devices. Here, we have systematically investigated the phase transition of MnGa thin films on SiO(001)/Si substrates under various growth parameters such as seeding layer structure, annealing conditions, and film thickness. The relatively thick MnGa films grown with Ru seeding exhibit a variety of polycrystalline hexagonal phases, including (002), and (201).

Prolonged lymphopenia and prognoses among inpatients with different respiratory virus infections: A retrospective cohort study.

Background: Lymphopenia is common in respiratory viral infection. However, no studies elucidated the impact of prolonged lymphopenia on worse outcome in the way of quantitative risk.

Methods: Adult patients with laboratory-confirmed respiratory virus infection (influenza, SARS-CoV-2, and other viruses) between January 1st, 2016, and February 1, 2023 were enrolled in this retrospective cohort study.

Chirality-Dependent Valley Polarization in Magnetic van der Waals Heterostructures via Spin-Selective Charge Transfer.

Magnetic proximity interaction provides a promising route to manipulate the spin and valley degrees of freedom in van der Waals heterostructures. Here, we report a control of valley pseudospin in the WS/MoSe heterostructure by utilizing the magnetic proximity effect of few-layered CrBr and, for the first time, observe a substantial difference in valley polarization of intra/interlayer excitons under different circularly polarized laser excitations, referred to as chirality-dependent valley polarization. Theoretical and experimental results reveal that the spin-selective charge transfer between MoSe and CrBr, as well as between MoSe and WS, is mostly responsible for the chiral feature of valley polarization in comparison with the proximity exchange field.

Efficacy and safety of anticoagulant for treatment and prophylaxis of VTE patients with renal insufficiency: a systemic review and meta-analysis.

Patients with venous thromboembolism (VTE) comorbid renal insufficiency (RI) are at higher risk of bleeding and thrombosis. Recommendations in guidelines on anticoagulation therapy for those patients remain ambiguous. The goal of this study is to compare the efficacy and safety between different anticoagulant regimens in VTE patients comorbid RI at different stages of treatment and prophylaxis.

Simultaneously Regulated Highly Polarized and Long-Lived Valley Excitons in WSe/GaN Heterostructures.

Interlayer excitons, with prolonged lifetimes and tunability, hold potential for advanced optoelectronics. Previous research on the interlayer excitons has been dominated by two-dimensional heterostructures. Here, we construct WSe/GaN composite heterostructures, in which the doping concentration of GaN and the twist angle of bilayer WSe are employed as two ingredients for the manipulation of exciton behaviors and polarizations.

Risk factors for venous thromboembolism in patients with pneumonia in the pre-COVID-19 era: a meta-analysis and systematic review.

Background: Elevated risk of venous thromboembolism (VTE) in patients with coronavirus disease 2019 (COVID-19) pneumonia has been recognized, while the risk factors associated with VTE in patients with non-COVID-19 pneumonia remain to be defined. This study aimed to conduct a meta-analysis and systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify potential risk factors for VTE in patients with pneumonia from the pre-COVID-19 era.

Methods: PubMed, EMBASE, and Cochrane Library were searched.

Clot ratio, new clot burden score with deep learning, correlates with the risk stratification of patients with acute pulmonary embolism.

Background: Risk stratification for patients with acute pulmonary embolism (APE) is significantly important for treatment and prognosis evaluation. We aimed to develop a novel clot burden score on computed tomography pulmonary angiography (CTPA) based on deep learning (DL) algorithm for risk stratification of APE.

Methods: The study retrospectively enrolled patients newly diagnosed with APE in China-Japan Friendship Hospital consecutively.

A machine learning model for diagnosing acute pulmonary embolism and comparison with Wells score, revised Geneva score, and Years algorithm.

Background: Acute pulmonary embolism (APE) is a fatal cardiovascular disease, yet missed diagnosis and misdiagnosis often occur due to non-specific symptoms and signs. A simple, objective technique will help clinicians make a quick and precise diagnosis. In population studies, machine learning (ML) plays a critical role in characterizing cardiovascular risks, predicting outcomes, and identifying biomarkers.

Nitrogen doped CoP on ammoniated black phosphorus nanosheets enabling highly efficient hydrogen evolution electrocatalysis.

Developing a rational and cost-effective approach for designing highly-efficient and sustainable electrocatalysts is essential for clean and renewable hydrogen energy. Herein, we report nitrogen-doped CoP on two-dimensional ammoniated black phosphorus (BP) nanosheets (N-CoP/NH-BP) as novel and highly-active heterostructure electrocatalysts for the hydrogen evolution reaction (HER). Using the reactive defects on the BP nanosheets as the original sites under NH gas, N-doped CoP nanocrystals were grown on the surface of the BP nanosheets that were functionalized with NH groups at their edge.

Proteome-wide mendelian randomization identifies causal plasma proteins in venous thromboembolism development.

Genome-wide association studies (GWAS) have identified numerous risk loci for venous thromboembolism (VTE), but it is challenging to decipher the underlying mechanisms. We employed an integrative analytical pipeline to transform genetic associations to identify novel plasma proteins for VTE. Proteome-wide association studies (PWAS) were determined by functional summary-based imputation leveraging data from a genome-wide association analysis (14,429 VTE patients, 267,037 controls), blood proteomes (1348 cases), followed by Mendelian randomization, Bayesian colocalization, protein-protein interaction, and pathway enrichment analysis.

Controllable Resistive Switching in ReS /WS Heterostructure for Nonvolatile Memory and Synaptic Simulation.

Memristors with nonvolatile storage performance and simulated synaptic functions are regarded as one of the critical devices to overcome the bottleneck in traditional von Neumann computer architecture. 2D van der Waals heterostructures have paved a new way for the development of advanced memristors by integrating the intriguing features of different materials and offering additional controllability over their optoelectronic properties. Herein, planar memristors with both electrical and optical tunability based on ReS /WS van der Waals heterostructure are demonstrated.

Case report: Pulmonary arterial hypertension in -related hereditary hemorrhagic telangiectasia.

A young adult woman presented with exertional dyspnea and she had had recurrent epistaxis for more than 10 years. On physical examination, cyanosis was noted on the lips, and telangiectasias were seen on the oral mucosa and fingertips. Routine investigations revealed iron deficiency anemia and slightly elevated bilirubin.