Causal relationship between plasma liposomes and autoimmune thyroid disease: a Mendelian randomization study.

Background: Autoimmune thyroid disease is an autoimmune disease. Observational studies have shown that individuals with thyroid dysfunction have dyslipidemia. However, it is uncertain whether there is a causal relationship between the two.

Carbon Monoxide Exposure Stimulates Growth and Activity of Primary Producers in Diverse Soil Ecosystems.

Carbon monoxide (CO) is both a potent poison for many aerobic organisms and a desirable energy source for diverse microorganisms. Atmospheric emissions of this gas have increased since industrialization, and their levels are highly elevated in many urban and natural environments; however, it is unresolved whether elevated levels of CO at environmentally relevant concentrations are primarily stimulatory or inhibitory to soil microbial communities. Here, we showed that CO exposure minimally affects microbial abundance, richness, and composition in diverse ecosystem soils, suggesting that most microbes are tolerant of this gas.

20(S)-Ginsenoside Rg3 Partially Induces Maturation of HepG2 Cells via the AMPK/HNF4A Pathway.

Background: We aimed to investigate whether 20(S)-ginsenoside Rg3 (Rg3) reduced heterogeneity by inducing the maturation of HepG2 cells via the AMP-activated protein kinase (AMPK)/hepatocyte nuclear factor 4A (HNF4A) pathway.

Methods: This in vitro cell research study was conducted under the guidance of Hebei Medical University, Hebei, China, from Sep 2022 to Dec 2023. HepG2 cells were treated with varying concentrations of Rg3 in a low glucose microenvironment.

Lumbar methicillin-resistant infection caused by a peripherally inserted central catheter: A case report.

Background: Peripherally inserted central catheters (PICCs) are widely used for administering chemotherapy to breast cancer patients due to their long-term indwelling capability, versatility in drug administration, and flexibility. PICCs infection are a relatively common occurrence, yet there were no reported instances that it can metastasise to the lumbar spine.

Case Summary: This case report describes a breast cancer patient who developed a methicillin-resistant Staphylococcus aureus lumbar vertebral infection secondary to a PICC-related infection during chemotherapy.

Response of biological nitrogen-fixation to polychlorinated biphenyls varies with soil type and associated diazotrophic community changes.

Biological nitrogen fixation (BNF) by diazotrophs is a fundamental process that sustains life on Earth and represents a critical natural source of bioavailable nitrogen in nitrogen-limited, organically polluted soils. However, there is limited knowledge regarding the effects of organic pollutants on the structure and function of diazotrophic communities across different soil types. This study investigated the relationship between changes in the structure and function of the soil diazotrophs and the effects of the representative pollutant tetrachlorobiphenyl (PCB52) across three soil types, paddy soil (PS), black soil (BS), and red soil (RS), corresponding to Anthrosols, Mollisols, and Ultisols, respectively, using soil microcosms.

Intranasal Immunotherapy with Allergen-Loaded Extracellular Vesicles from Mast Cells Alleviates Allergic Asthma Inflammation in a Murine Model.

Allergen immunotherapy (AIT) is the only treatment that can alter the course of allergic diseases by inducing immune tolerance through long-term, repeated low-dose allergen exposure. Nonetheless, AIT persistently faces challenges necessitating resolution, particularly in relation to treatment duration, the incidence of adverse reactions, and patient adherence. Extracellular vesicles (EVs) are promising drug delivery carriers for medications, vaccines, and targeted antibodies.

Preparation of a vegetable-oil film-type emulsion dust suppressant and adsorption performance study on road dust surface in open-pit coal mines.

Open-pit mine pavements have a low moisture content, and water is easily evaporated from the pavement surface. In this study, a dust suppressant was developed using an oil film-type emulsion with a high moisturizing effect to enhance the road dust surface moisture content and to reduce environmental hazards associated with the use of conventional heavy oil films. The characteristics and dust suppression properties of the emulsion were analyzed, and the emulsification mechanism and microscopic adsorption mechanism of the dust suppressant were studied through molecular dynamics simulations.

Mixotrophic cyanobacteria are critical active diazotrophs in polychlorinated biphenyl-contaminated paddy soil.

Biological nitrogen fixation by diazotrophs is a crucial biogeochemical process in global terrestrial ecosystems, especially in nitrogen-limited, organic-contaminated soils. The metabolic activities of diazotrophs and their ability to supply fixed nitrogen may facilitate the transformation of organic pollutants. However, the active diazotrophic communities in organic-contaminated soils and their potential metabolic functions have received little attention.

CIP2A promotes bronchiolitis obliterans by activating the NF‑κB pathway.

Bronchiolitis obliterans (BO) is a destructive fibrotic lung disease, which can be partly induced by 2,3‑butanedione [also known as diacetyl (DA)]; however, the mechanism underlying the effects of DA on BO is not clear. In the present study, a bioinformatics analysis was performed using DA‑treated or untreated lung tissues of rats, and it was observed that cell proliferation regulating inhibitor of protein phosphatase 2A (CIP2A) was significantly increased in samples from the DA group. CIP2A is associated with inflammation and epithelial‑mesenchymal transition (EMT), and facilitates lung injury; however, its effect on DA‑induced BO and the underlying mechanism remain unknown.

Tauroursodeoxycholic acid inhibits endothelial-mesenchymal transition in high glucose-treated human umbilical vein endothelial cells.

The high glucose-induced endothelial-mesenchymal transition (EndMT) may be the initial and underlying mechanism of diabetic vascular complications. Although tauroursodeoxycholic acid (TUDCA) plays various protective roles in diabetes and its complications, it's unclear whether TUDCA inhibits the high glucose-induced EndMT. In this study, human umbilical vein endothelial cells (HUVECs) were treated with high glucose and intervened with TUDCA.

Development and Validation of a Nomogram for Predicting Long-Term Net Adverse Clinical Events in High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention.

Background: Patients with a high risk of bleeding undergoing percutaneous coronary intervention (PCI-HBR) were provided consensus-based criteria by the Academic Research Consortium for High Bleeding Risk (ARC-HBR). However, the prognostic predictors in this group of patients have yet to be fully explored. Thus, an effective prognostic prediction model for PCI-HBR patients is required.

Demyelination of the amygdala mediates psychological stress-induced emotional disorders partially contributed by activation of P2X7R/NLRP3 cascade.

Psychological stress can lead to emotional disorders, such as anxiety and depression; however, the underlying mechanisms are complicated and remain unclear. In this study, we established a mouse psychological stress model using an improved communication box, in which the psychologically stressed mice received visual, auditory, and olfactory emotional stimuli from the mice receiving electric foot shock, thus avoiding physical stress interference. After the 14-day psychological stress paradigm, our mice exhibited a significant increase in depressive and anxious behaviors.

Effect of subcutaneous adipose tissue-associated CSRP2 on the progression of prostate cancer via the WDR5/USP44 pathway.

Elevated subcutaneous adipose tissue in obese men correlates strongly with a higher risk of aggressive prostate cancer and poor treatment outcomes, but the exact mechanism underlying the increased risk remains elusive. To address this question, we analyzed prostate cancer transcriptomic data from The Cancer Genome Atlas as well as single-cell RNA sequencing and tissue microarray data from prostate cancer cells. Subcutaneous adipose tissue-associated cysteine-rich protein 2 (CSRP2) was significantly downregulated in prostate cancer epithelial cells.

Eimeria tenella rhoptry neck protein 2 plays a key role in the process of invading the host intestinal epithelium.

The Apicomplexa parasitic phylum rhoptry neck protein 2 (RON2) plays a key role in the process of invading host cells. Eimeria tenella, an intracellular protozoan shares a similar conserved invasion pattern. However, whether E.

Prevalence and Clinical Relevance of Anti-FcεRI Autoantibody in Crohn's Disease.

Background: Mast cells can be activated in various ways and were shown to be involved in the development of Crohn's disease (CD). The diagnosis of CD is still challenging, and seeking novel biomarkers is a worthwhile endeavor.

Methods: An indirect enzyme-linked immunosorbent assay (ELISA) was successfully established for semi-quantitative detection of IgG anti-FcεRI in serum using human FcεRIα coated microplates and an enzyme-labeled anti-human IgG as secondary antibodies.

In Situ Studies on the Influence of Surface Symmetry on the Growth of MoSe Monolayer on Sapphire Using Reflectance Anisotropy Spectroscopy and Differential Reflectance Spectroscopy.

The surface symmetry of the substrate plays an important role in the epitaxial high-quality growth of 2D materials; however, in-depth and in situ studies on these materials during growth are still limited due to the lack of effective in situ monitoring approaches. In this work, taking the growth of MoSe as an example, the distinct growth processes on AlO (112¯0) and AlO (0001) are revealed by parallel monitoring using in situ reflectance anisotropy spectroscopy (RAS) and differential reflectance spectroscopy (DRS), respectively, highlighting the dominant role of the surface symmetry. In our previous study, we found that the RAS signal of MoSe grown on AlO (112¯0) initially increased and decreased ultimately to the magnitude of bare AlO (112¯0) when the first layer of MoSe was fully merged, which is herein verified by the complementary DRS measurement that is directly related to the film coverage.

Protection against DSS-induced colitis in mice through FcεRIα deficiency: the role of altered Lactobacillus.

The role of mast cells (MCs) in ulcerative colitis (UC) development is controversial. FcεRI, the IgE high-affinity receptor, is known to activate MCs. However, its role in UC remains unclear.

Selection criteria and method for deep inspiration breath-hold in patients with left breast cancer undergoing PMRT/IMRT.

Purpose: This study explored whether a free-breathing mean heart dose (FB-MHD) of 4 Gy is a reliable dose threshold for selecting left breast cancer patients after modified radical mastectomy suitable for deep inspiration breath-hold (DIBH) and developed anatomical indicators to predict FB-MHD for rapid selection.

Materials And Methods: Twenty-three patients with left breast cancer treated with DIBH were included to compare FB and DIBH plans. The patients were divided into the high-risk (FB-MHD ≥ 4 Gy) and low-risk (FB-MHD < 4 Gy) groups to compare dose difference, normal tissue complication probability (NTCP) and the DIBH benefits.

Rapid Selection of Patients Suitable for Deep Inspiration Breath-Hold Using an Automatic Delineating System and RapidPlan Model in Patients With Left Breast Cancer Undergoing Adjuvant Radiation Therapy With IMRT.

Purpose: This study aimed to determine whether radiation therapy plans created using an automatic delineating system and a RapidPlan (RP) module could rapidly and accurately predict heart doses and benefit from deep inspiratory breath-hold (DIBH) in patients with left breast cancer.

Methods And Materials: One hundred thirty-six clinically approved free breathing (FB) plans for patients with left breast cancer were included, defined as manual delineation-manual plan (MD-MP). A total of 104 of 136 plans were selected for RP model training.

A Reinforcement Ensemble Learning Method for Rolling Bearing Fault Diagnosis under Variable Work Conditions.

Ensuring the smooth operation of rolling bearings requires a precise fault diagnosis. Particularly, identifying fault types under varying working conditions holds significant importance in practical engineering. Thus, we propose a reinforcement ensemble method for diagnosing rolling bearing faults under varying working conditions.

Bilateral axillo-breast approach robotic thyroglossal duct cyst resection in an adolescent: a case report and literature review.

Background: Thyroglossal duct cyst (TGDC) is a common congenital neck mass that is the most frequent cause of neck swelling in children. The traditional open Sistrunk procedure for TGDC often leaves a visible scar on the neck. Therefore, it is essential to consider the impact of neck scarring on the quality of life for children and adolescents.

Biohydrogen utilization in legume-rhizobium symbiosis reveals a novel mechanism of accelerated tetrachlorobiphenyl transformation.

Symbiosis between Glycine max and Bradyrhizobium diazoefficiens were used as a model system to investigate whether biohydrogen utilization promotes the transformation of the tetrachlorobiphenyl PCB77. Both a H uptake-positive (Hup) strain (wild type) and a Hup strain (a hupL deletion mutant) were inoculated into soybean nodules. Compared with Hup nodules, Hup nodules increased dechlorination significantly by 61.