Biodegradable Quercetin-Incorporated Poly(Lactic Acid)/Chitosan Functional Films: A Study of the Properties and Application in Enhancing Fish Preservation.

Traditional plastic packaging materials have brought serious environmental pollution and a number of health risks; so the development of biodegradable polymers as an alternative has received increasing attention. Here, active packaging materials with antioxidant, antimicrobial, and biodegradable properties were prepared using poly(lactic acid) (PLA) and chitosan loaded with quercetin. The experimental results demonstrate that the PLA/chitosan/quercetin film achieved an impressive ABTS radical scavenging rate of up to 98.

Radial-Hierarchical Chromatomimetic E-Nose for Spatiotemporal VOC Diffusion Mapping.

This study introduces a radial-hierarchical, diffusion-enhanced spatiotemporal sensing paradigm for volatile organic compound (VOC) analysis via an integrated microchamber paper-based chromatomimetic e-nose. The proposed system synergizes interlayer spatiotemporal dynamics with planar spatial variance by employing a radially symmetric electrode array and a hierarchical porous chemoresistive ink (CuP@G). This design leverages molecular diffusion gradients across the sensing plane, enabling precise discrimination of complex VOC mixtures through multidimensional "spatiotemporal fingerprints".

Correction: Proteome-wide characterization of PTMs reveals host cell responses to viral infection and identifies putative antiviral drug targets.

[This corrects the article DOI: 10.3389/fimmu.2025.

Core Transcriptional Regulatory Circuit-Regulated IGF2BP3 Stabilizes E2F2 mRNA via m6A Modification in Neuroblastoma.

Neuroblastoma (NB) is a pediatric tumor with diverse outcomes and unknown underlying mechanisms. The core transcriptional regulatory circuit (CRC) and N6-methyladenosine (m6A) are key factors that control cell identity and fate. IGF2BP3 is an m6A reader protein that is transcriptionally regulated by CRC transcription factors (TFs).

Glycyrrhizic acid inhibited inflammatory response in LPS-stimulated microglial BV2 cells via MAPK, Akt and NF-κB signaling pathways.

Activation of microglia plays a pivotal role in the pathogenesis of neuroinflammation-mediated neurodegenerative diseases. Glycyrrhizic acid (GA), a principal triterpenoid saponin in , has been reported to exhibit a range of biological activities. Nevertheless, the function of GA in microglia activation remains unclear.

Lactylation of Mitochondrial Adenosine Triphosphate Synthase Subunit Alpha Regulates Vascular Remodeling and Progression of Aortic Dissection.

Aortic dissection (AD) is a cardiovascular disorder with a high mortality rate. Lysine Lactylation (Kla), a novel posttranslational modification, critically regulates inflammation, tumors, and cardiovascular diseases. However, its specific role in AD pathogenesis remains unexplored.

A novel anthropometric method to accurately evaluate tissue deformation.

Introduction: Biomechanical imaging through body scanning can provide a more comprehensive understanding of the soft tissue deformation exerted by compression sportswear, which is crucial in sports science research and functional sportswear design. However, displacement from movement affects alignment so accurately measuring tissue deformation with different wear conditions becomes challenging.

Methods: To address this issue, an analytical model is constructed to predict tissue deformation by using the Boussinesq solution, which is based on the elastic theory and stress function method.

Effects of electron beam irradiation pretreatment on the physicochemical components, sensory properties, and aroma compounds of mulberry leaf tea fermented with Eurotium cristatum.

Mulberry leaf tea is favored for flavor and health benefits. However, the market products sometimes exhibit astringency, insufficient aroma, and low nutritional content due to limitations in fermentation conditions. The study investigated the effects of electron beam irradiation (EBI) on the chemical composition, sensory quality, and aroma of fermented mulberry leaf tea.

Retinal parameter analysis and diagnostic potentail exploration in familial exudative vitreoretinopathy using ultra-widefield fundus photography.

Background: Familial Exudative Vitreoretinopathy (FEVR) is a monogenic disorder causing retinal vascular impairment, often underdiagnosed due to its variable presentation and reliance on invasive methods like fundus fluorescein angiography (FFA). Through the utilization of non-invasive ultra-widefield fundus photography (UWFFP), this research explored both the diagnostic potential of integrated retinal parameters for the detection of FEVR, and their characteristic changes during the early stage progression.

Methods: Retinal parameters were systematically extracted and quantified from UWFFP of 114 FEVR patients and 114 matched controls using the EVision AI cloud platform.

Role and mechanism of piR-0228 targeting RIPK1 to regulate vascular remodeling and aortic dissection.

The diagnosis and management of aortic dissection (AD), a critical cardiovascular disease (CVD), remains significant challenges in clinical practice. PIWI-interacting RNAs (piRNAs), a newly discovered class of non-coding small RNAs, play key regulatory role in various CVDs. However, the mechanism of their action in AD remains unclear.

Nitrogen limitation causes a seismic shift in redox state and phosphorylation of proteins implicated in carbon flux and lipidome remodeling in Rhodotorula toruloides.

Background: Oleaginous yeast are prodigious producers of oleochemicals, offering alternative and secure sources for applications in foodstuff, skincare, biofuels, and bioplastics. Nitrogen starvation is the primary strategy used to induce oil accumulation in oleaginous yeast as part of a global stress response. While research has demonstrated that post-translational modifications (PTMs), including phosphorylation and protein cysteine thiol oxidation (redox PTMs), are involved in signaling pathways that regulate stress responses in metazoa and algae, their role in oleaginous yeast remain understudied and unexplored.

Irisin regulates integrin αvβ5/FAK/ERK to inhibit neutrophil extracellular traps formation and reduce pancreatic beta-cells pyroptosis in type 2 diabetes mellitus.

Background: Dysregulation of neutrophil extracellular traps (NETs), through overproduction or poor clearance, can lead to tissue damage and is linked to inflammatory conditions like type 2 diabetes mellitus (T2DM). Irisin, a hormone believed to modulate energy metabolism and enhance insulin sensitivity, holds promise as a potential treatment for T2DM. This study aims to investigate the role of Irisin in alleviating β-cell pyroptosis by inhibiting NETs formation and elucidating the underlying molecular mechanisms.

LncRNA 91234.1 targets PRMT1/ASCL4/GPX4 axis to regulate formaldehyde-induced cardiomyocyte ferroptosis and congenital heart disease.

Congenital heart disease (CHD) are the predominant cause of neonatal mortality and the most prevalent congenital malformation. Additionally, CHD can impact cardiovascular health in adulthood and exacerbate cardiovascular conditions in the elderly. Emerging studies indicate that both genetic predispositions and environmental factors may contribute to the development of this condition.

MRI-based texture analysis for the evaluation of the response to neoadjuvant chemoimmunotherapy in locally advanced head and neck squamous cell carcinoma.

Background: Neoadjuvant chemoimmunotherapy (NCIT) has emerged as a promising approach for patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC). However, the risk of immune-related adverse events (irAEs) should be taken seriously. And subsequent treatment strategies are determined on the basis of the neoadjuvant effect.

KIF11 promotes AML progression, and its inhibition by SB-743921 suppresses disease advancement through mitotic G2/M phase arrest.

Acute myeloid leukaemia (AML) is a heterogeneous haematological malignancy. Despite advances in therapy, its prognosis remains poor with limited improvement in survival. KIF11 (Eg5), a kinesin motor protein essential for spindle dynamics during mitosis, interacts with microtubules.

Supramolecular nanocrystalline membranes with well-aligned subnanochannels for enhanced reverse osmosis desalination.

Thin-film composite membranes are integral to the reverse osmosis (RO) process, effectively converting seawater and brackish water into potable water. While significant strides have been made in improving water permeability and salt rejection, there has been a corresponding lag in enhancing chlorine resistance and boron rejection. This study presents a suprasmolecular nanocrystalline membrane (SNM) with abundant subnanometer channels created through precisely assembled and well-oriented tetra-oligomer chains, enhanced by interfacial hydrogen bonding under nanoconfined space.

[Advance in genetics research on Gastrointestinal polyposis syndromes].

Gastrointestinal polyposis syndromes are primarily characterized by multiple polyps in the gastrointestinal tract, with their pathogenic mechanisms largely related to genetic factors and involving multiple signaling pathways. Adenomatous polyposis syndromes are mainly associated with APC gene variants, while some cases may arise from MUTYH gene variants. Peutz-Jeghers syndrome is primarily linked to STK11 gene variants.

Liraglutide use in pediatric type 2 familial partial lipodystrophy caused by LMNA mutation: a case report.

Background: Type 2 familial partial lipodystrophy (FPLD2), or Dunnigan syndrome, is a rare genetic disorder characterized by selective subcutaneous fat loss, metabolic complications, and insulin resistance due to LMNA gene mutations. This case report describes the clinical presentation and treatment of a Chinese family with FPLD2, highlighting liraglutide's role in glycemic and lipid control.

Case Presentation: The index patient is a 14-year-old girl, presenting with fat accumulation in the neck, loss of subcutaneous fat on the face, arms, legs, and trunk, and metabolic complications including diabetes mellitus with insulin resistance, hepatomegaly, and dyslipidemia.

Donor Human Milk Bacterial Microbiota Composition is Shaped by Breastfeeding Mode.

Background: Human milk contains a diverse community of microbes. The composition of this microbiota varies across different regions, and there is ongoing debate regarding its determinants.

Research Aim: To profile the bacterial composition of donor human milk samples from Shanghai, China, and to explore the factors influencing its composition.

Maternal Discharge Preparation Needs for Preterm Infants With Less Than 32 Weeks of Gestation: A Qualitative Study.

Aims: To explore mothers' specific discharge preparation needs for preterm infants born before 32 gestational weeks, providing a foundation for developing effective discharge education programmes.

Design: A qualitative descriptive design.

Methods: A semi-structured interview was conducted of 16 mothers of preterm infants less than 32 weeks gestation within 1 week post-discharge in March-June 2024.

Vacancy-Rich S-Scheme Core-Shell-Like ZnO@ZnS for Visible-Light Photocatalytic Degradation of Oxytetracycline and Hydrogen Production in Seawater.

Reducing seawater antibiotic pollution while producing hydrogen is a major challenge crucial for environmental protection and easing energy shortages. In this work, an S-scheme heterojunction ZnO@ZnS with a large number of vacancies [including zinc, sulfur, and oxygen vacancies (V, V, V)] was prepared in situ using metal-ligand coordination polymers as templates. The characterization results demonstrated that ZnS, synthesized using a metal-ligand template agent, progressively develops into a core-shell heterojunction semiconductor wherein it serves as the core with ZnO functioning as the shell, depending on varying calcination temperatures.

Dynamic Shielding of Arsenic-loaded Transferrin with Calcium Manganese Carbonate Potentiates Antitumor Effects via Self-enhanced Synergistic Therapy.

Arsenic trioxide is a frontline drug for leukemia treatment; however, its successful application in solid tumors has not yet been fully achieved. Transferrin is an endogenous protein containing iron-binding sites that can be used for loading arsenic for targeted delivery to solid tumors. However, the nonspecific expression of the transferrin receptor greatly limits transferrin-based nanomedicines.

Proteome-wide characterization of PTMs reveals host cell responses to viral infection and identifies putative antiviral drug targets.

Post-translational modifications (PTMs) are biochemical modifications that can significantly alter protein structure, function, stability, localization, and interactions with other molecules, thereby activating or inactivating intracellular processes. A growing body of research has begun to highlight the role of PTMs, including phosphorylation, ubiquitination, acetylation, and redox modifications, during virus-host interactions. Collectively, these PTMs regulate key steps in mounting the host immune response and control critical host pathways required for productive viral replication.