Analysis of Oral Microbiota in Herpetiform Aphthous Ulcers Patients.

Purpose: To examine the microbiota in the oral mucosa and saliva of patients with herpetiform aphthous ulcers (HAU) and compare it with healthy individuals.

Materials And Methods: 16S rRNA sequencing was employed to analyze the oral mucosal bacterial communities of healthy individuals (healthy controls) and HAU patients (ulcerated sites, healthy sites, and healed ulcer sites).

Results: Species richness in patients with HAU was statistically significantly lower than in healthy individuals.

Core Transcriptional Regulatory Circuit-Regulated IGF2BP3 Stabilizes E2F2 mRNA via m6A Modification in Neuroblastoma.

Neuroblastoma (NB) is a pediatric tumor with diverse outcomes and unknown underlying mechanisms. The core transcriptional regulatory circuit (CRC) and N6-methyladenosine (m6A) are key factors that control cell identity and fate. IGF2BP3 is an m6A reader protein that is transcriptionally regulated by CRC transcription factors (TFs).

Rare mycetoma caused by species, a mangrove-derived dematiaceous fungus in a kidney transplant patient.

We report a rare case of mycetoma after renal transplant in a patient with distant exposure to mangroves during disaster relief efforts in the Caribbean. Histopathology and fungal culture from the skin biopsy revealed findings consistent with chronic mycetoma caused by a dematiaceous mold. Next Generation Sequencing (NGS) identified the organism as closely related to , a fungus originally isolated from mangroves.

Outbreak of New Delhi metallo-β-lactamase carbapenemase-producing Pseudomonas aeruginosa infections in a Southern California hospital.

Background: Carbapenemase-producing carbapenem-resistant Pseudomonas aeruginosa (CP-CRPA) is a major public health threat due to limited treatment options and high transmissibility. Though widespread globally, few instances of locally transmitted New Delhi metallo-β-lactamase (NDM)-producing CP-CRPA have been documented in the United States. Here, a cluster of locally transmitted NDM-1 CP-CRPA infections in Southern California is reported.

Hui-Jing technique for one-stage severe primary hypospadias repair: Long-term analysis compared to the Cloutier/ Bracka technique.

Purpose: This study aims to evaluate the long-term outcomes of the Hui-Jing technique (lingual mucosa combined with longitudinal preputial island flap onlay urethroplasty and tubularized incised plate glansplasty), a one-stage surgical technique developed by Dr. Huixia Zhou and Dr. Weijing Ye for the severe primary hypospadias repair, focusing on evaluating complication rates, functional success, and cosmetic satisfaction with comparisons to the two-stage Bracka technique.

Optimized deep learning model for diagnosing tonsil and adenoid hypertrophy through X-rays.

Objective: To explore the application of a deep learning model based on lateral nasopharyngeal X-rays in diagnosing tonsillar and adenoid hypertrophy.

Methods: A retrospective study was conducted using DICOM images of lateral nasopharyngeal X-rays from pediatric outpatients aged 2-12 at our hospital from July 2014 to July 2024. The study included patients exhibiting varying degrees of respiratory obstruction symptoms (disease group).

Bartonella quintana Endocarditis and Pauci-Immune Glomerulonephritis in Patient with Known Risk Factors, USA, 2024.

We report an unexpected case of Bartonella quintana endocarditis and pauci-immune glomerulonephritis in a patient without known risk factors in Los Angeles, California, USA, highlighting that infection can occur in the general population without a history of homelessness. The diagnosis was challenging and made definitively through extensive diagnostic tests and multidisciplinary investigation.

Glaesserella parasuis induces tissue transglutaminase-mediated fibrinogen crosslinking through NF-κB activation.

Glaesserella parasuis (GPS) is the causative agent of Glässer's disease, leading to significant economic losses in the global swine industry. During post-mortem inspection, the main observation in pigs affected by Glässer's disease is the presence of serofibrinous or fibrinopurulent exudate on the mucosal surface. Nevertheless, the mechanism by which fibrinogen is converted into a fibrin clot during Glässer's disease is not fully understood.

Comparison of Robot-assisted Laparoscopic Extravesical Ureteral Reimplantation for Primary Vesicoureteral Reflux in Infants Under One Year of Age and Older Children.

Purpose: To assess the surgical outcomes of Robot-Assisted Laparoscopic Extravesical Ureteral Reimplantation (RALUR-EV) in infants under one year of age with primary vesicoureteral reflux (VUR) as compared to older children.

Materials And Methods: A retrospective analysis was conducted on 48 children with VUR who underwent unilateral or bilateral RALUR-EV between June 2018 and December 2022. Patients were divided into two groups: Group A (25 infants under one year) and Group B (23 children over one year).

Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations.

Background: High myopia (HM), characterized by a severe myopic refractive error, stands as a leading cause of visual impairment and blindness globally. HM is a multifactorial ocular disease that presents high genetic heterogeneity. Employing a genetic risk score (GRS) is useful for capturing genetic susceptibility to HM.

Advancements and Future Prospects in Ocean Wave Energy Harvesting Technology Based on Micro-Energy Technology.

Marine wave energy exhibits significant potential as a renewable resource due to its substantial energy storage capacity and high energy density. However, conventional wave power generation technologies often suffer from drawbacks such as high maintenance costs, cumbersome structures, and suboptimal conversion efficiencies, thereby limiting their potential. The wave power generation technologies based on micro-energy technology have emerged as promising new approaches in recent years, owing to their inherent advantages of cost-effectiveness, simplistic structure, and ease of manufacturing.

Butyricimonas paravirosa bacteremia associated with acute terminal ileitis: Case report and literature review.

We present the first described case of bacteremia due to Butyricimonas paravirosa, a commensal gram-negative anaerobic bacterium identified by whole-genome sequencing in an elderly patient with acute terminal ileitis, who was successfully treated with ceftriaxone and metronidazole. We reviewed eleven previous cases of infection due to other Butyricimonas spp, which can cause a range of diseases but may be treated conservatively with a short antimicrobial course in the appropriate clinical setting. Additionally, while most Butyricimonas spp are susceptible to empiric anaerobic therapy, drug resistance has been reported in some cases.

The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma.

Background: Osteosarcoma (OS) is one of the most common primary malignant tumors of bone in children, which develops from osteoblasts and typically occurs during the rapid growth phase of the bone. Recently, Super-Enhancers(SEs)have been reported to play a crucial role in osteosarcoma growth and metastasis. Therefore, there is an urgent need to identify specific targeted inhibitors of SEs to assist clinical therapy.

Targeting RBM39 through indisulam induced mis-splicing of mRNA to exert anti-cancer effects in T-cell acute lymphoblastic leukemia.

Background: Despite the use of targeted therapeutic approaches, T-cell acute lymphoblastic leukemia (T-ALL) is still associated with a high incidence of complications and a poor prognosis. Indisulam (also known as E7070), a newly identified molecular glue compound, has demonstrated increased therapeutic efficacy in several types of cancer through the rapid degradation of RBM39. This study aimed to evaluate the therapeutic potential of indisulam in T-ALL, elucidate its underlying mechanisms and explore the role of the RBM39 gene.

Enhancing surgical decision-making in NEC with ResNet18: a deep learning approach to predict the need for surgery through x-ray image analysis.

Background: Necrotizing enterocolitis (NEC) is a severe neonatal intestinal disease, often occurring in preterm infants following the administration of hyperosmolar formula. It is one of the leading causes of neonatal mortality in the NICU, and currently, there are no clear standards for surgical intervention, which typically depends on the joint discretion of surgeons and neonatologists. In recent years, deep learning has been extensively applied in areas such as image segmentation, fracture and pneumonia classification, drug development, and pathological diagnosis.

Super-enhancer-driven IRF2BP2 enhances ALK activity and promotes neuroblastoma cell proliferation.

Background: Super-enhancers (SEs) typically govern the expression of critical oncogenes and play a fundamental role in the initiation and progression of cancer. Focusing on genes that are abnormally regulated by SE in cancer may be a new strategy for understanding pathogenesis. In the context of this investigation, we have identified a previously unreported SE-driven gene IRF2BP2 in neuroblastoma (NB).

Ag Modified SnS Monolayer as a Potential Sensing Material for CFN Decompositions: A Density Functional Theory Study.

As the field of 2D materials rapidly evolves, substances such as graphene, metal dichalcogenides, MXenes, and MBenes have garnered extensive attention from scholars in the gas sensing domain due to their unique and superior properties. Based on first-principles calculations, this work explored the adsorption characteristics of both intrinsic and silver (Ag) doped tin disulfide (SnS) toward the decomposition components of the insulating medium CFN (namely, CF, CF, and COF), encompassing the adsorption energy, charge transfer, density of state (DOS), band structure, and adsorption stability. The results indicated that Ag-doped SnS exhibited an effective and stable adsorption for CF and COF, whereas its adsorption for CF was comparatively weaker.

AMPK signaling pathway regulated the expression of the ApoA1 gene via the transcription factor Egr1 during G. parasuis stimulation.

Glaesserella parasuis (G. parasuis) is the causative agent of porcine Glässer's disease, resulting in high mortality rates in pigs due to excessive inflammation-induced tissue damage. Previous studies investigating the protective effects of G.

The effect of first-wave COVID-19 restrictions on HCV testing in Alberta, Canada: A trend analysis from 2019 to 2022.

Background: Prior to the COVID-19 pandemic, Alberta was on track to meet national HCV elimination targets by 2030. However, it is unclear how the pandemic has affected progress. Here, we aim to assess the impact of first-wave COVID-19 restrictions on Alberta HCV testing trends.