Long-term outcomes of robotic-assisted laparoscopic pyeloplasty for unilateral ureteropelvic junction obstruction in infants.

Purpose: This study aims to assess the long-term outcomes of robotic-assisted laparoscopic pyeloplasty (RALP) for the treatment of ureteropelvic junction obstruction (UPJO) in infants under 3 months of age, and to compare these outcomes with those of infants aged 3-12 months.

Materials And Methods: A retrospective cohort analysis was performed on 226 infants who underwent RALP between March 2017 and December 2021. Patients were stratified into two groups: Group A (aged <3 months, n = 114) and Group B (aged 3-12 months, n = 112).

Robot-assisted pedicled colonic flap pyeloplasty for the treatment of complicated ureteropelvic junction obstruction: technique and outcomes from a single center.

Background: The treatment of complicated ureteropelvic junction obstruction (UPJO) is challenging. We introduce robot-assisted pedicled colonic flap pyeloplasty (RA-PCFP) for the treatment of complicated UPJO.

Methods: Fourteen patients (eleven females, three males) who underwent RA-PCFP between December 2020 and November 2023 at our center were included.

Comparison of robot-assisted and laparoscopic pyeloplasty with flexible ureteroscopy for managing concomitant ureteropelvic junction obstruction and renal calculi in children.

Background: Ureteropelvic junction obstruction (UPJO) with renal calculi is a common cause of renal impairment in pediatric patients. Surgical intervention, including laparoscopic pyeloplasty (LP) and robot-assisted laparoscopic pyeloplasty (RALP) combined with flexible ureteroscopy, are frequently employed to address both the obstruction and stones. This study aims to compare the safety and efficacy of RALP and LP combined with flexible ureteroscopy in treating pediatric UPJO with renal calculi.

Succinate Facilitates CD4 T Cell Infiltration and CCL1 Production to Promote Myofibroblast Activation and Renal Fibrosis in UUO Mice.

Aim: Obstructive nephropathy is a leading cause of kidney injury and fibrosis, which is always associated with metabolic aberrations and chronic inflammation. Succinate is an important intermediate metabolite involved in inflammatory responses and various diseases. However, the precise pathogenic mechanisms of succinate in obstructive nephropathy remain to be elucidated.

Impact of three urethral stent types on outcomes following one-stage hypospadias repair: a multi-center retrospective controlled study.

Purpose: To evaluate whether the double cannula urethral stents (DCUS) are superior to traditional silicone Foley catheters (FC) or gastric tubes (GT) in hypospadias repair to decrease complications.

Patients And Methods: This retrospective cohort study included 224 patients with hypospadias who underwent placement with DCUS (group DCUS), FC (group FC), and GT (group GT) after hypospadias repair between August 2019 and June 2023. The occurrence of early and late complications was assessed.

Hui-Jing technique for one-stage severe primary hypospadias repair: Long-term analysis compared to the Cloutier/ Bracka technique.

Purpose: This study aims to evaluate the long-term outcomes of the Hui-Jing technique (lingual mucosa combined with longitudinal preputial island flap onlay urethroplasty and tubularized incised plate glansplasty), a one-stage surgical technique developed by Dr. Huixia Zhou and Dr. Weijing Ye for the severe primary hypospadias repair, focusing on evaluating complication rates, functional success, and cosmetic satisfaction with comparisons to the two-stage Bracka technique.

Long-term Outcomes of Multi-institutional Minimally Invasive Appendiceal Onlay Ureteroplasty for Managing Complex Proximal Ureteral Strictures in Pediatric Patients.

Purpose: We report the long-term outcomes of laparoscopic and robotic-assisted appendiceal onlay ureteroplasty (AOU) for complex proximal ureteral (CPU) strictures in children across multiple institutions.

Methods: Retrospective review of patients who underwent laparoscopic or robotic AOU for CPU between 2010 and 2020. Patient characteristics, perioperative surgical data, and follow-up data are described.

Neutrophil extracellular traps license macrophage production of chemokines to facilitate CD8+ T cell infiltration in obstruction-induced renal fibrosis.

Renal fibrosis is a common mechanism leading to kidney failure in chronic kidney diseases (CKDs), including obstructive nephropathy (ON). Dysregulated inflammation is central to the development of renal fibrosis, but how local immune cells within the tissue microenvironment integrate and coordinate to drive this condition remains largely unknown. Herein, we documented that neutrophils were abundantly recruited and expelled neutrophil extracellular traps (NETs) in human and mouse fibrotic kidneys.

Comparison of Robot-assisted Laparoscopic Extravesical Ureteral Reimplantation for Primary Vesicoureteral Reflux in Infants Under One Year of Age and Older Children.

Purpose: To assess the surgical outcomes of Robot-Assisted Laparoscopic Extravesical Ureteral Reimplantation (RALUR-EV) in infants under one year of age with primary vesicoureteral reflux (VUR) as compared to older children.

Materials And Methods: A retrospective analysis was conducted on 48 children with VUR who underwent unilateral or bilateral RALUR-EV between June 2018 and December 2022. Patients were divided into two groups: Group A (25 infants under one year) and Group B (23 children over one year).

Identification and optimization of relevant factors for chronic kidney disease in abdominal obesity patients by machine learning methods: insights from NHANES 2005-2018.

Background: The intake of dietary antioxidants and glycolipid metabolism are closely related to chronic kidney disease (CKD), particularly among individuals with abdominal obesity. Nevertheless, the cumulative effect of multiple comorbid risk factors on the progression and complications of CKD remains inadequately characterized.

Methods: This study analyzed data from the National Health and Nutrition Examination Survey (NHANES) dat abase (2005-2018), to examine potential factors related to CKD, including glycolipid metabolism, dietary antioxidant intake, and pertinent medical history.

Modified robotic-assisted laparoscopic pyeloplasty in children for ureteropelvic junction obstruction with long proximal ureteral stricture: The "double-flap" technique.

Objective: The objective of this study is to introduce a novel technique of robotic-assisted laparoscopic pyeloplasty (RALP) for ureteropelvic junction obstruction (UPJO) with long proximal ureteral stricture in children.

Materials And Methods: Clinical information on patients who underwent a modified RALP between July 2018 and May 2019 in our center was collected retrospectively. Our surgical modifications mainly include "double-flap" tailoring of the renal pelvis and anastomosis of spatulate ureter with the double-flap.

Modified technique for robot-assisted laparoscopic infantile ureteral reimplantation for obstructive megaureter.

Purpose: To describe a novel modification of technique to improve efficacy of robot-assisted laparoscopic extravesical ureteral reimplantation (RALUR-EV) in infants.

Materials And Methods: Between April 2017 and July 2019, sixteen infants with primary obstructive megaureter (POM) (Age range: 4-12 months) underwent robot-assisted ureteral reimplantation were reviewed in this series. In addition to the conventional Lich-Gregoir technique, the detrusor tunnel has been extended to the mobilized anterior bladder wall to guarantee sufficient tunnel length/ureter diameter ratio and avoid ureteral angulation.

Robot-Assisted Laparoscopic Management of Bladder/Prostate Rhabdomyosarcoma in Children: Initial Series and 1-Year Outcomes.

To present our preliminary experiences of robot-assisted laparoscopic radical or partial cystectomy for bladder/prostate rhabdomyosarcoma (B/P RMS) in children. A retrospective study was conducted with children who underwent robot-assisted laparoscopic surgery for B/P RMS between July 2018 and March 2020 under the approval of IRB of our center. The patient characteristics, tumor position, perioperative information, short time oncologic survival outcomes, and urinary function were recorded and evaluated.

Early Robotic-Assisted Laparoscopic Pyeloplasty for Infants Under 3 Months With Severe Ureteropelvic Junction Obstruction.

To present our primary experience of robotic-assisted laparoscopic pyeloplasty (RALP) for severe ureteropelvis junction obstruction (UPJO) infants under 3 months. We performed a retrospective study of 9 infants under 3 months who underwent RALP for severe UPJO between April 2017 and March 2019 in our center. The severe UPJO was defined as infants with severe hydronephrosis (Society of Fetal Urology grades III or IV, anteroposterior diameter >3 cm or split renal function <40% or T 1/2 >20 min) involving bilateral, solitary kidney, or contralateral renal hypoplasia UPJO at the same time.

Robot-assisted Laparoscopic Radical Cystectomy and Sigmoid Orthotopic Neobladder Reconstruction for a Bladder Rhabdomyosarcoma Child: Case Report and Literature Review.

A six-month-old child was admitted into our center with complaint of hydronephrosis in June 2018. He was diagnosed as embryoid rhabdomyosarcoma after cystoscopy with biopsy. After 22 Gy radiotherapy and 4 cycles chemotherapy (VAC), robot-assisted radical cystectomy was performed.

Abdominal wall elasticity of children during pneumoperitoneum.

Objective: Laparoscopic surgery in children is often hampered by limited working space. This is partially compensated by stretching the child's abdominal wall. The volume of space that can be gained and changes to abdominal wall elasticity with respect to age are unknown.

Laparoscopic Yang-Monti Ureteral Reconstruction in Children.

Objective: To investigate the clinical outcome of surgical treatment for long ureteral defect in children, we evaluated our experience of managing 6 children with the long defect utilizing laparoscopic ureteral reconstruction technique using Yang-Monti technique.

Materials And Methods: Six children with long ureteral defect who underwent laparoscopic Yang-Monti ureteral reconstruction between January 2013 and March 2016 were reviewed. The diagnosis and outcomes of long ureteral defects were reviewed based on clinical and imaging data.

Transumbilical multi-port laparoscopic pyeloplasty versus transumbilical single-site laparoscopic pyeloplasty for ureteropelvic junction obstruction in children: A retrospectively comparative study.

Introduction: Laparoscopic pyeloplasty has achieved good cosmetic and functional outcomes. Both transumbilical single-site and transumbilical multi-port approaches are currently being used. No comparison of transumbilical single-site laparoscopic pyeloplasty (TSLP) and transumbilical multi-port laparoscopic pyeloplasty (TMLP) has been reported in the literature.

Comparison of Laparoscopic Approaches for Dismembered Pyeloplasty in Children With Ureteropelvic Junction Obstruction: Critical Analysis of 11-Year Experiences in a Single Surgeon.

Objective: The choice of different laparoscopic approaches of laparoscopic pyeloplasty (LP) in children remains controversial. We present a comparison of different approaches of LP in children and a critical analysis of 11-year experiences in a single surgeon.

Materials And Methods: There were 1750 patients (1889 sides) who underwent LP between 2003 and 2014 reviewed.

A modified technique of paraumbilical three-port laparoscopic dismembered pyeloplasty for infants and children.

Background: Common causes of complications of laparoscopic pyeloplasty in children include anastomotic stricture, poor drainage due to high ureteropelvic anastomosis, and torsion of ureter. Herewith, we described our modified technique of paraumbilical three-port laparoscopic dismembered pyeloplasty (PTLDP) to minimize these complications.

Patients And Methods: Data from 62 patients (age: 1-180 months, median: 12 months) with ureteropelvic junction obstruction (UPJO) who underwent pyeloplasty using our modified technique of PTLDP between February 2014 and September 2014 at our institution were reviewed.

Effects of alginate on frozen-thawed boar spermatozoa quality, lipid peroxidation and antioxidant enzymes activities.

Although alginate was reported to play an important role as free radical scavengers in vitro and could be used as sources of natural antioxidants, there was no study about the cryoprotective effects of alginate on boar spermatozoa freezing. The objective of this research was to evaluate the effects of different concentrations of alginate added to the freezing extenders on boar spermatozoa motility, plasma membrane integrity, acrosomal integrity, mitochondrial activities, lipid peroxidation and antioxidative enzymes activities (SOD and GSH-Px) after thawing. Alginate was added to the TCG extender to yield six different final concentrations: 0, 0.