Dual-responsive fluorescent sensors for the detection and discrimination of sulphur and nitrogen mustards.

Mustard agents, including sulphur mustard (SM) and nitrogen mustard (NM), are chemical warfare agents that can cause blistering of the skin and mucous membranes upon contact. Although SM and NM both have dermal effects, their medical management of systemic poisoning differs significantly. A rapid and simple method for detecting and discriminating between SM and NM would be greatly valuable.

How category frameworks shape the pre-activation of attentional templates: Evidence from high-resolution SSVEPs.

During visual search, when targets are defined by specific categories, category-based attentional templates (CATs) enhance search efficiency by being pre-activated and modulated by their underlying category frameworks, thereby facilitating the detection of target objects. Previous studies employing the Rapid Serial Probe Presentation (RSPP) paradigm (20 Hz sampling rate) lacked the temporal resolution to continuously track CAT pre-activation dynamics. To address this, we used steady-state visual evoked potentials (SSVEPs) to capture real-time dynamics of CAT pre-activation, improving temporal resolution by 50 times (from 50 ms to 1 ms), enabling the detection of previously inaccessible transient neural processes.

Application value of transparent-cap-assisted colonoscopy: A randomized clinical trial.

Colonoscopy provides limited protection against interval colorectal cancer. This study aims to investigate the application value of transparent-cap-assisted colonoscopy (CAC) regarding cecal intubation time and polyp detection rate. This prospective randomized controlled trial recruited 480 patients in our hospitals.

Dysfunction of Autophagy in Adipose Tissue Macrophages Regulated via FoxO1 in Obesity-Related Severe Acute Pancreatitis.

Adipose tissue macrophages (ATMs) play important roles in the progression of obesity-related severe acute pancreatitis (SAP). This study aimed to investigate the alterations of autophagic flux within ATMs, as well as the possible regulatory mechanisms. Obese mice were induced via high-fat diets.

Synergistic enhancement of PLA nanocomposites via functionalized CNTs and MOFs: Multifunctional improvements in mechanical strength, thermal stability, and biomedical compatibility.

In pursuit of a sustainable alternative to conventional petroleum-derived polymers, this study aims to enhance the comprehensive performance of polylactic acid (PLA). Despite its inherent biocompatibility and biodegradability, the intrinsic brittleness of PLA significantly restricts its broader applicability, particularly in the medical domain. To overcome this limitation, we utilized the Hummers method to functionalize the surface of carbon nanotubes (CNTs) with carboxylic acid groups, followed by a green and highly efficient solution-mixing approach to immobilize the modified CNTs onto the surface of HKUST-1, a metal-organic framework (MOF).

EFHD1: A Potential Prognostic Biomarker Related to Mitochondrial Function and Aging in Atherosclerosis Plaque.

Introduction: Atherosclerosis (AS) is prevalent among the elderly population and poses a significant global health burden. However, the precise underlying mechanisms linking aging and mitochondrial dysfunction in AS remain unclear.

Methods: Through comprehensive utilization of databases including the Gene Expression Omnibus (GEO), MitoCarta, Molecular Signatures Database (MSigDB), and Human Aging Genomic Resources (HAGR), we employed various bioinformatics methods to explore the possible function of EF-hand domain family member D1 (EFHD1).

Transcriptome sequencing and bioinformatics analysis of hippocampus in aged rats with cognitive decline.

Age-related cognitive decline poses significant challenges to healthy aging, yet its underlying molecular mechanisms remain poorly understood. In this study, we employed Morris Water Maze and hippocampal transcriptome analysis to investigate age-related cognitive decline in a rat model. Aged rats (RA) exhibited significant spatial memory deficits compared to young rats (RY).

The Lnc-Gm20716/miR-20b-5p/ULK1 axis regulates HDM-induced endoplasmic reticulum stress and Golgi fragmentation in mouse bronchial epithelial cells.

Asthma is a chronic inflammatory disease affecting bronchi, and it is a global challenge to find an effective treatment for this disease. Lnc-Gm20716 is significantly expressed in cases of bronchial epithelial cell injury. Furthermore, studies indicate that ULK1 is implicated in the development of inflammatory diseases.

China completes world's largest ground-based network for space weather monitoring.

The network can continuously track space weather from the Sun's surface to interplanetary space and Earth's atmosphere.

The prognostic value of the triglyceride-glucose index in predicting recurrence of acute pancreatitis: a retrospective cohort study.

Background: Investigating the risk of acute pancreatitis (AP) recurrence is crucial because it affects public health and medical resources. The triglyceride-glucose index (TyG-i) is recognized as a reliable marker of insulin resistance (IR), which occurs after an AP attack. However, the predictive value of the TyG-i during the first AP for subsequent recurrence remains unclear.

Community burden of acute respiratory infections in Shanghai, a longitudinal cohort study in respiratory pathogens, China, 2024-2027.

Purpose: We are conducting a longitudinal cohort study-the Community Burden of Acute Respiratory Infections in Shanghai-to assess age-stratified incidence, healthcare utilisation and risk factors of influenza virus, respiratory syncytial virus (RSV) and SARS-CoV-2 associated acute respiratory infections (ARIs) in Shanghai, China.

Participants: Study participants were enrolled by family doctors in all 47 community health services centres in Pudong New Area District, Shanghai, China. All permanent residents 6 months and older living in Pudong for at least 6 months were eligible for enrolment; residents who planned to leave Pudong for more than 1 month in the first study year were excluded.

HER2-targeted PET/CT imaging provides potential biomarkers for differentiating HER2-zero, -low, and -positive breast cancer.

Purpose: Human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugates (ADCs) in breast cancer is progressing rapidly, asking for precise categorization of HER2 expression. Our aim was to explore the HER2-affibody uptake characteristics in breast cancer and to find potential biomarkers for differentiating HER2 status, in comparison with F-FDG PET/CT.

Methods: In this prospective study conducted from May 2024 to Jan 2025, participants with newly diagnosed breast cancer underwent both Ga-HER2-affibody and F-FDG PET/CT examinations.

CD36 Induces Inflammation by Promoting Ferroptosis in Pancreas, Epididymal Adipose Tissue, and Adipose Tissue Macrophages in Obesity-Related Severe Acute Pancreatitis.

Severe acute pancreatitis (SAP) is mainly triggered by the abnormal activation of pancreatic enzymes. Obesity acts as an independent risk factor for SAP; however, the underlying mechanism has not been fully elucidated. In this study, SAP models were established in mice with normal and high-fat diets.

Dose-Effect Relationship of Hyperbaric Oxygen Therapy in Rats with Amnestic Mild Cognitive Impairment.

Introduction: Amnestic mild cognitive impairment (aMCI) represents an intermediate stage between normal aging and dementia. Hyperbaric oxygen (HBO) therapy has shown promise in enhancing brain oxygenation and promoting neural stem cell proliferation.

Methods: Eighty SD male adult rats were randomly divided into control group, amnestic mild cognitive impairment group (aMCI group), and hyperbaric oxygen group (HBO group).

Demethylase FTO mediates m6A modification of ENST00000619282 to promote apoptosis escape in rheumatoid arthritis and the intervention effect of Xinfeng Capsule.

Introduction: The pathological mechanisms of rheumatoid arthritis (RA) are closely associated with the apoptosis escape of fibroblast-like synoviocytes (FLS). The m6A modification of long non-coding RNAs (lncRNAs) plays a critical regulatory role in RA pathogenesis. Xinfeng Capsule (XFC), a clinically effective traditional Chinese medicine formulation, has been shown to alleviate RA by inhibiting FLS apoptosis escape.

Acute Pain Management with Ultrasound-Guided Erector Spinae Plane Block and Serratus Anterior Plane Block in Patients Undergoing Coronary Artery Bypass via Mini-thoracotomy: A Randomized Controlled Trial.

Objective: This study was designed to examine the analgesic efficacy of erector spinae plane (ESP) block or combined ESP and superficial serratus anterior plane (SAP) block in patients undergoing elective coronary artery bypass via mini-thoracotomy.

Design: Randomized controlled study.

Setting: Operating room, intensive care unit, and ward.

Mediating and moderating roles of individual resilience, caring ability and social support: a cross-sectional study on the association between family resilience and caregiving burden among primary family caregivers of cancer patients in China.

Objectives: This study aimed to evaluate the caregiving burden among primary caregivers of cancer patients, clarify the relationship between family resilience and caregiving burden, and explore the mediation and moderation effects.

Design: A cross-sectional study design was used.

Setting: The study was conducted at a specialised tumour hospital in Harbin, China.

MGST1 Protects Pancreatic Ductal Cells from Inflammatory Damage in Acute Pancreatitis by Inhibiting Ferroptosis: Bioinformatics Analysis with Experimental Validation.

Numerous animal experiments have implicated ferroptosis in the pathogenesis of acute pancreatitis (AP). Nonetheless, due to sampling constraints, the precise role of ferroptosis in the human body during AP remains elusive. Method: Peripheral blood sequencing data of patients with acute pancreatitis (GSE194331) were obtained from the Gene Expression Omnibus (GEO) database.

Inhibition of Hippocampal Neuronal Ferroptosis by Liproxstatin-1 Improves Learning and Memory Function in Aged Mice with Perioperative Neurocognitive Dysfunction.

Background: Perioperative neurocognitive disorders (PND) are common in elderly patients after surgery, leading to long-term cognitive decline and reduced quality of life. The mechanisms are unclear, but ferroptosis, a key cell death pathway, may be involved in the disruption of brain homeostasis during perioperative stress.

Methods: In this study, we used the SAM-P8 mouse model to simulate brain aging and observe isoflurane-induced ferroptosis.

A novel scheme for non-invasive drug delivery with a magnetically controlled drug delivering capsule endoscope.

There is a lack of effective means for precise drug delivery of gastrointestinal diseases. Herein we report a novel magnetically controlled drug delivering capsule endoscope (MDCE) to achieve precision drug delivery for gastrointestinal diseases. MDCE integrates a drug delivery system into conventional capsule endoscope.

Marein alleviates the development of atherosclerosis through targeting miR-126/lipoprotein-associated phospholipase A axis.

As a classical precious medicine, Coreopsis tinctoria Nutt. (C. tinctoria) is widely utilized for treatment of cardiometabolic diseases, while the important compound of C.

Disrupting of IGF2BP3-stabilized CLDN11 mRNA by TNF-α increases intestinal permeability in obesity-related severe acute pancreatitis.

Background: Obesity is a significant risk factor for severe acute pancreatitis (SAP) and is typically associated with increased intestinal permeability. Understanding the role of specific molecules can help reduce the risk of developing SAP. Claudin 11 (CLDN11), a member of the Claudin family, regulates the permeability of various internal barriers.

Clinical indicators for distinguishing septic arthritis from paediatric transient synovitis of the hip: a systematic review and meta-analysis.

Background: Septic arthritis (SA) of the hip joint is a serious infection that can result in irreversible complications. Distinguishing septic arthritis from transient synovitis, the most common cause of hip pain in children, is crucial for preventing severe outcomes. Existing research has primarily focused on identifying clinical signs and laboratory findings that indicate high-risk patients who may need invasive diagnostic procedures; however, results have been inconsistent.