Case Report: A case of occupational methyl iodide-induced encephalopathy.

Iodomethane is a commonly used methylation reagent in organic synthesis. However, reports of acute iodomethane poisoning are rare. Herein, we report the successful treatment of a patient with acute iodomethane poisoning.

Case Report: Third-degree atrioventricular block and respiratory failure caused by clozapine poisoning.

Background: This case report details the management of a patient who presented with third-degree atrioventricular block and rhabdomyolysis secondary to clozapine intoxication.

Case Summary: The patient was a 55-year-old man who took 100 tablets of clozapine and was transferred to our hospital from a lower-level hospital for treatment. Upon arrival at our hospital, he was in a coma and was assisted with mechanical ventilation.

Pulmonary artery hypertension-induced vascular structure analysis using label-free fluorescence lifetime imaging.

Pulmonary artery hypertension (PAH) is a chronic condition characterized by pathological remodeling of the vascular structures and poor clinical prognosis. Therefore, early interventional treatment is essential to slow disease progression, improve survival rates, and enhance quality of life. In animal models of pulmonary hypertension, analyzing the remodeling of the pulmonary artery tissue and collagen deposition usually involves computed tomography and tissue staining.

LAMP2-Mediated Autophagy Plasticity Deters Lysosomal Uptake of Platinum Ions to Reverse Cisplatin-Induced Glioma Progression in a Macrophage Dependent Manner.

Glioblastoma Multiforme (GBM) is the most common aggressive primary brain malignancy, with unsatisfactory overall survival. The role of lysosomal function, including autophagy, in GBM cisplatin resistance is critical for its continuous application in clinical practice. However, how they promote antitumor immunity in tumors and macrophages is poorly understood, and the underlying mechanisms are elusive.

Local optogenetic control of genome editing and tumorigenesis using wireless implantable optoelectronics.

Precise spatial regulation of site-specific DNA recombination (SSR) remains a challenge due to limited tunability of current platforms. Here, we present an optogenetic approach that overcome these limitations by employing engineered light-regulated recombinase E-LightR-Cre and tunable wireless implantable optoelectronic devices. E-LightR-Cre meets the key criteria for spatial regulation of SSR , showing no detectable activity in the dark, while demonstrating robust activation upon blue-light illumination.

Transcriptome sequencing and bioinformatics analysis of hippocampus in aged rats with cognitive decline.

Age-related cognitive decline poses significant challenges to healthy aging, yet its underlying molecular mechanisms remain poorly understood. In this study, we employed Morris Water Maze and hippocampal transcriptome analysis to investigate age-related cognitive decline in a rat model. Aged rats (RA) exhibited significant spatial memory deficits compared to young rats (RY).

Falls, Sleep Disorders and Cognitive Frailty in Hospitalized Older Adults with Hypertension:A Cross-Sectional Study.

Purpose: Falls and fall-related injuries are highly prevalent among older adults. Falls negatively impact functional independence and quality of life, and are associated with increased morbidity, mortality, and healthcare costs. Sleep disorders in the older adults are a common phenomenon, with sleep quality gradually deteriorating as age increases.

Factors Determining Kinesin Motors in a Predominant One-Head-Bound or Two-Heads-Bound State During Its Stepping Cycle.

At physiological or saturating ATP concentrations, some families of kinesin motors, such as kinesin-1 and kinesin-2, exhibit a predominant two-heads-bound (2HB) state during their stepping cycle on microtubules, while others, such as kinesin-3, exhibit a predominant one-head-bound (1HB) state. An interesting but unclear issue is what factors determine a kinesin motor in the predominant 1HB and 2HB states. Here, on the basis of the general chemomechanical pathway of the kinesin motors, a theory is given on fractions of 1HB and 2HB states.

Transcriptomic analysis reveals potential targets associated with hippocampus vulnerability in spatial cognitive dysfunctionof type 2 diabetes mellitus rats.

Background: Cognitive dysfunction is one of the major complications of T2DM.However, the precise molecular mechanism underlying this relationship remains unclear. Present study aimed to identify potential predictors of cognitive dysfunction associated with T2DM specifically within the hippocampus.

Towards global reaction feasibility and robustness prediction with high throughput data and bayesian deep learning.

Predicting organic reaction feasibility and robustness against environmental factors is challenging. We address this issue by integrating high throughput experimentation (HTE) and Bayesian deep learning. Diverging from existing HTE studies focused on niche chemical spaces, in this work, our in-house HTE platform conducted 11,669 distinct acid amine coupling reactions in 156 working hours, yielding the most extensive single HTE dataset at a volumetric scale for industrial delivery.

Metabolic products comparison in autotrophic and heterotrophic nitrogen removal: Insights into membrane fouling.

Metabolic products play a significant role in membrane fouling during biological wastewater treatment. However, the differences in metabolic product composition and membrane fouling potentials between autotrophic (anammox, AN) and heterotrophic (denitrification, DN) nitrogen removal systems are not well understood. This study cultivated autotrophic and heterotrophic nitrogen removal systems and analyzed the compositions of their metabolic products.

Co-colonization and Co-culture of Lung Alveoli Epithelial Stem Cells and Their Endothelial Niche Cells.

The maintenance of lung function relies crucially on the homeostatic replacement and post-injury regeneration of the lung alveolar epithelium (Hogan et al., Cell Stem Cell 15(2):123-138, 2014). Dysfunctions in these processes contribute to the pathogenesis of numerous lung diseases (Hogan et al.

Case report: Accidental aconitine poisoning caused by the inappropriate use of a type of Chinese patent medicine.

Background: Compound schizonepeta fumigation lotion is a type of Chinese patent medicine for external use. It has the effect of dispelling wind, eliminating dampness, reducing swelling, and relieving pain. Clinically, it is used for anal fumigation and treatment of external hemorrhoids, anal fissures, and other diseases.

Progress and Gaps in Respiratory Disease Research and Treatment: Highlights of the IRM 2024 in Shanghai.

Respiratory diseases pose a major public health challenge globally, necessitating collaborative efforts between basic researchers and clinicians for effective solutions. China, which is heavily impacted by a broad spectrum of respiratory disorders, has made notable strides in both research and clinical management of these diseases. The International Respiratory Medicine (IRM) meeting was organized with the primary goal of facilitating the exchange of recent research developments and promoting collaboration between Chinese and American scientists in both basic and clinical research fields.

A newly characterized CFSH gene in sex chromosomes is associated with growth instead of sexual development in the prawn Macrobrachium rosenbergii.

Crustacean female sex hormone (CFSH) was first identified as a female eyestalk-specific factor involved in the female sexual development in blue crab. Whether CFSH has conserved role in other decapod species remains to be clarified. In this study, we identified a CFSH gene (MrCFSH) in the Z and W chromosomes from the prawn Macrobrachium rosenbergii genome.

Case Report: Sudden death caused by methylene chloride poisoning.

Dichloromethane is widely used as an organic solvent in aerospace, electronics, and medicine. Cases of poisoning caused by this substance are rare. Recently, we successfully treated a patient with an acute dichloromethane poisoning.

Typical Heterotrophic and Autotrophic Nitrogen Removal Process Coupled with Membrane Bioreactor: Comparison of Fouling Behavior and Characterization.

There is limited research on the relationship between membrane fouling and microbial metabolites in the nitrogen removal process coupled with membrane bioreactors (MBRs). In this study, we compared anoxic-oxic (AO) and partial nitritation-anammox (PNA), which were selected as representative heterotrophic and autotrophic biological nitrogen removal-coupled MBR processes for their fouling behavior. At the same nitrogen loading rate of 100 mg/L and mixed liquor suspended solids (MLSS) concentration of 4000 mg/L, PNA-MBR exhibited more severe membrane fouling compared to AO-MBR, as evidenced by monitoring changes in transmembrane pressure (TMP).

Exploring transformation of dissolved organic matters and dissolved organic nitrogen in full-scale anammox wastewater treatment: Temperature and microbial roles.

Variation of dissolved organic matters (DOM) in mainstream anammox process has received limited attention. This study systematically characterized DOM and dissolved organic nitrogen (DON) in a full-scale mainstream anammox wastewater treatment plant (WWTP) using spectroscopy and Fourier transform-ion cyclotron resonance mass spectrometry. Roles of bacterial community structures related with temperatures on DOM and DON transformations were analyzed.

Determination and Characterization of Novel Papillomavirus and Parvovirus Associated with Mass Mortality of Chinese Tongue Sole () in China.

A massive mortality event concerning farmed Chinese tongue soles occurred in Tianjin, China, and the causative agent remains unknown. Here, a novel papillomavirus (CsPaV) and parvovirus (CsPV) were simultaneously isolated and identified from diseased fish via electron microscopy, virus isolation, genome sequencing, experimental challenges, and fluorescence in situ hybridization (FISH). Electron microscopy showed large numbers of virus particles present in the tissues of diseased fish.

Progress in Research on White Organic Light-Emitting Diodes Based on Ultrathin Emitting Layers.

White organic light-emitting diodes (WOLEDs) hold vast prospects in the fields of next-generation displays and solid-state lighting. Ultrathin emitting layers (UEMLs) have become a research hotspot because of their unique advantage. On the basis of simplifying the device structure and preparation process, they can achieve electroluminescent performance comparable to that of doped devices.

Characterization of perivascular alveolar epithelial stem cells and their niche in lung homeostasis and cancer.

Lung alveolar structure and function are maintained by subsets of alveolar type II stem cells (AT2s), but there is a need for characterization of these subsets and their associated niches. Here, we report a CD44 subpopulation of AT2s characterized by increased expression of genes that regulate immune signaling even during steady-state homeostasis. Disruption of one of these immune regulatory transcription factor STAT1 impaired the stem cell function of AT2s.

Suppression of lysosome metabolism-meditated GARP/TGF-β1 complexes specifically depletes regulatory T cells to inhibit breast cancer metastasis.

Regulatory T cells (Tregs) prevent autoimmunity and contribute to cancer progression. They exert contact-dependent inhibition of immune cells through the production of active transforming growth factor-β1 (TGF-β1). However, the absence of a specific surface marker makes inhibiting the production of active TGF-β1 to specifically deplete human Tregs but not other cell types a challenge.