The U-Shaped Relationship Between Serum Bicarbonate Levels and 28-Day Mortality in Patients With Sepsis: A Retrospective Cohort Study of MIMIC-IV Database.

Background: The elevated mortality rate associated with sepsis is a primary global health concern. The correlation between bicarbonate levels and mortality risk in sepsis remains unclear.

Method: A retrospective cohort study was conducted using data from the MIMIC-IV database, including 12 744 adult sepsis patients.

Relationship of the oxidative balance score with the risk of frailty and mortality in patients with asthma: a mediation analysis of NHANES.

Background: The high risk of frailty in patients with asthma is of increasing concern. Oxidative stress is an important mechanism in the pathogenesis of asthma, and the oxidative balance score (OBS) is a new index reflecting the state of oxidative homeostasis in the body that integrates dietary and physical activity factors. However, the relationship between the OBS and risk of frailty in patients with asthma remains unclear.