[Rapid screening of 111 pesticides and veterinary drugs in livestock and poultry meat by ultra performance liquid chromatography-quadrupole-time of flight mass spectrometry].

The consumption of agricultural products has increased in recent years owing to abundant production and improved living standards. Veterinary drugs are highly commercialized and widely used in animal husbandry to ensure animal health and production performance. Moreover， pesticides can become enriched during animal breeding， resulting in animal-derived food pollution through foraging， drinking， and environmental disinfection that can potentially damage human health.

Integrated acupuncture-pharmacotherapy for perimenopausal insomnia: a systematic review and meta-analysis.

Objective: Insomnia is a prevalent symptom among perimenopausal women, mainly attributed to estrogen-progesterone imbalance and neuropsychiatric factors, significantly impacting their quality of life. This article seeks to systematically evaluate the efficacy of integrated acupuncture-pharmacotherapy (AP) in treating perimenopausal insomnia (PMI), offering new insights for the management of insomnia in women.

Methods: Searches were conducted in 8 databases: PubMed, Web of Science (WOS), Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), China Biology Medicine Disc (CBM), Wanfang Academic Journal Full-text Database (Wanfang), and Chongqing VIP Database (CQVIP).

Precision treatment patterns and prognostic analysis: A retrospective study of small-cell lung cancer.

Introduction: In the past decade, the treatment methods for small-cell lung cancer (SCLC) have undergone advances and diversification. This study aimed to explore the treatment patterns of patients with SCLC and evaluate the efficacy of SCLC treatments in a real clinical setting.

Materials And Methods: This retrospective study included patients with limited-stage (LS) and extensive-stage (ES) SCLC who received treatment at Qingdao Central Hospital (Qingdao, China) from August 1, 2016, to April 30, 2023.

High-throughput discrimination of chlorogenic acid isomers in Lonicerae Japonicae Flos by U-shaped mobility analyzer-mass spectrometer.

Chlorogenic acids (CGAs), bioactive polyphenols with structural similarities and labile characteristics, pose analytical challenges for isomer differentiation. This study introduces a rapid U-shaped mobility analyzer-mass spectrometry (UMA-MS) method for high-resolution characterization of 13 CGAs, including five isomeric groups. The technique achieved complete separation within 2 s, with a total analysis time of 2 min per sample.

Molecular Genetic Basis of Reproductive Fitness in Tibetan Sheep on the Qinghai-Tibet Plateau.

: Complete environmental adaptation requires both survival and reproductive success. The hypoxic Qinghai-Tibet Plateau (>3000 m) challenges reproduction in indigenous species. Tibetan sheep, a key plateau-adapted breed, possess remarkable hypoxic tolerance, yet the genetic basis of their reproductive success remains poorly understood.

Influence of Hip Prosthesis Position on Postoperative Gait After Primary THA in Patients With Unilateral Femoral Head Necrosis.

To investigate the effect of hip component position on gait after primary THA in patients with unilateral femoral head necrosis. A total of 40 patients underwent primary THA due to unilateral femoral head osteonecrosis were enrolled in this study. The gait data and CT images of the hip and knee joints were obtained before and 3 months after operation.

Characterization of the Probiotic Properties and Cholesterol Metabolism Regulation Potential of Lactiplantibacillus plantarum QL-19.

Lactic acid bacteria (LAB) play a crucial role in food fermentation and human health. This study introduces Lactiplantibacillus plantarum (L. plantarum) QL-19, a novel probiotic strain isolated from traditional Hunan pickles and characterized via whole-genome sequencing and in vitro functional assays.

Fluorescence Imaging-Activated Microfluidic Particle Sorting Using Optical Tweezers.

The precise and efficient sorting of microscopic particles is critical in diverse fields, including biomedical diagnostics, drug development, and environmental monitoring. Fluorescence imaging-activated sorting refers to a strategy where fluorescence images are used to dynamically identify target particles and trigger selective manipulation for sorting purposes. In this study, we introduce a novel microfluidic particle sorting platform that combines optical tweezers with real-time fluorescence imaging for detection.

An improved multi-strategy equilibrium optimizer for surface marine vehicle path planning.

To address the limitations of the standard equilibrium optimizer (EO) in terms of insufficient optimization capability, multiple strategies are proposed to enhance its performance. These include a reverse equilibrium state pool, a non-uniform equilibrium state selection strategy, and an equilibrium state mutation strategy. The reverse equilibrium state pool is introduced to encourage candidate solutions with poorer positions to search in a wider search space, under such considerations the global search ability of the improved EO can be enhanced.

Inhibition of 12/15-LOX hyperactivation mitigates cognitive decline in a chronic cerebral hypoperfusion mouse model and in HO-induced HT22 cells: therapeutic effects of brozopine.

Brozopine (BZP), a novel inhibitor of 12/15-lipoxygenase (12/15-LOX), has previously demonstrated efficacy in mitigating inflammatory and oxidative stress-related injury in cerebral ischaemia models. This study aimed to evaluate the therapeutic potential and underlying mechanisms of BZP in a mouse model of vascular dementia induced by chronic cerebral hypoperfusion. BZP was administered for 28 days following right unilateral common carotid artery occlusion (rUCCAO) in mice.

Super-enhancer inhibitors THZ2 and JQ1 reverse temozolomide resistance in glioblastoma by suppressing SE-driven SOX9 expression.

Glioblastoma (GBM) is the most malignant grade of glioma, characterized by high recurrence, poor prognosis, and frequent chemoresistance. There is an urgent need for alternative treatment strategies. In this study, we evaluated the effects of THZ2, a covalent inhibitor targeting the super-enhancer (SE) component CDK7, on GBM growth and chemoresistance.

Lenvatinib-Associated Non-Tuberculous Mycobacterial Pulmonary Disease: A Case Report.

A 64-year-old man, with a history of hepatocellular carcinoma and long-term oral lenvatinib treatment, was hospitalised in our institution twice due to 'cough'. During hospitalisation, the patient underwent multiple bronchoscopies, with lavage fluid sent for pathogen testing, which returned negative results. Finally, was detected via next-generation sequencing (NGS).

Impact of chest computed tomography-determined low skeletal muscle mass on the survival of patients with acute heart failure.

Background: Computed tomography (CT)-determined low skeletal muscle mass (SMM) has been reported to be associated with poor clinical outcomes in various diseases; however, limited information is available regarding patients with heart failure (HF). Our research aimed to investigate the prognostic significance of low SMM assessed by chest CT scans in hospitalized patients with acute heart failure (AHF).

Methods: Skeletal muscle index (SMI) was assessed using chest CT scans at the twelfth thoracic vertebra (T12) level, and sex-specific optimal cutoff values for T12 SMI were determined using the X-tile program based on all-cause mortality.

Spin excitations and flat electronic bands in a Cr-based kagome superconductor.

In the quest for topology- and correlation-driven quantum states, kagome lattice materials have garnered significant interest for their band structures, featuring flat bands (FBs) from the quantum destructive interference of the electronic wavefunction. Tuning an FB to the chemical potential could induce electronic instabilities and emergent orders. Despite extensive studies, direct evidence of FBs tuned to the chemical potential and their role in emergent orders in bulk materials remains lacking.

Biodegradable microplastics exacerbate the risk of antibiotic resistance genes pollution in agricultural soils.

The widespread emergence of antibiotic resistance genes (ARGs) poses a severe global health threat, exacerbated by agricultural practices such as fertilization and plastic mulch use. While biodegradable plastics are promoted as environmentally friendly alternatives to conventional plastics, their ecological impact on soil ARGs remains poorly understood. This study conducted incubation experiments using soils with distinct long-term fertilization histories (no fertilization CK, chemical fertilizer CF, and pig manure PM) collected from 14-year field experiment sites at Changshu National Agro-Ecosystem Observation and Research Station.

Design method for a rotating multi-structure spectrometer.

With the advancement of spectral technologies, fiber spectrometers have found widespread applications in scientific research, agriculture, biomedicine, and industrial production. Currently, conventional fiber spectrometers typically employ dispersive elements such as gratings or prisms in combination with array detectors to capture spectral information in a single exposure. However, the fixed detector size imposes a trade-off between spectral range and spectral resolution, thereby limiting instrument performance.

Associations of macronutrient intake patterns with accelerated biological ageing and life expectancy: Evidence from a population-based study in the UK Biobank.

Background: The associations of macronutrient intake with accelerated biological aging and life expectancy remain unclear.

Methods: In total, 56,555 participants in the UK Biobank were included. Macronutrient intake patterns, including overall low-carbohydrate-diet (LCD), low-fat-diet (LFD), low-protein-diet (LPD), low-animal-protein diet (LAPD), low-vegetable-protein diet (LVPD), low-animal-fat diet (LAFD), low-vegetable-fat diet (LVFD), and healthful plant-based diet index (hPDI), were assessed via the Oxford WebQ.

Laccase immobilized on amino acid ionic liquid-modified magnetic lignin nanoparticles and its degradation of 2,4-dichlorophenol.

Immobilized laccase demonstrates significant potential for 2,4-dichlorophenol (2,4-DCP) degradation in environmental remediation applications. However, challenges persist in optimizing carrier materials for enzyme immobilization. In this study, a magnetic lignin-based nanocomposite (FeO-SL) was synthesized and further functionalized with amino acid-derived ionic liquids (AAILs).

Exomeres From Adventitial Fibroblasts of Spontaneously Hypertensive Rats Promote Vascular Remodelling via Transferring Osteopontin.

Vascular adventitial fibroblasts (VAFs) contribute to vascular remodelling in hypertension. However, the mechanisms by which VAFs regulate vascular smooth muscle cells (VSMCs) in vascular remodelling are not well known. Here we report the crucial roles of extracellular nanoparticles exomeres (EMs) derived from VAFs in promoting VSMCs proliferation, migration and vascular remodelling in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR).

Investigation of in vitro delivery conditions for self-amplifying mRNA.

Self-amplifying mRNA (SAM) shows promise for vaccines and gene therapy because of its self-replicating ability. However, current studies lack sufficient information for systematic parameter optimization and differentiation from conventional non-replicating mRNA (NRM). Therefore, the transfection efficiency of NRM and SAM platforms was evaluated by comparing delivery vectors and optimizing parameters for the SAM protocol.

Association between serum uric acid levels and white matter hyperintensities in patients with mild ischemic stroke.

Objective: This study aims to investigate the association between uric acid (SUA) level and white matter hyperintensities (WMH) in patients with mild ischemic stroke.

Methods And Results: This study retrospectively analyzed 290 patients with mild ischemic Stroke who were hospitalized at the Second Hospital of Hebei Medical University from March 2021 to January 2022. General clinical information and laboratory test results were collected.

Oligosaccharide elicitors in plant immunity: Molecular mechanisms and disease resistance strategies.

The recognition of oligosaccharide elicitors, which originate from both pathogens and hosts, by membrane-localized receptors is of fundamental importance for triggering host immunity and disease resistance. It is therefore a topic of utmost significance for agricultural and botanical research. This review provides a comprehensive analysis of our current understanding of the types of oligosaccharide elicitors.